The use of cervical pedicle screws as anchors in posterior reconstruction surgery has not been widely accepted due to the neurological or vascular injury. We thus sought to investigate the accuracy of free-handed pedicle screw placement in the cervical and upper thoracic spine at the early stage of clinical application. Eight patients (five males and three females) were included in this study. Mean age was 63 years (31 to 78 years). There were three patients with rheumatoid arthritis, three with cervical fracture-dislocation, and two with spinal metastasis. Twenty-four pedicle screws (3.5 mm diameter: Vertex, Medtronic Sofamordanek) were placed into the pedicle from C2 to T2 level by free-handed technique2). Grade of breaching of pedicle cortex was divided into four groups (Grade 0–3). In addition, screw axis angle (SAA) were calculated from the horizontal and sagittal CT images and compared with pedicle transverse angle (PTA). Furthermore, perioperative complications were also examined. Our free-handed pedicle screw placement with carving technique is as follows: A longitudinal gutter was created at the lamina-lateral mass junction and then transverse gutter perpendicular to the longitudinal gutter was made at the lateral notch of lateral mass. The entry point of the pedicle screw was on the midline of lateral mass. Medial pedicle cortex through the ventral lamina was identified using the probes to create the hole within the pedicle. The hole was tapped and the screw was gently introduced into the pedicle to ensure the sagittal trajectory using fluoroscopy. In the transverse direction, 22 out of 24 screws (92%) were entirely contained within the pedicle (Grade 0). In contrast, only teo screws (8%) produced breaches less than half the screw diameter (Grade 1). In the sagittal direction, all screws were within the pedicle (Grade 0). Screw trajectories were not consistent with anatomical pedicle axis angle; the mean SAA were smaller than the mean PTA at all levels. The pedicle diameter ranged from 3.9 to 9.2 mm. The mean value gradually increased toward the caudal level. There were no neurological and vascular complications related to screw placement

Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional deformity of the spine characterized by a Cobb angle of at least 10 degrees. The goal of surgery is to not only prevent progression but restore sagittal and coronal balance, protecting cardiopulmonary function and improving cosmesis. We reviewed the impact of deformity correction surgery in terms of radiology and patient reported outcome(PROMs). The senior authors prospectively maintained database from 2003 –2022 was retrospectively analysed in terms of pre- and post-operative patient reported outcome measures (SRS 22) as well as radiological parameters. 44 patients with AIS were identified with pre and post op PROMS. The average age at surgery was 15yrs with 84% female. 38% had a Lenke 1 curve and 3 patients had Lenke 6 curves. 73% had posterior surgery. There was a total improvement in SRS 22 scores by 7.8%. Patients reported significant satisfaction with treatment 4.8/5 and improvement in self-image with a change of 0.4 (p<0.001). However, no difference in function, pain and mental health were recorded. Overall, proximal thoracic (PT) curves improved from 24 degrees to 11 degrees (p<0.001), Main thoracic (MT) curve 55 degrees to 19 degrees and Thoracolumbar/Lumbar curves (TL/L) 45 degreesto 11 degrees. Pre-operative flexibility and post-operative correction were 0.40 and 0.41 respectively for PT curve. MT was 0.32 and 0.67. That for TL/L was 0.57 and 0.71 respectively. Surgery yields significant main curve correction correlating with high patient reported satisfaction rate. Although total SRS 22 score yielded 7.8% improvement, sub-analysis of self-image showed the most significant improvement

