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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_12 | Pages 25 - 25
23 Jun 2023
Ricard M Pacheco L Koorosh K Poitras S Carsen S Grammatopoulos G Wilkin G Beaulé PE
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Our understanding of pre-arthritic hip disease has evolved tremendously but challenges remain in categorizing diagnosis, which ultimately impacts choice of treatments and clinical outcomes. This study aims to report patient reported outcome measures (PROMs) comparing four different condition groups within hip preservation surgery by a group of fellowship-trained surgeons.

From 2018 to 2021, 380 patients underwent hip preservation surgery at our center and were classified into five condition groups: dysplasia: 82 (21.6%), femoro-acetabular impingement (FAI): 173 (45.4%), isolated labral tear: 103 (27.1%), failed hip preservation: 20 (5.3%) and history of childhood disease/other: 2 (0.5%). International hip outcomes Tool 12 (IHOT-12), numeric pain score and patient-reported outcomes measurement information system (PROMIS) were collected pre-operatively and at 3 months and 1 year post-operatively, with 94% and 82% follow-up rate respectively.

Arthroscopy (75.5%) was the most common procedure followed by peri-acetabular osteotomy (PAO) (22.4%) and surgical dislocation (2.1%). Re-operation rate were respectively 18.3% (15), 5.8% (10), 4.9% (5), 30% (6) and 0%. There were 36 re-operations in the cohort, 14 (39%) for unintended consequences of initial surgery, 10 (28%) for mal-correction leading to a repeat operation, 8 (22%) progression of arthritis, and 4 (11%) for incorrect initial diagnosis/intervention. Most common re-operations were hardware removal 31% (7 PAO, 3 surgical hip dislocation and 1 femoral de-rotational osteotomy), arthroscopy 31% (11) and arthroplasty 28% (10). All groups had significant improvements in their IHOT-12 as well as PROMIS physical and numerical pain scales, except those with failed hip preservation. Dysplasia group showed a slower recovery.

Overall, this study demonstrated a clear relation between the condition groups, their respective intervention and the significant improvements in PROMs with isolated labral pathology being a valid diagnosis. Establishing tertiary referral centers for hip preservation and longer follow-up is needed to monitor the overall survivorship of these various procedures.


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_11 | Pages 3 - 3
7 Jun 2023
Verhaegen J Devries Z Horton I Slullitel P Rakhra K Beaule P Grammatopoulos G
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Traditional radiographic criteria might underestimate or fail to detect subtle types of acetabular dysplasia. Acetabular sector angles (ASA) can measure the degree of anterior and posterior coverage of the femoral head on computed tomography (CT). This study aims to determine ASA values at different axial levels in a cohort of (1) asymptomatic, high-functioning hips without underlying hip pathology (controls); and (2) symptomatic, dysplastic hips that underwent periacetabular osteotomy (PAO). Thereby, we aimed to define CT-based thresholds for hip dysplasia and its subtypes.

This is an IRB approved cross-sectional study of 51 high functioning, asymptomatic patients (102 hips) (Oxford Hip Score >43), without signs of osteoarthritis (Tönnis grade≤1), who underwent a CT scan of the pelvis (mean age: 52.1±5.5 years; 52.9% females); and 66 patients (72 hips) with symptomatic hip dysplasia treated with peri-acetabular osteotomy (PAO) (mean age: 29.3±7.3 years; 85.9% females). Anterior and posterior acetabular sector angles (AASA & PASA) were measured by two observers at three CT axial levels to determine equatorial, intermediate, and proximal ASA. Inter- and intra-observer reliability coefficient was high (between 0.882–0.992). Cut-off values for acetabular deficiency were determined based on Receiver Operating Characteristic (ROC) curve analysis, area under the curve (AUC) was calculated.

The dysplastic group had significantly smaller ASAs compared to the Control Group, AUC was the highest at the proximal and intermediate PASA. Controls had a mean proximal PASA of 162°±17°, with a cut-off value for dysplasia of 137° (AUC: 0.908). At the intermediate level, the mean PASA of controls was 117°±11°, with a cut-off value of 107° (AUC 0.904). Cut-off for anterior dysplasia was 133° for proximal AASA (AUC 0.859) and 57° for equatorial AASA (AUC 0.868). Cut-off for posterior dysplasia was 102° for intermediate PASA (AUC 0.933).

Measurement of ASA on CT is a reliable tool to identify dysplastic hips with high diagnostic accuracy. Posterior ASA less than 137° at the proximal level, and 107° at the intermediate level should alert clinicians of the presence of dysplasia.


Bone & Joint Open
Vol. 3, Issue 12 | Pages 924 - 932
23 Dec 2022
Bourget-Murray J Horton I Morris J Bureau A Garceau S Abdelbary H Grammatopoulos G

Aims

The aims of this study were to determine the incidence and factors for developing periprosthetic joint infection (PJI) following hemiarthroplasty (HA) for hip fracture, and to evaluate treatment outcome and identify factors associated with treatment outcome.

Methods

A retrospective review was performed of consecutive patients treated for HA PJI at a tertiary referral centre with a mean 4.5 years’ follow-up (1.6 weeks to 12.9 years). Surgeries performed included debridement, antibiotics, and implant retention (DAIR) and single-stage revision. The effect of different factors on developing infection and treatment outcome was determined.


Bone & Joint Open
Vol. 3, Issue 10 | Pages 804 - 814
13 Oct 2022
Grammatopoulos G Laboudie P Fischman D Ojaghi R Finless A Beaulé PE

Aims

The primary aim of this study was to determine the ten-year outcome following surgical treatment for femoroacetabular impingement (FAI). We assessed whether the evolution of practice from open to arthroscopic techniques influenced outcomes and tested whether any patient, radiological, or surgical factors were associated with outcome.

Methods

Prospectively collected data of a consecutive single-surgeon cohort, operated for FAI between January 2005 and January 2015, were retrospectively studied. The cohort comprised 393 hips (365 patients; 71% male (n = 278)), with a mean age of 34.5 years (SD 10.0). Over the study period, techniques evolved from open surgical dislocation (n = 94) to a combined arthroscopy-Hueter technique (HA + Hueter; n = 61) to a pure arthroscopic technique (HA; n = 238). Outcome measures of interest included modes of failures, complications, reoperation, and patient-reported outcome measures (PROMs). Demographic, radiological, and surgical factors were tested for possible association with outcome.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_4 | Pages 11 - 11
1 Apr 2022
McGoldrick NP Cochran M Biniam B Bhullar R Beaulé PE Kim PR Gofton W Grammatopoulos G
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Short cementless femoral stems are increasingly popular as they allow for less dissection for insertion. Use of such stems with the anterior approach (AA) may be associated with considerable per-operative fracture risk. This study's primary aim was to evaluate whether patient-specific femoral- and pelvic- morphology and surgical technique, influence per-operative fracture risk. In doing so, we aimed to describe important anatomical thresholds alerting surgeons.

