The optimum indications for debridement, antibiotics and implant retention (DAIR) are unclear. Previous studies have demonstrated higher
Aims. Fracture-Related Infection (FRI) is a severe complication caused by microbial infection of bone. It is imperative to gain more insight into the potentials and limitations of Debridement, Antibiotics and Implant Retention (DAIR) to improve future FRI treatment. The aims of this study were to: 1) determine how time to surgery affects the
This study aimed to identify the
One in five patients remain unsatisfied due to ongoing pain and impaired mobility following total knee arthroplasty (TKA). It is important if surgeons can pre-operatively identify which patients may be at risk for poor outcomes after TKA. The purpose of this study was to determine if there is an association between pre-operative measures and post-operative outcomes in patients who underwent TKA. This study included 28 patients (female = 12 / male = 16, age = 63.6 ± 6.9, BMI = 29.9 ± 7.4 kg/m2) with knee osteoarthritis who were scheduled to undergo TKA. All surgeries were performed by the same surgeon (GD), and a subvastus approach was performed for all patients. Patients visited the gait lab within one-month of surgery and 12 months following surgery. At the gait lab, patients completed the knee injury and osteoarthritis outcome score (KOOS), a timed up and go (TUG), and walking task. Variables of interest included the five KOOS sub-scores (symptoms, pain, activities of daily living, sport & recreation, and quality of life), completion time for the TUG, walking speed, and peak knee biomechanics variables (flexion angle, abduction moment, power absorption). A Pearson's product-moment correlation was run to assess the relationship between pre-operative measures and post-operative outcomes in the TKA patients. Preliminary analyses showed the relationship to be linear with all variables normally distributed, as assessed by Shapiro-Wilk's test (p > .05), and there were no outliers. There were no statistically significant correlations between any of the pre-operative KOOS sub-scores and any of the post-operative biomechanical outcomes. Pre-operative TUG time had a statistically significant, moderate positive correlation with post-operative peak knee abduction moments [r(14) = .597, p < .001] and peak knee power absorption [r(14) = .498, p = .007], with pre-operative TUG time explaining 36% of the variability in peak knee abduction moment and 25% of the variability in peak knee power absorption. Pre-operative walking speed had a statistically significant, moderate negative correlation with post-operative peak knee abduction moments [r(14) = -.558, p = .002] and peak knee power absorption [r(14) = -.548, p = .003], with pre-operative walking speed explaining 31% of the variability in peak knee abduction moment and 30% of the variability in peak knee power absorption. Patient reported outcome measures (PROMs), such as the KOOS, do indicate the TKA is generally successful at relieving pain and show an overall improvement. However, their pre-operative values do not correlate with any biomechanical indicators of post-operative
Aim.
Aim. There is a constant increase of total joint arthroplasties to improve the quality of life of an aging population. Prosthetic-joint infections are rare, with an incidence of 1–2%, but they represent serious complications in terms of morbidity and mortality. Different therapeutic options exist, but their management is still poorly standardized because of the lack of data from randomized trials. The aim of this retrospective study is to assess the infection eradication
The diagnosis of prosthetic-joint infection (PJI) is challenging, as bacteria adhere on implant and form biofilm. Therefore, current diagnostic methods, such as preoperative culture of joint aspirate have limited sensitivity with false-negative results. Aim. To evaluate the performance of measurement synovial fluid (SF) D-lactate (as a pathogen-specific marker) for the diagnosis of PJI and estimate of treatment
Purpose. To determine how patient characteristics; health status and pre-operative knee function effect patient reported satisfaction and operative
To study the antimicrobial effect of a gentamicin loaded bio-composite bone void filler in relation to a limited or extensive debridement of osteomyelitis lesions, respectively. Nine pigs were inoculated into the right proximal tibial bone with a high virulent gentamicin sensitive strain of Aim
Methods
Aim. The aim of this study is to evaluate the value of inflammatory parameters normalization and/or increased time between stages necessary in predicting healing and preventing infection recurrence. Method. We retrospectively studied all cases of total hip and knee arthroplasty that underwent revision for infection in our institution between 2011 and 2014. We revised the clinical and laboratory information from 55 patients (27 hips: 28 knees) with a mean age of 68 years. The average values before the first stage were 88.6 mm/h (15–134) and 59.1 mg/L (2–279) for the erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) serum respectively. In 10 cases (18.2%) it was not possible to perform the second stage. Moreover, in the other 45 cases of re- arthroplasty, the mean follow-up was 32 months (1 year). Results. Among the 45 cases in which the two stages were completed, only 3(6.7%) had recurrence of infection. No significant differences between the two groups regarding the absolute values of ESR