Purpose of the study. To review the primary bone tumours of the spine treated at our unit. Description of methods. Retrospective review of folders and x-rays of all the patients with primary bone tumours of the spine treated at our unit between 2005 and 2012. All haematological tumours were excluded. Summary of results. We treated 15 cases during this period. The median age at presentation was 36 years (8–65). There was a significant delay from onset of symptoms to diagnosis in most cases (median 7 months). Histological diagnoses included:. -Benign tumours.  Active. Hemangioma. 3. Osteoid osteoma. 1. Eosinophilic granuloma. 1.  Aggressive. Osteoblastoma. 1. Giant cell tumours. 2. Aneurysmal bone cysts. 4. -Malignant tumours.  Osteosarcomas. 2.  Leiomyosarcoma of bone. 1. A variety of definitive surgical methods were utilised. Seven patients had a debulking or intralesional resection of the tumour. Eight patients had an attempted marginal excision. This was achieved through anterior surgery only in 1 case, posterior only surgery in 6 cases and combination anterior and posterior surgery in 8 cases. The anterior and posterior surgery was performed in a single sitting in 5 cases and in a staged fashion in 3 cases. Adjuvant radiotherapy and chemotherapy were used where indicated. Three cases presented with significant neurological impairment. Of these 2 made a significant recovery. There were no cases of neurological deterioration following surgery. All 3 patients with malignant tumours died in the follow up period. We had 1 case of hardware failure due to chronic sepsis. Conclusion. Primary bone tumours of the spine are associated with a significant delay in diagnosis. Surgical treatment options and adjuvant therapy should be tailor made for each case depending on the diagnosis. Acceptable results with minimal complications can be achieved with this approach

Introduction:. Circumferential arthrodesis of the spine may be achieved by posterior-only or anterior and posterior surgery. Posterior-based interbody fusions have significant limitations including unreliable improvement of segmental lordosis and variable rates of post-operative radiculopathy. Combined anterior and posterior surgery introduces significant cost and peri-operative morbidity. The purpose of this paper is to report the radiographic and clinical outcomes of posterior-based circumferential arthrodesis using a novel expandable interbody cage. Methods:. A prospective pilot clinical trial with one year follow-up of the only expandable cage approved by the FDA for interbody application. Clinical outcomes measured include ODI and VAS for back and leg. Radiographic outcomes include arthrodesis rates based upon CT scan. Statistical significance for change in health status was calculated using Student's t-test. Results:. 10 consecutive patients (11 levels) with lumbar degenerative pathology underwent circumferential arthrodesis with a transforaminal interbody approach. 10 of 11 levels were fused based upon CT scan. ODI scores improved a median of 37 to 20 at 6 months and 17 at one year (p = 0.0003). The VAS for back and leg pain likewise from 6 to 2 at 12 months (p = −.003). No patient reported an increase in leg pain from pre-op to post-op. One patient with a 2-level fusion had a non-union at 1 level requiring revision surgery. Conclusion:. Circumferential arthrodesis with a TLIF approach is an important technique for the management of lumbar degenerative pathology. The experience with a novel expandable TLIF cage demonstrates excellent results based upon clinical outcome and fusion rates. The expandable interbody cage allows in-situ height increase which is useful for optimizing clinical and radiographic outcomes in TLIF surgery

Aim. Nasal colonization with S.aureus (SA) is a risk factor for developing nosocomial infections in cardiac surgery. However, the risk in orthopedic surgery remains unclear, especially in adolescent idiopathic scoliosis (AIS) surgery were data are missing. This study aims to evaluate the efficacy of a preoperative nasal decontamination program in SA healthy carriers on early surgical site infections (SSI) after AIS posterior surgery in a pediatric universitary Parisian hospital. Method. Between 01-01-2014 and 03-31-2017, all AIS patients were screened preoperatively with nasal swabs and decontaminated with mupirocine if positive during the 5 days before surgery. Early SSI were prospectively identified and microorganisms' findings were compared to a previous serie published before the beginning of the decontamination program (2007–2011). Results. Among the 316 AIS posterior procedures performed during the study period, nasal swabs were performed at the average of 100 ± 92 days before surgery. Incidence of positive nasal swab was 22 % (n=71) and all were preoperatively decontaminated. Compared to the series (n=496) published before the decontamination program, the early SSI rate remains stable (8.2% versus 8.5%). But incidence of S.aureus early SSI decreased to 1% (n=4), while it represented 5% (n=25) in the previous study. In our study, none of the S. aureus decontaminated patients had an early S.aureus SSI. For the 4 S.aureus early SSI, preoperative nasal swab was negative, but done with a mean delay of 328 days before surgery, suggesting a possible S.aureus intermittent carriage and the need of shorter delays between nasal swab and surgery to improve the screening. Moreover, the stable rate of early SSI between the 2 periods is due to an increase rate of Propionibacterium acnes, which incidence grown from 0.08% to 6% in our actual series. Conclusions. To conclude, in our study, nasal decontamination divided by 5 the incidence of S.aureus SSI. It seems that nasal swabs should be performed as close as possible to the surgery to optimise the S.aureus screening. In addition, the SSI rate remains very high with the emergence of Propionibacterium acnes and is currently addressed by a multifactorial approach

