Aims. The aim of this study was to determine whether early surgical treatment results in better neurological recovery 12 months after injury than late surgical treatment in patients with acute traumatic spinal cord injury (tSCI). Methods. Patients with tSCI requiring surgical spinal decompression presenting to 17 centres in Europe were recruited. Depending on the timing of decompression, patients were divided into early (≤ 12 hours after injury) and late (> 12 hours and < 14 days after injury) groups. The American Spinal Injury Association neurological (ASIA) examination was performed at baseline (after injury but before decompression) and at 12 months. The primary endpoint was the change in Lower Extremity Motor Score (LEMS) from baseline to 12 months. Results. The final analyses comprised 159 patients in the early and 135 in the late group. Patients in the early group had significantly more severe neurological impairment before surgical treatment. For unadjusted complete-case analysis, mean change in LEMS was 15.6 (95% confidence interval (CI) 12.1 to 19.0) in the early and 11.3 (95% CI 8.3 to 14.3) in the late group, with a mean between-group difference of 4.3 (95% CI -0.3 to 8.8). Using multiply imputed data adjusting for baseline LEMS, baseline ASIA Impairment Scale (AIS), and propensity score, the mean between-group difference in the change in LEMS decreased to 2.2 (95% CI -1.5 to 5.9). Conclusion. Compared to late surgical decompression, early surgical decompression following acute tSCI did not result in statistically significant or clinically meaningful neurological improvements 12 months after injury. These results, however, do not impact the well-established need for acute, non-surgical tSCI management. This is the first study to highlight that a combination of baseline imbalances, ceiling effects, and loss to follow-up rates may yield an overestimate of the effect of early surgical decompression in unadjusted analyses, which underpins the importance of adjusted statistical analyses in acute tSCI research. Cite this article: Bone Joint J 2023;105-B(4):400–411

Aim of our study was the investigation and the cross-correlation of various neurologic scales to estimate, comparatively with the functional results of patients after damage of spinal cord injuries. Between 1989 – 2005, 115 patients were submitted in stabilization of Lower Cervical Spine that was judged unstable. The neurologic situation was certified with the scales: Frankel, ASIA motor score, NASCIS motor score, FIM scale, and MBI scale. In the protocol took part the 94 patients for that existed in neurologic details and long follow-up for at least two years. From the study of course of scores of all scales was not found statistically important difference between ASIA, NASCIS and other motor scales. However 12 patients with important improvement of mobility at ASIA motor score and NASCIS motor score they have not difference in Frankel scale, despite the make that the MRP (Motor Percentage Recovery) was improved: 21.5%. Also 8 patients with relatively big improvement in their total scores did not have corresponding functional improvement (FIM scale, and [MBI] scale). A lot of neurologic methods – scales were used and are used today. However for the essential and modern follow-up of patients with spinal cord injuries, it needs certification with a scale of classic team of (measurement of mobility) and a scale of functional faculties of the patient

Aim of study: To establish whether there was a correlation between the degree of bony spinal canal encroachment and initial neurological deficit and subsequent neurological recovery. Methodology and Results: Twenty-six Patients with Thoraco-lumbar Burst fractures presenting with Frankel Grades C, D and E were studied retrospectively. All the Patients were admitted to the spinal injury centre within seven days of injury and were managed conservatively with bed rest for six weeks (mean) followed by brace or a POP jacket for a further period of approximately six weeks. Neurological progress was assessed by Frankel Grade and American Spinal Injury Association (ASIA) motor score. The degree of spinal canal encroachment was determined from coronal sections of the CT scan by measuring the antero- posterior diameter (APD) and the surface area (Area). (APD 18.84% – 80.62%, Area 9.5% – 81.29%). Average period of follow up was 24.8 months. All Frankel Group C improved to Frankel D and six out of the 13 Frankel D patients improved to Frankel E. The other seven Frankel D patients out of the 13 patients also had improvement in motor scores but did not change Frankel grade. Conclusion: There appeared to be no statistically significant correlation between the degree of canal encroachment, the degree of initialneurological impairment or the degree of neurological recovery in patients who had motor sparing within one week of injury

Initial treatment of traumatic spinal cord injury remains as controversial in 2023 as it was in the early 19th century, when Sir Astley Cooper and Sir Charles Bell debated the merits or otherwise of surgery to relieve cord compression. There has been a lack of high-class evidence for early surgery, despite which expeditious intervention has become the surgical norm. This evidence deficit has been progressively addressed in the last decade and more modern statistical methods have been used to clarify some of the issues, which is demonstrated by the results of the SCI-POEM trial. However, there has never been a properly conducted trial of surgery versus active conservative care. As a result, it is still not known whether early surgery or active physiological management of the unstable injured spinal cord offers the better chance for recovery. Surgeons who care for patients with traumatic spinal cord injuries in the acute setting should be aware of the arguments on all sides of the debate, a summary of which this annotation presents.