This is a single-centre, multi-surgeon retrospective, case-control matched study. Of 1145 primary THAs with a short, cementless stem inserted via the AA, 39 periprosthetic fractures (3.4%) were identified. These were matched for factors known to increase fracture risk (age, gender, BMI, side, Dorr classification, stem offset and indication for surgery) with 78 THAs that did not sustain a fracture. Radiographic analysis was performed using validated software to measure femoral- (canal flare index [CFI], morphological cortical index [MCI], calcar-calcar ratio [CCR]) and pelvic- (Ilium-ischial ratio [IIR], ilium overhang, and ASIS to greater trochanter distance) morphologies and surgical technique (% canal fill). Multivariate and Receiver-Operator Curve (ROC) analysis was performed to identify predictors of fracture.

Femoral factors that differed included CFI (3.7±0.6 vs 2.9±0.4, p<0.001) and CCR (0.5±0.1 vs 0.4±0.1, p=0.006). The mean IIR was higher in fracture cases (3.3±0.6 vs 3.0±0.5, p<0.001). % Canal fill was reduced in fracture cases (82.8±7.6 vs 86.7±6.8, p=0.007). Multivariate analysis and ROC analyses revealed a threshold CFI of 3.17 was predictive of fracture (sensitivity:84.6% / specificity:75.6%). Fracture risk was 29 times higher when patients had CFI>3.17 and II ratio>3 (OR:29.2 95%CI: 9.5–89.9, p<0.001).

Patient-specific anatomical parameters are important predictors of fracture-risk. When considering the use of short stems via the AA, careful radiographic analysis would help identify those at risk in order to consider alternative stem options.


Bone & Joint Open
Vol. 3, Issue 1 | Pages 12 - 19
3 Jan 2022
Salih S Grammatopoulos G Burns S Hall-Craggs M Witt J

Aims

The lateral centre-edge angle (LCEA) is a plain radiological measure of superolateral cover of the femoral head. This study aims to establish the correlation between 2D radiological and 3D CT measurements of acetabular morphology, and to describe the relationship between LCEA and femoral head cover (FHC).

Methods

This retrospective study included 353 periacetabular osteotomies (PAOs) performed between January 2014 and December 2017. Overall, 97 hips in 75 patients had 3D analysis by Clinical Graphics, giving measurements for LCEA, acetabular index (AI), and FHC. Roentgenographical LCEA, AI, posterior wall index (PWI), and anterior wall index (AWI) were measured from supine AP pelvis radiographs. The correlation between CT and roentgenographical measurements was calculated. Sequential multiple linear regression was performed to determine the relationship between roentgenographical measurements and CT FHC.


Bone & Joint Open
Vol. 2, Issue 9 | Pages 757 - 764
1 Sep 2021
Verhaegen J Salih S Thiagarajah S Grammatopoulos G Witt JD

Aims

Periacetabular osteotomy (PAO) is an established treatment for acetabular dysplasia. It has also been proposed as a treatment for patients with acetabular retroversion. By reviewing a large cohort, we aimed to test whether outcome is equivalent for both types of morphology and identify factors that influenced outcome.

Methods

A single-centre, retrospective cohort study was performed on patients with acetabular retroversion treated with PAO (n = 62 hips). Acetabular retroversion was diagnosed clinically and radiologically (presence of a crossover sign, posterior wall sign, lateral centre-edge angle (LCEA) between 20° and 35°). Outcomes were compared with a control group of patients undergoing PAO for dysplasia (LCEA < 20°; n = 86 hips). Femoral version was recorded. Patient-reported outcome measures (PROMs), complications, and reoperation rates were measured.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_10 | Pages 25 - 25
1 Aug 2021
Adamczyk A Nessek H Kim P Feibel R McGoldrick N Beaulé P Grammatopoulos G
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Over 62,000 total hip arthroplasty (THA) cases are performed each year in Canada, with an estimated annual healthcare system cost of $1.4 billion and resulting in 4 billion tonnes of waste annually (6,600 tonnes per day). The aims of this study were 1) Assess satisfaction of current/standard set-up amongst different stakeholders. 2) Assess energy, economic and waste cost of current set up and apply lean methodology to improve efficiency 3. Design and test SLIM setup based on lean principles and its ability to be safely implemented into everyday practice.

A Needs Assessment Survey was circulated to OR nursing staff to assess the need for change in the current THA OR setup at an academic tertiary referral hospital. Through feedback, surgeon input, and careful analysis of current instrumentation, the “SLIM setup” was created. Standard instrument tray numbers for elective THA were reduced from 9 to 3 trays. Eighty patients were then randomised to either the standard or SLIM setup. Four staff arthroplasty surgeons each randomised 20 patients to either standard or SLIM setup. OR time, blood loss, 90-day complication rates, cost/case, instrument weight (kg/case), total waste in kg/case (non-recyclable), case set-up time, and number of times and number of extra trays required were compared between groups.

The majority of nursing staff demonstrated dissatisfaction with the current THA setup and felt current processes lacked efficiency. Use of the SLIM setup, was associated with the following savings in comparison to standard (Trays = −6 (720kg/case); Waste = −1.5 kg/case; Cost = − $560 ($50.00 × 6 trays + 10min saved × $26.00 /min OR setup time)). OR time, blood loss and 90-day complication rate were not statistically different (p >0.05); however, set up time was significantly shorter in comparison to standard. Extra instrumentation was opened in < 10% of cases.

A more minimalist approach to THA can be undertaken using the SLIM setup, potentially resulting in cost, energy and waste savings. Estimate savings of $560,000 and 1.65 tonnes reduction in waste per 1,000 THAs performed may be realised.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_10 | Pages 37 - 37
1 Aug 2021
Falsetto A Sanders E Weishorn J Gill H McGoldrick N Beaulé P Innmann M Merle C Grammatopoulos G
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This matched cohort study aims to (a) assess differences in spinopelvic characteristics of patients having sustained a dislocation following THA and a control THA group without dislocation; (b) identify spinopelvic characteristics associated with risk of dislocation and; (c) propose an algorithm to define the optimum cup orientation for minimizing dislocation risk.

Fifty patients with a history of THA dislocation (29 posterior-, 21 anterior dislocations) were matched for age, gender, body mass index, index diagnosis, and femoral head size with 100 controls. All patients were reviewed and underwent detailed quasi-static radiographic evaluations of the coronal- (offset; center-of-rotation; cup inclination/anteversion) and sagittal- reconstructions (pelvic tilt, pelvic incidence, lumbar lordosis, pelvic-femoral-angle, cup ante-inclination). The spinopelvic balance (PI-LL), combined sagittal index (CSI= Pelvic-femoral-angle + Cup Anteinclination) and Hip-User-Index were determined. sagittal index (CSI= Pelvic-femoral-angle + Cup Anteinclination) and Hip-User-Index were determined. Parameters were compared between the two groups (2-group analysis) and between controls and per direction of dislocation (3-group analysis).

