Introduction. Temporary spanning fixation aims to provide bony stability whilst allowing access and resuscitation of traumatised soft-tissues. Conventional monolateral fixators are prone to half-pin morbidity in feet, variation in construct stability and limited weight-bearing potential. This study compares traditional delta-frame fixators to a circular trauma frame; a virtual tibial ring block spanned onto a fine-wire foot ring fixation. Materials and Methods. The two cohorts were compared for demographics and fracture patterns. The quality of initial reduction and the maintenance of reduction until definitive surgery was assessed by two authors and categorised into four domains. Secondary measures included fixator costs, time to definitive surgery and complications. Results. Fifty-six delta-frames and 48 circular fixators were statistically matched for demographics and fracture pattern. Good or excellent initial reduction was achieved in 51 (91%) delta-frames and 48 (100%) circular fixators (p=0.022). Loss of reduction was observed in 15 (27%) delta-frames and 3 (6%) circular fixators (p<0.001). Post-fixator dislocation occurred in five (9%) delta-frames and one (2%) circular fixator (p=0.147). Duration in spanned fixation was equivalent (11.5 and 11.6 days respectively, p=0.211). Three (5%) delta-frames and 12 (25%) circular fixators were used as definitive fixation. The mean hardware cost was £3,116 for delta-frames and £2,712 for circular fixators. Conclusions. Temporary circular fixation offers statistically superior intra-operative reduction and maintenance of reduction, facilitates weight-bearing and provides more opportunity as the definitive fixation. Circular fixation hardware proved to be less expensive and protected against further scheduled and unscheduled operations

Introduction. The vast majority of orthopaedic surgeons use C-arm fluoroscopy in the operating theatre when building a circular external fixator. In the absence of previous research in this area, we hypothesised that the surgeon who builds a circular external fixator is exposed to a greater amount of radiation purely as a result of the presence of the metallic fixator in the x-ray beam. The aim of our study therefore was to investigate how the presence of a circular external fixator affects the radiation dose to the surgeon and the surgical assistant. Materials & Methods. A simulated environment was created using a radiolucent operating table, an acrylic lower limb phantom (below knee segment), various configurations of metalic circular external fixation, and a standard size C-arm image intensifier. The variables investigated were 1. the amount of metal in the beam 2. the orientation of the beam (PA vertical vs lateral) 3. the horizonal distance of the person from the beam (surgeon vs assistant) and 4. the vertical distance of the various body parts from the beam (e.g. thyroid, groin). In terms of radiation dose, we recorded two things : 1. the dose produced by the image intensifier 2. the dose rate at standardised positions in the operating theatre. The latter was done using a solid-state survey sensor. These positions represented both where the surgeon and surgical assistant typically stand plus the heights of their various body regions relative to the operating table. Results. The effect of the presence of the circular external fixator : all frame constructs tested resulted in a statistically significant greater radiation dose both produced by the image intensifier and received by the surgical team. The effect of the beam orientation : the PA (vertical) orientation resulted in a statistically significant greater radiation dose for the surgeon than did the lateral orientation, but made no difference for the assistant. The effect of horizontal distance from the beam : unsurprisingly, the surgeon (who was closer to the beam) received a statistically significant greater radiation dose than the assistant. The effect of vertical distance from the beam : for the surgeon, the dose received was highest at the level of the phantom leg / frame, whilst for the assistant there was no statistically significant difference for any level. Conclusions. To our knowledge, this is the first study investigating the radiation dose rate to the orthopaedic surgeon when building a circular external fixator. We found that the surgeon does indeed receive a ‘double whammy’ because the image intensifier puts out a greater amount of radiation plus the metalic frame scatters more of the x-ray beam. Whilst the amounts are relatively small, we think that it's important to quantify doses that orthopaedic surgeons receive to ensure optimal radiation practices