and/or CRP before the second stage or variation between the first and second stage of revision were seen. Interestingly, in the group of cases where there was recurrence of infection, the average values of CPR and ESR before the second stage were even lower: 6.0 vs. 11.8 mg/L and 19.3 vs. 28.7 mm/h respectively. Analysing the temporal influence on the recurrence rate, we find that the 17 cases in which the second stage was performed in less than 90 days, there were no recurrences. The three recurrences occurred in the group of patients with an interval > 90 days (3/28 – 11%). Conclusions. Knowing when to perform the second stage safely is one of the most difficult decision in two-stage procedures. Tradition mandates waiting for complete normalization of inflammatory parameters sometimes for a long period of time in order to identify cases at risk. However, this approach involves an increased disability time and significant quality of life decrease for patients and lacks adequate scientific support. This study confirms that this traditional approach does not increase the chances of
In recent years, cementless stems have dominated the North American market. There are several categories of cementless stems, but in the past 20 years, the two most popular designs in the United States have been the extensively coated cylindrical cobalt-chrome (Co-Cr) stem and the proximally coated tapered titanium stem, which in recent years has become the most common. The 10 year survival for both stem types has been over 95% with a distinction made on factors other than stem survival, including thigh pain, stress shielding, complications of insertion, and ease of revision. Conventional wisdom holds that proximally coated titanium stems have less stress shielding, less thigh pain, and a higher quality clinical result. Recent studies, however, including randomised clinical trials have found that the incidence of thigh pain and clinical result is essentially equivalent between the stem types, however, there is a modest advantage in terms of stress shielding for a tapered titanium stem over an extensively coated Co-Cr stem. One study utilising pain drawings did establish that if a Co-Cr cylindrical stem was utilised, superior clinical results in terms of pain score and pain drawings were obtained with a fully coated versus a proximally coated stem. In spite of the lack of a clinically proven advantage in randomised trials, tapered titanium stems have been favored because of the occasional occurrence of substantial stress shielding, the increased clinical observation of thigh pain severe enough to warrant surgical intervention, ease of use of shorter tapered stems that involve removal of less trochanteric bone and less risk of fracture both at the trochanter and the diaphysis due to the shorter, and greater ease of insertion through more limited approaches, especially anterior approaches. When tapered stems are utilised, there may be an advantage to a more rectangular stem-cross-section in patients with type C bone. In spite of the numerous clinical advantages of tapered titanium stems, there still remains a role for more extensively coated cylindrical stems in patients that have had prior surgery of the proximal femur, particularly for a hip fracture, which makes proximal fixation, ingrowth, and immediate mechanical stability difficult to assure consistently. Cement fixation should also be considered in these cases. While the marketplace and the clinical evidence strongly support routine use of tapered titanium proximally coated relatively short stems with angled rather than straight proximal lateral geometry in the vast majority of cases, there still remains a role for more extensively coated cylindrical and for specific indications.
Up until this point in time, total knee replacement implants have relied on standardised sizes and shapes. The design process for the ‘off-the-shelf’ implants has typically involved designing a standard size implant and then scaling the design up and down to provide a series of standard sizes. More recently, some suppliers have paid more attention to providing sizes that meet the particular needs for either women or men, but these implants are largely standard designs with adjustments to the medial to lateral width or the anterior to posterior depth. To design an implant that not only provides the correct size for every patient's knee, but more importantly to provide an implant that duplicated the patient's exact geometry is the goal. A CT scan is obtained of the patient's lower limb. The CT data is converted into a surface model of the knee joint with proprietary software. The surface model is then utilised to create a near exact match of the articular surface in a knee femoral component. The sagittal geometry is preserved for the medial, trochlear and lateral ‘J’ curves with correction for disease as required. The coronal trochlear and condyle geometries are engineered surfaces that respect the laws of knee design for low contact stress. The bone cuts are individualised for each femoral component based on maximising bone preservation and utilising design rules that are based on finite elemental analysis and fatigue testing. The tibial articular surface geometry is derived from the femoral component. Separate medial and lateral inserts are supplied in varying thicknesses that allow precise balancing of the joint. Patient specific instrumentation is supplied with the implant that allows either femur first or tibial first techniques.