There were marginal coronal differences between the groups. Sagittal parameters (lumbar-lordosis, pelvic-tilt, CSI, PI-LL and Hip-User-Index) differed significantly. PI-LL (>10°) and standing pelvic tilt (>18°) were the strongest predictors of dislocation risk (sensistivity:70%/specificity:70%). All hips with a standing CSI<195° dislocated posteriorly and all with CSI>260° dislocated anteriorly. A CSI between 200–245° was associated with significantly reduced risk of dislocation (OR:6; 95%CI:2.5–15.0; p<0.001). In patients with unbalanced and/or rigid lumbar spine, standing CSI of 215–245° was associated with significantly reduced dislocation risk (OR:10; 95%CI:3.2–29.8; p<0.001).

PI-LL and standing pelvic-tilt determined from pre-operative, standing, lateral spinopelvic radiograph can be useful screening tools, alerting surgeons of patients at increased dislocation risk. Measurement of the pelvic-femoral angle pre-operatively provides valuable information to determine the optimum, cup orientation associated with reduced dislocation risk by aiming for a standing CSI of 200–245°.


The Bone & Joint Journal
Vol. 103-B, Issue 7 Supple B | Pages 46 - 52
1 Jul 2021
McGoldrick NP Fischman D Nicol GM Kreviazuk C Grammatopoulos G Beaulé PE

Aims

The aim of this study was to radiologically evaluate the quality of cement mantle and alignment achieved with a polished tapered cemented femoral stem inserted through the anterior approach and compared with the posterior approach.

Methods

A comparative retrospective study of 115 consecutive hybrid total hip arthroplasties or cemented hemiarthroplasties in 110 patients, performed through anterior (n = 58) or posterior approach (n = 57) using a collarless polished taper-slip femoral stem, was conducted. Cement mantle quality and thickness were assessed in both planes. Radiological outcomes were compared between groups.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_10 | Pages 12 - 12
1 Oct 2020
Lamontagne M Catelli DS Cotter B Mazuchi FAS Grammatopoulos G
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Introduction

Spinopelvic mobility has been associated with THA outcome. To-date spine assessments have been made quasi-statically, using radiographs, in standing and seated positions but dynamic spinopelvic mobility has not been well explored. This study aims to determine the association between dynamic (motion analysis) and quasi-static (radiographic) sagittal assessments and examine the association between axial and sagittal spinal kinematics in hip OA patients and controls.

Methods

This is a prospective, IRB approved, cohort study of 12 patients with hip OA pre-THA (6F/6M, 67±10 years) and six healthy controls (3F/3M, 46±18 years). All underwent lateral spinopelvic radiographs in standing and seated bend-and-reach (SBR) positions. Pelvic tilt (PT), pelvic-femoral-angle (PFA) and lumbar lordosis (LL) angles were measured in both positions and the differences (Δ) in angles between SBR and standing were computed. All participants performed two dynamic tasks at the motion laboratory: seated maximal trunk rotation (STR) and seated bend and reach (SBR). Three-dimensional joint motion data were collected and processed by a 10-camera infrared motion analysis system (Vicon, Nexus 2.10, UK). Total axial and sagittal spine (mid-thoracic to lumbar) range of motion (ROM) were calculated for STR and SBR, respectively.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 36 - 36
1 Jul 2020
DaVries Z Salih S Speirs A Dobransky J Beaule P Grammatopoulos G Witt J
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Purpose

Spinopelvic parameters are associated with the development of symptomatic femoroacetabular impingement and subsequent osteoarthritis. Pelvic incidence (PI) characterizes the sagittal profile of the pelvis and is important in the regulation of both lumbar lordosis and pelvic orientation (i.e. tilt). The purpose of this imaging-based study was to test the association between PI and acetabular morphology.

Methods

Measurements of the pelvis and acetabulum were performed for 96 control patients and 29 hip dysplasia patients using 3D-computed topography (3D-CT) scans. Using previously validated measurements the articular cartilage and cotyloid fossa area of the acetabulum, functional acetabular version/inclination, acetabular depth, pelvic tilt, sacral slope, and PI were calculated. Non-parametric statistical tests were used; significance was set at p<0.05.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 29 - 29
1 Jul 2020
Innmann M Reichel F Schaper B Merle C Beaulé P Grammatopoulos G
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Aims

Our study aimed to 1) determine if there was a difference for the HOOS-PS score between patients with stiff/normal/hypermobile spinopelvic mobility and 2) to investigate if functional sagittal cup orientation affected patient reported outcome 1 year post-THA.

Methods

This prospective diagnostic cohort study followed 100 consecutive patients having received unilateral THA for end-stage hip osteoarthritis. Pre- and 1-year postoperatively, patients underwent a standardized clinical examination, completed the HOOS-PS score and sagittal low-dose radiographs were acquired in the standing and relaxed-seated position. Radiographic measurements were performed for the lumbar-lordosis-angle, pelvic tilt (PT), pelvic-femoral-angle and cup ante-inclination. The HOOS-PS was compared between patients with stiff (ΔPT<±10°), normal (10°≤ΔPT≤30°) and hypermobile spinopelvic mobility (ΔPT>±30°).


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 19 - 19
1 Jul 2020
Innmann M Reichel F Schaper B Merle C Beaulé P Grammatopoulos G
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Aims

Our study aimed to 1) Describe the changes in spinopelvic mobility when transitioning from standing, to ‘relaxed-seated’ and thereafter to ‘deep-seated’ position and 2) Determine the change in spinopelvic mobility types 1 year post-THA compared to preoperatively.

Methods

This prospective diagnostic cohort study followed 100 consecutive patients 1 year post-THA. Preoperatively and one year postoperatively, radiographic measurements were performed for the lumbar-lordosis-angle, pelvic tilt and pelvic-femoral-angle on lateral radiographs in the standing, ‘relaxed-seated’ and ‘deep-seated’ position (torso maximally leaning forward). Patients were classified according to their spinopelvic mobility type, according to the change in PT between the standing and relaxed-seated position (stiff:ΔPT<±10°, normal:10°≤ΔPT≤30°, hypermobile:ΔPT>±30°).


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 4 - 4
1 Jul 2020
Salih S Grammatopoulos G Witt J
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Acetabular dysplasia (AD) can cause hip pain and early osteoarthritis. Lateral Centre Edge Angle (LCEA) and sourcil angle (AI) are plain radiographic measures of acetabular morphology, however there is little agreement as to what constitutes mild, moderate or severe dysplasia. This study aims to establish the correlation, if any, between two-dimensional (XR) and three-dimensional (CT) measurements of acetabular morphology and to establish the level of femoral head cover (CTFHC) for different levels of dysplasia.