Aim. Infection after vertebroplasty (VP) is a rare but serious complication. Previous literatures showed most pathogens for infection after VP were bacteria; tuberculosis (TB) induced infection after VP was extremely rare. In this study, we reported our treatment experiences of 18 cases with infectious spondylitis after VP, and compared the differences between developed pyogenic and TB spondylitis. Method. From January 2001 to December 2015, 5749 patients underwent VP at our department were reviewed retrospectively. The causative organisms were obtained from tissue culture of revision surgery. Parameters including type of surgery, the interval between VP and revision surgery, neurologic status, and visual analog scale of back pain were recorded. Laboratory data at the time of VP and revision surgery were collected. Risk factors including the Charlson comorbidity index (CCI), preoperative bacteremia, urinary tract infection (UTI), pulmonary TB history were also analyzed. Results. 18 patients developed infectious spondylitis after VP (0.32%, 18/5749). Two were male and 16 were female. The median age at the time of VP was 73.4 years. The mean CCI score was 1.7. The causative organisms were TB in nine patients (Fig. 1), and bacteria in nine patients (Fig. 2). The interval between VP and revision surgery ranged from 7 to 1140 days (mean 123.2 days). C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were elevated in most patients especially at readmission. The most common type of revision surgery was anterior combined posterior surgery. Seven patients developed neurologic deficit before revision surgery. Three patients died within 6 months after revision surgery, with a mortality of 16.7%. Finally, VAS of back pain was improved from 7.4 to 3.1. 7 patients could walk normally, 5 patients needed walker support, 3 patients depended on wheelchair for ambulation (Table 1). Both pyogenic and TB group had similar age, sex, and CCI distribution. The interval between VP and revision surgery was shorter in the patients with pyogenic organisms (75.9 vs 170.6 days). At revision surgery, WBC and CRP were prominently elevated in the pyogenic group. Five in the pyogenic group had UTI or bacteremia; five in TB group had a history of lung TB (Table 2). Conclusions. VP is a minimal procedure but sustains possibility of postoperative infection, which required major surgery for salvage with a relevant part of residual disability. Before surgery, any bacteremia/ UTI or history of pulmonary TB should be reviewed rigorously; any elevation of infection parameters should be scrutinized strictly. For any figures and tables, please contact authors directly (click on ‘Info & Metrics’ tab above for contact details)

Aim. Spinal infection is the most frequent complication of spine surgery. Its incidence varies between 1% and 14% in the literature, depending on various studied populations and surgical procedures. The aim of this study was to describe a consecutive 2706 case series. Method. We analyzed a prospective cohort of 2706 patients operated for spine disease between 2013 and 2016 in a University Hospital. The infection rates, germs, time between surgery and infection and outcomes after surgical revision were assessed with a minimum follow-up of 7 months. We developed a mathematical model to analyze risk factors in this difficult-to-treat population. Results. Among 2706 patient who underwent spinal surgery during the three-year study period, 106 developed a postoperative spine infection. Clinical indicators for infection were the sudden onset of local pain and swelling without fever after an initial pain-free interval. We observed a masculine predominance (68%); the median age was 56 years. The rate of infection was comprised between 0,3% (discal herniation surgery) to over 20% in posterior cervical instrumented surgery (acute cervical fractures), with a global rate of 4%. Polymicrobial infections with more than 3 germs were found in only 2 case, with 3 germs in 8 cases, 2 germs in 27 cases and 1 germ in 69 cases. Staphylococcus aureus, Propionibacterium acnes and Staphylococcus epidermidis were the three main germs identified (53, 36 and 22 respectively). Propionibacterium acnes was involved with a higher rate in instrumented surgery but also in 8% of conventional non-instrumented surgery, with a median relapse time of 24 days (12 days to 4 years). Staphylococcus aureus was involved at a higher rate in posterior non-instrumented surgery with a median relapse time of 18 days (8–66 days). The rate of infection per month was globally stable along the year except an increased rate in February-March. All patients with a suspicion of post-op infection were initially treated with wound/deep tissues revision within the first month after surgery and associated with implant removal after one-month post-op. Pejorative outcomes were associated with incomplete revision surgery, several surgeries and polymicrobial infection. Conclusions. In this study, the rate of postoperative infection is comparable to the literature. In contrast, Propionibacterium incidence is high, especially for acute infections. This unexpected rate can be linked to technical improvements in culture detection but this should also lead us to further discuss the natural process of spine/disk colonization of this germ