Cite this article: Bone Joint J 2023;105-B(4):347–355.

Introduction We have undertaken a retrospective study to identify prognostic factors predictive of neurological recovery after spinal cord injury (SCI). Methods During the year 1999 to 2000, 403 patients with SCI were admitted and 91 patients could be followed-up for more than one year. Improvement in the motor score (ASIA) were taken as indicative of functional neurological recovery. Prognostic factors were simplified into static (which do not change with time) and dynamic (which may change with time). Variables like age, sex, mode of injury, mechanism of injury and skeletal level were static. Neurological level, sacral sparing, duration of spinal shock, reflex recovery, sensory & motor scores and complications like bedsores, flexor spasms, UTI, URTI, & DVT were dynamic. These were recorded at admission, at weekly intervals until discharge and at three monthly intervals in follow-up. They were correlated for any association with neurological recovery at one year. Regressive analysis of static and dynamic factors was done. Results No significant correlation of static variables with the neurological recovery was found. First aid and transportation, duration of spinal shock, sacral sparing, rate of reflex recovery, flexor spasms and bedsores had a significant correlation with neurological recovery. Pin-prick sparing, spinal shock of < 24 hours and early appearance of deep tendon reflexes were good prognostic factors. Complete lesion, spinal shock for > 1 week, flexor spasms within three weeks and bedsore within one week were worst prognostic factor. Initial three weeks following injury was the critical period influencing final neurological and functional outcome

Recent advances in spinal cord injury(SCI) management have markedly reduced mortality & morbidity, but concern regarding final neurological outcome is still at large. Global search is for prognostic-factors to predict neurological recovery. We statistically analyzed different variables to review the established and determine newer predictors of neurological recovery in SCI. During 1999–2000, 403 patients were admitted. 91 could be followed up for more than one year. Improvement in the motor score (ASIA) was taken as indicative of functional neurological recovery Prognostic factors were simplified into static(which do not change with time) and dynamic(which may change with time). Variables like age, sex, mode/mechanism of injury and skeletal level were static. These were recorded at admission and correlated for any association with neurological recovery at one year. Variables like neurological level, sacral sparing, duration of spinal shock, reflex recovery, sensory & motor scores and complications like bedsores, flexor spasms, UTI, URTI, & DVT were dynamic. These were recorded at admission, at weekly intervals till discharge and at 3 monthly intervals in follow-up. Bivariant & Regressive analysis of static and dynamic factors was done. No significant correlation of static variables was found with the neurological recovery. On bivariant analysis Pin-prick sparing, intact bladder, spinal shock of < 24 hours and early appearance of deep tendon reflexes were good prognostic factors. Complete lesion, priapism, spinal shock for > 1 week, bedsore within 1 week and flexor spasms within 3 weeks were worst prognostic factor. When regressive linear analysis was done speed of recovery in the initial three weeks was the most important prognostic factor irrespective of other variables studied against the final neurological recovery. All variables affecting neurological recovery have an effect on the speed of recovery, which is the single most important prognostic factor influencing ultimate recovery. The initial 3 weeks following injury were the critical period influencing final neurological & functional outcome

