Dexmedetomidine, an alpha 2 agonist, has been approved for providing sedation in the intensive care unit. Along with sedative properties, it has analgesic activity through its highly selective action on alpha 2 receptors. Recent studies have examined the use of dexmedetomidine as an adjuvant to prolong the duration of peripheral nerve blocks. Studies showing effectiveness of dexmedetomidine for adductor canal block in knee surgery are small. Also, its effectiveness has not been compared to Epinephrine which is a strong alpha and beta receptor agonist. In a previous study, we showed that motor sparing knee blocks significantly increased the duration of analgesia compared with periarticular knee infiltration using local anesthetic mixture containing Epinephrine following total knee arthroplasty (TKA). In this study, we compared two local anesthetic mixtures: one containing Dexmedetomidine and the other Epinephrine for prolongation of motor sparing knee block in primary TKA patients.

After local ethics board approval and gaining Notice of Compliance (NOC) from Health Canada for use of Dexmedetomidine perineurally, 70 patients between the ages 18 – 95 of ASA class I to III undergoing unilateral primary total knee arthroplasty were enrolled. Motor sparing knee block − 1) Adductor canal continuous catheter 2) Single shot Lateral Femoral Cutaneous Nerve block 3) Single shot posterior knee infiltration was performed in all patients using 60 ml mixture of 0.5% Ropivacaine, 10 mg Morphine, 30 mg Ketorolac. Patients randomized into the Dexmedetomidine group (D) received, in addition to the mixture, 1mcg/kg Dexmedetomidine and the Epinephrine (E) group received 200mcg in the mixture. The primary outcome was time to first rescue analgesia as a surrogate for duration of analgesia and secondary outcomes were NRS pain scores up to 24 hours and opioid consumption.

The time to first rescue analgesia was not significantly different between Epinephrine and dexmedetomidine groups, Mean and SD 18.45 ± 12.98 hours vs 16.63 ± 11.80 hours with a mean difference of 1.82 hours (95% CI −4.54 to 8.18 hours) and p value of 0.57. Pain scores at 4, 6, 12, 18 and 24 hours were comparable between groups. Mean NRS pain scores Epinephrine vs Dexmedetomidine groups were 1.03 vs 0.80 at 4 hours, 1.48 vs 3.03 at 6 hours, 3.97 vs 4.93 at 12 hours, 5.31 vs 6.18 and 6.59 v 6.12 at 24 hours. Opioid consumption was also not statistically significant between both groups at 6, 12 18, 24 hours (p values 0.18, 0.88, 0.09, 0.64 respectively).

Dexmedetomidine does not prolong the duration of knee motor sparing blocks when compared to Epinephrine for total knee arthroplasty. Pain scores and opioid consumption was also comparable in both groups. Further studies using higher dose of dexmedetomidine are warranted.

Introduction

Total hip arthroplasty (THA) is an effective surgery for the treatment of advanced osteoarthritis but increasing numbers of these procedures are having a significant impact on healthcare budgets. One route to mitigate the increasing costs is outpatient THA, discharging patients on the same day as their surgery. The purpose of this study was to determine the cost of outpatient THA compared to standard overnight stay in hospital.

Purpose

Patient expectations of total knee arthroplasty (TKA) can be managed through education. E-learning is the application of information technology to education. Providing information to patients at the place and time of their choosing, e-learning has the potential to broaden the reach of existing services for patients. This study evaluated whether an e-learning tool could affect whether patients felt their expectations were met and whether they were satisfied with surgery one year following primary TKA.

The purpose of our study was to prospectively examine early functional differences in gait between the direct anterior and direct lateral surgical approaches for total hip arthroplasty over the first three months postoperatively.

Forty participants were prospectively enrolled to either the direct anterior (20 patients) or direct lateral group (20 patients) based on their surgeon's expertise. Outcome measures were collected preoperatively at their preadmission appointment and postoperatively at discharge from the hospital, two weeks, six weeks and three months. We used the GAITRite® system to measure gait velocity, stride length, single-limb support and single-limb support symmetry. We also had participants complete the Timed Up and Go test and a series of questionnaires at each visit: WOMAC, SF-12, Harris Hip Score, and pain VAS.

