To determine the risk of total knee replacement (TKR) for primary osteoarthritis (OA) associated with overweight/obesity in the Australian population. This population-based study analyzed 191,723 cases of TKR collected by the Australian Orthopaedic Association National Joint Registry and population data from the Australian Bureau of Statistics. The time-trend change in incidence of TKR relating to BMI was assessed between 2015-2018. The influence of obesity on the incidence of TKR in different age and gender groups was determined. The population attributable fraction (PAF) was then calculated to estimate the effect of obesity reduction on TKR incidence. The greatest increase in incidence of TKR was seen in patients from obese class III. The incidence rate ratio for having a TKR for obesity class III was 28.683 at those aged 18-54 years but was 2.029 at those aged >75 years. Females in obesity class III were 1.7 times more likely to undergo TKR compared to similarly classified males. The PAFs of TKR associated with overweight or obesity was 35%, estimating 12,156 cases of TKR attributable to obesity in 2018. The proportion of TKRs could be reduced by 20% if overweight and obese population move down one category. Obesity has resulted in a significant increase in the incidence of TKR in the youngest population in Australia. The impact of obesity is greatest in the young and the female population. Effective strategies to reduce the national obese population could potentially reduce 35% of the TKR, with over 10,000 cases being avoided

Background and purpose

The STarT Back trial demonstrated benefits from a stratified primary care model that targets low back pain (LBP) treatment according to patient prognosis (low-, medium-, or high-risk). The current IMPaCT Back study implemented this approach in everyday primary care to investigate; i) changes in GPs' and physiotherapists' attitudes, confidence and behaviours, ii) patients' clinical outcomes, and iii) cost-effectiveness.

Objectives. To assess the sensitivity and specificity of self-reported osteoporosis compared with dual energy X-ray absorptiometry (DXA) defined osteoporosis, and to describe medication use among participants with the condition. Methods. Data were obtained from a population-based longitudinal study and assessed for the prevalence of osteoporosis, falls, fractures and medication use. DXA scans were also undertaken. Results. Overall 3.8% (95% confidence interval (CI) 3.2 to 4.5) of respondents and 8.8% (95% CI 7.5 to 10.3) of those aged ≥ 50 years reported that they had been diagnosed with osteoporosis by a doctor. The sensitivity (those self-reporting osteoporosis and having low bone mineral density (BMD) on DXA) was low (22.7%), although the specificity was high (94.4%). Only 16.1% of those aged ≥ 50 years and with DXA-defined osteoporosis were taking bisphosphonates. Conclusions. The sensitivity of self-reporting to identify osteoporosis is low. Anti-osteoporotic medications are an important part of osteoporosis treatment but opportunities to use appropriate medications were missed and inappropriate medications were used

Background and purpose. Over the past decade, it has become apparent that more often than not musculoskeletal pain occurs in more than one site in an individual, and traditional approaches, where pain has been studied as a narrow site-specific problem, are often not feasible. The overall aim of this study is to describe clusters of pain using a large population-based sample. This presentation will focus specifically on musculoskeletal co-complaints in back pain sufferers. Methods and results. The Danish National Institute of Public Health has since 1987 conducted national representative health interview surveys of the adult Danish population some of which have included questions on musculoskeletal complaints. We used latent class analysis to identify latent classes of musculoskeletal complaints that occurred alongside a primary complaint of back pain. In addition, probabilities that specific sites occurred as co-complaints were determined. Three latent classes were identified and they exhibited quite different patterns of musculoskeletal co-complaints. The most commonly occurring class had a low probability of any co-complaints, the second most commonly occurring class had a high probability of pain in the neck, shoulders and mid-back, while the least commonly occurring class had very high probabilities of pain at all other body sites. Conclusions. Latent class analysis can be used to identify distinctly different groups of pain patterns in persons primarily complaining of back pain. The three groups identified likely have very different prognoses. Conflicts of Interest. None. Source of Funding. None. This abstract has not been previously published in whole or substantial part nor has it been presented previously at a national meeting