Methods

Governance board approved retrospective study. 353 PAOs performed by the senior author between January 2014 and December 2017 were included. Exclusion criteria were inadequate pre-operative CT imaging and/or plain radiographs, previous pelvic/hip surgery, acetabular retroversion, or femoral head asphericity. Of the remainder, 84 had 3D analysis by clinical graphics giving measurements for CTFHC, LCEA at 1100, 1200, 1300 and sourcil angle (AI). XRLCEA, AI, posterior wall index (PWI), and anterior wall index (AWI), were measured from supine AP pelvis radiographs. Pearson correlation coefficient, and mean CTFHC for stratified LCEAs were calculated. A linear regression model to predict CTFHC from XRLCEA was validated against these.

Results

XRLCEA correlated very strongly with total femoral head coverage (Pearson=0.917, p<0.001). Mean CTFHC with XRLCEA between 15°-19.9° was 55% (range 51–59%). At 25° −29.9° mean CTFHC was 61%.

There was a linear relation of CTFHC with XR LCEA such that CTFHC = 41.5 + 0.78(XRLCEA). This linear regression model predicted CTFHC 55% (95%CI 54–56%) for XRLCEA of 17.5°, and CTFHC 63% (95%CI 62–64%) for XRLCEA 27.5°.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 17 - 17
1 Jul 2020
Innmann M Merle C Phan P Beaulé P Grammatopoulos G
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Introduction

Patients with reduced lumbar spine mobility are at higher risk of dislocation after THA as their hips have to compensate for spinal stiffness. Therefore our study aimed to 1) Define the optimal protocol for identifying patients with mobile hips and stiff lumbar spines and 2) Determine clinical and standing radiographic parameters predicting high hip and reduced lumbar spine mobility.

Methods

This prospective diagnostic cohort study followed 113 consecutive patients with end-stage hip osteoarthritis (OA) awaiting THA. Radiographic measurements were performed for the lumbar lordosis angle, pelvic tilt and pelvic-femoral angle on lateral radiographs in the standing, ‘relaxed-seated’ and ‘deep-seated’ (i.e. torso maximally leaning forward) position. A “hip user index” was calculated in order to quantify the contribution of the hip joint to the overall sagittal movement performed by the femur, pelvis and lumbar spine.


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Aims

The aims of the study were to determine the differences in spinopelvic mobility between a cohort of hip OA patients and a control group for the 1) standing to relaxed-seated and 2) standing to deep-seated task.

Methods

A cohort of 40 patients with end-stage hip OA and a control group of 40 subjects, matched for age, gender and BMI were prospectively studied. Clinical data and lateral view radiographs in different positions were assessed. Sagittal spinopelvic mobility was calculated as the change when moving from the standing to relaxed-seated and standing to deep-seated positions for the lumbar lordosis angle, pelvic tilt and pelvic-femoral angle.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_12 | Pages 65 - 65
1 Oct 2019
Beaulé PE Slullitel PA Dobransky J Kreviazuk C Kim JK Grammatopoulos G
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Introduction

Porous coated cups have a low modulus of elasticity that enhances press-fit and a surface that promotes osseointegration as well as permitting modularity. Monoblock ceramic acetabular cups represent a subtype of uncemented cup permitting the use of large femoral heads. The aim of this study was to compare the short-term clinical and radiographic performances of both cups.

Methods

This was a prospective RCT of 86 unilateral THA patients (M: 40, F: 48; mean age: 59.5 ± 10.6) randomized to either a porous-coated, modular metal-on-polyethylene (MoP) acetabular component (pore size 250µm, 45% mean volume porosity)(n=46) or a hydroxyapatite (HA) and titanium-coated monoblock shell with ceramic-on-ceramic(CoC) bearing (pore size 300µm, 48% mean volume porosity & 80nm HA coating thickness)(n=42). All sockets were under-reamed by 1 mm. Two-year radiographs and patient-reported outcomes (PROMs) were available.


The Bone & Joint Journal
Vol. 101-B, Issue 8 | Pages 902 - 909
1 Aug 2019
Innmann MM Merle C Gotterbarm T Ewerbeck V Beaulé PE Grammatopoulos G

Aims

This study of patients with osteoarthritis (OA) of the hip aimed to: 1) characterize the contribution of the hip, spinopelvic complex, and lumbar spine when moving from the standing to the sitting position; 2) assess whether abnormal spinopelvic mobility is associated with worse symptoms; and 3) identify whether spinopelvic mobility can be predicted from static anatomical radiological parameters.

Patients and Methods

A total of 122 patients with end-stage OA of the hip awaiting total hip arthroplasty (THA) were prospectively studied. Patient-reported outcome measures (PROMs; Oxford Hip Score, Oswestry Disability Index, and Veterans RAND 12-Item Health Survey Score) and clinical data were collected. Sagittal spinopelvic mobility was calculated as the change from the standing to sitting position using the lumbar lordosis angle (LL), sacral slope (SS), pelvic tilt (PT), pelvic-femoral angle (PFA), and acetabular anteinclination (AI) from lateral radiographs. The interaction of the different parameters was assessed. PROMs were compared between patients with normal spinopelvic mobility (10° ≤ ∆PT ≤ 30°) or abnormal spinopelvic mobility (stiff: ∆PT < ± 10°; hypermobile: ∆PT > ± 30°). Multiple regression and receiver operating characteristic (ROC) curve analyses were used to test for possible predictors of spinopelvic mobility.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_6 | Pages 5 - 5
1 May 2019
Roussot M Salih S Grammatopoulos G Witt J
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Introduction

Acetabular dysplasia is typically characterised by insufficient antero-superior femoral head coverage. It is postulated (yet unproven) that patients with dysplasia compensate by reducing pelvic tilt (anterior pelvic rotation), effectively retroverting their acetabulum to improve antero-superior cover. We aimed to 1) define pelvic tilt (PT) in patients with bilateral and unilateral dysplasia, and 2) quantify PT changes following a successful periacetabular osteotomy (PAO).

Patients/Materials and Methods

We retrospectively reviewed 16 patients (14 females) who underwent successful, bilateral, staged, PAOs (32 PAOs). These cases were matched for age and gender with 32 unilaterally dysplastic hips that underwent successful PAO for a similar degree of acetabular dysplasia as per pre-operative imaging. Supine and AP radiographs pre-PAO and at latest follow-up were used to measure centre-edge-angle (CEA) and Tönnis-angle (TA). PT was measured using two validated methods (Sacro-Femoral-Pubic (SFP) angle and Pubic-Symphysis to Sacro-Iliac (PS-SI) Index with excellent correlation (ρ=0.8, p<0.001).


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_6 | Pages 3 - 3
1 May 2019
Thiagarajah S Verhaegen J Balijepalli P Bingham J Grammatopoulos G Witt J
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Introduction

The periacetabular osteotomy (PAO) improves hip joint mechanics in patients with symptomatic dysplasia. As a consequence of the multi-planar acetabular re-orientation, the course of the iliopsoas tendon over the hip may be affected, potentially resulting in iliopsoas tendon-related pain. At present, little information regarding the incidence of iliopsoas-related pathology following PAO exists.