Our primary outcome, gait velocity, was significantly greater in the direct anterior group at discharge and six weeks postoperatively with adjusted mean differences of 0.12m/s and 0.17m/s respectively. Single-limb support symmetry was also significantly better in the direct anterior group at two weeks, six weeks and three months with adjusted mean differences of 0.10, 0.09 and 0.04 respectively. The direct anterior group also had significantly shorter times to complete the Timed Up and Go test at two and six weeks with adjusted mean differences of −9.02s and −2.64s. There were no differences between the groups at any time point for the WOMAC, SF-12, Harris Hip Score, or pain VAS.

Preliminary results of our expertise-based study have found the direct anterior approach to total hip arthroplasty offers better early functional outcomes than the direct lateral approach.

The benefit of using a long intramedullary device for the treatment of geriatric intertrochanteric hip fractures is unknown. The InterTAN device (Smith and Nephew, Memphis TN) is offered in either Short (180–200 mm) or Long (260–460 mm) constructs and was designed to provide stable compression across primary intertrochanteric fracture fragments. The objective of our study was to determine whether Short InterTANs are equivalent to Long InterTANs in terms of functional and adverse outcomes for the treatment of geriatric intertrochanteric hip fractures.

108 patients with OTA classification 31A–1 and 31A–2 intertrochanteric hip fractures were included in our study and prospectively followed at one of four Canadian Level-1 Trauma Centres. Our primary outcomes included two validated primary outcome measures: the Functional Independence Measure (FIM), to measure function, and the Timed Up and Go (TUG), to measure motor performance. Secondary outcome measures included blood loss, length of procedure, length of stay and adverse events. A pre-injury FIM was measured by retrospective recall and all postoperative outcomes were assessed on postoperative day 3, at discharge, at 6 weeks, 3 months, 6 months and 12 months postoperatively. Unpaired t-tests and Chi-square tests were used for the comparison of continuous and categorical variables respectively between the Short and Long InterTAN groups. A statistically significant difference was defined as p<0.05.

Our study included 71 Short InterTAN and 37 Long InterTAN patients with 31A–1 and 31A–2 intertrochanteric hip fractures. Age, sex, BMI, side, living status and comorbidities were similar between the two groups. The mean operative time was significantly lower in the Short InterTAN group (61 mins) as compared to the Long InterTAN group (71 mins)(p0.05). There were 5 periprosthetic femur fractures in the short InterTAN group versus 1 in the long InterTAN group. Non-mechanical adverse outcomes such as myocardial infarction, pulmonary embolism, urinary tract infections, pneumonia and death all had similar incidence rates between the two InterTAN groups.

Both the Short and Long InterTAN patient cohorts displayed similar improvements in performance and overall function over the course of a year following intertrochanteric hip fracture fixation. The recorded operative times for Short InterTAN fixation were significantly shorter than those recorded for the Long InterTAN patients. Alternatively, a significantly higher proportion of Short InterTAN patients sustained periprosthetic femur fractures within a year of implantation as compared to the Long InterTAN group.

Pain immediately following total knee arthroplasty (TKA) is often severe and can inhibit patients' rehabilitation. Recently, adductor canal blocks have been shown to provide adequate analgesia and spare quadriceps muscle strength in the early postoperative period. We devised a single injection motor sparing knee block (MSB) by targeting the adductor canal and lateral femoral cutaneous nerve with a posterior knee infiltration under ultrasound. Our primary objective was to evaluate the analgesia duration of the MSB in comparison to a standard periarticular infiltration (PAI) analgesia using patients' first rescue analgesia as the end point. Secondary outcomes measured were quadriceps muscle strength and length of stay.

We randomised 82 patients scheduled for elective TKA to receive either the preoperative MSB (0.5% ropivacaine, 2.5ug/ml epinephrine, 10mg morphine, and 30mg ketorolac) or intraoperative periarticular infiltration (0.3% ropivacaine, 2.5ug/ml epinephrine, 10mg morphine, and 30mg ketorolac). Duration of analgesia, postoperative quadriceps power, and length of stay were evaluated postoperatively.

