Background:. Full thickness cartilage defect of the knee frequently resulted in fibrous tissue formation, and larger lesions often lead to degenerative arthritis of the knee. Many techniques are designed to repair the cartilage defect including chondrocyte transplantation, microfracture and osteochondral graft. Each method has achieved some success but no universal results. Autologus osteochondral graft has gained in clinical popularity because of its technical feasibility and cost effectiveness. Purpose:. The purpose of this retrospective study was to evaluate the medium-term results of autologous osteochondral graft for focal contained articular cartilage defects of the knee in 25 patients with 26 knees with 2- to 7-year follow-up. Patients and Methods:. The cohort consisted of 17 men and 8 women with an average age of 31.3 ± 11.8 (range 20 to 65) years. One patient had bilateral knees. The diagnosis included 9 osteonecrosis, 10 osteochondritis dessicans, and 7 traumatic defects. A 1.0 mm oversized 10 mm long ossteochondral plug was harvested from either from the sulcus terminalis or the intercondylar notch, and implanted into the recipient site The numbers of osteochondral plug ranged from 1 to 3. In larger lesions, osteochondral grafts were implanted in the weight bearing area, and microfracture in non-weight bearing area. Postoperative management included crutch walking with non-weight bearing for 6 weeks, then partial weight bearing for another 6 weeks before full weight bearing. Range of knee motion, quadriceps and hamstring strengthening exercises were encouraged. The evaluations included functional assessment, radiograph of the knee and second look arthroscopy. Results:. At follow-up of 52.9 ± 20.3 (range 25 to 84) months, the results were 50% excellent, 35% good, 11% fair and 4% poor. Overall satisfactory results were noted in 85%. The improvements in pain and function of the knee ranged from 8 to 16 weeks after surgery. There was no correlation of the clinical results with the diagnosis of the lesion. However, the lesion size greater than 500 mm. 2. is associated with failure. Radiographic degenerative changes were noticed in 6 (23%) and 7 (27%) in medial compartment, 5 (19%) and 5 (19%) in lateral compartment, and 1 (4%) and 2 (8%) in the patellofemoral compartment pre- and postoperatively (P > 0.05). Twelve knees underwent a second look arthroscopy. Of the 11 asymptomatic knees, 8 knees with the defect smaller than 500 mm. 2. showed complete bonding of the graft to the adjacent host cartilage, and 3 cases showed minimal fissuring and fibrous tissue formation between graft and host tissue. One symptomatic knee with greater than 500 mm. 2. lesion showed extensive fibrous tissue between the graft and host cartilage. Conclusion:. Autologous osteochondral graft provides good or excellent results in 85% of patients with focal contained chondral and osteochondral defects of the knee. There was no correlation of the clinical results with the nature of the disease and the size of the lesion smaller than 500 mm. 2. Any lesion larger than 500 mm. 2. is prone to poor clinical outcome

Shoulder arthritis in the young adult is a deceptive title. The literature is filled with articles that separate outcomes based on an arbitrary age threshold and attempt to provide recommendations for management and even potential criteria for implanting one strategy over another using age as the primary determinant. However, under the age of 50, as few as one out of five patients will have arthritis that can be accurately classified as osteoarthritis. Other conditions such as post-traumatic arthritis, post-surgical arthritis including capsulorrhaphy arthropathy, and rheumatoid arthritis create a mosaic of pathologic bone and soft tissue changes in our younger patients that distort the conclusions regarding “shoulder arthritis” in the young adult. In addition, we are now seeing more patients with unique conditions that are still poorly understood, including arthritis of the pharmacologically performance-enhanced shoulder. Early arthritis in the young adult is often recognised at the time of arthroscopic surgery performed for other preoperative indications. Palliative treatment is the first option, which equals “debridement.” If the procedure fails to resolve the symptoms, and the symptoms can be localised to an intra-articular source, then additional treatment options may include a variety of cartilage restoration procedures that have been developed primarily for the knee and then subsequently used in the shoulder, including microfracture, and osteochondral grafting. The results of these treatments have been rarely reported with only case series and expert opinion to support their use. When arthritis is moderate or severe in young adults, non-arthroplasty interventions have included arthroscopic capsular release, debridement, acromioplasty, distal clavicle resection, microfracture, osteophyte debridement, axillary nerve neurolysis, and bicep tenotomy or tenodesis, or some combination of these techniques. Again, the literature is very limited, with most case series less than 5 years of follow-up. The results are typically acceptable for pain relief, some functional improvement, but not restoration to completely normal function from the patient's perspective. Attempts to resurface the arthritic joint have resulted in limited benefits over a short period of time in most studies. While a few remarkable procedures have provided reasonable outcomes, they are typically in the hands of the developer of the procedure and subsequently, other surgeons fail to achieve the same results. This has been the case with fascia lata grafting of the glenoid, dermal allografts, meniscal allografts, and even biologic resurfacing with large osteochondral grafts for osteoarthritis. Most surgical interventions that show high value in terms of improvement in quality of life require 10-year follow-up. It is unlikely that any of these arthroscopic procedures or resurfacing procedures will provide outcomes that would be valuable in terms of population healthcare; they are currently used on an individual basis to try to delay progression to arthroplasty, with surgeon bias based on personal experience, training, or expert opinion. Arthroplasty in the young adult remains controversial. Without question, study after study supports total shoulder arthroplasty over hemiarthroplasty once the decision has been made that joint replacement is the only remaining option