We aimed to identify the incidence of iliopsoas-related pain following PAO. Secondarily, we aimed to identify any risk factors associated with this pathology.

Methods

We retrospectively reviewed the PAO's performed from 2014–2017, for symptomatic dysplasia in our unit (single-surgeon, minimum 1-year follow-up). All patients with adequate pelvic radiographs were included. Radiographic parameters of dysplasia were measured from pre- and post-operative AP pelvic radiographs using a validated software (SHIPS)1. The degree of pubis displacement was classified according to our novel system. Cases were defined as those with evidence of iliopsoas-related pain post PAO (positive response to iliopsoas tendon-sheath steroid/local anaesthetic injection).


The Bone & Joint Journal
Vol. 101-B, Issue 5 | Pages 540 - 546
1 May 2019
Juneau D Grammatopoulos G Alzahrani A Thornhill R Inacio JR Dick A Vogel KI Dobransky J Beaulé PE Dwivedi G

Aims

Cardiac magnetic resonance (CMR) was used to assess whether cardiac function or tissue composition was affected in patients with well-functioning metal-on-metal hip resurfacing arthroplasties (MoMHRA) when compared with a group of controls, and to assess if metal ion levels correlated with any of the functional or structural parameters studied.

Patients and Methods

In all, 30 participants with no significant cardiac history were enrolled: 20 patients with well-functioning MoMHRA at mean follow-up of 8.3 years post-procedure (ten unilateral, ten bilateral; 17 men, three women) and a case-matched control group of ten non-MoM total hip arthroplasty patients (six men, four women). The mean age of the whole cohort (study group and controls) at the time of surgery was 50.6 years (41.0 to 64.0). Serum levels of cobalt and chromium were measured, and all patients underwent CMR imaging, including cine, T2* measurements, T1 and T2 mapping, late gadolinium enhancement, and strain measurements.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_6 | Pages 2 - 2
1 May 2019
Verhaegen J Salih S Thiagarajah S Grammatopoulos G Witt J
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Introduction

Peri-acetabular-osteotomy (PAO) was initially described for the correction of acetabular dysplasia. Anteverting PAO is an established treatment for acetabular retroversion. By reviewing a large cohort, we aimed to (1) Test whether PAO outcome is equivalent in different types of deformity (classic dysplasia vs. retroversion) and (2) Determine whether outcome in acetabular retroversion is different between impinging-only hip and hips with combined pathology (impingement & dysplasia).

Methods

A single-centre, retrospective cohort study was performed on a group of patients (n=183) with acetabular retroversion (n=90) or lateral-under-coverage dysplasia (n=93) treated with PAO. Acetabular deformity was defined on pelvic radiographs and 3-D CTs using a number of parameters. Hips with retroversion, were sub-divided into combined pathology - retroversion with dysplasia (lateral centre-edge [LCEA] < 25°), or retroversion-only (LCEA≥25°). The mean age at time of the procedure was 29+/−7 years and most hips were in females (n=171). Complication (as per Dindo-Clavien)-, re-operation-, hip preservation rates and patient-reported-outcome measures were measured using the Non-Arthroplasty-Hip-Score (NAHS).


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_6 | Pages 4 - 4
1 May 2019
Salih S Grammatopoulos G Beaule P Witt J
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Introduction

Acetabular retroversion (AR) can cause pain and early osteoarthritis. The sagittal pelvic position or pelvic tilt (PT)has a direct relationship with acetabular orientation. As the pelvis tilts anteriorly, PT reduces and AR increases. Therefore, AR may be a deformity secondary to abnormal PT (functional retroversion) or an anatomical deformity of the acetabulum and/or pelvic ring.

This study aims to:

Define PT at presentation is in AR patients and whether this is different to controls (volunteers without pain).

Assess whether the PT changes following a anteverting periacetabular osteotomy (PAO).

Methods

PT was measured for 51 patients who underwent a successful PAO. Mean age at PAO was 29±6 years and 48 were females. PT, pelvic incidence (PI), anterior pelvic plane (APP), and sacral slope (SS) were measured from CT data in 23 patients and compared to 44 (32±7 years old, 4 females) asymptomatic volunteers. Change in pelvic tilt in all 51 patients was measured using the Sacro-Femoral-Pubic angle (SFP), a validated method, from pre- and post-operative radiographs at a mean interval of 2.5(±2) years.


The Bone & Joint Journal
Vol. 100-B, Issue 10 | Pages 1280 - 1288
1 Oct 2018
Grammatopoulos G Gofton W Cochran M Dobransky J Carli A Abdelbary H Gill HS Beaulé PE

Aims

This study aims to: determine the difference in pelvic position that occurs between surgery and radiographic, supine, postoperative assessment; examine how the difference in pelvic position influences subsequent component orientation; and establish whether differences in pelvic position, and thereafter component orientation, exist between total hip arthroplasties (THAs) performed in the supine versus the lateral decubitus positions.

Patients and Methods

The intra- and postoperative anteroposterior pelvic radiographs of 321 THAs were included; 167 were performed with the patient supine using the anterior approach and 154 were performed with the patient in the lateral decubitus using the posterior approach. The inclination and anteversion of the acetabular component was measured and the difference (Δ) between the intra- and postoperative radiographs was determined. The target zone was inclination/anteversion of 40°/20° (± 10°). Changes in the tilt, rotation, and obliquity of the pelvis on the intra- and postoperative radiographs were calculated from Δinclination/anteversion using the Levenberg–Marquardt algorithm.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_9 | Pages 27 - 27
1 May 2018
Innmann M Merle C Gotterbarm T Beaulé P Grammatopoulos G
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Introduction

The changes in sagittal spino-pelvic balance from standing to sitting in patients with end-stage osteoarthritis (OA) of the hip remain poorly characterized. Our aim was to 1) investigate the contribution of sagittal spino-pelvic movement and hip flexion when moving from a standing to sitting posture in patients with hip OA; 2) determine the proportion of OA-patients with stiff, normal or hypermobile spino-pelvic mobility and 3) identify radiographic parameters correlating with spino-pelvic mobility.

Methods

This prospective diagnostic cohort study followed 116 consecutive patients with end-stage osteoarthritis awaiting THR. All patients underwent preoperative standardized radiographs (lateral view) of the lumbar spine, pelvis and proximal femur using EOS© in standing position and with femurs parallel to the floor in order to achieve a 90°-seated position. Radiographic measurements performed included lumbar lordosis (LL), sacral slope (SS), pelvic tilt (PT), pelvic incidence (PI) and pelvic-femoral-angle (PFA). The difference in PT between standing and seated allowed for patient classification based on spino-pelvic mobility into stiff (<±10°), normal (±10–30°), or hypermobile (>±30°).