Retrospective review of seventeen consecutive survivors of craniocervical dissociation (CCD). Thirteen patients had delay in diagnosis, with associated neurologic deterioration in five. Diagnosis of CCD was entertained after lateral C-spine x-ray in only two patients, and after screening C-spine CT in two others. At fifteen-month average follow-up, mean ASIA motor score improved from fifty preoperatively to seventy-nine postoperatively. One patient had temporary postoperative neurologic decline. There were no pseudarthroses. The diagnosis of CCD is often missed, with potentially severe neurologic consequences. Early diagnosis and stabilization are neuroprotective. A classification that identifies minimally displaced yet unstable injuries may improve diagnostic accuracy. To identify the timing and method of diagnosis, diagnostic reliability of screening lateral radiographs, effect of delayed diagnosis, complications of treatment, and neurologic outcome of this life-threatening condition. Diagnosis of craniocervical dissociation (CCD) was frequently delayed, increasing the risk of neurologic decline. Early diagnosis and stabilization protected against worsening spinal cord injury. This study highlights the importance of disciplined evaluation of the lateral cervical spine radiograph of poly-traumatized patients. Head-injured patients with cranio-facial trauma and asymmetric high cervical spinal cord injuries should heighten clinicians’ suspicion of CCD. CCD was identified or suspected on two of seventeen (12%) initial lateral cervical spine radiographs, and on screening CT scan in only two additional patients (12%), despite an abnormal dens-basion relationship in 16/17 (94%) patients. Of the thirteen patients with (two-day average) delay in diagnosis, 5/13 (38%) had profound neurologic deterioration. One patient worsened temporarily after fixation. There were no pseudarthroses at fifteen-month average follow-up. Mean ASIA motor score of fifty improved to seventy-nine, and the number of patients with useful motor function (ASIA D or E) increased from seven (41%) preoperatively to thirteen (76%) postoperatively. Four patients with severe craniocervical instability had < 3 mm displacement. We therefore adopted a classification based on provocative traction testing of minimally displaced injuries.(Table). Retrospective review of seventeen consecutive CCD survivors identified between 1994–2002 through institutional databases. Radiographic and clinical results were evaluated, emphasizing timing of diagnosis, effect of delayed diagnosis, clinical or radiographic warning signs, and response to treatment. Please contact author for tables and /or diagrams

Study design: Retrospective, descriptive study. Objectives: To describe the characteristics and outcomes of patients with spinal canal stenosis who suffer significant spinal cord injury (SCI) due to hyperextension injury of the cervical spine. To compare their characteristics and outcomes with all patients suffering traumatic cervical SCI and with the total cohort of patients admitted to a Spinal Injuries Unit for rehabilitation. Setting: Spinal Injuries Unit (SIU), Princess Alexandra Hospital, Brisbane. Methods: Demographic, injury and outcome data were obtained from an existing database and by review of the medical records of 575 patients admitted to and discharged from the SIU between July 1st, 1995 and July 1st 2002. Main outcome measures were: change in American Spinal Injury Association (ASIA) scale category, change in ASIA motor score, discharge Functional Independence Measure (FIM) score and change in FIM score, length of stay (LOS), primary means of mobility at discharge and discharge destination. Standard statistical methods were used to compare groups. Results: A total of 18 (3%) of the 575 patients were found to have cervical canal stenosis and hyperextension injury (the CCS/HI group). This represents 8% of the total group suffering traumatic injury to the cervical spinal cord (the total cervical trauma: TCT group, n = 225). This CCS/HI group was found to have a mean age at injury of 55.1 years compared to 37.1 and 37.8 years respectively for the TCT and total groups. Ninety-four percent of patients were found to have a neurological level at admission at C1–3 or C4–5 compared to 75.6% of the TCT group and only 5.6% of patients had an ASIA Impairment Category A lesion at admission compared to 38.7% of the TCT group. Falls (55.6%) was the most common cause of injury in the CCS/HI group with motor vehicle accidents (33.8%) most common in the TCT group. The mean change in ASIA motor score between admission and discharge was 34.7 compared to 20.4 for the TCT group. Degree of impairment (measured by a change in ASIA Category) improved in 28% of patients and mean change in total FIM score was 41.3. There was no difference seen with the TCT group. LOS was shorter for these patients (111.1 days vs. 161.6 days). The primary means of mobility at discharge was “walking” for 50% of this group (compared to 28.4% for the TCT group) while the next most common means of mobility was “power wheelchair” at 28% (17% of TCT group). Most patients (55.4%) were discharged to their previous home following rehabilitation and 22.3% were discharged to another rehabilitation unit or acute hospital. Conclusions: Patients with cervical spinal canal stenosis who suffer hyperextension injury constitute a distinct subgroup with the total group of traumatic cervical spinal cord injuries. This study suggests that they are older at the time of injury, have more rostral cervical injuries, are more likely to have incomplete injuries and that falls is the most common cause of injury. They have greater improvement in motor function but this does not appear to result in greater function at discharge as measured by the FIM. There appears to be a dichotomy with results for mobility at discharge with patients either being able to walk or requiring a power wheelchair. LOS in the SIU is shorter but a higher percentage are discharged to another hospital or rehabilitation unit

