Reverse total shoulder arthroplasty (RSA) with glenoid bone grafting has become a common option for the management of significant glenoid bone loss and deformity associated with glenohumeral osteoarthritis. Despite the increasing utilization of this technique, our understanding of the rates of bone graft union, complications and outcomes are limited. The objectives of this systematic review are to determine 1) the overall rate of bone graft union, 2) the rate of union stratified by graft type and technique, 3) the reoperation and complication rates, and 4) functional outcomes, including range of motion (ROM) and functional outcome scores following RSA with glenoid bone grafting. A comprehensive search of MEDLINE, Embase, and CINAHL databases was completed for studies reporting outcomes following RSA with glenoid bone grafting. Inclusion criteria included clinical studies with greater than 10 patients, and minimum follow up of one year. Studies were screened independently by two reviewers and quality assessment was performed using the MINORs criteria. Pooled and frequency-weighted means and standard deviations were calculated where applicable. Overall, 15 studies were included, including nine retrospective case series (level IV), four retrospective cohort studies (level III), one prospective cohort study (level II) and one randomized control trial (level I). The entire cohort consisted of 555 patients with a mean age of 71.9±2.1 years and 70 percent female. The mean follow-up was 33.8±9.4 months. Across all procedures, 84.9% (N=471) were primary arthroplasties, and 15.1% (N=84) were revisions. The overall graft union rate was 89.2%, but was higher at 96.1% among studies that used autograft bone (9 studies, N=308). When stratified by technique, bone graft for the purposes of lateralization resulted in a 100% union rate (4 studies, N=139), while eccentric bone grafts used in asymmetric bone loss resulted in a lower union rate of 84.9% (10 studies, N=345). The overall revision rate was 6.5%, and was lowest following primary cases at 1.8% (11 studies, N=393). The pooled mean scapular notching rate was 20.1% (12 studies, N=497). Excluding notching, the pooled mean complication rate was 21.5% for all cases and 13% for primary cases (11 studies, N=393). When reported, there was significant improvement in post-operative ROM in all planes. There was also improvement in functional outcome scores, whereby the frequency-weighted mean Constant score increased from 25.9 to 67.2 (8 studies, N=319), ASES score increased from 34.7 to 75.2 (4 studies, N=142), and SST score increased from 2.1 to 7.6 (5 studies, N=196) at final follow up. This review demonstrates that glenoid bone grafting with RSA results in good mid-term clinical and radiographic outcomes. Union rate appears to depend highly on graft type and technique, whereby the highest union rates were seen following the use of autograft bone for the purposes of lateralization. Interestingly, the union rate of autograft bone for the purposes of augmentation in eccentric bone loss is considerably lower and its impact on the long-term survivorship of the implant remains unknown

Lumbar fusion surgery is an established procedure for the treatment of several spinal pathologies. Despite numerous techniques and existing devices, common surgical trends in lumbar fusion surgery are scarcely investigated. The purpose of this Canada-based study was to provide a descriptive portrait of current surgeons’ practice and implant preferences in lumbar fusion surgery while comparing findings to similar investigations performed in the United Kingdom. Canadian Spine Society (CSS) members were sampled using an online questionnaire which was based on previous investigations performed in the United Kingdom. Fifteen questions addressed the various aspects of surgeons’ practice: fusion techniques, implant preferences, and bone grafting procedures. Responses were analyzed by means of descriptive statistics. Of 139 eligible CSS members, 41 spinal surgeons completed the survey (29.5%). The most common fusion approach was via transforaminal lumber interbody fusion (TLIF) with 87.8% performing at least one procedure in the previous year. In keeping with this, 24 surgeons (58.5%) had performed 11 to 50 cases in that time frame. Eighty-six percent had performed no lumbar artificial disc replacements over their last year of practice. There was clear consistency on the relevance of a patient specific management (73.2%) on the preferred fusion approach. The most preferred method was pedicle screw fixation (78%). The use of stand-alone cages was not supported by any respondents. With regards to the cage material, titanium cages were the most used (41.5%). Published clinical outcome data was the most important variable in dictating implant choice (87.8%). Cage thickness was considered the most important aspect of cage geometry and hyperlordotic cages were preferred at the lower lumbar levels. Autograft bone graft was most commonly preferred (61.0%). Amongst the synthetic options, DBX/DBM graft (64.1%) in injectable paste form (47.5%) was preferred. In conclusion, findings from this study are in partial agreement with previous work from the United Kingdom, but highlight the variance of practice within Canada and the need for large-scale clinical studies aimed to set specific guidelines for certain pathologies or patient categories