Introduction. Circular external fixators are fundamental to lower limb reconstruction, primarily in situations with a high risk of infection such as open fractures. During the Covid-19 pandemic, use of circular frames in our unit decreased, following departmental approval, due to resource management and in keeping with BOA guidelines as we opted to “consider alternative techniques for patients who require soft tissue reconstruction to avoid multiple operations”. These alternatives included the use of internal fixation (plate osteosynthesis and intramedullary nailing) as a measure to reduce the number of hospital attendances for patients and to conserve resources. This change in practice has continued in part following the pandemic with the increased use of internal fixation in cases previously deemed unsuitable for such techniques. We present our experience of this treatment strategy in the management of complex lower limb injuries, focusing on outcomes and consider the lessons learnt. Materials & Methods. Data of patients with complex lower limb injuries treated before, during and after the pandemic were collected from our in-house trauma database, theatre records and follow up clinics. The rationale for choosing other techniques over a circular frame, the type of alternative technique used, the cost of such alternatives, the need for soft tissue reconstruction, time to recovery, complications and amputation rates were compared among groups. Results. These data suggest comparable outcomes between circular frames and alternative techniques can be achieved. A notable reduction in the number of circular frames applied during the review period was observed. Furthermore, frame fixation was associated with more frequent outpatient review and the associated implications for resource management. Conclusions. Conclusion: The Covid-19 pandemic has posed great challenges to the Trauma and Orthopaedic community, forcing us to be flexible by adopting alternative treatment methods to traditional circular external fixation. These alternatives have proven feasible and potentially more cost effective, prompting their adoption in the post pandemic era. However, this change of practice is not without potential consequences and continued investigation is warranted

Purpose of Study. Bicondylar tibial plateau fractures are serious injuries to a major weight bearing joint. These injuries are often associated with severe soft tissue injuries that complicate the surgical management. This retrospective study evaluates the management of these high-energy injuries with the use of limited open reduction and fine wire circular external fixation. Methods. Between July 2008 and June 2012, 54 consecutive patients (19 females and 35 males) with high-energy tibial plateau fractures were treated at our tertiary level government hospital. All patients were treated with limited open reduction, and cannulated screw fixation combined with fine wire circular external fixators as the definitive management. The records of these patients were reviewed. Results. Forty-six patients met the inclusion and exclusion criteria. Thirty-six patients had Schatzker type-VI and ten patients had Schatzker type-V fractures. All fractures united without loss of operative reduction. No wound complications, osteomyelitis or septic arthritis occurred. Average Knee Society Clinical Rating Score was 81.6, translating to good clinical results. Minor pin tract infection was the most common complication encountered. Conclusion. Fine wire circular external fixation combined with limited open reduction and cannulated screw fixation consistently produced good functional results without serious complications. NO DISCLOSURES

Purpose of the study:. Is circular external fixation a safe and effective method of managing closed distal third tibia fractures. These fractures are conventionally treated with plaster casts, intramedullary nails or plate fixation. These treatment modalities have complication rates in the literature of up to 16% malunion, 12% non-union, and 17% deep infections. Description and Methods:. Retrospective review of 18 patients with closed distal third tibia fractures, with or without extension into the ankle joint, treated with circular fixator systems and minimal percutaneous internal fixation of the intra-articular fragment if required. Patients were followed up for time to union, malunion incidence as well as incidence of pin tract and deep infection. Distal third fractures which were extra articular or with simple intra articular extension were included. (AO 43 A, B1, C1, C2 + AO 42 in distal third) Patients with pilon fractures (AO 43 B2, B3 and C3) were excluded. Summary of results:. The average time to union in these patients was 16 weeks (11–33 weeks). The non-union rate was 11.1% in comparison to 12% with conventional treatment. The malunion rate was 0% compared to 16% with conventional treatment. The incidence of pin tract infection was 16.6%, but no deep infections were noted, whilst conventional treatment shows deep infection in up to 17%. Conclusion:. Circular external fixation is a safe and efficient option in the treatment of distal tibia fractures. The incidence of complications is significantly reduced in comparison to conventional treatment

Introduction

Ilizarov fixators are reliant on tensioned fine wires for stability. The tension in the wires is generated using specific tensioning devices. Loss of wire tension over time may lead of loss a stability and complications. A series of in vitro experiments were undertaken to explore wire tensioner accuracy, the impact of fixation bolt torque and initial tension on loss of tension in ilizarov constructs under static and dynamic loads.

Purpose:. This study attempts to establish whether biomechanical manipulation through distraction can result in fracture union. Method:. A retrospective clinical audit of 15 patients with delayed or hypertrophic non-unions treated successfully with closed distraction in circular external fixation. Average time to union, complications and complication rates were also reviewed. Inclusion criteria: all patients with delayed or hypertrophic non-union, treated by closed distraction between 2004 and 2011. Results:. Fifteen patients included in the study. The average time to union was 188 days. The most common complication was local pin tract sepsis. The most serious complication was a broken fixation ring that needed replacement. Conclusion:. Biomechanical fracture strain is calculated by dividing the fracture gap distance by the change in the fracture distance i.e. FRACTURE STRAIN = DIFFERENCE IN L/L Hypertrophic non-union occurs when the fracture strain is more than 10 %. This formula shows that by increasing the fracture gap, the fracture strain will decrease This concept is contrary to the current practice of compressing the fracture. This study shows that distraction can be used to manipulate the biomechanical circumstances that dictate the development of fracture non-union. Furthermore ring fixators are ideal devices to use for biomechanical manipulation