STUDY DESIGN: Retrospective, descriptive study. OBJECTIVES: To describe the characteristics and outcomes of patients with spinal canal stenosis who suffer significant spinal cord injury (SCI) due to hyperextension injury of the cervical spine. To compare their characteristics and outcomes with all patients suffering traumatic cervical SCI and with the total cohort of patients admitted to a Spinal Injuries Unit for rehabilitation. SETTING: Spinal Injuries Unit (SIU), Princess Alexandra Hospital, Brisbane. METHODS: Demographic, injury and outcome data were obtained from an existing database and by review of the medical records of 575 patients admitted to and discharged from the SIU between July 1st, 1995 and July 1st 2002. Main outcome measures were: change in American Spinal Injury Association (ASIA) scale category, change in ASIA motor score, discharge Functional Independence Measure (FIM) score and change in FIM score, length of stay (LOS), primary means of mobility at discharge and discharge destination. Standard statistical methods were used to compare groups. RESULTS: A total of 18 (3%) of the 575 patients were found to have cervical canal stenosis and hyperextension injury (the CCS/HI group). This represents 8% of the total group suffering traumatic injury to the cervical spinal cord (the total cervical trauma: TCT group, n = 225). This CCS/HI group was found to have a mean age at injury of 55.1 years compared to 37.1 and 37.8 years respectively for the TCT and total groups. Ninety-four percent of patients were found to have a neurological level at admission at C1-3 or C4-5 compared to 75.6% of the TCT group and only 5.6% of patients had an ASIA Impairment Category A lesion at admission compared to 38.7% of the TCT group. Falls (55.6%) was the most common cause of injury in the CCS/HI group with motor vehicle accidents (33.8%) most common in the TCT group. The mean change in ASIA motor score between admission and discharge was 34.7 compared to 20.4 for the TCT group. Degree of impairment (measured by a change in ASIA Category) improved in 28% of patients and mean change in total FIM score was 41.3. There was no difference seen with the TCT group. LOS was shorter for these patients (111.1 days vs. 161.6 days). The primary means of mobility at discharge was “walking” for 50% of this group (compared to 28.4% for the TCT group) while the next most common means of mobility was “power wheelchair” at 28% (17% of TCT group). Most patients (55.4%) were discharged to their previous home following rehabilitation and 22.3% were discharged to another rehabilitation unit or acute hospital. CONCLUSIONS: Patients with cervical spinal canal stenosis who suffer hyperextension injury constitute a distinct subgroup with the total group of traumatic cervical spinal cord injuries. This study suggests that they are older at the time of injury, have more rostral cervical injuries, are more likely to have incomplete injuries and that falls is the most common cause of injury. They have greater improvement in motor function but this does not appear to result in greater function at discharge as measured by the FIM. There appears to be a dichotomy with results for mobility at discharge with patients either being able to walk or requiring a power wheelchair. LOS in the SIU is shorter but a higher percentage are discharged to another hospital or rehabilitation unit

This review provides a concise outline of the advances made in the care of patients and to the quality of life after a traumatic spinal cord injury (SCI) over the last century. Despite these improvements reversal of the neurological injury is not yet possible. Instead, current treatment is limited to providing symptomatic relief, avoiding secondary insults and preventing additional sequelae. However, with an ever-advancing technology and deeper understanding of the damaged spinal cord, this appears increasingly conceivable. A brief synopsis of the most prominent challenges facing both clinicians and research scientists in developing functional treatments for a progressively complex injury are presented. Moreover, the multiple mechanisms by which damage propagates many months after the original injury requires a multifaceted approach to ameliorate the human spinal cord. We discuss potential methods to protect the spinal cord from damage, and to manipulate the inherent inhibition of the spinal cord to regeneration and repair. Although acute and chronic SCI share common final pathways resulting in cell death and neurological deficits, the underlying putative mechanisms of chronic SCI and the treatments are not covered in this review.