Aim. infected segmental bone defect (ISBD) is frequent in developing countries. The aim of this study was to assess the efficacy of the Masquelet technique in the treatment of ISBD in a low-resource setting. Patients and Method. We performed a prospective cohort study during the period from 2018 to 2022. Patients with infected bone defect of long bones were included. Management protocol consisted of two stages in all patients. The first stage consisted in debridement, tissues biopsy for microbiological culture, stabilization with external fixator and defect filling with gentamicin cement spacer. The second stage consisted of reconstruction using a cancellous bone autograft alone, or a mixture of autograft with allograft (demineralized bone matrix + tricalcium phosphate) and 1 gram of vancomycin powder. All patients were followed-up for at least one year. The results were assessed based on both objective (clinical and radiographic evaluation) and subjective (limb function and patient satisfaction) criteria. Main outcomes were bone union, reoperation and failure rates, union time, and limb function. Results. We included 31 patients in this study (80.6% men), with a median age of 35 [9 – 80] years. The tibia was affected in 12 cases and the femur in 15 cases. The median size of bone defect was 4 [1.5 – 12] cm. The most prevalent microorganisms were Klebsiella pneumoniae and Staphylococcus aureus. The mean interval between both stages was 14 (8 – 36) weeks and the median follow-up period after the second stage was 20 [12-62] months. External fixation was used in both stages in 25(80%) cases. Bone union was achieved in 26 (83.8%) patients of whom 24 without recurrence of infection, over a median time of 9 [6 – 16] months. All patients with a mixed graft (allograft and autograft) impregnated with local antibiotics achieved bone union. Two patients needed reoperation for relapse of infection between both stages, and subsequently achieved bone union without recurrence of infection. There were three cases of failure related to persistent infection or insufficient fixation stability in the second stage. Conclusions. Masquelet technique is a reliable procedure that can be safely performed in limited resources settings with satisfactory results. The mixture of autograft and allograft when available, all mixed with vancomycin seems to give promising results

Introduction. Purpose: Injuries to the long bones of the upper limb resulting in bone defects are rare but potentially devastating. Literature on the management of these injuries is limited to case reports and small case series. The aim of this study was to collate the most recent published work on the management of upper limb bone defects to assist with evidence based management when confronted with these cases. Materials and Methods. Methods: Following a preliminary search that confirmed the paucity of literature and lack of comparative trials, a scoping review using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) was conducted. A literature search of major electronic databases was conducted to identify journal articles relating to the management of upper limb long bone defects published between 2010 and 2020. Results. Results: A total of 46 publications reporting on the management of 341 patients were reviewed. Structural autograft, bone transport, one-bone forearm and the induced membrane technique were employed in an almost equal number of cases. The implemented strategies showed similar outcomes but different indications and complication profiles were observed. Conclusions. Conclusion: Contemporary techniques for the management of post-traumatic upper limb bone defects all produce good results. Specific advantages, disadvantages and complications for each modality should be considered when deciding on which management strategy to employ for each specific patient, anatomical location, and defect size

