Increasing expectations from arthroscopic anterior cruciate ligament (ACL) reconstructions require precise knowledge of technical details such as minimum intra-femoral tunnel graft lengths. A common belief of having ≥20mm of grafts within the femoral tunnel is backed mostly by hearsay rather than scientific proof. We examined clinico-radiological outcomes in patients with intra-femoral tunnel graft lengths <20 and ≥20mm. Primary outcomes were knee scores at 1-year. Secondarily, graft revascularization was compared using magnetic resonance imaging (MRI). We hypothesized that outcomes would be independent of intra-femoral tunnel graft lengths. This prospective, single-surgeon, cohort study was conducted at a tertiary care teaching centre between 2015–2018 after obtaining ethical clearances and consents. Eligible arthroscopic ACL reconstruction patients were sequentially divided into 2 groups based on the intra-femoral tunnel graft lengths (A: < 20 mm, n = 27; and B: ≥ 20 mm, n = 25). Exclusions were made for those > 45 years of age, with chondral and/or multi-ligamentous injuries and with systemic pathologies. All patients were postoperatively examined and scored (Lysholm and modified Cincinnati scores) at 3, 6 and 12 months. Graft vascularity was assessed by signal-to-noise quotient ratio (SNQR) using MRI. Statistical significance was set at p<0.05. Age and sex-matched patients of both groups were followed to 1 year (1 dropout in each). Mean femoral and tibial tunnel diameters (P =0.225 and 0.595) were comparable. Groups A (<20mm) and B (≥20mm) had 27 and 25 patients respectively. At 3 months, 2 group A patients and 1 group B patient had grade 1 Lachman (increased at 12 months to 4 and 3 patients respectively). Pivot shift was negative in all patients. Lysholm scores at 3 and 6 months were comparable (P3= 0.195 and P6= 0.133). At 1 year both groups showed comparable Cincinnati scores. Mean ROM was satisfactory (≥130 degrees) in all but 2 patients of each group (125–130 degrees). MRI scans at 3 months and 1 year observed anatomical tunnels in all without any complications. Femoral tunnel signals in both groups showed a fall from 3–12 months indicating onset of maturation of graft at femoral tunnel. Our hypothesis, clinical and radiological outcomes would be independent of intra-tunnel graft lengths on the femoral aspect, did therefore prove correct. Intra-femoral tunnel graft lengths of <20 mm did not compromise early clinical and functional outcomes of ACL reconstructions. There seems to be no minimum length of graft within the tunnel below which suboptimal results should be expected

Increased collection of patient-reported outcome measures (PROM) in registries enables international comparison of patient-centered outcomes after knee and hip replacement. We aimed to investigate 1) variations in PROM improvement, 2) the possible confounding factor of BMI, and 3) differences in comorbidity distributions between registries. Registries affiliated with the International Society of Arthroplasty Registries (ISAR) or OECD membership countries were invited to report aggregate EQ-5D, OKS, OHS, HOOS-PS and KOOS-PS values. Eligible patients underwent primary total, unilateral knee or hip replacement for osteoarthritis within three years and had completed PROMs preoperatively and either 6 or 12 months postoperatively, excluding patients with subsequent revisions. For each PROM cohort, Chi-square tests were performed for BMI distributions across registries and 12 predefined PROM strata (male/female, age 20-64/65-74/>75, high or low preoperative PROM scores). Comorbidity distributions were reported for available comorbidity indexes. Thirteen registries from 9 countries contributed data, n~130000 knee (range 140 to 79848) and n~113000 hip (range 137 to 85281). Mean EQ-5D index values (10 registries) ranged from 0.53 to 0.71 (knee) and 0.50 to 0.70 (hips) preoperatively and 0.78 to 0.85 (knee) and 0.83 to 0.87 (hip) postoperatively. Mean OKS (6 registries) ranged from 19.3 to 23.6 preoperatively and 36.2 to 41.2 postoperatively. Mean OHS (7 registries) ranged from 18.0 to 23.2 preoperatively and 39.8 to 44.2 postoperatively. Four registries reported KOOS-PS and three reported HOOS-PS. Proportions of patients with BMI >30 ranged from 35 to 62% (10 knee registries) and 16 to 43% (11 hip registries). For both knee and hip registries, distributions of patients across six BMI categories differed significantly among registries (p30 were for patients in the youngest age groups (20 to 64 and 65 to 74 years) with the lowest baseline scores. Additionally, females with lowest preoperative PROM scores had highest BMI. These findings were echoed for the OHS and OKS cohorts. Proportions of patients with ASA scores ≥3 ranged from 7 to 42% (9 knee registries) and 6 to 35% (8 hip registries). PROM-score improvement varies between international registries, which may be partially explained by differences in age, sex and preoperative scores. BMI and comorbidity may be relevant to adjust for