Introduction. Neurological involvement occurs in 10-30% cases of caries spine. Surgical debridement and stabilisation is needed to decompress the cord and prevent progression of deformity. This prospective study was undertaken to determine the efficacy of operative treatment in the management and neurological recovery in patients with caries spine with neural deficit. Material & methods. 20 patients, 14 male, 6 female, were included and followed up for 1 year after surgery. The mean age was 39.45 years. 10 patients had complete paraplegia and 9 patients had paraparesis. 1 patient with cervical involvement had quadriplegia. Anterior decompression and stabilisation was done in all the cases. Objective of surgery was adequate debridement of diseased foci, decompression of cord and stabilisation of spine with correction of deformity. In 19 (95%) patients there with thoraco-lumbar involvement. This was addressed with a titanium mesh cage filled with impacted bone graft and supplemented with 2 Moss Miami screws and a rod construct. In the cervical spine, cervical spine locking plate was used for stabilisation after decompression and bone grafting (tricortical iliac crest graft). Results. Fifteen patients had complete and 5 patients had incomplete neurologic recovery. Neurological recovery started as early as first post-op week (range 3 days to 12 weeks). The ASIA motor score improved from 60.80 (60.80 +/− 20.206) before surgery to 73.55 (73.55 +/− 13.828) at 1 month and 95.30 (95.30+/−11.934) at 6 months after surgery. The ASIA sensory score improved from 173.30 (173.30 +/− 50.689), to 186.85 (186.65 +/− 37.452) at one month and 218.45 (218.45 +/−11.843) at 6 months. All 8 patients with bladder and bowel involvement recovered normal bladder and bowel functions at 6 months. There was no recurrence of infection. Bony fusion was achieved in all patients and there were no implant failures. Conclusion. Anterior debridement, decompression, stabilisation and anti-tubercular chemotherapy resulted in neurological recovery in the majority of the patients

Purpose: Prospective Observational Population Study to describe the incidence, demographics and pattern of spinal cord injury in British Columbia, Canada, for 10 years to 2004. Method: Systematic analysis of prospectively collected spine registry data (Vertebase) at Vancouver General Hospital, B.C., Canada from 1995–2004. Results: During the 10-year study period the 938 patients were admitted with a traumatic spinal cord injury. The Annual Population-Standardized Incidences ranged from 19.94 to 27.27 per million, with a median incidence of 23.34/million and with no significant change over the study period. The mean age was 39.7 years (34.73 in 1995 and 42.1 in 2004, p< 0.05) with a range of 16–92 years. 79.74 % were males. 48.2% of patients were AISA A on admission, of which 48% were quadraparetic. The most common levels of spinal cord injury were C5 (17.3%), C6 (10%), T1 (9.4%), T12 (5.8%). The Mean ASIA score was 50.22 with a range from 0–100. 19.8% of patients had a GCS£13. The mean ISS was 26.02, range of 0 – 75. Motor vehicle collisions and falls were responsible for 59% and 30% of admissions respectively. Mean length of in-hospital stay was 34 days, ranging from 1 – 275 days. In hospital mortality rate was 2.9%. ASIA Grade, Total Motor Score and anatomical level of injury all correlated directly with Length of stay (p< 0.0001). Conclusion: Acute Traumatic Spinal Cord Injury remains a major cause of significant morbidity among young males. The incidence appears to be increasing in the elderly. Modern multidisciplinary care has greatly reduced the associated acute mortality. Despite multiple prevention strategies the Annual Population-Standardized Incidence remained unchanged over the study period

We studied 32 patients with central cord syndrome who were managed conservatively. Six were under 50 years of age (group 1), 16 between 50 and 70 years (group 2) and ten over 70 years (group 3). At the time of discharge all patients in group 1 could walk independently and had good bladder control compared with 11 (69%) and 14 (88%) in group 2 and four (40%) and two (20%) in group 3, respectively. At follow-up after a mean of 8.6 years (4 to 15), ten patients had died leaving 22 in the study. All those in group 1 were alive, could walk independently and had bladder control. In group 2, 13 were alive of whom ten (77%) could walk independently and nine (69%) had bladder control. In group 3 only three were alive of whom only one was independent and none had bladder control. Function at discharge as measured by the ASIA motor scoring system was usually maintained or improved at follow-up, but patients over 70 years of age at injury did poorly