Statement of Purpose. To compare the functional outcome of Distal Tibial Metaphyseal fracture treated with Circular frame compared vs. Locking Plate. Methods and Results. Distal Tibial Metaphyseal fractures were retrospectively identified over an 18 month period. Each fracture was assessed individually using radiographs. All paediatric, compound, tibial plateau and intra-articular fractures were excluded from the study. Other methods of fixation including intramedullary nailing were also excluded. The remaining fractures were assigned to either the circular frame fixation or the locking plate intervention group. Outcomes were assessed using radiographs for union dates and microbiology results for evidence of infection. Patients were followed up by postal questionnaires, which included a modified American Orthopaedic Foot and Ankle Score (AOFAS), the Olerud and Molander Score (O&M) and a custom questionnaire. The custom questionnaire asked about co-morbidities, smoking status and work days lost following surgery. After exclusions, 30 patients (Frame=15, Plate=15), were sent out questionnaires via post. We received completed questionnaires from 21 patients (Frame=11, Plate=10) giving us a response rate of 70%. Results show no difference in infection rates, skin necrosis, non-union or re-operation rates. There was also no significant difference in patient AOFAS and O&M scores at follow up. Conclusion. There is no significant difference in complications and functional Outcomes between locking plate fixation and circular frames in the treatment of distal Tibial Metaphyseal fractures

Background:. Various surgical flaps have been described for the reconstruction of post traumatic soft tissue defects of the heel. These techniques are not all familiar to orthopaedic surgeons. The presented technique is based on the use of a reverse flow island sural flap combined with a circular external fixator. Material:. This presentation is a review of 8 cases performed between 2003 and 2012. Results:. All cases were males with an average age of 39 years (16–56) with a follow up period between 2 and 10 years. The soft tissue defects were located around the heel and Achilles tendon as a result of road traffic accidents involving motor cycles. Six patients had associated bony injuries of the foot and ankle related to the soft tissue defect. All flaps remained viable, and cover was easily achieved with direct closure. Three cases required debridement of subsequent superficial necrosis and additional split skin grafting. Although the flaps are insensate per design, there were no associated problems of late onset pressure ulcers. The circular fixation added the additional benefit of protection and easy access of the posterior flap during the post-operative period. Mild venous congestion was a temporary feature, of no long term consequence. Conclusion:. The sural fasciocutaneous flap is a useful adjunct for the treatment of complex soft tissue defects around the heel and ankle. The main advantages include simplicity of design and easy execution, avoids the need for complex microsurgical techniques and can be performed with simple loupe magnification, and thus realistically falls within the realm of the treating orthopaedic surgeon

Introduction

Schatzker V & VI tibial plateau fractures are serious life-changing injuries often resulting in significant complications including post-traumatic arthritis. Reported incidence of secondary TKA following ORIF of all tibial plateau fractures is 7.3% and 13% for Schatzker V & VI tibial. This study reports a 15-year single centre experience of CEF of Schatzker V & VI fractures including PROMs and incidence of secondary TKA. This study was approved by the local Institutional board.

Introduction. The various problems that are managed with circular external fixation (e.g. deformity, complex fractures) also typically require serial plain x-ray imaging. One of the challenges here is that the relatively radio-opaque components of the circular external fixator (e.g. the rings) can obscure the view of the area of interest (e.g. osteotomy site, fracture site). In this presentation we describe how the geometry of the x-ray beam affects the produced image and how we can use knowledge of this to our advantage. Whilst this can be applied to any long bone, we have focused on the tibia, given that it's the most common long bone that is treated by circular external fixation. Materials & Methods. In the first part of the presentation we describe the known attributes (geometry) of the x-ray beam and postulate what effect it would have when we x-ray a long bone that is surrounded by a circular external fixator. In the second part we demonstrate this in practice using a tibia and a 3 ring circular external fixator. Differing x-ray beam orientations are used to demonstrate both how the geometry of the beam affects the produced image and how we can use this to our advantage to better visualise part of the bone. Results. The practical part of the study confirmed the theoretical part. Conclusions. Knowledge of the beam geometry can be used to minimise the obscuring nature of the circular fixator. This technique is simple and can be easily taught to the radiographer. It is a useful adjunct for the limb reconstruction surgeon