The autologous osteochondral grafting represents a treatment option for osteochondral lesions of the weight bearing articular surfaces of femoral condyles and talus. The aim of our study was to evaluate the MRI findings and to determine the correlation between the radiological and the functional outcome in the early follow up. We performed a retrospective study and followed up 33 patients 1 to 4 years after osteochondral auto-grafting. The grafts were harvested from the anterolateral region on the lateral femoral condyle of the ipsilateral knee using an insider rinsing diamond bone-cutting instrument (DBCS). The grafts were implanted using press fit technique and mosaic plasty. Sixteen (48%) women and 17 men were included in our follow up with an average age of 38.4 years (age range-16 to 58 yrs). The Lysholm and Foot and Ankle Osteoarthritis Scores were used for the assessment of the functional outcome. MRI scans were performed by all patients. While the MRI results illustrated graft incorporation, the cartilage contour interruption, irregularity of the subchondral lamina, inhomogeneity and subchondral oedema are typical findings between host and graft tissues. The clinical outcome demonstrated pain relief and improved function. There was no statistically significant correlation between radiological and functional outcome (p>0.05). The MRI is a well-recognised non-invasive diagnostic tool to assess the integration of osteochondral grafts and to evaluate the articular surface but it has a reduced clinical significance on the early post operative stages. The long-term prognostic value of the unsatisfying MRI results is unknown

An osteochondral defect greater than 3cm in diameter and 1cm in depth is best managed by an osteochondral allograft. If there is an associated knee deformity, then an osteotomy is performed. In our series of osteochondral allografts for large post-traumatic knee defects realignment osteotomy is performed about 60% of the time in order to off-load the transplant. To correct varus we realign the proximal tibia with an opening wedge osteotomy. To correct valgus, we realign the distal femur with a closing wedge osteotomy. Our results with osteochondral allografts for the large osteochondral defects of the knee both femur and tibia, have been excellent in 85% of patients at an average follow-up of 10 years. The Kaplan-Meier survivorship at 15 years is 72%. At an average follow-up of 22 years in 58 patients with distal femoral osteochondral allograft, 13 have been revised (22%). The 15-year survivorship was 84%. Retrieval studies of 24 fresh osteochondral grafts obtained at graft revision or conversion total knee replacement at an average of 12 years (5 – 25) revealed the following. In the areas where the graft was still intact, the cartilage was of normal thickness and architecture. Matrix staining was normal except in the superficial and upper mid zones. Chondrocytes were mostly viable but there was chondrocyte clusters and loss of chondrocyte polarity. Host bone had extended to the calcified cartilage but variable remnants of dead bone surrounded by live bone persisted. With a stable osseous base the hyaline cartilage portion of the graft can survive for up to 25 years