Analgesic duration was found to be significantly different between groups. The MSB had a mean duration of 18.06 ± 1.68 hours while the PAI group had a mean duration of 9.25 ± 1.68 hours for a mean difference of 8.8 hours (95% CI 3.98 to 13.62), p<0.01. There were no significant differences between groups in quadriceps muscle strength power at 20 minutes (p=0.91) or 6 hours (p=0.66) after block administration. Length of stay was also not significantly different between the groups (p=0.29).

Motor sparing blocks provide longer analgesia than patients receiving periarticular infiltration while not significantly reducing quadriceps muscle strength or increasing length of hospital stay.

Purpose

Blood transfusions cause morbidity and complications in hip fracture patients. This includes increased risk of bacterial infection, potentially increased mortality, and higher hospital costs. Factors such as delay from admission to surgery, fracture pattern, method of fixation, operating time, age, and gender, may affect transfusion requirements. The purpose of this study was to evaluate the effect of patient and operative factors on blood loss and transfusion requirements.

Purpose: A major issue in the Canadian health care system are the extensive wait times for consultation with an orthopaedic surgeon. We identified that a high percentage of patients referred to shoulder surgery sub-specialists for chronic full thickness rotator cuff tears had not undergone appropriate non-operative treatment prior to being referred, and ultimately did not require surgery. In an effort to improve the referral process and to optimize patient care, we sought to identify clinical predictors for outcome of non-operative treatment of chronic full-thickness rotator cuff tears. This would allow general practitioners to clearly identify patients who are most likely to fail non-operative treatment and actually require surgical consultation. The primary purpose of this study was to determine if the outcome of non-operative treatment in chronic, symptomatic, full-thickness rotator cuff tears could be predicted based upon presenting clinical characteristics, including: age, dominant extremity involvement, gender, duration of symptoms, onset (acute or chronic), forward elevation range of motion, external rotation strength, size of tear, smoking status, and the Rotator Cuff Quality of Life Questionnaire score (RCQOL).

Method: Fifty patients, between the ages of 40 and 85 years, with a documented full-thickness tear on ultrasound or magnetic resonance imaging (MRI), were recruited prospectively. They underwent a three month home-based program of non-operative treatment under the supervision of an experienced physiotherapist and sport medicine physician. At the conclusion of the three month program, patients were evaluated by an orthopaedic surgeon and were defined as having been successful or as having failed non-operative treatment. Successful patients declined surgical treatment after consulting with the surgeon, whereas failed patients elected to undergo surgery, or, if avoiding surgery for other health or “life” reasons, had not experienced adequate improvement with the non-operative program to have been considered successful. The patient’s baseline clinical characteristics were analyzed using logistic regression to determine which characteristics were predictive of outcome.

Results: Thirty-eight of 50 (76%) of patients were successful with the non-operative program. Univariate analysis showed that a patient’s Rotator Cuff Quality of Life questionnaire score was a significant predictor of outcome of non-operative treatment (p = 0.017). Patients who were successful with non-operative treatment had a mean baseline RCQOL score of 49/100, whereas patients who failed non-operative treatment had a mean baseline RCQOL score of 31/100. The two factors of patient age and dominant extremity involvement also trended toward significance.

Conclusion: Baseline RCQOL score can predict which patients will be successful with non-operative treatment and which patients will fail non-operative treatment for a chronic, full-thickness rotator cuff tear.

Purpose: Medial compartment osteoarthritis (OA) is the most common primary osteoarthritis of the knee, but the treatment of this disease in young patients remains controversial. High tibial osteotomy (HTO), medial unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) are all viable options. Gait analysis is one tool available to clinically assess knee kinematics, and may prove to be a good way of predicting functional outcomes of these different surgical procedures. The purpose of this study was to compare the knee kinematics, function, and quality of life of patients that underwent either a medial opening wedge HTO, UKA, or TKA for primary medial compartment OA.