Introduction. Open tibial fractures typically occur as a consequence of high energy trauma in patients of working age resulting in high rates of deep infection and poor functional outcome. Whilst improved rates of limb salvage, avoidance of infection and better ultimate function have been attributed to improved centralisation of care in orthoplastic units, there remains no universally accepted method of definitive management of these injuries. The aim of this study is to the report the experience of a major trauma centre utilising circular frames as definitive fixation in patients sustaining Gustilo-Anderson (GA) 3B open fractures. Materials & Methods. A prospectively maintained database was interrogated to identify all patients. Case notes and radiographs were reviewed to collate patient demographics and injury factors . The primary outcome of interest was deep infection rate with secondary outcomes including time to union and secondary interventions. Results. 247 open tibial fractures with a soft tissue manipulation in order to achieve skin cover, of which 203 had a minimum follow up of 2 years. Mean age was 43.2 years old, with 72% males, 34% smokers and 3% diabetics. Total duration of frame management averaged 6.4 months (SD 7.7). Nine (4.4%) patients developed a deep infection and 41 (20%) exhibited signs of a pin site infection. Seventy-five (37%) of patients had a secondary intervention of which; 8 comprised debridement of deep infection, 1 amputation for deep infection and the remainder adjustments of frames. Conclusions. Orthoplastic care including circular frame fixation for GA 3B fractures of the tibia results in a low rate of deep infection, around a quarter of contemporary literature for internal fixation

Introduction. By utilising the inherent variability achievable with circular frames, surgeons can manage a wide spectrum of complex injuries, and can deal with deformity at multiple levels, in multiple planes. The aim of this study was to assess functional outcomes utilising patients reported outcome measures (PROMs) of patients being treated with circular (Ilizarov) frame fixation for complex lower limb injuries and assess these results in conjunction with the observed postoperative alignment of the patients’ limbs. Materials & Methods. Cases were identified using a prospectively collected database of adult patients presenting between July 2018 and August 2021. Functional outcomes were assessed using the American Orthopaedic Foot and Ankle Score (AOFAS), the 5-level EQ-5D (EQ5D5L), the Lysholm Knee Scoring Scale (LKSS), the Olerud-Molendar Ankle Score (OMAS), and the Tegner Activity Scale (TAS). Postoperative radiographs were analysed for fracture union and to quantify malunion (as described in Dror Paleys Principles of Deformity Correction). Results. The mean AOFAS, EQ5D5L, LKSS and OMAS scores showed an initial drop from pre-op to early time points and then steady increase over the early, mid, late and frame-off time points, with a resultant score higher than pre-op. Malunion was found in 35 (41.7%) patients, 7 patients had a malunion within 5 degrees of normal, 15 from 5–10 degrees of normal, 12 from 10–15 degrees of normal and 2 out with 15 degrees of normal. Conclusions. Circular frame fixation is an attractive option in complex lower limb trauma where alternative fixation methods are unsuitable. Whilst post-operative success to the surgeon might be determined radiographically, patient reported outcomes give a functionally important, objective measure of the success of the surgery to the patient

Introduction. External fixators are common surgical orthopaedic treatments for the management of complex fractures and in particular, the use of circular frame fixation within patients requiring limb reconstruction. It is well known that common complications relating to muscle length and patient function without rehabilitation can occur. Despite this there remains a lack of high-quality clinical trials in this area investigating the role of physiotherapy or rehabilitation in the management of these patients. We aim to complete a systematic review of rehabilitation techniques for patients undergoing external fixator treatment for Limb Reconstruction of the lower limb. Materials & Methods. A comprehensive search of AMED, CINAHL, MEDLINE and COCHRANE databases was conducted to identify relevant articles for inclusion, using a search strategy developed in collaboration with a research librarian. Inclusion criteria consisted of adults aged 18 years and over who have experienced leg trauma (open fracture, soft tissue damage), elective leg deformity corrective surgery, bone infection or fracture non-union who have been treated with the use of an external fixator for fixation. Specific exclusion criteria were patients below the age of 18 years old, patients with cancer, treatment of the injury with internal nail, patients who underwent amputation, the use of external fixators for soft tissue contracture management, editorials, comment papers, review papers, conference proceedings and non-English papers. Titles, abstracts, and full texts were screened for suitability by pairs of reviewers according to the inclusion and exclusion criteria using Rayyan QCRI online software. Any conflicts were resolved through discussion with three independent specialist senior reviewers. Following full text screening, references lists of included articles were manually searched to ensure that all relevant studies were identified. Due to lack of evidence, forward searching was also completed for studies included in the review. Data quality was assessed using the mixed methods appraisal tool and the CERT assessment tool was utilised to look at completeness of reporting of exercise interventions. Results. A total number of 832 articles were initially retrieved from our search once duplicate articles removed. After title and abstract screening, 45 articles remained for full text screening. Of these, 11 articles met our inclusion criteria and included for data extraction. Conclusions. We expect high variability of results due to our inclusion criteria and therefore plan to conduct a narrative synthesis to summarise the findings whilst measing against the mixed methods appraisal tool and CERT assessment scores to assess the data quality. We anticipate lower assessment scores within the fewer articles found and therefore poorer-quality data. We currently are in the process of finalising this data extraction. This will be completed ready for submission and potential presentation at the BLRS conference in March 2023