In total knee arthroplasty (TKA), both intravenous (IV) and/or intra-articular (IA) administration of tranexamic acid (TXA) were showed to reduce blood loss. Moreover, research suggesting TXA decreases postoperative knee swelling, but it is unknown whether this results in improved postoperative rehabilitation outcome. Thus, the aim of this study was to evaluate whether combined IV and IA administration of TXA would associate with improved early rehabilitation outcomes. In this institutional review board approved randomized controlled trial, 179 patients scheduled for unilateral TKA were randomized to one of three regimens: (1) IA administration of 1gm TXA at end of procedure only, (2) additional preoperative IV dose of 15 mg/kg 30min before tourniquet inflation, and (3) additional postoperative dose 4hrs after preoperative dose. Primary outcomes included knee range of motion, Knee Society Score (KSS) at 6-month postoperatively, haemoglobin drop at day-2 post-operatively, and transfusion rate. Secondary outcome was venous thromboembolism (VTE) complications. Baseline characteristics were comparable between the allocation groups. Patients in regimen (3) showed statistically significant better knee extension range (6.2°, 5.9°, 2.9°, p=0.01), and KSS (88.5, 89.9, 93.0, p=0.02) at 6-month postoperatively, and lesser drop in haemoglobin at day-2 post-operatively (2.72, 2.47, 1.75 g/dL, p=0) when compared with patients in other regimens. No patients required transfusion, or complicated by VTE. The combined administration of IA and IV TXA, including both preoperative and postoperative doses, associated with statistically significantly improved early rehabilitation outcomes. The improvement may be related to higher haemoglobin level and decreased knee swelling in patients having regimen (3). For any reader queries, please contact . cpk464@yahoo.com.hk

Fifteen-year survivorships studies demonstrate that total knee replacements have excellent survivorship, with reports of 85 to 97%. However, excellent survivorship does not equate to excellent patient reported outcomes. Total knee imbalance with either too tight or loose soft tissues account for up to 54% of revisions in one series. This may account for many of the 20% unsatisfactory total knee arthroplasty outcomes. Soft tissue balancing technique is more like an art. The surgeon relies on subjective feel for appropriate ligamentous tension. Surgical experience and case volume play a major role in each surgeon's relative skill in balancing the knee properly. New technology of “smart trials” with embedded microelectronics and accelerometers, used in the knee with the medial retinaculum closed, can provide dynamic, intraoperative feedback regarding knee quantitative compartment pressures and component tracking. After all bone cuts are made using the surgeon's preferred techniques, trial components with the sensor tibial trial are inserted and the knee is taken through a passive range of motion. After visualizing the resultant compartment pressures and tracking data on a graphical interface, imbalance situations such as a too tight MCL or ITB, an incompetent or too tight PCL, or malrotated femoral or tibial component can be identified. A decision can be made as to whether to recut the bone to realign components, do a soft tissue release, or a combination of both. Soft tissue releases can be titrated while observing equalizing compartment pressures. Sensor feedback improves soft tissue balancing. More balanced compartments occur using a sensor trial than with standard soft tissue balancing technique blinded to sensor information. A multicenter three year study has shown that having the medial and lateral compartments in flexion and extension balanced within 15 pounds provides better outcomes. Patients with quantitatively balanced TKA with <15lbf mediolateral load differential have better forgotten knee scores at six weeks and six months. Use of smart trials is a new approach to total knee replacement surgery allowing fine tune balancing and takes soft tissue balancing from art to science