In the first year of existence of the Acute Spinal Injury Unit, 162 patients were admitted. A large number of injuries were the result of interpersonal violence. Case notes and radiographs of 49 consecutive patients with gunshot injuries to the spine were reviewed. The mean age of the 38 male and 11 female patients was 27.5 years (15 to 51). The mean length of stay in the unit was 30 days (4 to 109). The 46 associated injuries were 11 fractures, 14 haemopneumothoraces, and one soft palate, nine visceral, two vascular, four brachial plexus, three oesophageal and two tracheal injuries. Non-spinal surgery was required in 17 patients. The spinal injury was complete in 38 patients and incomplete in eight. Three had no neurological deficit. The involved level was cervical in 13, thoracic in 24 and lumbar in 12. The spine was considered stable in 43 patients. Six patients underwent surgical stabilisation. In 11 patients the bullets were in the canal and were removed. One case of discitis was debrided. Complications included three deaths, discitis in three patients, pneumonia in six and pressure sores in six. The ASIA motor score improved marginally in nine patients and one patient had true functional improvement. Gunshot injuries lead to a high incidence of permanent severe neurological deficit, but usually the spine remains mechanically stable. Most of the management revolves around the associated injuries and consequences of the neurological deficit

Purpose of the study: Construction of a key grip is the final objective of programmed functional surgery of the upper limb in the tetraplegic. Three phases are necessary: activation of the grip, simplification of the poly-articular chain, and positioning the thumb column. For this operative phase, two techniques can be used, either fusion of the articulation with a trapezometacarpal arthrodesis (TMA) or a soft tissue procedure (tenodesis of the abductor pollicis longus). Our study compared analytically these two techniques, considering grip force and stability and the quality of the key grip opening. Material and methods: This was a retrospective study of 38 key grips with a mean follow-up of 7.4 years in a population of tetraplegic patients (groups 1 – 5 in the International Classification of Giens. Seventeen active key grips including 11 with TMA and 21 passive key grips including 16 without TMA with regulation of the thumb position by soft tissue procedures. The active and passive grips according to the procedures were comparable statistically for their median ASIA motor scores. Results: The force of the active key grips with TMA (mean 2.7± 1.3 kg) was significantly greater than that obtained after tenodesis (1.3±0.7 kg) (p=0.05). For passive key grips, the difference was not significant, 1.1±0.6 kg with TMA versus 1.0±0.9 kg without. Twenty-three percent of the grips were unstable after TMA versus 24% after tenodesis. Regarding grip opening, the mean distance between the pulp of the thumb and the index was 3.7 cm for active key grips after TMA by tenodesis effect and 5.4 cm for holding large objects while without TMA these values were 3.2 cm and 6.4 cm respectively. For passive grips, these same values were 2.2 and 3.4 cm after TMA versus 2.4 and 6.8 after tenodesis. Discussion: For the active key grip, TMA enables a stronger grip but with loss of opening distance for large objects. Conversely, for the passive key grip, TMA does not enable a stronger grip but significantly limits passive opening. Globally TMA yields a more constant result. In patients with a limited motor potential, it is important to favour the creation of two different grips

Purpose: To determine whether neural axis level of injury (SCI, CMI, or CEI) is related to motor improvement, as defined by the International Standards for Neurological Classification of Spinal Cord Injury motor score (MS), in patients with a thoracolumbar (T11-L3) spine injury. Method: Fifty-three patients who sustained a neurological deficit secondary to a thoracolumbar spinal injury between 1995–2003 had injury details and MS collected prospectively. An independent evaluation determined the follow-up MS and SF-36 generic health-related quality of life (HrQOL) at a mean of 6.6 (SD 2.5) years post-injury. All patients had an MRI reviewed by a spine surgeon and neuroradiologist to determine the location of their conus medullaris and precise level of neural axis injury. Results: Nineteen patients (37%) had SCI, 20 (39%) had CMI, and 12 (24%) had CEI, while two could not be classified. Patients with SCI improved their MS by an average 7.0 motor points (SD 9.8); CMI improved 11.9 (SD 11.8); and CEI improved 16.8 (SD 16.0). This trend did not achieve statistical significance (p=0.09). Multivariate analyses demonstrated that initial MS had a significant interaction with neural axis level of injury with respect to the primary outcome. Specifically, CEI showed the greatest improvement in MS only when the initial MS was less than 75. Absence of initial anal sensation, a fracture-dislocation injury type and increasing time to surgery were all statistically associated with less improvement in MS. The mean follow-up SF-36 physical component score (PCS) was 37.3 (SD 10.1) and the mean mental component score (MCS) was 51.4 (SD 11.8). There was no significant difference in mean PCS and MCS for varying levels of neural axis injury. Conclusion: Patients with a CEI demonstrated the most improvement in MS, while absent anal sensation, a fracture-dislocation, and long delay to surgery were poor prognostic indicators for motor recovery. The HrQOL outcomes did not vary with neural axis level of injury. The results of this study assist in determining a prognosis for patients that sustain these common injuries. Future research should focus on how specific pre- and peri-operative variables affect outcomes in patients with neurological deficits secondary to thoracolumbar injuries