Summary Statement. For RA patients undergoing TKR, the gain in function at 6 months following surgery is less than that experienced by OA patients; for THR, however, gains are similar in OA and RA patients. Introduction. Total joint replacement (TJR) is commonly used in rheumatoid arthritis (RA) patients and yet little information is available to quantify their functional gain following surgery and how it differs from what the osteoarthritis (OA) population experiences. Therefore, we examined 6-month functional outcomes of TJR in a population-based observational cohort of RA and OA patients who underwent total hip (THR) or knee (TKR) replacement. Methods. Patients undergoing primary TKR from 7/1/11 through 12/3/12 were identified from the FORCE-TJR national research consortium which enrolls patients from 111 surgeons across 27 states in the US. The registry gathers data from patients, surgeons and hospitals on patient demographics, underlying type of arthritis, operative joint severity based on the estimated Western Ontario and McMaster Universities Arthritis Index (WOMAC) using the Hip and Knee Disability and Osteoarthritis Outcome Scores, function based on the Short Form 36 Physical Component Score (PCS), and mental health using the SF-36 Mental Component Score (MCS). Descriptive statistics were performed. Results. There were 95 RA and 991 OA patients who underwent primary TKR, and 59 RA and 740 OA patients who underwent primary THR. Among TKR patients, RA patients are more likely to be women (68% vs. 61%), nonwhite (17% vs. 9%), unmarried (59% vs. 70%) with an annual income of ≤$45,000 (57% vs. 39%) as well as lower baseline emotional health (48 vs. 52) and functioning (31 vs 33). Among THR patients, RA patients are more likely to be nonwhite (18% vs. 8%), unmarried (66% vs. 69%) with an annual income of ≤$45,000 (54% vs. 34%) as well as lower baseline emotional health (46 vs. 51) and functioning (30 vs 32). RA patients undergoing TKR have less functional gain 6 months post-surgery (6.6 vs. 9.7; p=0.002) as compared to OA patients. In contrast, RA patients who undergo THR have similar functional gain (11.6 vs. 13.8; p=0.13) as compared to OA patients. Discussion/Conclusion. RA patients have less functional improvement as compared to those with OA when undergoing TKR but similar gains when undergoing THR

Summary Statement. A population based finite element study that accounts for subject-specific morphology, density and load variations, suggests that osteoporosis does not markedly lower the mechanical compliance of the proximal femur to routine loads. Introduction. Osteoporosis (OP) is a bone disease defined by low bone density and micro-architectural deterioration. This deterioration is neither uniform nor symmetric at the proximal femur. Evidence from analyses performed at the tissue level suggests that the cortical shell at the femoral neck is thinner in OP patients, especially in the superior regions, but not in the infero-anterior ones [Poole, Rubinacci]. Analogously, OP femurs show a higher anisotropy of the trabecular bone than controls [Ciarelli], suggesting a preservation of load bearing capacity in the principal loading direction vs. the transverse one. There is general consensus that the regions subjected to higher loads during walking, which is the predominant motor activity in the elderly, are mostly preserved. All these findings suggest that the OP femur should exhibit an almost normal mechanical competence during daily activities. This would be in accordance with the very low incidence of spontaneous fractures [Parker] and with the moderate fracture predictivity of BMD. Although reasonable, this hypothesis has never been tested at the organ level. Aim of the present study was to verify it with a population-based finite element (FE) study. Patients & Methods. Whole femur Computed Tomography (CT) scans of 200 patients (115 women) with normal femoral anatomy were retrieved from a repository of the Istituto Ortopedico Rizzoli. The database is representative of an adult Italian population (mean 57yrs, range 23–84), and spans a wide range of morphological and densitometric characteristics (CT-simulated T-score of femoral neck BMD ranging from 1 to −4.6). Personalised FE models of all femurs were built from CT data using a validated procedure [Schileo]. A personalised estimate of the variability of loads acting on the proximal femur during normal walking (NW) and stair climbing (SC) was obtained by querying an indexed and searchable database of joint and muscle loads obtained from musculoskeletal models of 90 subjects. 78 possible loading combinations for NW and 50 for SC were defined for each subject, taking into account individual characteristics (height, weight, femoral antetorsion, CCD angle and neck length). Risk of fracture (RF) was defined for each subject as the maximum principal strain / limit strain (1.04% compressive, 0.73% tensile) ratio over the whole loading spectrum. Results and Discussion. No fracture was predicted by the FE models throughout the entire population, yielding an average safety coefficient of between 4 and 5, which is consistent with experimentally determined failure loads in the single leg stance configuration (around 11 BW [Cristofolini]). While a general inverse association was observed with R2∼0.2, no clear correlation was present between the fracture risk and the T-score. The hypothesis that OP does not macroscopically influence the mechanical competence of the femur for daily activities was therefore corroborated, suggesting that the highest risk of fracture in OP patients might be related to a lower OP induced compliance to accidental loads

Objectives

Given the function of adiponectin (ADIPOQ) on the inflammatory condition of obesity and osteoarthritis (OA), we hypothesized that the ADIPOQ gene might be a candidate gene for a marker of susceptibility to OA.

Objectives

Metabolic syndrome and low-grade systemic inflammation are associated with knee osteoarthritis (OA), but the relationships between these factors and OA in other synovial joints are unclear. The aim of this study was to determine if a high-fat/high-sucrose (HFS) diet results in OA-like joint damage in the shoulders, knees, and hips of rats after induction of obesity, and to identify potential joint-specific risks for OA-like changes.

Aims

Osteoporosis and abnormal bone metabolism may prove to be significant factors influencing the outcome of arthroplasty surgery, predisposing to complications of aseptic loosening and peri-prosthetic fracture. We aimed to investigate baseline bone mineral density (BMD) and bone turnover in patients about to undergo arthroplasty of the hip and knee.