Introduction. Early complication post total knee replacement reported to be higher in obese patient in general. Also the outcome of cruciate retaining and PS knee has been fully discussed before and there was no major difference in the outcomes for all the patients overall regardless of their weight. However, the purpose of this paper is to find out if the CR knee has superiority over PS knee in terms of clinical and functional outcomes and if early complication postTKR such as fracture and instability is more common in PS implant than in CR knee. This is a retrospective study comparing two groups of obese patients. The first using PS implant and the other using CR implant. These two groups were matched for age, body mass and severity of deformity. Materials & Methods. At our institution we have been using Persona implant which has the option of using PS insert or a CR. The decision to proceed with CR or PS mainly depends on the availability of the implant and also the ability to well balance the knee in patients. In most patients we try to proceed with CR implant. However, the flow of implant sometime sometimes limit us from using CR or the imbalance in the ligament force us to process with PS implant. We have reviewed a chart of over 200 patients in each group of obese patient they were done within the last three years. All cases had a minimum follow up of 6 months. Those groups were matched for body mass, age and severity of deformity. After matching the groups we documented Knee Society Score (KSS), Knee Society Function Score (KSFS), blood loss, post – operative pain and complications. All surgeries were performed by the same surgeon. Results. Our study showed that the clinical scores (KSS) in both groups were very close while significant differences were observed in functional scores (KSFS) for the CR knee. We had 8 cases of per-prosthetic fracture in the PS group and one in the CR implant. We had 4 revisions in the PS group for instability and MCL insufficiency and non in the CR implant. Infection, wound complication, blood loss, and patient satisfaction were same in both groups. Discussion. This study suggests a significant difference in functional outcomes, especially walking, stair climbing and the use of walking aids, between CR and PS that favors CR implant which may be related to the CR knee retaining proprioception and ligaments tension with balance. In addition, PS knee have more varus-valgus and mid-flexion laxity than CR knee throughout the range of motion which appear clearly in obese patient. On the other hand, the study clearly shows that the decrease incidence of peri-prosthetic fracture in the CR implant which could be easily explained by the fact that a good cortical bone is resected in order to make room for the PS spine. Also, the fact that resecting the posterior cruciate ligament might cause more stress on the implant versus the CR. Instability also were more common in the PS group. We believe this has to do with the fact that the PCL serve as a secondary constraint to the MCL. The presence of the PCL help maintain the stability in case of incidental injury to the MCL during surgery which was reported to be higher in obese patients. Conclusion. There is clear advantage of improving the outcomes or knee scores and decreasing the early postoperative complications in obese patient using CR knee and we strongly recommend using CR implant in obese patients in order to restore functionality faster and reduce the incidence of peri-prosthetic fracture and the revision for instability

The purpose of the following study was to present the general strategy for preserving the lower extremity by knee arthrodesis and to analyze the outcome of knee arthrodeses performed by a special modular system. Between 2009 and 2014 35 knee arthrodeses were performed. 23 patients were male, 12 female. The average age was 66 years (42 to 83 years). The patients underwent an average of 6 operations because of infected knee arthroplasties previous to the knee arthrodesis. The main pathogen was S. epidermidis followed by MRSA. The arthrodeses system included a non cemented femoral and tibial stem (press fit application plus two static locking screws). These were connected by a special stem to stem clamp. Immediate postoperative full weight-bearing was possible in 32 of 35 patients. We saw 4 recurrent infections (all connected to the patients, who did not show a full weight bearing after knee arthrodesis). In two cases re-revision surgery was successful and lead to a sufficient re-arthrodesis. In two cases above-knee-amputation was necessary. Peri-implant fractures were detected in 3 cases. All of them could be cured by changing the arthrodesis stem and to a longer one bridging the fracture. In one case a stem loosening was seen. This was as well addressed by the use of a longer stem. Knee arthrodesis by a modular non cemented system is a god alternative in order to preserve the weight-bearing lower extremity. The complication rate is rather high due to the fact, that this procedure presents the final alternative to do so in patients, who are in extremis in terms of a long lasting aggressive peri-arthroplasty infection the lead to massive destruction of the soft tissue around the knee and a significant loss of function