Purpose: To evaluate the demographics, presentation, treatment and outcomes of spinal infection in a population of Intravenous Drug Users. Method: Data on all patients with pyogenic spinal infection presenting to a quaternary referral center was obtained from a prospectively maintain database. Results: Over the five-year study period, there were 102 patients treated for Primary Pyogenic Infection of the Spine of which 51 were Intravenous Drug Users (IVDU). Of this IVDU group there were 34 males. Mean age was 43 years (range 25 – 57). Twenty-three had HIV, 43 Hepatitis C and 13 Hepatitis B. All were using cocaine, 26 were also using Heroin and 44 more than three recreational drugs. Thirty patients presented with axial pain with a mean duration of 51 days (range 3–120). Thirty-one were ASIA D or worse with eight ASIA A. Mean Motor Score of patients with deficit was 58.6. Most common ASIA Motor Levels were C4 and C5. Mean duration of neurological symptoms was seven days (range 1–60). Blood parameters on admission were in keeping with sepsis in immunocompromised patients. None had previous surgery for spinal infection. Twenty-sex were receiving IV antibiotics for known spinal infection. 44 patients were treated surgically. 32 had infection of the cervical spine, 9 Thoracic and 3 Lumbar. 22 had a posterior approach alone, 13 had anterior only while 9 required combined. Mean operative time was 263 mins (range 62 – 742). 13 required tracheostomy. 7 required early revision for hardware failure and 2 for surgical wound infection. Mean duration of antibiotic treatment was 49 days (range 28–116). 26 patients had single agent therapy. 17 had MSSA and 17 MRSA. At discharge 28 patients had neurological improvement (mean 20 ASIA points, range 1–55), 11 had deterioration (mean 13, range 1–50) and 5 were unchanged. There were no in-hospital deaths. At 2 years after index admission 13 patients were dead and none were attending the unit for follow-up. Conclusion: Primary pyogenic spinal infection in IVDU’s typically presents with sepsis and acute cervical quadriplegia. Surgical management must be prompt and aggressive with significant neurological improvement expected in the majority of patients

Introduction: The poor correlation between neurological injury and degree of retropulsion in thoracolumbar burst fractures has been identified, but not adequately explained. We have examined the possibility that variation in the termination of the conus medullaris may offer protection from neurological injury in a proportion of these fractures. Methods: A retrospective study was made of 39 patients presenting with single level thoracolumbar burst fractures between June 1998 and April 2001. Admission MRI was performed on all patients. Age, sex, ISS, neurological status, mode of treatment and any neurological recovery were recorded. From the MRI scans the levels of the conus and the fracture were noted. Transverse Spine Area(TSA) was measured at the cranial, caudal and injured levels. A predicted TSA and % TSA for the injury level was calculated from the mean of the two other levels. Analysis was of severity of neurological injury in relation to canal compromise and involvement of the conus. Results: 26 male and 13 female patients of mean age 35.9 (SD 17) years and mean ASIA motor score 90.4 (SD 23) were studied. Neither sex nor age distribution differed between 18 neurologically injured and 21 intact patients. Mean ISS was 20.2 in the neurologically injured and 10.5 in the intact (p=0.0005). Mean TSA of the canal was 218mm2 in the intact and 150mm2 in the injured groups (p=0.006) and mean %TSA was 70 and 49 respectively (p=0.007). The conus lay between T12 and L2 in all. When the conus lay cranial to the fracture (n=13), 38% were neurologically intact. When the conus lay at the level of the fracture (n=26), 62% were intact (NS). Neurological deficit did not occur in the absence of neurological compression on MRI. Conclusions: Neurological injury is not less likely when the conus lie outside the fracture zone. Canal compromise is a highly significant factor in neurological injury