Background. Synthetic interbody spinal fusion devices are used to restore and maintain disc height and ensure proper vertebral alignment. These devices are often filled with autograft bone to facilitate bone bridging through the device while providing mechanical stability. Nonporous polyetheretherketone (PEEK) devices are widely used clinically for such procedures. 1. Trabecular Metal devices are an alternative, fabricated from porous tantalum. It was hypothesized that the porous Trabecular Metal device would better maintain autograft viability through the center of the device, the ‘graft hole’ (GH). Methods. Twenty-five goats underwent anterior cervical discectomy and fusion using a Trabecular Metal or PEEK device for 6, 12 or 26 weeks. The GH of each device was filled with autograft bone morsels harvested from the animal at implantation. Fluorochrome labeling oxytetracycline was administered to the animals and used to determine bone viability in the device regions. Following necropsy, the vertebral segments were embedded in poly(methyl methacrylate) sectioned and analyzed using fluorescence and backscatter electron (BSE) imaging. The percent of bone tissue present within the GH was measured as a volume percent using BSE images (Fig. 1). Results. Bone percent analysis demonstrated that there was no significant difference (p<0.05) in volume of bone tissue within the GH of the two devices at 6 and 26 weeks (Fig. 2). At 12 weeks the animals implanted with the Trabecular Metal device had significantly greater volumes of bone within the GH region. Viable bone was observed in the host bone region and periprosthetic to the implant of all PEEK (n=12) and Trabecular Metal (n=12) animals within the study, determined by the presence of fluorescent labels (Fig. 3). Viable bone was also observed in the GH region of all animals with a Trabecular Metal device. However, only 5 of 12 PEEK animals showed bone viability within the GH (2 at 12 weeks and 3 at 26 weeks). A Fisher's exact comparison of the number of animals with viable bone in the GH showed a significant difference between the two devices, p<0.05. Conclusion. Autograft viability was better maintained within the GH for the porous Trabecular Metal device compared to the PEEK device. Although the amount of bone tissue within the GH of the PEEK devices was determined to have no significant difference compared to the Trabecular Metal devices at 6 and 26 weeks, the GH bone tissue was not viable in a number of the PEEK animals at each time point. The interconnected network and high volume porosity of the Trabecular Metal device may have allowed for fluid exchange, angiogenesis and increased blood supply to the autograft morsels. The viability of the autograft morsels also played an important role in the success of bone bridging through the GH between the vertebral endplates. In this animal model it was demonstrated that the autograft bone placed within the PEEK spinal fusion device did not always remain viable after implantation, but sometimes only filled the GH and did not necessarily facilitate fusion between the vertebrae as intended

Autologous bone has been the gold standard for grafting material in foot and ankle arthrodesis. While autograft use has been effective, the harvest procedure does present risks to the patient including readmission, infection, and persistent graft harvest site pain. Previous studies have examined graft harvest site pain, but most have focused on the iliac crest and none have long term follow-up. The purpose of this study was to examine long-term (7–10 year) harvest site pain in subjects undergoing autograft harvest from multiple sites for hindfoot and/or ankle arthrodesis. Sixty (60) subjects underwent hindfoot or ankle arthrodesis supplemented with autograft as part of the control arm of a prospective, randomized trial. The mean subject age was 59.4 years (range, 24.7–76.8) and mean body mass index was 30.6 kg/m2 (range, 22.0–44.0). There were 29 males and 31 female subjects. Subjects had the tibiotalar (37.9%), subtalar (24.1%), talonavicular (10.3%), subtalar/talonavicular (5.1%), or subtalar/calcaneocuboid/talonavicular (22.4%) joints arthrodesed. Autograft was harvested from either the proximal tibia (51.7%), iliac crest (17.2%), calcaneous (15.5%), distal tibia (6.8%), or other location (8.6%). Graft harvest site pain was evaluated using a 100-point visual analog score (VAS), with clinically significant pain being any score greater than 20. Subjects were followed a mean of 9.0 years (range, 7.8–10.5). The percentage of subjects who reported clinically significant pain was 35.7%, 21.4%, 18.2%, 10.5%, 8.9%, and 5.2% at 2, 6, 12, 24, 52 weeks, and final follow-up (7.8–10.5 years), respectively. The mean VAS autograft harvest site pain at final follow-up was 4.4 (range, 0.0–97.0), with 37.9% of subjects reporting at least some pain. For three subjects (5%) with clinically significant pain (VAS >20) at final follow-up, two had proximal tibial harvest sites and one had an iliac crest harvest site. There was no correlation between graft volume and harvest site pain. This study is the first to examine long-term pain following autologous bone graft harvest for hindfoot and/or ankle arthrodesis. Over a third of patients reported having some pain at an average follow-up of nine years, with 5% experiencing clinically significant pain. The results of this study suggest that harvesting autograft bone carries a risk of persistent, long-term pain regardless of the volume of graft that is harvested. This potential for persistent pain should be considered when informing patients of procedure risks and when deciding to use autograft or a bone graft substitute material