The simple dictum of the late Prof. Alf Nachemson was that ‘surgery should very rarely, if ever, be performed in adult scoliotic patients for lumbar curves when pain is the most serious problem’. Today, the complexity of intercurrent neural symptoms, the advancing age of the population and the increasing demands and expectations of modern living require a somewhat more flexible approach to this increasingly common problem. Treatment of adult deformity has improved along with our understanding of the radiological features of the condition most likely to be associated with disabling pain and also with our appreciation of the adverse significance of patient co-morbidity. In those patients where conservative measures have failed and where an acceptable quality of life has been lost, surgical management may be undertaken, but must address all the symptomatic aspects of the deformity in one episode of care. Primary objectives include the restoration of satisfactory sagittal plane correction using the minimum number of operated levels whilst providing adequate spinal stability. Meticulous preoperative planning from a clinical and radiological perspective maximises the possibility of a satisfactory outcome and in this regard patient expectation is of prime importance. The questions of operative approach and levels of fixation are ever present and recent advances in our understanding of distal end fixation are worthy of consideration. Finally, exemplary cases and our series of 23 patients undergoing surgical treatment of adult scoliosis will be presented. Mean coronal curve correction by anteroposterior approach was 60.4% and by posterior only approach 40.3%. Patient satisfaction was 77.8% by combined approach and 58.9% by posterior only approach. The rate of reoperation was 66.7% for posterior surgery alone and 11.1% for combined approach corrections

Introduction. Luk (Luk et al. Spine vol 23(21) 2303-2307 1998) has shown that in posterior surgery, the correction achieved can be predicted by fulcrum bending films. The relevance to anterior correction has been disputed, as this commonly involves shortening the spine by the removal of intervertebral discs. The aim of the study was to see whether the pre-operative bending angle reflected the degree of correction achieved. Method. 91 patients with a structural thoracic curve had an anterior endoscopic correction using a single rod. The mean age was 16.1 years. (range 10-46) The majority of curves were Lenke type 1 (79%) or Type 2 (8%). In all cases disc clearance and bone grafting were performed. All had pre-operative fulcrum bending films. The mean Cobb angle achieved at the pre-operative bending film was compared with the post-operative correction at 2 months. The FBCI (Fulcrum Bending Correction Index) and correction rates were also calculated. The FBCI is calculated by dividing the correction rate by the fulcrum flexibility and expressed as a percentage. It takes into account the pre-operative flexibility of the curve. Results. The mean Cobb angle achieved at the pre-operative bending film was 20.4 degrees. The mean Cobb angle of the corrected curve at 2 months following surgery was 20.4 degrees, (p=0.96). The mean FBCI was 107%. The overall correction rate was 60.1%. Conclusion. In our series fulcrum bending films have been highly predictive of the correction achieved following anterior endoscopic correction. The correction rate of 60.1% is in keeping with other series. In addition, the FBCI was 107%. The instrumentation had corrected to the flexibility achieved at the time of the pre-operative bending films. This implies that the discectomies performed at time of surgery had not significantly increased the correction achieved