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_9 | Pages 20 - 20
1 May 2018
Grammatopoulos G Gofton W Cochran M Dobransky J Carli A Abdelbary H Gill H Beaulé P
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Introduction

The resultant cup orientation depends upon the orientation of the pelvis at impaction. No studies to date have assessed whether patient-position during total hip arthroplasty (THA) has an effect on cup orientation. This study aims to 1) Determine the difference in pelvic position that occurs between surgery and radiographic, supine, post-operative assessment; 2) Examine how the difference in pelvic position influences subsequent cup orientation and 3) Establish whether pelvic orientation, and thereafter cup orientation, differences exist between THAs performed in the supine versus the lateral decubitus positions.

Patients/Materials & Methods

This is a retrospective, multi-surgeon, single-centre, consecutive series. 321 THAs who had intra-operative, post-cup impaction, AP pelvic radiograph, in the operative position were included; 167 were performed with the patient supine (anterior approach), whilst 154 were performed in the lateral decubitus (posterior approach). Cup inclination/anteversion was measured from intra- and post-operative radiographs and the difference (Δ) was determined. Change in pelvic position (tilt, rotation, obliquity) between surgery and post-operatively was calculated from Δinclination/anteversion using the Levenberg-Marquardt algorithm.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_9 | Pages 21 - 21
1 May 2018
Grammatopoulos G Gofton W Coyle M Dobransky J Kreviazuk C Kim P Beaulé P
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Introduction

The mechanisms of how spinal arthrodesis (SA) affects patient function after total hip replacement (THA) remain unclear. The objectives of this study were to a) Determine how outcome post-THA compares between patients with- and without-SA, b) Characterize sagittal pelvic changes that occur when moving between different functional positions, and test for differences between patients with- and without-SA, and c) Assess whether differences in sagittal pelvic dynamics are associated with outcome post-THA.

Patients/Materials & Methods

Forty-two patients with THA-SA (60 hips) were case-control matched for age, gender, BMI with 42 THA-only patients (60 hips). All presented for review where outcome, PROMs [including Oxford-Hip-Score(OHS)] and 4 radiographs of the pelvis and spino-pelvic complex in 3 positions (supine, standing, deep-seated) were obtained. Cup orientation and various spino-pelvic parameters [including pelvic tilt (PT) and Pelvic-Femoral-Angle (PFA)] were measured. The difference in PT between standing and seated allowed for patient classification based on spino-pelvic mobility into normal (±10–30°), stiff (<±10°) or hypermobile (>±30°).


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_9 | Pages 1 - 1
1 May 2018
Grammatopoulos G Speirs A Ng G Riviere C Rakhra K Lamontagne M Beaule PE
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Introduction

Acetabular and spino-pelvic (SP) morphological parameters are important determinants of hip joint dynamics. This study aims to determine whether acetabular and SP morphological differences exist between hips with and without cam morphology and between symptomatic and asymptomatic hips with cam morphology.

Patients/Materials & Methods

A prospective cohort of 67 patients/hips was studied. Hips were either asymptomatic with no cam (Controls, n=18), symptomatic with cam (n=26) or asymptomatic with cam (n=23). CT-based quantitative assessments of femoral, acetabular, pelvic and spino-pelvic parameters were performed. Measurements were compared between controls and those with a cam deformity, as well as between the 3 groups. Morphological parameters that were independent predictors of a symptomatic Cam were determined using a regression analysis.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_9 | Pages 25 - 25
1 May 2018
Grammatopoulos G Jamieson P Dobransky J Rakhra K Carsen S Beaule P
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Introduction

This study aims to determine how the acetabular version changes during the key developmental stage of adolescence, and what contributes to this change. In addition, we examined whether patient factors (BMI, activity levels) or the femoral-sided anatomy contribute to any observed changes.

Patients/Materials & Methods

This prospective longitudinal cohort study included 19 volunteers (38 healthy hips). The participants underwent clinical examination (BMI, range of movement assessment), MRIs of both hips at recruitment and at follow-up (6 ± 2 years) and HSS Paediatric Functional Activity Brief Scale (Pedi-FABS) questionnaire. MRI scans were assessed at both time points to determine change of the tri-radiate cartilage complex (TCC), the acetabular anteversion, the degree of anterior, posterior, and superior femoral head coverage by the acetabulum, and anterior and antero-superior alpha angles. We investigated if the change in anteversion and sector angles was influenced by the BMI, range of movement measurements, the Pedi-FABS or the alpha angle measurements.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_9 | Pages 7 - 7
1 May 2018
Grammatopoulos G Pascual-Garrido C Nepple J Beaule P Clohisy J
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Introduction

Acetabular dysplasia is associated with an increased risk of hip pain and early development of osteoarthritis (OA). The Bernese peri-acetabular osteotomy (PAO) is the most well-established technique in the Western world for the treatment of symptomatic acetabular dysplasia. This case-control study aims to assess whether the severity of acetabular dysplasia has an effect on outcome following Peri-Acetabular Osteotomy (PAO) and/or the ability to achieve desired acetabular correction.

Patients/Materials & Methods

A prospective, multicentre, longitudinal cohort of consecutive PAOs was reviewed. Of the available 381 cases, 61 hips had pre-PAO radiographic features of lesser-dysplasia [Acetabular-Index (AI)<15° and Lateral-Centre-Edge-Angle (LCEA)>15°) and comprised the ‘study-group’. ‘Study-Group’ was matched for all factors known to influence outcome post-PAO [age, gender, BMI, Tönnis-grade and joint congruency (p=0.6–0.9)] with a ‘Comparison-Group’ of pronounced dysplasia (n=183). Clinical outcomes, complications and the ability to achieve optimum correction (LCEA: 25°–40°/AI: 0°–+10°) were compared.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 52 - 52
1 Jun 2017
Pradhan R Grammatopoulos G Wilson H Asopa V Andrade T
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A modular hemiarthroplasty has a Metal-on-Metal (MoM) taper-trunnion junction, which may lead to increased wear and Adverse-Reaction-to-Metal-Debris (ARMD). To-date no wear related issues have been described in the elderly and less active that receives a hemiarthroplasty. This study aims to determine in vivo wear (i.e. serum metal ion levels) in hip hemiarthroplasty, and identify factors associated with increased wear.

This is a prospective, IRB approved, single-centre, cohort study of patients that received an uncemented, modular hemiarthroplasty of proven design for the treatment of hip fracture between 2013–2015. All, alive, patients at 12-months post-implantation with AMTS≥6 were invited to participate. Of the 125 eligible patients, 50 accepted the invitation and were reviewed, including clinical/radiological assessment, metal-ion ([Chromium (Cr) and Cobalt (Co)]) measurement and Oxford Hip Score (OHS). Acetabular erosion was graded (0–3: normal-protrusio). Metal ion levels were considered high if ≥7ppb.