Introduction. Acetabular fractures management is controversial since, despite a good anatomical reduction, clinical outcome is not satisfactory very often and the probability of a total hip arthroplasty (THA) is high. Surgical treatment include long operating times, large approach, blood loss, neural and muscle damage, and a high risk of failure and secondary osteoarthritis related to bone necrosis, cartilage damage, and bone loss. We hypothesized that the acetabular fracture management affected the clinical and radiological outcome of THA after posttraumatic arthritis. Materials and Methods. We compared 49 patients (49 hips) initially treated conservatively followed some months later by THA in conjunction with acetabular reconstruction (group 1); and 29 patients (29 hips) who had undergone THA after a failed osteosynthesis (group 2). There were more associated fractures according to Letournel in group 2. The mean age was 59.3±15.8 years for group 1 and 52.9±15.2 years for group 2. The mean delay between fracture and THA was 75.4±5 months for group 1 and 59.4±5 for group 2. The mean follow-up was 11.7 in group 1 and 10.2 in group 2. Preoperative bone defect was similar. We used bone autograft in 13 hips (26.5%) in group 1 and four (13.6%) in group 2. We used acetabular reconstruction plates in 2 hips with a pelvic discontinuity in group 1. Complications, clinical outcome according to Harris Hip Score, and radiological reconstruction were compared. Two-way ANOVA with repeated measures were used for comparison. Results. There were 5 cups revised for aseptic loosening in group 1 and 2 in group 2. The cumulative probability of not having a cup revision at 16 years was 90.6% (95% confidence interval (CI) 78,1 to 100) for group 1 and 94.1% (95% CI 86.5 to 100) for group 2 (p=0.76). There were 4 sciatic palsies in group 2, 4 of which developed after trauma and 2 after osteosynthesis. There were no infections. Although pre-operative clinical score was better in group 1, post-operatively at latest follow-up there were no differences. The radiological reconstruction was better in group 1 for version angle (p=0.03) and abductor lever arm (p=0.02). The change from the pre- to post-operative situation was greater in group 2 for the latter (Delta value, p=0.002). The rate of post-operative heterotopic ossifications was greater in group 2 (p=0.04). Conclusions. Long-term clinical and radiograph results are good in patients who underwent THA after a complex acetabular fracture, however, primary THA in conjunction with acetabular reconstruction had a lower number of complications and a better radiographic acetabular reconstruction than a THA after failed osteosynthesis

Introduction. Implantation of total hip replacement (THR) remains a concern in patients with developmental dysplasia of the hip (DDH) because of bone deformities and previous surgeries. In this frequently young population, anatomical reconstruction of the hip rotation centre is particularly challenging in severe, low and high dislocation, DDH. The basic principles of the technique and the implant selection may affect the long-term results. The aim of the study was to compare surgical difficulties and outcome in patients who underwent THR due to arthritis secondary to moderate or severe DDH. Material and Methods. We assessed 131 hips in patients with moderate DDH (group 1) and 56 with severe DDH (Group 2) who underwent an alumina-on-alumina THR between 1999 and 2012. The mean follow-up was 11.3 years (range, 5 to 18). Mean age was 51.4 years in group 1 and 42.2 in group 2. There were previous surgery in 5 hips in group 1 and in 20 in group 2 (p<0.001). A dysplastic acetabular shape type C according to Dorr and a radiological cylindrical femur were both more frequent in group 2 (in both cases p<0.001). We always tried to place the acetabular component in the true acetabulum. Smaller cups (p<0.001), screw use for primary fixation (p<0.001) and bone autograft used as segmental reinforcement in cases of roof deficiency (p<0.001) were more frequent in group 2. Radiological analysis of the cup included acetabular abduction, version and Wiberg angles, horizontal, vertical, and hip rotation centre distances, and acetabular head index. Abductor mechanism reconstruction according to the lever arm distance and height of the greater trochanter was also evaluated. Cup placement within or outside Lewinnek´s safe zone was recorded. Two-way ANOVA with repeated measures were used to analyse clinical and radiological changes. Results. There were 6 cups revised for aseptic loosening, three in each group. Survivorship analysis at 15 years: 97.3% (95% IC 94.4–100) for group 1 and 93.0% (95% IC 85.2–100) for group 2 (p=0.186). Despite a worse preoperative status in group 2, the outcome improved similarly in both groups. Postoperative radiological measurements were better in group 1 except for acetabular acetabular and version angles. The improvement from the pre- to the post-operative situation was greater in group 2 except for the height of the greater trochanter. Acetabular component placement within the Lewinnek´s safe zone was similar in both groups. All revised cups were outside this zone. No osteolysis or complications related to the use of ceramics were found. Conclusions. The alumina-on-alumina THR provided good results in both groups including pain relief and functional improvement. Placing the acetabular component in the true acetabulum inside the Lewinnek safe zone can ensure a good result in these challenging dysplastic hips