Introduciton Diagnosis of cranio-cervical dissociaton is frequently delayed, and neurological consequences may be severe. Our purpose was to identify problems with the diagnosis and treatment of craniocervical dissociation, while reporting the results of early craniocervical fusion with posterior segmental fixation. Methods We present a retrospective review of 17 survivors of cranio-cervical dissociation identified through institutional spine and trauma registries. Medical records, radiographs, and prospectively collected data were used to identify the timing and method of diagnosis, and the effect of delayed diagnosis. Radiographic and clinical results of treatment were evaluated. Emphasis was placed on identifying missed or delayed diagnoses, decline in neurologic function, potential clinical or radiographic warning signs, and response to treatment. Results Despite an abnormal Basion-Dens relationship in all but one patient, cranio-cervical dissociation was identified or suspected on the initial lateral cervical spine radiograph in only two patients (12%), and was diagnosed in only four patients (24%) following initial trauma evaluation (lateral radiograph and CT of cervical spine). The two day average delay in diagnosis was associated with profound neurologic deterioration in five patients. One patient had post-operative neurologic worsening. No patients developed craniocervical pseudarthrosis or hardware failure after a 15-month average follow-up period. The mean ASIA motor score of 50 improved to seven, and the number of patients with useful motor function (ASIA D or E) increased from seven patients (41%) pre-operatively to 13 (76%) post-operatively. The typical patient profile was of a polytraumatized patient with associated head injuriy, cranio-facial trauma, and asymmetric motor deficits extending above the C5 level. Conclusions Better clinician awareness and disciplined review of screening C-spine radiographs are important for prompt diagnosis and stabilization of craniocervical instability. Of 17 patients with CCD necessitating internal fixation (stage two and three), 13 had a delay in diagnosis either at our institution or the transferring hospital, with severe neurological consequences in five patients. Significant recovery of neurologic function was a consistent post-operative finding, confirming the importance of prompt diagnosis and operative stabilization of these devastating injuries

Background: It has been reported that there is poor correlation between neurological injury and degree of bony retropulsion in thoracolumbar burst fractures. 1. Wilcox et al. 2. showed biomechanically that there was poor concordance between the extent of post impact spinal canal occlusion and the maximum amount of occlusion that occurred at the moment of impact. In the current study we examined the possibility that variation in the termination of the conus medullaris may offer protection from neurological injury in a proportion of these fractures. Methods: A retrospective study was made of 39 patients (26M:13M, mean age 35.9 years, range 15 – 75 years) presenting with a single level thoracolumbar burst fracture (T12–L2) between 1998 and 2001. A whole spine MRI scan was performed on all patients and the level of the conus noted. Age, sex, injury severity score (ISS), neurological status (ASIA motor score) and the transverse spinal canal area (TSCA) of the vertebral levels either side of the fractured vertebra was measured. A predicted TSCA for the injured level was then calculated from the mean of the TSCA’s of the adjacent levels. The actual TSCA of the injured level was calculated and this enabled a percentage decrease of the TSCA to be worked out from the predicted value. Analysis was made of the presence or absence of neurological injury in relation to canal compromise and involvement of the conus. Results: Eighteen patients with neurological compromise and 21 with intact neurology (the age and sex distribution in the two groups were similar). The mean ± SD ASIA motor score of the patients studied was 90.4 ± 23. Mean ISS was 20.2 in the neurologically injured and 10.5 in the intact (p=0.0005). Mean TSCA of the canal was 218mm. 2. in the intact and 150mm. 2. in the injured groups (p=0.006) and mean %TSCA was 70 and 49 respectively (p=0.007). The conus lay between T12 and L2 in all patients. When the conus lay cranial to the fracture (n=13), 38% were neurologically intact. When the conus lay at the level of the fracture (n=26), 62% were intact (NS). Neurological deficit did not occur in the absence of neurological compression on MRI. Conclusion: Our study showed that the risk of neurological injury from a thoracolumbar burst fracture was not decreased when the conus lay outside the fracture zone. However, there was a statistically significant difference in percentage of canal compromise when the patients with neurological impairment were compared with those that were neurologically intact