Aim. We report our ten year experience of primary haematogenous non-tuberculous spinal infection. Method. Retrospective case note review of 42 patients presented to our institution with primary spinal infection during 1995-2005 was carried out. Demographic data, timing and modes of presentation, investigations, and methods of treatment were analysed. The cost benefit of Home Intravenous Antibiotics Service (HIAS) was also investigated. Results. Mean age was 59.9 years (1-85) with almost equal gender distribution (M 20: F 22). Axial pain was universal. Pyrexia was seen in 62% and major neurological deficit in 10% of cases. Time from presentation to diagnosis averaged 19 days (range 0-172). Sensitivity for MRI and plain x-ray was 100% and 46% respectively. Blood culture was as sensitive as percutaneous biopsy in patients with pyrexia. Staphylococcus Aureus was the most common organism. Treatment ranged from intravenous antibiotics alone to combined anterior and posterior surgery depending on the presence or absence of significant abscess collection, neurological deficit and structural threat. Mean duration of intravenous antibiotics was 54 days (range 13-240). At mean follow up of 5.4 years (0.6-10.5) there was no mortality directly related to the infection. Recurrence rate was 14%. Significant past medical history (p=0.001), constitutional symptoms (p=0.001) and pyrexia at presentation (p=0.001) and possible male gender (p=0.01) were positively associated with recurrence. Although firm conclusions can not be drawn due to sample size, duration of symptoms (p=0.27) did not appear to affect the risk of recurrence. When inpatient days were subtracted from days on IV antibiotics for all the patients, HIAS was found to have saved a total of 940 inpatient days. Conclusion. In spinal infection, disease and patient characteristics dictate the management strategy. Longer antibiotic therapy in patients with positive risk factors for recurrence may be indicated. Finally, HIAS was cost effective in this group of patients

Background. The anterior approach for total hip arthroplasty has recently been hypothesized to result in less muscle damage. While clinical outcome studies are essential, they are subject to patient and surgeon bias. We prospectively analyzed biochemical markers of muscle damage and inflammation in patients receiving anterior and posterior minimally-invasive total hip arthroplasty to provide objective evidence of the surgical insult. Methods. 29 patients receiving an anterior and 28 patients receiving a posterior total hip arthroplasty were analyzed. Peri-operative and radiographic data were collected to ensure similar cohorts. Creatine kinase, C-reactive protein, Interleukin-6, Interleukin-1beta, and Tumor necrosis factor-alpha were collected pre-operatively, post-operatively, and on post-operative days 1 and 2. Comparisons between the groups were made using the Student's t-test and Fisher's Exact test. Independent predictors of elevation in markers of inflammation and muscle damage were determined using multivariate logistic regression analysis. Results. Markers of inflammation were slightly decreased in direct anterior group (mean differences in C-reactive protein 27.5 [95% confidence interval −24.7–79.6] mg/dL, Interleukin-6 13.5 [95% confidence interval −11.5–38.4] pg/ml, Interleukin-1beta 42.6 [95% confidence interval −10.4–95.6], and Tumor necrosis factor-alpha 148.6 [95% confidence interval −69.3–366.6] pg/ml). The rise in creatine kinase was 5.5 times higher in the post anesthesia care unit (mean difference 150.3 [95% confidence interval 70.4–230.2] units/L, p < 0.05) and nearly twice as high cumulatively in the miniposterior approach group (305.0 [95% confidence interval −46.7–656.8] units/L, p < 0.05). Conclusion. Anterior total hip arthroplasty caused significantly less muscle damage compared to traditional posterior surgery as indicated by creatine kinase levels. The clinical importance of this rise needs to be delineated by further clinical studies. The overall physiologic burden as measured by markers of inflammation, however, appears to be similar. Objective measurement of muscle damage and inflammation provides an unbiased way of determining the immediate effects of surgical intervention in total hip arthroplasty patients

During the pandemic of COVID-19, some patients with COVID-19 may need emergency surgeries. As spine surgeons, it is our responsibility to ensure appropriate treatment to the patients with COVID-19 and spinal diseases. A protocol for spinal surgery and related management on patients with COVID-19 has been reviewed. Patient preparation for emergency surgeries, indications, and contraindications of emergency surgeries, operating room preparation, infection control precautions and personal protective equipments (PPE), anesthesia management, intraoperative procedures, postoperative management, medical waste disposal, and surveillance of healthcare workers were reviewed. It should be safe for surgeons with PPE of protection level 2 to perform spinal surgeries on patients with COVID-19. Standardized and careful surgical procedures should be necessary to reduce the exposure to COVID-19.