No consensus exists regarding the optimal graft choice between allogenic and autologous graft. Incidence of septic arthritis following ACL reconstruction is rare but may dependent on the graft type. Our meta-analysis assesses the difference in incidence of septic arthritis after ACL reconstruction across three groups of grafts: hamstring autografts, bone patellar tendon bone (BPTB) autografts and allografts of any type. A literature search was performed without language restriction on PubMed and EMBASE databases. We identified 245 infected ACL grafts across 15 included studies that provided a breakdown of infection incidence by graft type. A meta-analysis was performed using a random-effects model to estimate the overall infection rates and those for different graft types. Summary risk ratios and 95% confidence intervals (CIs) were calculated and reported for each outcome. Publication bias with respect to infection rates was estimated using a funnel plot. Our meta-analysis shows an overall ACL graft infection rate of 0.6% (CI 0.3% – 1.3%). The incidence was highest in autologous hamstring grafts at 1.1% at (CI 0.8% – 1.6%). That of allografts and autologous BPTB grafts was similar at 0.5% (CI 0.2%–1.0%) and 0.4% (CI 0.2% – 0.7%), respectively. Full breakdown of the meta-analysis results by study and graft type is reported in Figure 1. Septic arthritis after ACL reconstruction remains a rare (<1%) but a serious complication. Allograft rates of infection were not higher than those the autografts, contrary to the theoretical concerns. Therefore a higher infection risk should not be cited as a reason for not using it. The reason for the apparently higher infection rate with hamstring autografts is unclear and requires further research. The results of our meta-analysis may aid informed discussions between surgeons and patients about the risk of infection after ACL reconstructive surgery and graft choice

Allograft materials have been the mainstay in addressing bone deficiencies in knee and hip replacement and revision surgery for decades because of the associated donor site morbidity of autografts. Bone graft substitutes have been developed to address allograft issues including potential contamination, disease transmission, and availability. Although non-autogenous products have no osteogenic potential, they do have a variable degree of osteoinductive and osteoconductive properties. Unfortunately, there are limited reports regarding use of bone graft substitutes for use in total hip and knee arthroplasty. Bone graft substitutes have most frequently been used as an “extender”, in combination with morsellised allograft, to fill cavitary defects. Incorporation of this bone graft substitute and morsellised allograft combination appears to occur incompletely. Stable implant fixation appears to be a prerequisite for incorporation of bone graft substitutes, as these cannot be relied upon for structural support. Although bone graft substitutes appear to perform satisfactorily as “fillers” for contained cavitary bone defects, ultraporous metal augments have become the preferred method of providing structural support for some defects. In view of their substantial cost, high quality clinical, radiographic and retrieval data regarding performance of bone graft substitutes is needed

Acetabular protrusio is defined radiographically as migration of the femoral head medial to Kohler's line (a line from the lateral border of the obturator foramen to the medial border of the sciatic notch). Protrusio can develop in association with metabolic bone diseases such as osteogenesis imperfecta, Marfan's Syndrome, and Paget's disease, inflammatory arthritis or osteoarthritis, tumors, or result from prior trauma. Acetabular protrusio can cause limited hip motion due to impingement of the femoral neck against the acetabular rim. When protrusio develops in association with osteoarthritis, coxa vara is often also present. Surgical treatment of acetabular protrusio during total hip arthroplasty should lateralise the center of the hip to its anatomic position. This typically can be achieved with use of a larger, slightly oversized, rim fit cementless acetabular component and medial morselised femoral head bone autograft. In cases with more severe deformity, a reconstruction cage may be required. Alternatively a medialised acetabular shell can be used with a lateralised liner. If coxa vara is also present, standard femoral component position (approximately 1cm above the lesser trochanter) can result in an increase in leg length. Careful pre-operative templating should be performed and may require more distal placement of the femoral component to avoid overlengthening the limb