Anterior supine intermuscular total hip arthroplasty (ASI-THA) has emerged as a muscle sparing, less-invasive procedure. The anterior interval is both intermuscular and internervous, providing the advantages of little or no muscle dissection, and a true minimally invasive alternative. It is versatile, with reported use expanding beyond the primary realm to revision and resurfacing THA as well as treatment of acute fracture in elderly patients, who due to their diminished regenerative capacity may benefit more from the muscle-sparing nature of the anterior approach. The ASI approach involves the use of a standard radiolucent operative table with the table extender at the foot of the bed and the patient supine. Fluoroscopy is used in every case. A table-mounted femur elevator is utilised to facilitate femoral preparation. A retrospective review identified 824 patients undergoing 934 consecutive primary ASI-THA performed between January 2007 and December 2010. Age averaged 63.2 years (27‐92), BMI averaged 29.9 kg/m2 (16.9–59.2). Gender was 49% males and 51% females. Stem types were short in 82% and standard length in 18%. Follow-up averaged 23.1 months (1‐73). Operative time averaged 63.1 minutes (29‐143). Blood loss averaged 145.3 mL (25‐1000). Transfusion rate was 3.3% (30 of 914) in single procedures and 80% (8 of 10) in simultaneous bilateral procedures. Length of stay averaged 1.7 days (1‐12). Intraoperatively there were 3 calcar cracks and 1 canal perforation treated with cerclage cables. There were 6 wound complications requiring debridement. Four hips had significant lateral femoral cutaneous nerve parathesias not resolved at 12 months. One femoral nerve palsy occurred. At up to 73 months follow-up there have been 21 revisions (2.2%): 2 infection, 1 malpositioned cup corrected same day, 5 metal complications, 2 dislocations, 2 loose cups with one requiring concomitant stem revision secondary to inability to disarticulate trunnion, 1 femoral subsidence and 8 periprosthetic femoral fractures. Primary THA can be safely performed utilising this muscle-sparing approach. We did not see an alarmingly high rate of complications. Instead, rapid recovery and quick return to function were observed. ASI-THA appears to be safe. The recovery advantage utilising this surgical approach is irrefutable. There are complications, most notably periprosthetic femur fracture. The rate, however, appears to be low and decreases with increased experience. There is no need for a special operative or fracture table to perform the procedure. Whether the complication rate is higher with the use of these expensive devices is unknown, but our results demonstrate a 2.2% reoperation rate with the use of the ASI approach performed on a standard OR table. Continued refinement of the technical aspects of ASI-THA may lessen the complication rate.
Recent Department of Health guidelines have recommended that bunion surgery should be performed as a day case in a bid to reduce hospital costs, yet concurrently improving patient outcomes. Following an audit in 2012/3, we implemented a number of measures in a bid to improve the rates of day case first ray surgery. In this paper, we look to see if these measures were effective in reducing the length of stay in first ray surgery. We performed a prospective case note review of all patients undergoing first ray surgery between 01/01/2012 and 01/02/2013, and found the rates of same day discharge in this group to be lower than expected at just 24.19%. We recognised that the most commonly cited reasons for delayed discharge were that patients not being assessed by physiotherapy, and were unable to have their take home medication (TTO's) dispensed as pharmacy had closed. To address this, we implemented a pre-operative therapy led foot school, and organised ward analgesia packs which may be dispensed by ward staff, thus bypassing the need for pharmacy altogether. Together, we coined the term “care package” for these measures. We then performed a post implementation audit between 01/01/2014 to 01/01/2015 to ascertain if these measures had been effective. We identified 62 first ray procedures in the preliminary audit, with an average age of 50.5 years (range 17–78 years) and a M:F ratio of 1:5. The most commonly performed procedures were Scarf osteotomy, 1st MTPJ fusion, and distal Chevron osteotomy. We compared this to 63 first ray procedures post implementation of the care package. The average age was 55.3 years (range 15–78 years) and the M:F ratio was 1:2.5, and there was a similar distribution in terms of specific procedures. We found the length of stay had reduced from 1.00 to 0.65 days (p= 0.0363), and the rate of same day discharge had increased from 24.6% to 44.6% (p= 0.0310). We also noted that St Helens Hospital (SHH), the dedicated day case surgery unit, had a significantly increased rate of same day discharge than Whiston Hospital (WH- the main hospital) at 87.5% and 28.89% respectively (p= 0.0002). Preoperative physiotherapy assessment is an important tool in reducing length of stay for first ray surgery. The use ward analgesia packs has a synergistic effecting in increasing day case first ray surgery. We therefore commend its use to other centers. Additionally, we have shown dedicated day case surgery units are more effective at achieving same day discharge than general hospitals.