The mean OHS was 37 (SD: 10). No acetabular erosion was detected in 21, whilst the remaining had either grade-1 (n=21) or grade-2 (n=8). The median Cr and Co levels were 2.9 (SD:9) and 2.2 (SD:4) respectively. There were 8 cases (16%) with high ion levels. To-date only 2 of them has an ARMD lesion, and none have been revised. Patients with metal ion levels had similar pre-fall mobility, taper- and head- size and OHS to those with low metal ion levels (p=0.2–0.7) However, all hips with high metal ion levels had evidence of acetabular erosion (≥1).

Modular Hip hemiarthroplasties and their taper-trunnion junction are not immune to high wear and ARMD despite being implanted in a less active cohort. Acetabular erosion should alert clinicians, as it is associated with 20× increased-risk of taper wear, presumably due to the increased transmitted torque. Whether the use of modular hemiarthroplasties should remain is debatable.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 23 - 23
1 Jun 2017
Parker S Grammatopoulos G Dhaliwal K Pradhan R Marshall R Andrade A
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Degenerative hip and spine pathologies often co-exist, as Hip-Spine-Syndrome (HSS). Many patients eventually need surgery in both hip (THR) and spine [decompression-spinal-arthrodesis (DSA)]. This case-control study aims to determine whether the presence of a DSA compromised THR outcome and whether outcome of THR is better if performed prior to- (THR-1st) or after- DSA (THR-2nd).

This is a single centre, multi-surgeon, retrospective, case-control study. Of the 748 patients that underwent DSA between 2004–15, 43 patients (54 THRs) have also had a 1° THR(s) at our unit and formed the cases. Thirty-two THRs were performed prior to the DSA (THR-1st) and 22 were done following the DSA (THR-2nd). Most cases had either 1- (n=3) or 2-level (n=20) DSA. The most common DSA level was L4/5 (n=23). The mean THR-DSA interval was 3.6 years. Controls were patients (n=67) without DSA or previous spinal surgery, that had a THR in our unit over the same study period matched for age, gender and type of THR implanted.

Patient Reported Outcome Measures (PROMs) were obtained using the Oxford-Hip- and Harris-Hip-Scores (OHS/HHS), with the difference between post- and pre-operative scores defined as Δ. Outcome was compared between Cases and Controls and between THR-1st and THR-2nd Groups. Outcome measures included complications, revisions, PROMs and cup orientations achieved.

The mean age at THR was 67 years old (SD: 11) and most patients were female (n=82, 68%). The mean cup inclination and anteversion angles were 41° (SD:8) and 21° (SD:8). At a mean follow-up of 6 years, the OHS improved from OHSpre:16 (SD: 7) to OHSfu:41 (SD:10) and the HHS improved from HHSpre:51 (SD:14) to HHSfu:88 (SD:13).

A greater incidence of complications were seen in the Cases (n=10; ARMD-3, infection-4, loosening-2, dislocation-1) compared to the Controls (n=3; dislocation-2, loosening-1) (p=0.01). Consequently, more THRs required revision in the Cases (n=7) compared to the Controls (n=1) (p=0.01). There were no differences in OHSpre/OHSfu/ΔOHS/HHSpre/HHSfu/ΔHHS between cases and controls (p=0.1 – 0.9).

There were no difference in complications (7/29 Vs. 3/25; p=0.3), nor revision rates (5/29 Vs. 2/25; p=0.3) between THA-1st and THA-2nd Groups. Greater differences in PROMs were detected between the groups. The THA-1st Group, compared to the THA-2nd Group had higher OHSpre (19 Vs 12), HHSpre (54 Vs 48), OHSfu (43 Vs 32) and HHSfu (93 Vs 76), (p=0.001–0.005). However, no statistically significant difference in ΔOHS (24 Vs 17) and ΔHHS (39 Vs 26) were seen between the THA-1st and THA-2nd Groups (p=0.1).

Patients with a 1° THR and DSA, had a greater rate complications and revisions compared to a matched control. Overall, no difference in PROMs were seen between Cases and Controls. No significantly increased risk of dislocation was seen in this predominantly 1- and 2-level DSA cohort. The superior PROMs detected in the THA-1st Group provide evidence that the hip pathology should be addressed 1st (in cases with 1- or 2-level planned DSA).


The Bone & Joint Journal
Vol. 99-B, Issue 5 | Pages 614 - 622
1 May 2017
Grammatopoulos G Bolduc M Atkins BL Kendrick BJL McLardy-Smith P Murray DW Gundle R Taylor AH

Aims

Advocates of debridement, antibiotics and implant retention (DAIR) in hip periprosthetic joint infection (PJI) argue that a procedure not disturbing a sound prosthesis-bone interface is likely to lead to better survival and functional outcome compared with revision. This case-control study aims were to compare outcome of DAIRs for infected primary total hip arthroplasty (THA) with outcomes following primary THA and two-stage revision of infected primary THAs.

Patients and Methods

We retrospectively reviewed all DAIRs, performed for confirmed infected primary hip arthropasty (n = 82) at out institution, between 1997 and 2013. Data recorded included full patient information and type of surgery. Outcome measures included complications, mortality, implant survivorship and functional outcome. Outcome was compared with two control groups matched for gender and age; a cohort of primary THAs (n = 120) and a cohort of two-stage revisions for infection (n = 66).


The Bone & Joint Journal
Vol. 98-B, Issue 11 | Pages 1463 - 1470
1 Nov 2016
Grammatopoulos G Alvand A Martin H Whitwell D Taylor A Gibbons CLMH

Objectives

A possible solution for the management of proximal femoral bone loss is a modular femoral endoprosthesis (EPR). Although the outcome of EPRs in tumour surgery has been well described, the outcome of their use in revision hip surgery has received less attention. The aim of this study was to describe the outcome of using EPR for non-neoplastic indications.

Methods

A retrospective review of 79 patients who underwent 80 EPRs for non-neoplastic indications was performed, including the rates of complication and survival and the mean Oxford Hip Scores (OHS), at a mean of five years post-operatively. The mean age at the time of surgery was 69 years (28 to 93) and the mean number of previous operations on the hip was 2.4 (0 to 17). The most common indications for EPR implantation were periprosthetic joint infection (PJI) (n = 40), periprosthetic fracture (n = 12) and failed osteosynthesis of a proximal femoral fracture or complex trauma (n = 11).


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_11 | Pages 18 - 18
1 Jun 2016
Grammatopoulos G Hodhody G Lane J Taylor A Kendrick B Glyn-Jones S
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Image-guided intra-articular hip injection of local-anaesthetic and steroid is commonly used in the management of hip pain. It can be used as a diagnostic and/or therapeutic tool and is of low cost (£75). The aim of this study was to assess how often a hip injection has a therapeutic effect.

