The purpose of this study was to analyze the patellofemoral kinematics in neglected adult developmental dysplasia of the hip patients with patellofemoral symptoms and tried to clarify the affect of the severity of dislocation, the amount of limb length discrepancy, the deviation of mechanical axis and the changes in femoral anteversion on patellofemoral alignment. The dynamic patellofemoral CT results of 39 patients with DDH suffering from knee pain were reviewed. The mean age was 40.07 (range: 22–61). 14 of them were bilateral and 25 were unilateral neglected DDH patients. The CT results of 12 patients suffering from unilateral patellofemoral pain following the treatment of locked intramedullary nailing was taken as control group. In this patients atraumatic and asymptomatic normal site was taken as control group.Aim
Methods
Because endothelins (ET) have effects on functions of both osteoblasts and osteoclasts, it is thought that these peptides may be one of the mediators of coupling phenomena that maintain the connection and regulation between bone formation and resorption process in osteogenesis. Along with their demonstrated effects on osteogenic cells they have dual activity on both mineralization and resorption process. So it is also thought that they may have a major role in bone turnover and remodeling processes. We aimed to investigate if ET had a role in the pathophysiology of osteoporosis. Therefore we looked for a difference in ET plasma levels between osteoporotic and normal people. 86 patients (16 men and 70 women) with a mean age of 62.6 (ranges: 51–90) years were included in this study. All patients were examined by dual energy X-ray absorbsiometry evaluation at first. Patients were divided into 3 groups regarding reported T scores. T-scores less than −2.5 on either total lumbar spine or total hip were accepted as osteoporosis, while scores between −1 and −2.5 were accepted as osteopenia and scores above −1 were accepted as normal according to the suggestions of World Health Organization. According to these criteria 19 patients were normal, 43 were osteopenic and 24 were osteoporotic. Then total plasma level of ET was measured in all patients with monoclonal antibody based sandwich immunoassay (EIA) method. One-way analysis of variance test was used to compare endothelin values between normals, osteopenics and osteoporotics regardless of gender and for each gender. A value of p<
0.05 was considered as significant. Endothelin total plasma level in patients with osteoporosis was a mean of 98.3663.96 pg/ml, a mean of 100.9247.2 pg/ml in osteopenic group and a mean of 99.5656.6 pg/ml in normal group. The difference between groups was not significant (p>
0.05). In men with osteoporosis endothelin level was a mean of 185.7017.2 pg/ml and this was significantly higher than osteopenic men (124.8059.6 pg/ml) (p<
0.05) and normal men (93.0050.1pg/ml) (p<
0.05). In women there was not any significant difference between groups (normal:102.0060.7pg/ml, osteopenics: 94.7042.7pg/ml, osteoporotics: 79.9053.8pg/ml) (p>
0.05). We found out that plasma ET levels of osteoporotic men were significantly higher than normal men. But comparison regardless of gender among osteoporotics, osteopenics and normals and comparison of female osteoporotics, osteopenics and normals yielded no significant differences. We think that the reason for differences in our results regarding gender may be the higher estrogen level of the females even if they were in the postmenopausal period and thus estrogens’ possible effect of down regulation in ET-1. Considering these results we think that ET may have a role in the pathophysiology of the men osteoporosis and it can be used as a marker for diagnosis and treatment follow-up of osteoporosis.
We aimed to determine if there are mechanoreceptors in hip joint capsule and ligamentum capitis femoris of the patients with developmental dysplasia of the hip. We took capsule and ligamentum capitis femoris biopsies from 20 hips of 20 patients who were operated because of developmental dysplasia of the hip. Meanage was 10.2 months (ranges 6-20 months) on the time of surgery. There were 12 girls and 8 boys. Teratologic and secondary hip dislocations were not included in this study. 0.5x 0.5 cm full thickness anterior capsule and liga-mentum capitis femoris portions were taken for biopsy specimen. Specimens were stained with hemotoxylin eosin and examined immunohistochemically using poly-clonal antibodyagainst S-100 Protein. In both analysis no mechanoreceptors was found in any samples of capsule and ligamentum capitis femoris. Conclusion: We think that there is a possibility that developmental dysplasia of the hip can be caused from a defect in formation of mechanoreceptors on localized capsule and ligamentum capitis femoris and we emphasize the need for further studies on the subject.