Purpose. One of the current research topics is the aim to produce tissue engineered osteochondral grafts for future treatment of osteochondral lesions (OCL) of the talus. For the exact anatomic reconstruction, the dimensions of the medial and lateral talar dome must be considered. Sparse data is available regarding the normal anatomic talar dimensions on standard radiographs of ankle joints [1, 2]. The purpose of this study was to describe normal anatomy of different sections of the talar dome on 3D reconstructions of computertomographic (CT) images. Method. CT data sets (Somatom 10, Siemens Erlangen, Germany) of 82 patients (86 ankles) (28 female, 54 male; average age 41.9y (range 15–76y)) without talar pathologies were included. Measurements were performed with a geometry analysis software (VGStudio MAX 2.0, Volume Graphics, Heidelberg, Germany). To assure measurement reproducibility, the reference planes were defined in a first step. To measure the frontal talar edge radius, circles were fitted into the medial and lateral talar edge on frontal planes. To allow measurement of different segments of the talus, the frontal plane was tilted through the center of the talus (defined as a circle fitted to the talus on sagittal view) at 15 and 30 anteriorly and posteriorly. To measure the sagittal radius of the medial and talar edge, ircles were fitted into the medial and lateral talar edge on sagittal planes. Results. The talar edge radius in the frontal plane at 0 wa s 4.9 mm medially (3.0 mm laterally), at 15 ant. 4.2 mm (3.1 mm), at 30 ant. 4.6 mm (3.1 mm), at 15 post. 4.5 mm (3.9 mm), and at 30 post 4.1 mm (6 mm). There was a significant difference (p<0.01) between the mean medial and lateral talar edge radius at all angles. The talar edge radius in the sagittal plane was 20.4 mm medially and 20.3 laterally. There was no significant difference between the mean medial and lateral sagittal talar edge radius. Conclusion. This study shows a significant difference between physiological medial and lateral edge configuration at different frontal planes of the talar dome. No difference was found comparing the sagittal radius of the medial and talar dome. The assessed data provides important aid for engineering of pre-formed, pre-sized osteochondral grafts. Such pre-shaped grafts could help restoring the physiological joint surface by matching exactly into the lesion and consequently achieving the recovery of the physiological joint biomechanics and prevention of secondary degenerative disease

An osteochondral defect greater than 3cm in diameter and 1cm in depth is best managed by an osteochondral allograft. If there is an associated knee deformity, then an osteotomy was performed. In our series of osteochondral allografts for large post-traumatic knee defects, realignment osteotomy is performed about 60% of the time in order to off load the transplant. To correct varus we realign the proximal tibia with an opening wedge osteotomy. To correct valgus, we realign the distal femur with a closing wedge osteotomy. Our results with osteochondral allografts for the large osteochondral defects of the knee both femur and tibia, have been excellent in 85% of patients at an average follow-up of 10 years. The Kaplan-Meier survivorship at 15 years is 72%. At an average follow-up of 22 years in 58 patients with distal femoral osteochondral allograft, 13 have been revised (22%). The 15-year survivorship was 84%. Retrieval studies of 24 fresh osteochondral grafts obtained at graft revision or conversion to total knee replacement at an average of 12 years (5 – 25) revealed the following. In the areas where the graft was still intact, the cartilage was of normal thickness and architecture. Matrix staining was normal except in the superficial and upper mid-zones. Chondrocytes were mostly viable but there was chondrocyte clusters and loss of chondrocyte polarity. Host bone had extended to the calcified cartilage but variable remnants of dead bone surrounded by live bone persisted. With a stable osseous base the hyaline cartilage portion of the graft can survive for up to 25 years

Large osteochondral defects of the glenohumeral joint are difficult to treat in young, active patients. When initial non-operative treatment with physical therapy, non-steroidal anti-inflammatory medications, corticosteroid injections, and viscosupplementation fails, surgery may become an option for some patients. Traditional shoulder arthroplasty and hemiarthroplasty provide excellent function and pain relief that can be long-lasting, but these treatments are still very likely to fail during a young patient's lifetime, and results have been unsatisfactory in many younger patients. Microfracture and autologous chondrocyte implantation (ACI) have been used in the shoulder, but their use has been limited to small defects. Other techniques that incorporate soft-tissue coverage of larger osteochondral defects have the benefit of preserving bone, but have not provided consistently good results. Advanced surgical techniques have been developed including all-arthroscopic osteochondral graft resurfacing of the humerus and glenoid for the treatment of osteoarthritis. This method of ‘biological resurfacing’ of the joint without using prosthetic implants may offer potential benefits to these young patients with shoulder arthritis including faster rehabilitation, pain relief, and easier revision surgery, if necessary. Early outcomes are encouraging in many cases, but inconsistent overall, with pain relief being the most reliable indicator of patient satisfaction