Introduction. Total hip arthroplasty (THA) is a common operation. Different operative approaches have specific benefits and compromises. Soft tissue injury occurs in total hip arthroplasty. This prospective study objectively measured muscle volume changes after direct anterior and posterior approach surgeries. Methods. Patients undergoing Direct Anterior Approach (DAA) and Posterior Approach (PA) THA were prospectively evaluated. 3 orthopaedic surgeons performed all surgeries. Muscle volumes of all major muscles around the hip were objectively measured using preoperative and 2 different postoperative follow-up MRIs. 2 independent measurers performed all radiographic volume measurements. Repeated-measures ANOVA was used to compare mean muscle volume changes over time. Student's t-test was used to compare muscle volumes between groups at specific time intervals. Results. MRIs for 10 DAA and 9 PA patients were analyzed. No significant differences between groups were found in BMI or Age. Pre-operative muscle volume comparisons showed no significant differences. Average postoperative follow-up times were 9.6 and 24.3 weeks. First follow-up showed significant atrophy for the DAA in Gluteus Medius (−7.3%), Gluteus Minimus (−17.5%), and Obturator Internus (−37.3%) muscles. Final follow-up showed significant recovery in Gluteus Medius (+12%) and Minimus (+11.1%) muscles. In the PA, atrophy was significant at first follow-up for Gluteus Minimus (−11.8%), Obturator Internus (−46.8%) and Externus (−16%), Piriformis (−26.5%), and Quadratus Femoris (−30.4%) muscles. Recovery was not seen in any of the significantly atrophied muscles. Muscles with significant quantified fatty atrophy at final follow-up were Obturator Internus [+5.51% (DAA); +7.65% (PA)] and Obturator Externus [+5.55% (PA)]. 3/9 PA patients demonstrated abductor tendinosis, while no DAA patients demonstrated tendinosis. Discussion. Significant atrophy for each group was seen more commonly in the anatomic regions disturbed by each approach respectively. In both approaches, muscles surgically released from their insertion showed greater atrophy, and incomplete recovery

Cervical spine fusion have gained interest in the literature since these procedures are now ever more frequently being performed in an outpatient setting with few complications and acceptable results. The purpose of this study was to assess the rate of blood transfusion after cervical fusion surgery, and its effect, if any on complication rates. The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was used to identify patients that underwent cervical fusion surgery from 2010 to 2013. Univariate and multivariate regression analysis was used to determine post-operative complications associated with transfusion and cervical fusion. We identified 11,588 patients who had cervical spine fusion between 2010 and 2013. The overall rate of transfusion was found to be 1.47%. All transfused patients were found to have increased risk of: venous thromboembolism (TBE) (OR 3.19, CI: 1.16–8.77), myocardial infarction (MI) (OR 9.12, CI: 2.53–32.8), increased length of stay (LOS) (OR 28.03, CI: 14.28–55.01) and mortality (OR 4.14, CI: 1.44–11.93). Single level fusion had increased risk of: TBE (OR 3.37, CI: 1.01–11.33), MI (OR 10.5, CI: 1.88–59.89), and LOS (OR 14.79, CI: 8.2–26.67). Multilevel fusion had increased risk of: TBE (OR 5.64, CI: 1.15–27.6), surgical site infection (OR 16.29, CI: 3.34–79.49), MI (OR 10.84, CI: 2.01–58.55), LOS (OR 26.56, CI: 11.8–59.78) and mortality (OR 10.24, CI: 2.45–42.71). ACDF surgery had an increased risk of: TBE (OR 4.87, CI: 1.04–22.82), surgical site infection (OR 9.73, CI: 2.14–44.1), MI (OR 9.88, CI: 1.87–52.2), LOS (OR 28.34, CI: 13.79–58.21) and mortality (OR 6.3, CI: 1.76–22.48). Posterior fusion surgery had increased risk of: MI (OR 10.45, CI: 1.42–77.12) and LOS (OR 4.42, CI: 2.68–7.29). Our results demonstrate that although cervical fusions can be done as outpatient procedures special precautions and investigations should be done for patients who receive transfusion after cervical fusion surgery. These patients are demonstrated to have higher rate of MI, DVT, wound infection and mortality when compared to those who do not receive transfusion