Extracorporeal irradiation of resected bone segments has been used for pelvic reconstruction for 12 years in our unit. The technique allows for a perfect fit, preservation of muscle attachments, and thus, facilitating reconstruction, more rapid osteotomy of autograft bone, low cost, and a low infection rate. Of particular interest is its use in children; revascularisation appears more complete with irradiated autograft, as compared to allograft. There is sparing of adjacent growth plates if the irradiation is given outside the body, whereas external beam radiation would destroy the proximal femoral growth plate—leading to significant leg length discrepancy. Avoiding external beam irradiation also removes any risk of late radiation induced sarcoma and removes the late effects of soft tissue fibrosis due to external beam irradiation. Twenty-seven pelvic reconstructions have been done over a 12-year period, with three failures due to infection and seven due to further disease. Four of these have been for de-differentiated chondrosarcoma of the pelvis, where local recurrence led to failure. In the presence of de-differentiated pelvic chondrosarcoma, we do not recommend this form of reconstruction. Long term functional outcome scores for the first 50 cases completed between August 1996 and June 2003 gave a TESS score of 82% and MSTS score of 78%. This is more than comparable to published series using other forms of reconstruction

Large femoral neck defects pose a great challenge for orthopedic surgeons and are frequently associated with neglected femoral neck fractures, post infective sequale and failed implants around femoral neck. We present our technique (AIIMS Box Technique) of neck reconstruction aiming to preserve the natural femoral head and restoring the function of hip in cases of large femoral neck defects. A total number of 52 patients (age range 20 to 56 years with an average of 38 years) with large femoral neck defects were treated from January 1990 to May 1997 and were followed for a minimum of 10 years (range 10 to 17 years). Neck defect was converted into a box using osteal flaps (Base from greater trochanter, Anterior wall from head, Quadratus Femoris muscle pedicle graft posteriorly). This box was filled with cancellous bone autograft along with three cancellous screw fixation. Union occurred in all patients in a mean time of 16 weeks (range 12–20 weeks). One patient in our series had avascular necrosis (AVN) of femoral head. Eighteen out of 52 results were classified as excellent, 28 good and 6 fair. No patient had poor result. Good functional mobility including squatting was seen in all but two patients. Complications included coxa vara in two patients, hardware problems in four patients. Our study shows that large femoral neck defects can be managed successfully with preservation of vascularity of femoral head. This procedure can be considered an alternative to excisional or replacement arthroplasty, particularly in young adults

Protrusio acetabuli (arthrokatadysis or Otto pelvis) is a relatively rare condition associated with secondary osteoarthritis of the hip. Radiographically, protrusio acetabuli is present when the medial aspect of the femoral head projects medial to Kohler's (ilioischial) line. This results in medialization of the center of rotation (COR) of the hip. Protrusio acetabuli is typically associated with metabolic bone disease (osteoporosis, osteomalacia, Paget's disease) or inflammatory arthritis (RA or ankylosing spondylitis). Idiopathic acetabular protrusio can occur without the above associated factors however. Patients with protrusio acetabuli typically present with significant restriction of range of motion (ROM) of the hip due to femoral neck and trochanteric impingement in the deep acetabular socket and pain associated with secondary osteoarthritis (OA). Total hip arthroplasty (THA) in patients with protrusion acetabuli is more challenging than THA in patients with a normal hip COR. ROM is typically quite restricted which can compromise surgical exposure. Dislocation of the hip in the patient with a deep socket and medialised COR can be extremely difficult and associated with fracture of the femur if not carefully performed. Restoration of the hip COR to the normal more lateralised position is a principle goal of surgery. This restores more normal mechanics of the hip and has been associated with improved durability. A variety of techniques to accomplish this have been described including medial acetabular bone grafting with cemented cups, protrusio rings or porous coated cementless cups fixed with multiple screws. The latter technique has been shown to be more durable and associated with better outcomes. THA in protrusio acetabuli starts with templating of the preoperative x-rays to determine the optimal acetabular implant size and final position of the acetabular component that restores the hip COR to the normal position. Patients with protrusio acetabuli often have varus oriented femoral necks and the femur needs to be carefully templated as well to insure that an appropriate femoral component is available that will allow for restoration of the patient's anatomy. Cartilage covering the thinned medial wall needs to be carefully removed without disruption of the medial acetabular wall. The acetabulum is then carefully reamed with the goal of obtaining stable peripheral rim support of a cementless socket and at least 50% contact of the implant on good quality host bone. Unlike acetabular preparation in the normal hip, preventing the reamer from “bottoming out” is essential in order to obtain desired rim support and return of the hip COR to the normal lateralised position. When good rim support of the reamer is obtained, a trial component is placed and intraoperative x-ray obtained to confirm fit, position and restoration of hip COR. Limited addition reaming can be performed to obtain desired degree of press fit (1‐2mm) and contact with host bone. Morselised autograft from the femoral head and neck is then packed into the medial defect and reverse reamed. The cementless acetabular component is then impacted into position and fixed with screws. Weight bearing is determined by bone quality, size and containment of the medial defect, amount of contact of the cementless cup with host bone and stability of the acetabular construct. Incorporation of autograft bone in the acetabulum and stable long term fixation occurs reliably if stable initial press-fit fixation of the cementless cup is obtained. Restoration of hip COR to within 7mm of its normal location is associated with better implant survival