Introduction. Osteochondral autologous autograft (also called mosaic arthroplasty) is the preferred treatment method for very large osteochondral defects in the ankle. For long-term success of this procedure, the transplanted plugs should reconstruct the curvature of the articular surface. The different curvatures between femoral-patella joint and the dome of the talus makes the reconstruction difficult and requires lots of experience. Material. Prior to the surgery a CT arthrogram of the ankle, as well as a CT of the knee were obtained and 3D bone models for the knee, the ankle as well as a model for the ankle cartilage were created. Using custom-made software a set of osteochondral grafts (“plugs”) positioned over the defect site were planned and an optimal harvest location for each plug was chosen. Intraoperatively, an optoelectronic navigation system was installed and sensors were attached to femur, talus, and conventional harvest and delivery chisels. A combined pair-point and surface matching was performed to register femur and talus. For each planned plug the surgeon positioned, oriented, and rotated the harvest and delivery chisels with respect to preoperative plan by using the visual and numerical feedback of the system. Results. We performed the above described procedure on a 37 year old female patient with osteochondral injury of the dome of the right talus with an approximate size of 20mm × 9mm. One 8mm and two 6mm plugs were planned and intraoperative navigated. At 6 months postoperative she had a significant improvement in her passive range of motion from 0–15° dorsi-flexion and 0–60° plantar-flexion, compared to her uninjured ankle of 0–15° dorsi-flexion and 0–80° plantar-flexion. The inversion and eversion of the ankle are normal and x-ray evaluation showed good and complete integration of the osteochrondal plugs. Discussion. A virtual preoperative planning tool helped to solve the complex geometrical problem of reconstructing the articular cartilage surface of the talus using multiple autologous osteochondral plugs from the knee. The intraoperative optoelectronic guidance allowed the surgeon to transfer this plan into the intraoperative situation

Introduction. Femoroacetabular impingement (FAI) causes anterior hip pain, labral tears and damage to the articular cartilage leading to early osteoarthritis of the hip. Surgical hip dislocation and osteoplasty of the femoral neck and acetabular rim is a technique pioneered by the Bernese group for the treatment of FAI. We present and discuss our results of this technique. Methods. Functional outcome was measured in hips with over 12 month follow-up using the Oxford hip and McCarthy non-arthritic hip scores pre- and post-operatively. Results. From March 2003 to December 2005, 79 hips underwent surgical hip dislocation for treatment of FAI. Ten were skeletally immature and excluded. In 16 hips, grade 4 osteoarthritis was present in greater than 10 × 10mm regions after reshaping of the abnormal anatomy. In these cases, hip resurfacing was performed. Of the 53 hips preserved (average age 37(17-65)), 35 had the labrum detached, debrided and reattached using bone anchors, 32 underwent recession of the acetabular rim at the site of impingement, 21 had chondral ‘carpet’ flaps debrided, 5 had removal of medial osteophytes, 7 had labral and/or bony cysts excised and grafted and 1 underwent an osteochondral graft. In 5 hips osteoarthritis progressed requiring hip resurfacing at an average of 8 months. Oxford Hip Score improved from an average 32 (range 13-59) to 23 (12-45) and McCarthy hip score from 50 (19-76) to 63 (28-79) in the preserved hips at an average 20 months following surgery (range 12-38 months). Conclusion. The early results of surgical hip dislocation are encouraging. The open procedure has distinct advantages compared to arthroscopy enabling a wider range of lesions to be treated. Careful patient selection is important in order to exclude patients with hip osteoarthritis. Long-term follow-up is required to see if this technique prevents the natural progression to osteoarthritis