We would like to present this case series of 10 adolescent patients with displaced, closed diaphyseal tibial fractures managed using the Taylor Spatial Frame. Management options for these injuries include non-operative treatment, antegrade nailing, flexible nailing systems, plating and external circular fixation. External circular fixation allows anatomical reduction avoiding potential complications such as growth arrest associated with antegrade nailing and retained metal work with plating. Flexible nailing system and cast immobilisation are unreliable for precise anatomical reduction. With limited evidence as to the extent of post-traumatic deformity that is acceptable, combined with the limited remodeling potential that this patient group possess, the precision of percutaneous fixation with the Taylor Spatial Frame system has clear advantages. This is a retrospective analysis of 10 adolescent patients with a mean age of 14.5 years (range 13 to 16 years). Data collected includes fracture configuration, deformity both pre and post operatively compared to post frame removal, length of time in frame and complications. The data was gathered using the patient case notes and the Picture Archiving and Communications System. The mean time in frame was 15.5 weeks (range 11 to 22 weeks). One non-union in a cigarette smoker was successfully managed with a second Taylor Spatial Frame episode. Our conclusion was that with careful patient selection the Taylor Spatial Frame allows successful treatment of closed tibial fractures in adolescents, avoiding complications such as growth arrest and post-traumatic deformity as well as avoiding retained metalwork

Introduction. Circular frame fixation has become a cornerstone of non-union and deformity management since its inception in the 1950s. As a consequence of modularity and heterogenous patient and injury factors, the prediction of the mechanobiological environment within a defect is subject to wide variations in practice. Given these wide range of confounding variables, clinical and cadaveric experimentation is close to impossible and frame constructs are based upon clinician experience. The Finite Element Analysis (FEA) method provides a powerful tool to numerically analyse mechanics. This work aims to develop an FEA model of a tibial defect and predict the mechanical response within the construct. Materials and Methods. The geometry of a tibia was acquired via CT and a series of bone defects were digitally created in the tibial diaphysis. A 4-ring, 10-wire Ilizarov fixator was constructed using 180mm stainless steel rings and 1.8mm stainless steel wires tensioned to 1200N. An axial load (800N) was applied to simulate single leg stance of an 80kg patient. The magnitude of displacement was measured for defects with varying sizes (5–40mm). A numerical analysis was performed in large-strain regime using open-source FEA library (MoFEM). Results. Defect size did not effect displacement, but significantly influenced strain. Measured displacements were 5.72–5.78mm, however strain ranged from 14.5–100%. Moreover, it was found that bone material properties also have no significant impact on the results. Conclusions. Accounting for FEA assumptions, this model predicted a strain environment which was above expected favourable range for bone healing. The addition of graft within the environment is likely to change the mechanobiological environment which warrants further investigation. We plan to develop this model to answer further research questions in the limb reconstruction discipline and validate its accuracy with mechanical data. We believe the presented approach can be a useful tool for investigating the performance circular frames