Method: A matched prospective cohort study of patients between the ages of 45 and 65 who had undergone an HTO, UKA, or TKA for primary medial compartment knee OA was undertaken over a 3-year period. Primary outcome measures were gait variables, namely knee adduction moments, as measured through gait analysis. Secondary measures included quality of life (WOMAC), functional performance tests (six minute walk and timed-up-and-go), self-reported functional ability (LEFS), and general health (SF-36). Gait and functional performance tests were evaluated preoperatively and at 6, 12, and 24 months postoperatively. Self-reported quality of life, function and general health were assessed preoperatively and at 3, 6, 12, and 24 months post-operatively.

Results: Twenty HTOs, 19 medial UKAs, and 17 TKAs were matched for Kellgren-Lawrence grade of medial OA, age at surgery, and body mass index. Significant differences were observed between the three groups in step length and peak adduction moments at 24 months. Significant differences were observed in preoperative WOMAC pain and function scores, KOOS pain scores, and LEFS, but no significantly different outcome measures were observed postoperatively. Lateral Black-burne-Peel and modified Insall-Salvati ratios were the only significant radiographic differences observed between groups at 24 months.

Conclusion: To our knowledge, no gait analysis study exists comparing the medial opening wedge HTO to UKA or TKA. The results of this study suggest that most gait variables except step length and knee adduction moments are similar between groups. Moreover, except for patellar height, there were no major functional or radiographic differences between these groups.

Purpose: The purpose of this randomised controlled trial was to compare outcomes of operative and non-operative management of Achilles tendon ruptures.

Method: Patients with acute complete Achilles tendon ruptures were randomised to receive open suture repair followed by graduated rehabilitation or graduated rehabilitation alone. The primary outcome measure was re-rupture rate. Assessments at three and six months, and one and two years included a modified Leppelhati score (no strength data), range of motion, calf circumference, and isokinetic strength at one and two years. We report the two year findings.

Results: Two centres randomized 145 patients (118 males and 27 females), mean age 40.9±8.8 years (22.5 – 67.2) to operative (n=73) and non-operative (n=72) treatment. Fourteen were lost to follow-up. Re-rupture occurred in three patients in both groups. The mean modified Lep-pelhati score (out of 85) was 78.2±7.7 in the operative group and 79.7±7.0 in the non-operative group, which was not significant (−1.5 95%CI −6.4 to 3.5, p=0.55). Mean side-to-side difference in plantar flexion and calf-circumference in the operative group was −2.0±3.2° and −1.4±1.2cm, and in the non-operative group −0.9±3.0°and −1.6±1.8cm respectively. Mean isokinetic plantar flexion strength was 62.4±24.2 for the operative and 56.7±19.3 for the non-operative group, which was not significant (5.7, 95%CI −3.1 to 14.5, p=0.20). There were a greater number of serious adverse events in the operative group, including pulmonary embolus in one patient, deep vein thrombosis in one and deep infections requiring irrigation and debridement in three.

Conclusion: This study suggests that non-operative management of Achilles tendon ruptures utilizing an accelerated rehabilitation programme may produce comparable results with fewer adverse events.

Purpose: To clinically evaluate the medium term outcome of a patient cohort age 55 years or older at the time of medial opening wedge high tibial osteotomy (MOWHTO).

Methods: Between January 1997 and January 2003, 60 patients (52 males) underwent 66 MOWHTOs. Following a systematic chart review 56 returned for follow up. Outcomes measures were KOOS, LEFS, SF-12, Cincinnati, Tegner scores, a new activity score and physical examination. Routine knee and long leg standing radiographs were compared to pre and early postoperative radiographs.

Results: Thirteen patients were not assessed further, 6 (7 MOWHTOs) had undergone total knee arthroplasty (TKA), 3 had passed away and 4 were lost to follow up. Thus the probability of survival (not converting MOWHTO to TKA) was 0.966 at 3 years, 0.927 at 4 years and 0.878 at 5 years. Quality of life, functional status and general health of the remaining 47 patients (52 HTOs) with a mean age of 62 years (55–75) at the time of surgery were assessed. At a mean follow up of 62 months (26–98), on the author’s activity score, 83% performed at least one high impact activity at moderate to high intensity an average of 4–7 times per week and 6% did not participate in any sport. Average participation in activities/sports was 3 per person at a participation level of 4.6 (Tegner). The mean Cincinnati score was 75% (SD=23, 14–95%). Mean scores for the KOOS and LEFS were 66% (SD=22, 7–99%) and 49 (SD=18, 5–80) respectively. Seventy–two percent were fully weight bearing by 3 months. There were 6 revisions for a combination of delayed and non-unions.