BACKGROUND:. Bony increased-offset reverse shoulder arthroplasty (BIO-RSA) creates a long-necked scapula, providing the benefits of lateralization. Experience with allogenic bone grafting of the glenoid in shoulder arthroplasty is mainly based on its use with total shoulder arthroplasty (TSA). Therefore, our study objectives were: 1) verify if the use of BIO-RSA together with glenoid surface grafting with allogenic bone would provide similar benefits (clinical and functional) as found with autologous bone, 2) determine if allograft could be a good alternative in the absence of (good quality) autograft bone, and 3) to see if the allograft would incorporate with the native glenoid bone. METHODS:. We included 25 patients (19 female, 6 male) in this prospective study. Indications for BIO-RSA were: fracture sequalle (n = 9), revisions (n = 11), 4-part humerus fracture (n = 1), rheumatoid arthritis (n = 1) and cuff tear arthropathy (CTA) with poor humeral head bone quality/osteonecrosis (n = 3). Mean (± SD) age 70 ± 11 years (range, 44–86). Clinical evaluation consisted of ROM, Constant scores, patient satisfaction (Subjective Shoulder Value (SSV)) and noted complications. Radiographic and CT scan evaluation consisted of bone graft healing, bone graft resorption/lysis, glenoid component loosening, inferior scapular notching, spur formation and anterior/posterior scapular notching. Mean follow-up was 34 ± 10 months (24–62). RESULTS:. Mean active mobility improved from 50 ± 39° to 123 ± 33° (50–170°) for anterior elevation, from 2.4 ± 17° to 12.1 ± 16° (−20–40°) for external rotation, and from 1.8 ± 2 to 4.7 ± 3 points (0–8) for internal rotation. Mean Constant scores improved from 19 ± 12 to 55 ± 16 points (30–83) and from 26 ± 16% to 77 ± 24% (40–111%). Mean SSV from 21 ± 16% to 65 ± 18% (30–100%). One patient sustained an acromial fracture (treated conservatively) and one patient had breakage of screws and complete glenoid component loosening (revised to a hemi arthroplasty). In 92% of cases (23 of 25) the allograft incorporated completely, partial lysis of the bone graft (n = 5), inferior scapular notching (n = 5), spur formation (n = 7), posterior notching (n = 5). CONCLUSIONS:. BIO-RSA with allograft bone grafting does not provide the same clinical and functional results as with autologous bone grafting. However, it does provide a good alternative in cases where humeral bone stock is not preserved and the allograft bone does incorporate with the native glenoid bone

The ability of mesenchymal stem cells (MSCs) to differentiate in vitro into chondrocytes, osteocytes and myocytes holds great promise for tissue engineering. Skeletal defects are emerging as key targets for treatment using MSCs due to the high responsiveness of bone to interventions in animal models. Interest in MSCs has further expanded in recognition of their ability to release growth factors and to adjust immune responses.

Despite their increasing application in clinical trials, the origin and role of MSCs in the development, repair and regeneration of organs have remained unclear. Until recently, MSCs could only be isolated in a process that requires culture in a laboratory; these cells were being used for tissue engineering without understanding their native location and function. MSCs isolated in this indirect way have been used in clinical trials and remain the reference standard cellular substrate for musculoskeletal engineering. The therapeutic use of autologous MSCs is currently limited by the need for ex vivo expansion and by heterogeneity within MSC preparations. The recent discovery that the walls of blood vessels harbour native precursors of MSCs has led to their prospective identification and isolation. MSCs may therefore now be purified from dispensable tissues such as lipo-aspirate and returned for clinical use in sufficient quantity, negating the requirement for ex vivo expansion and a second surgical procedure.

In this annotation we provide an update on the recent developments in the understanding of the identity of MSCs within tissues and outline how this may affect their use in orthopaedic surgery in the future.

Cite this article: Bone Joint J 2014;96-B:291–8.