In search for appropriate materials of potential use to relieve injured articular cartilage, we explored copolymers from HEMA (2-hydroxy-methyl-methacrylate) and MMA (methyl-methacrylate). Such copolymers can be synthesized by thermal or photochemical induced polymerization reaction. The water uptake by swelling to homogeneous hydrogels can easily be controlled by varying the mixing ratio of the hydrophilic (HEMA) and hydrophobic (MMA) monomer, and the nature and amount of added crosslinker (typically EGDA, ethyleneglycol-dimethacrylate). Essentially the same variables strongly influence the mechanical properties, i.e. modulus (stiffness), relaxation response, as well as tribological behavior. The polymer samples were engineered in molds from degassed formulations containing various amounts of HEMA and MMA, 10 % deionized water, and 0.01 % AIBN for thermal polymerization (12 h @ 70°C) or 0.5 % Darocur 1173 (2-hydroxy-2-methyl-1-phenyl-propane-1-one, for photopolymerization, 360 nm UV radiation, 5 to 7 min, sample thickness up to 5 mm). The samples were immersed in saline buffer after curing to allow free swelling to the equilibrium water content (EWC). Subsequently, samples were mechanically and tribologically tested. The mechanical moduli were determined at different strains and as a function of MMA content using a Zwicki Z5.0 (Zwick-Roell, Ulm, Germany). Tribological versus cartilage tissue was performed on an in-house-built pin-on-plate setup. Flat polymer samples were mounted and tested versus fresh porcine osteochondral grafts, harvested from humeral heads. Mechanical testing revealed that the elastic modulus of pHEMA can be tuned as a function of MMA (0–50%) with 1 to 2 % bifunctional crosslinker to values ranging between 0.5 to 50 MPa, and corresponding water content of 40 to 10 % (decreasing with increasing MMA content). Friction measurements revealed a very low friction coefficient of around 0.02 for pHEMA-cartilage pairings. The values are 2–5 fold smaller than typical values of CoCrMo or UHMWPE versus cartilage. Hydrogels from HEMA and MMA as main constituents are already rather well known for their biocompatibility. Knowledge of the dependence of e.g. the mechanical properties from chemical composition and polymer network structure makes this system ideal to design anisotropic specimen with controlled macrostructure to be used for temporal or permanent implants

INTRODUCTION. Osteochondral defects are still a challenge for the orthopaedic surgeon, since most of the current surgical techniques lead to fibrocartilage formation and poor subchondral regeneration, often associated to joint stiffness and/or pain. Thinking of the ideal osteochondral graft from both the surgical an commercial point of view, it should be an off-the-shelf product; this is the research direction and the explanation for the new biomaterials recently proposed to repair osteochondral defect inducing an “in situ” cartilage regeneration starting from the time of the implantation into the defect site. For the clinical pilot study we performed, a newly developed nanostructured biomimetic scaffold was used to treat chondral and osteochondral lesions of the knee; its safety and manageability, as much as the surgical procedure reproducibility and the clinical outcome, were evaluated in order to test its intrinsic potential without any cells colture aid. MATERIALS AND METHODS. A new osteochondral scaffold was obtained by enucleating equine collagen type 1 fibrils with hydroxyapatite nanoparticles in 3 different layers with 3 different gradient ratios at physiological conditions. 30 patients (9F, 21M, mean age 29,3yy) affected by either chondral or osteochondral lesions of the knee (8 medial femoral condyles, 5 lateral femoral condyles, 12 patellae, 8 femoral throcleas) underwent the scaffold implantation from January to July 2007. The sizes of the lesions were in between 2 and 6 squared cm. All patients and their clinical outcome were analyzed prospectively at 6, 12, 24 and 36 months using the Cartilage standard Evaluation Form as proposed by ICRS and an high resolution MRI. RESULTS. We observed a statistically significant scores improvement and function recovery comparing the pre-operative to the follow-up parameters evaluated. Moreover, we noticed a better improvement from 12 to 24mm follow up while the good results gained at 2yy were confirmed at 3yy follow up evaluation. The MOCART scoring scale was used to analyze the MRIs. In 80% of cases we obtained a complete filling of the cartilage defect and in some patients we even appreciated articular surface congruency. In this series we report 1 failure followed by a re-operation with different technique. CONCLUSIONS. This new minimally invasive one-step surgical approach to osteochondral defects seems to be an easy and effective procedure. The results obtained are very encouraging and this procedure show satisfactory outcomes even in big osteochondral defects

Hyaline articular cartilage has been known to be a troublesome tissue to repair once damaged. Since the introduction of autologous chondrocyte implantation (ACI) in 1994, a renewed interest in the field of cartilage repair with new repair techniques and the hope for products that are regenerative have blossomed. This article reviews the basic science structure and function of articular cartilage, and techniques that are presently available to effect repair and their expected outcomes.