Introduction. Measured outcomes from knee joint arthroplasty (TKA) have primarily focused on surgeon-directed criteria, such as alignment, range of motion measured in the clinic, and implant durability, rather than on functional outcomes. There is strong evidence that subjective reporting by patients fails to capture objective real-life function. 1,2. We believe that the recent emphasis on clinical outcomes desired by the patient, as well as the need to demonstrate value, requires a new approach to patient outcomes that directly monitors ambulatory activity after surgery. We have developed and tested a system that: 1) autonomously identifies patients who are not progressing well in their recovery from TKA surgery; 2) characterizes patient activity profiles; 3) automatically alerts health care providers of patients who should be seen for additional follow-up. We anticipate that such a system could decrease secondary procedures such as manipulation under anesthesia (MUA) and reduce hospital re-admission rates thereby resulting in significant cost savings to the patient, the care providers, and insurers. Methods. The components of the system include: 1) A sensor package that is mounted correctly in relation to the knee joint (Figure 1a) and is suitable for long term use; 2) An application that runs under the Android operating system to communicate with the sensor and to gather subjective information (pain, satisfaction, perceived stability etc. together with a photograph of the surgical site (Figure 1b); 3) Software to upload the data from the phone to a remote server; 4) An analysis and reporting package that generates, among other metrics, a profile describing the patient's activity throughout the day, trends in the recovery process, and alerts for abnormal findings (Figure 1c). The system was pilot tested on 12 patients (7 females) who underwent TKA. Complete days of data collection were scheduled for each patient every two weeks until 12 weeks, starting during the second week after surgery. Results. Patients tolerated the system well and datasets of up to 13 hours long were recorded. There was a considerable variation between patients in the use of the prosthetic knee joint at a given time point after surgery. At 6 weeks post-surgery, for example, some relatively inactive subjects had less than 50 excursions per hour while active subjects exhibited more than 750 excursions per hour. It was notable that, in activities of daily living, subjects rarely used the extremes of the flexion range that had been measured during post-operative clinic visits. Examples of activity recognition during free-living will be presented. Discussion. A remote knee monitoring system has been designed and successfully tested in an outpatient setting. The system has revealed discrepancies between knee function measured during clinic visits and that measured remotely during free living. Remote monitoring after orthopaedic procedures adds an important new dimension to the assessment of patient outcome. Acknowledgments. This work was supported by grants from the Washington Research Foundation and The Wallace H. Coulter Translational Partnership at the University of Washington

Purpose. Total knee arthroplasty (TKA) is the preferred treatment for those with end stage osteoarthritis (OA) and severe functional limitations. With the demographic transition in society, TKA is being offered to a younger patient population. Younger patients are generally more active requiring an increased range of motion, and place greater physiological demands on the prosthesis than typical older patients. The mobile bearing (MB) total knee prosthesis has theoretically been designed to meet these demands. We conducted a meta-analysis and systematic review of randomized controlled trials comparing outcomes of MB and fixed bearing (FB) TKA. Method. After testing for publication bias and heterogeneity, the data were aggregated by fixed effects modelling. Our searches identified 14 studies for reporting our primary outcome of Knee Society Scores (KSS). We also pooled data for post-operative range of motion (ROM) and Hospital for Special Surgery scores (HSS). Results. The standard difference in mean outcome scores for KSS and HSS demonstrated no difference between groups (p = 0.902, and p = 0.426 respectively). Similarly, the pooled data for ROM showed no difference between groups (p = 0.265). Conclusion. The results of our systematic review and meta-analysis of the literature indicate that there are no significant differences between MB and FB TKA in the outcome measures of KSS, ROM or HSS at final follow up. Only 3 of 12 studies found any benefit of MB knees in terms of patient reported pain. There were no differences found between FB and MB regarding patellar instability or stair climbing ability. Implant longevity remains the only outcome measure in which MB implants may provide an advantage

Statement of purpose. Cement fixation of total knee replacement (TKR) is commonly cited as being the gold standard, with better long-term survival rates when compared to uncemented fixation so the authors set out to analyse the longterm survivorship without aseptic loosening in a series of 471 uncemented TKR. Methods. A consecutive single surgeon series of patients undergoing routine follow up after a hydroxyapatite coated, uncemented and cruciate retaining TKR performed from 1992 to 1995 were analysed. All patients were invited for clinical review and radiological assessment. Revision of the TKR for aseptic loosening was the primary outcome. Secondary outcomes included Knee Society Score (0–200), range of movement, secondary surgical interventions and the presence of polyethylene wear or osteolysis on plain radiography. Results. 471 TKRs were performed in 356 patients (115 bilateral). 432 TKRs were accounted for through follow up. 39 TKRs in 31 pts were lost to follow-up representing 8% who had a mean KSS of 176 at 10 yr f/u. Mean f/u time period was 16.4 yrs (range 15.1–18.5 yrs). Average age at f/u was 81 yrs. 11 TKR had been revised for aseptic loosening. 19 TKRs in 19 patients had had revision of femoral/tibial components for any reason. A further 7 TKRs had undergone polyethylene insert exchange leaving an overall revision rate of 9% or 91% survival without revision. Survivorship without aseptic loosening was 96% (95%CI of 91.9–98.1%) at up to 18 years. A competing risks analysis was undertaken in order to avoid overestimation of survivorship adjusted for the competing risk of death within the study group. This analysis estimated a cumulative risk of revision for aseptic loosening at 18 years of 4.5%. Mean KSS was 176 (SD 21.5). Mean range of movement was 113 degrees of flexion. Conclusion. Uncemented hydroxyapatite coated total knee replacement can achieve favourable long-term survivorship at least as good as that of cemented designs