The purpose of this study was to determine the survivorship for a MOM implant series performed by a single community surgeon followed using a practical clinical model. A retrospective cohort of 104 primary MOM THA procedures (94 patients) were all performed by one surgeon at three local hospitals now with 10–13 years follow-up. Sixteen patients are deceased and 16 patients have been lost to follow-up. In the remaining 62 patients, 8 are bilateral providing a total of 70 THA for study. The clinical follow-up model included: hip scores, X-rays, ultrasound, and metal ion concentrations (Co, Cr, Ti). Due to the diversity of patient location, a variety of clinical labs were utilized for metal ions. Statistical methods included Kaplan-Meier survival curve and One-way ANOVA. Hip scores were available for 70 THA and of these 61 had a hip score (HHS) above 80 (87%). X-rays were available for 49 hips and of these 38 (78%) had lateral/version angles in the safe zone (Fig 1: inclination ≤ 55 and anteversion ≤ 35). Thirty-eight ultrasound exams were performed and of these three yielded fluid collections (8%). Metal ion concentrations were documented in 39 of 62 patients (63%, either serum or whole blood). Six outliers were identified with high concentrations of metal ions (Fig 2); Co 0.3–143.9 ppb (median 3.6), Cr 0.2–200.3 ppb (median 2.2) and Ti 2-110 ppb (median 54). Six patients were revised by the original surgeon. Three of six with elevated ions were documented as wear problems and the other three were revised for infection, femur fracture and metal-ion sensitivity. The survivorship of 92.5% at 10 years (Fig. 3) may be partly due to the exclusive use of antero-lateral approach performed by one surgeon with 78% of cups well placed and the MOM design used exclusively.
Kneeling is one of important motion in Asians culture, also there were teachers of tea or flower ceremony who sit seiza routinely. But also, people in the Middle East need deep flexion keeling when they pray. At the symposium with the title of “A Challenge of deep flexion after TKA”, held at the 33rd Annual Meeting of Japanese Society of Reconstructive Arthroplasty in 2003, it was agreed that the definition of post-operative deep flexion to be more than 130 degrees of flexion. Four hundred and seventy two patients treated with a
Two-stage revision is considered the gold standard for treatment of knee prosthetic joint infections. Current guidelines for selecting the most appropriate procedure to eradicate knee prosthetic joint infections are based upon the duration of symptoms, the condition of the implant and soft tissue evaluated during surgery and the infecting organism. A more robust tool to identify candidates for two-stage revision and who are at high risk for treatment failure might improve preoperative risk assessment and increase a surgeon's index of suspicion, resulting in closer monitoring, optimization of risk factors for failure and more aggressive management of those patients who are predicted to fail. Charts from 3,809 revision total joint arthroplasties were reviewed. Demographic data, clinical data and disease follow-up on 314 patients with infected total knee arthroplasty treated with two-stage revision were collected. Univariate analyses were performed to determine which variables were independently associated with failure of the procedure to eradicate the prosthetic joint infections. Cox regression was used to construct a model predicting the probability of treatment failure and the results were used to generate a nomogram which was internally validated using bootstrapping.Background
Methods
Despite 46 years clinical experience with ceramic-on-ceramic (COC) hip bearings, there is no data on what constitutes a successful long-term wear performance. There have been many studies of short-term failures (Dorlot, 1992; Nevelos, 2001, Walters, 2004). One retrieval study using optical-CMM technology (OCM) documented volumetric wear-rates ranging up to 7mm3/year on femoral heads (Esposito 2012). It was noted that 83% of these revisions showed stripe damage within 3–4 years. The supposition would appear to be that these were bearing-related failures. Our selected COC case for this study was particularly interesting, a female patient having her index surgery performed at age 17 and revised at age 49 (following onset of hip pain). This patient led an active lifestyle, went dancing multiple times per week, and was mother to three children. The 38mm AutophorTM THA (left hip) was eventually revised due to the cup painful migrating (Fig. 1: 32-years follow-up). Radiographs showed cup inclination at approximately 19°. Impingement marks were noted on the CoCr neck and collared stem (Fig. 2). Implant geometry and form factors were analyzed by standard contour measurement (CMM) while SEM and EDS imaging provided wear topography and evidence of metal contaminants. Linear and volumetric wear in head and cup were studied by OCM at Redlux (Southampton, UK). The head's main wear-pattern consisted of two overlapping circular areas (Fig. 3). The narrowest margin made by the wear-pattern was used to define the superior aspect of the head. By light microscopy, the superior main-wear zone covered 1490–1680mm2 area while the total bi-lobed area covered larger 2170mm2 area. OCM analysis delineated the same bi-lobed appearance of head wear with the superior worn area assessed at 1365mm2. The cup revealed a more extensive wear pattern that circumnavigated its surface. The black staining identified by EDS imaging in the cup revealed Co and Cr elements. By OCM technique the head volumetric wear was 179 mm³ and the cup was 214mm3 (Fig. 4), i.e. 20% greater than head. Volumetric wear-rate averaged 12.3mm3 per year for this pioneering alumina ceramic. This first demonstration of long-term, COC volumetric wear provides the foundation for retrieval and simulator studies alike. Our patient represented a “worst-case” scenario for hip-replacement surgery, due to extreme youth and long-term sporting life. While the superior wear pattern was not totally contained within the cup (Fig. 3), her implant positioning was clearly adequate. Nevertheless both cup edge-wear and CoCr contamination indicated this patient experienced habitual impingement, i.e. alumina cup rim wearing against CoCr femoral neck (Fig. 2). The head wear-pattern was distinctly bi-lobed but OCM images showed the majority of wear was in the superior hemisphere as noted in MOM retrievals (Clarke, 2013). The head wear-rate in this pioneering “Mittelmeier” THA averaged 5.6mm³/year over 32-years of follow-up. This appeared directly comparable to ceramic head wear measured with the same OCM-technique in modern ceramic THA (Esposito, 2012: 0.1 to 7mm3/year). This indicated to us that COC wear rates of the order 10–14mm3/year represented an acceptable “normal” level of performance in young and active individuals.
The appropriate treatment for chronically infected TKR is controversial. One-stage exchange is believed to be possible only in selected cases, but the respective indications and contra-indications and the criteria of selection are not fully validated. We wanted to test the relevance of the commonly used selection criteria by comparing two groups of patients: the control group operated on with a routine one-stage exchange without selection criteria, and the study group operated on by one stage exchange on selected patients only. We hypothesized that selected one-stage exchange gives fewer failures than routine one-stage exchange procedure. We performed a retrospective study of 108 cases selected in a database of 600 patients with an infected total knee arthroplasty. The database resulted from a French multicenter trial of specialized surgeons in reference institutions, including all consecutive cases operated on between 2000 and 2010. There were 64 women and 44 men with a mean age of 69 years. All patients were followed-up for a minimal period of two years or when septic failure occurred. The patients were divided into two groups: patients operated on in a center using a routine one-stage exchange policy, and patients operated on in a center using a selected one-stage exchange policy. Patients were matched in the two groups according to body mass index and the aspect of the wound at the initial examination (one scar, several scars, presence of a fistula). The results were expressed as: free of infection, relapse or persistence of the index infection, occurrence of a new infection. The repartition was compared in the two groups by a Chi² test at a 0.05 level of significance. The cumulative survivorship was plotted with infection recurrence for any reason as the end point.Objectives
Methods
Prosthetic joint infection (PJI) remains one of the most challenging complications to manage following total joint arthroplasty (TJA). There is a paucity of published data on the management of PJI in smaller, rural hospital settings. In this study, we investigate [1] the