Conclusions: MOWHTO remains a viable alternative for patients over the age of 55 with knee osteoarthritis and varus malalignment who would otherwise be candidates for arthroplasty and particularly for those wishing to maintain or regain a high level of activity.

To examine the effect of gender on outcome of high tibial osteotomy (HTO) for varus gonarthrosis at a minimum two year follow-up

Sixty-five patients (twenty-four female and forty-one male) participated in this investigation. Mean age at the time of surgery was fifty-five years and mean time to follow-up was 54.83 months. Multiple linear regression was used to estimate the strength of the association between post-operative WOMAC osteoarthritis index scores and the independent variables of gender, age, BMI, time (months from surgery) and pre and post operative mechanical axis angles (MAA) measured on standing double-leg hip-to-ankle radiographs.

This analysis revealed that none of the independent variables contributed significantly to the WOMAC outcome scores.

The results of this study indicate that gender is not a significant predictor of outome following medial opening wedge HTO. This is contrary to the view held by many.

The purpose of this study was to determine if there is a relationship between ultrasound measured gap size and functional outcomes in non-operatively treated achilles tendon ruptures.

Patients who presented with complete achilles tendon ruptures were prospectively randomised to operative or non-operative treatment groups and followed over a one year period. The non-operative patients were selected and reassessed at three months, six months and one year. Patients were included if seen within seven days of their injury and had ultrasound confirmation of a complete tear. Non-operative treatment consisted of a functional bracing protocol with an aircast boot. Ultrasound measures included tear location and gap size in neutral, dorsiflexion, and plantar flexion of the ankle. Outcome measures were re-rupture rates, complications, range of motion, calf circumference, strength, and functional outcome scores.

Twenty-five patients were included with complete data. The mean plantar flexion gap was 5.6(+/−7.5mm). The mean dorsiflexion gap was 13.7(+/−12.5mm). Proximal tears were found in 41% of patients, midsubstance in 27%, and distal tears in 32%. At one year follow-up 71% of patients had excellent results with the remaining 29% showing good results. Isokinetic strength, range of motion, and calf circumference measurements were all greater than 90% relative to the contralateral extremity. There were two reruptures and no other complications present. There were no significant relationships between plantar or dorsiflexion gap size and functional outcomes scores or tear location.

Gap size was not significantly related to functional outcomes. Non-operative treatment produced very good results at one year follow-up with low complication rates. These results suggest that ultrasound estimation of gap size and location may be of limited clinical value in the management of achilles tendon ruptures.

Summary Results of this two-group parallel design randomised controlled trial indicated one and two year outcomes following ACL reconstruction were not different in one hundred and fifty patients using either an ACL functional knee brace or neoprene knee sleeve. Introduction: The primary objective of this study was to compare postoperative outcomes in patients using an ACL functional knee brace and patients using a neoprene knee sleeve

One hundred and fifty patients were randomised to receive an ACL functional knee brace (n=76) or a neoprene sleeve (n=74) at their six week postoperative visit following primary ACL reconstruction. Patients were instructed to wear the knee orthosis during participation in all physical activities. Patients were assessed preoperatively, six weeks, six, twelve, eighteen and twenty-four months postoperatively. Outcome measures included disease-specific quality of life (ACL QOL), KT 1000 and single limb forward hop test administered by a blinded research assistant. One and two-year outcomes were compared after adjusting for baseline scores. A priori directional subgroup hypotheses based on time from injury to surgery, pre-operative KT 1000 scores, and one and two-year compliance scores were evaluated using tests for interactions. Analysis was completed on an intention-to-treat basis.

There were no significant between-group differences for any of the outcomes at one and two-year follow-ups. Mean between-group differences at two years were: 2.87% (95% CI: −3.85 – 9.60) for the ACL QOL, 0.07mm (95% CI: −0.80 – 0.93) for KT 1000 side-to-side difference, and 2.64% (95% CI: −4.57 – 9.85) for hop limb symmetry index. There were no significant subgroup findings and adverse events were similar between groups.