Background:. Wide resection of infected bone increases the chances of eradication of infection in patients with chronic osteomyelitis. Aggressive debridement is, however, frequently complicated by the creation of large bone defects. The use of antibiotic-impregnated PMMA spacers, as a customized dead space management tool, has recently grown in popularity. In addition to certain biological advantages, the spacer also offers a therapeutic benefit by serving as a vehicle for delivery of local adjuvant antibiotics. Methods:. This retrospective case series involved 11 patients with chronic osteomyelitis, managed with tibial bone transport through an induced membrane using circular external fixation. All patients were treated according to a standardized treatment protocol and we review the anatomic nature of the disease, the physiological status of the host, the surgical procedures performed, as well as the outcome of treatment in terms of eradication of infection, time to union and the complications that occurred. Results:. Nine patients, with a mean bone defect of 6 cm (range: 2–8 cm) were included in the study. At a mean follow-up of 24 months (range: 14–45 months) eradication of osteomyelitis was achieved in all patients without the need for reoperation for infection. Failure of the skeletal reconstruction occurred in two patients. Six major and four minor complications were experienced. After a mean time of 70 weeks (range: 30 to 104 weeks) in the circular external fixator all but one docking site had united and all regenerated segments were consolidated. Conclusion:. Bone transport, using circular external fixation, through the induced membrane created by the temporary insertion of a PMMA appears to be a useful technique in the management of post-infective tibial bone defects larger than 4 cm in size. Patient selection appears to be a crucial step in ensuring a successful outcome in terms of the resolution of infection

Purpose of study. The primary treatment of congenital talipes equinus varus with the Ponsetti method remains the gold standard of treatment. Relapsed, neglected and/or teratogenic clubfeet pose a significant treatment challenge as the long term outcome of posteromedial release surgery is poor. Advances in circular fixation offer predictable deformity correction without the need for extensive soft tissue release. The Taylor Spatial Frame utilizes the correction principles of the “Ponsetti Method”, but little literature exists describing the correction of relapsed clubfeet with these fixators. This study assesses the outcome of relapsed clubfeet treated with the Taylor Spatial Frame Circular fixator. Methods. Ethics approval was obtained for a prospective descriptive study (N10-10-338). Patients with clubfeet who met inclusion criteria were treated with a Taylor Spatial Frame. The International Clubfoot Study Group Score was used to assess the feet preoperatively and six months postoperative. This scoring system scores the morphology, functionality and radiographic parameters of the clubfoot. Quality of life was assessed by means of the Child Health Questionnaire. Results. Ten feet (6 bilateral, 4 unilateral) were included in the study. Seven male and three female patients with average age of 6 years (range 3 – 13 years, sd ±4) qualified for the study. Feet were scored using the International Clubfoot Study Group Score. All feet scored poor preoperatively (average score 37±6). Postoperatively two feet scored excellent, seven good and one fair (Average score 9±4). This was statistically significant, p=0.00000. Two patients required additional surgical procedures for residual deformity. Five patients had superficial pin tract infection and one tibia fracture occurred. Conclusion. Treatment of relapsed clubfeet with the Taylor Spatial Frame gives a predictable correction of deformities without the need for extensive soft tissue and bony procedures. TSF assisted clubfoot correction constitute a useful salvage treatment modality. NO DISCLOSURES

Aims

The standard of wide tumour-like resection for chronic osteomyelitis (COM) has been challenged recently by adequate debridement. This paper reviews the evolution of surgical debridement for long bone COM, and presents the outcome of adequate debridement in a tertiary bone infection unit.

Statement of purpose. To determine the outcome of the use of Bone Morphogenetic Protein 7 (BMP7) as a replacement for bone graft in a limb reconstruction unit. Methods. Retrospective case note and imaging review was performed on a cohort of 71 consecutive patients from October 2009 to October 2012 in whom BMP7 was used to achieve union. The patients were identified from a pharmacy database. Factors analysed included the perceived indication, location in the skeleton, age, comorbidities, type of procedure (non-union, fusion, docking site etc), complications and need for revision surgery. Results. BMP7 was used in 71 patients with a median age of 63 (mean 58, range 17–86). The majority of patients were in the seventh decade. 62 were non-unions, eight were for fusion of docking site and one for fusion of an osteotomy. Circular external fixation was used in 20, IM nails in four, and plate fixation in 47. Indications for using BMP7 as opposed to bone graft included advanced age, immunosuppressive comorbidities or medication and obesity. In 65 cases bony union was achieved after the index procedure and one patient needed further surgery. There were five failures: two patients died before union and three failed to heal with the index intervention, leading to 74 procedures in 71 patients. BMP7 was used in several anatomic sites: femur (n=29), humerus (n=15), tibia (n=18) and in fusion of a joint (n=9). Overall success rate for achieving union was 93%. Local inflammation lasting a mean of three weeks was seen in six cases, and five patients developed heterotopic ossification, of which one was symptomatic. Conclusion. BMP 7 can be used as a replacement for autologous bone graft with predictable success in situations where bone graft harvest may be deemed unsuitable either because of local or systemic factors