Confidence intervals for between-group differences are narrow and exclude clinically important differences. These findings suggest a functional knee brace does not result in superior outcomes over a neoprene sleeve following ACL reconstruction.

Purpose: To clinically and radiologically evaluate medium term outcome of a patient cohort age 55 years or older at the time of medial opening wedge high tibial osteotomy (MOWHTO).

Methods: Between January 1997 and January 2003, 60 patients (52 males) underwent 66 MOWHTOs. Following a systematic chart review 56 returned for follow up. Outcomes measures were KOOS, LEFS, SF-12, Cincinnati, Tegner scores, a new activity score and physical examination. Routine knee and long leg standing radiographs were compared to pre and early postoperative radiographs.

Results: Thirteen patients were not assessed further, 6 (7 MOWHTOs) had undergone total knee arthroplasty (TKA), 3 had passed away and 4 were lost to follow up. Thus the probability of survival (not converting MOWHTO to TKA) was 0.966 at 3 years, 0.927 at 4 years and 0.878 at 5 years. Quality of life, functional status and general health of the remaining 47 patients (52 HTOs) with a mean age of 62 years (55–75) at the time of surgery were assessed. At a mean follow up of 62 months (26–98), on the author’s activity score, 83% performed at least one high impact activity at moderate to high intensity an average of 4–7 times weekly and 6% did not participate in any sport. Average participation in activities/sports was 3 per person at a participation level of 4.6 (Tegner). The mean Cincinnati score was 75% (SD=23, 14–95%). Mean scores for the KOOS and LEFS were 66% (SD=22,7–99%) and 49 (SD=18, 5–80) respectively. The mean physical component score of the SF-12 was 42 (SD=11, 21.7–60.4) and the mean mental component score, 54 (SD=11, 26–68). Seventy–two percent were fully weight bearing by 3 months. There were 6 revisions performed for a combination of delayed and non-unions.

Conclusions: MOWHTO remains a viable alternative for patients over the age of 55 with knee osteoarthritis and varus malalignment who would otherwise be candidates for arthroplasty and particularly for those wishing to maintain or regain a high level of activity.

Purpose: To compare lateral closing to medial opening wedge HTO for a similar angle of correction with regard to change in proximal tibial bony anatomy and posterior cruciate ligament tibial attachment integrity following standard tibial arthroplasty resection.

Methods: Ten cadaveric lower limbs were randomized by side to receive a 12° lateral closing or 12.5mm medial opening wedge HTO. Anteroposterior, lateral and long leg AP radiographs were performed before and after each osteotomy. Pre and post osteotomy measurements of the coronal proximal tibial angle (PTA), sagittal tibial slope and anatomical femorotibial angle were completed and change in angles calculated. Prior to osteotomy, the tibial PCL attachment area was calculated. Post osteotomy, a standardized tibial arthroplasty resection was performed and the remaining percentage PCL attachment area recorded.

Results: Initial radiographs demonstrated little variation between matched pairs. Compared to the medial opening wedge group, the lateral closing wedge specimens demonstrated a statistically significant greater mean change in the PTA of 3.5° (95% C.I., 2.0 to 5.1°, p = 0.003) and an overall tendency for posterior tibial slope reduction with a mean change of −3.4 ± 4.9°. The average osteotomy angle in the medial opening wedge specimens was 11.9 ± 0.7°. Following tibial arthroplasty resection, there was a significant difference in the remaining PCL tibial attachment percentage area of 84.6 ±14.9 % for medial opening wedge and 50.8 ± 19.3 % for lateral closing wedge for a statistically significant mean difference of 33.8 % (95% C.I. 5.1 to 62.4, p = 0.031).

Conclusions: Despite similar correction angles of 12° for lateral closing and 11.9° for medial opening, the former specimens demonstrated a greater alteration in proximal tibial bony anatomy compared to the latter. In the lateral closing wedge group, the tendency to reduce posterior tibial slope and produce a greater than anticipated change in PTA had a significant effect on the integrity of the PCL’s tibial attachment following tibial arthroplasty resection.