This is a retrospective, consecutive, case series of intra-articular hip injections performed in a tertiary referral hospital over a 2-year period (2013–4). Patients were identified from the radiology department's prospectively entered database. Clinical information, reason for injection and subsequent management was obtained from hospital records. All patients prospectively reported their pain levels in a numeric pain scale diary (out of 10) at various time points; pre-, immediately post-, 1st day-, 2nd day- and 2 weeks- post-injection. Only patients with complete pain scores at all time points were included (n=200, of the 250 injections performed over study period, 80%).

The majority of injections were performed for osteoarthritis (OA) treatment (82%). The pain was significantly reduced from a pre-injection score of 7.5 (SD:2) to 5.0 (SD:3) immediately post-injection(p<0.001); only 24 (11%) reported any worsening of pain immediately post-injection. Pain significantly reduced further to 3.8(SD:3) at 2-weeks post-injection (p<0.001). 50% of patients had at least a 3 point drop in reported pain. No improvement was seen in 18 patients and 10 (5%) reported worse pain at 2-weeks compared to pre-injection. Of the OA cohort, 10% have required repeat injections, 45% required no further intervention and 45% underwent or are due for hip replacement. No immediate complications occurred.

Intra-articular hip injection reduced pain in 86% of cases and has delayed any further surgical treatment for at least 2 years in over 50% of OA cases. It is hence a cost-effective treatment modality. Further work is necessary to describe factors predicting response.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_11 | Pages 47 - 47
1 Jun 2016
Grammatopoulos G Alvand A Martin H Taylor A Whitwell D Gibbons M
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The management of proximal femoral bone loss is a significant challenge in revision hip arthroplasty. A possible solution is the use of a modular proximal femur endoprosthesis (EPR). Although the survivorship and functional outcome of megaprostheses used in tumour surgery has been well described, outcome of EPRs used in revision hip surgery has received less attention. The aim of this study was to determine the 5-year outcome following proximal femur EPR and determine factors that influence it.

This was a retrospective consecutive case series of all EPRs (n=80) performed for non-neoplastic indications, by 6 surgeons, in our tertiary referral centre, between 2005–2014. Patient demographics and relevant clinical details were determined from notes. The most common indications for the use of EPRs included infection (n=40), peri-prosthetic fracture (n=12) and failed osteosynthesis of proximal femoral fractures/complex trauma (n=11). Outcome measures included complication and re-operation rates, implant survival and assessment of functional outcome using the Oxford-Hip-Score (OHS).

The mean age at surgery was 69 years and mean follow-up was 4 (0 – 11) years. The mean number of previous hip operations was 2.4 (range: 0 – 17). Twenty-five patients sustained a complication (31%), the most common being infection (n=9) and dislocation (n=4). By follow-up, further surgery was required in 18 (22%) hips, 9 of which were EPR revisions. 5-yr implant survivorship was 87% (95%CI: 76 – 98%). Mean OHS was 28 (range: 4 – 48). Inferior survival and outcome were seen in EPRs performed for the treatment of infection. Infection eradication was achieved in 34/41 with the index EPR procedure and in 40/41 hips by follow-up.

Limb salvage was achieved in all cases and acceptable complication- and re-operation rates were seen. EPRs for periprosthetic fractures and failed osteosynthesis had best outcome. We recommend the continued use of proximal femur EPR in complex revision surgery.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_11 | Pages 52 - 52
1 Jun 2016
Grammatopoulos G Kendrick B Glyn-Jones S McLardy-Smith P Taylor A Gundle R
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Introduction

The value of Debridement-Antibiotics-and-Implant-Retention (DAIR) in prosthetic-joint-infection (PJI) is still a matter of debate as most studies to-date are underpowered with variable end-points. In our, tertiary referral, bone infection unit we consider DAIR to be a suitable option in all PJIs with soundly fixed prostheses, despite chronicity. The aims of this study were to define the long-term outcome following DAIR in hip PJI and identify factors that influence it.

Methods

This is a retrospective consecutive case series of DAIRs performed between 1997 and 2013. Only infected cases confirmed by established criteria were included. Data recorded included patient demographics, medical history (ASA grade, Charlson and KLICC scores), type of surgery performed (DAIR or DAIR + exchange of modular components) and organism grown. Outcome measures included complications, implant survivorship and functional outcome (Oxford Hip Score, OHS).


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 29 - 29
1 Nov 2015
Pollalis A Grammatopoulos G Wainwright A Theologis T McLardy-Smith P Murray D
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Introduction

Joint preserving procedures have gained popularity in an attempt to delay arthroplasty in young, dysplastic hips. Excellent results can be achieved with peri-acetabular osteotomy (PAO) in congruent non-arthritic hips. The role of salvage procedures such as the Shelf acetabuloplasty remains undefined. This study aims to determine the long-term survival and functional outcome following Shelf acetabuloplasty and to identify factors that influence outcome.

Patients/Materials & Methods

This is a retrospective, consecutive, multi-surgeon, case series from a UK referral centre. 125 Shelf procedures were performed between 1987–2013 on 117 patients for symptomatic hip dysplasia. Mean age was 33 years (15–53). Mean follow-up was 10 years (1–27). Radiographic parameters measured included pre-operative arthritis, acetabular-index, centre-edge-angle, joint congruency, subluxation and femoral sphericity. Oxford Hip and UCLA scores were collected at follow-up. Failure was defined as conversion to arthroplasty or OHS<20.


The Bone & Joint Journal
Vol. 97-B, Issue 2 | Pages 164 - 172
1 Feb 2015
Grammatopoulos G Thomas GER Pandit H Beard DJ Gill HS Murray DW

We assessed the orientation of the acetabular component in 1070 primary total hip arthroplasties with hard-on-soft, small diameter bearings, aiming to determine the size and site of the target zone that optimises outcome. Outcome measures included complications, dislocations, revisions and ΔOHS (the difference between the Oxford Hip Scores pre-operatively and five years post-operatively). A wide scatter of orientation was observed (2sd 15°). Placing the component within Lewinnek’s zone was not associated withimproved outcome. Of the different zone sizes tested (± 5°, ± 10° and ± 15°), only ± 15° was associated with a decreased rate of dislocation. The dislocation rate with acetabular components inside an inclination/anteversion zone of 40°/15° ± 15° was four times lower than those outside. The only zone size associated with statistically significant and clinically important improvement in OHS was ± 5°. The best outcomes (ΔOHS > 26) were achieved with a 45°/25° ± 5° zone.

This study demonstrated that with traditional technology surgeons can only reliably achieve a target zone of ±15°. As the optimal zone to diminish the risk of dislocation is also ±15°, surgeons should be able to achieve this. This is the first study to demonstrate that optimal orientation of the acetabular component improves the functional outcome. However, the target zone is small (± 5°) and cannot, with current technology, be consistently achieved.

Cite this article: Bone Joint J 2015;97-B:164–72.


The Bone & Joint Journal
Vol. 96-B, Issue 10 | Pages 1290 - 1297
1 Oct 2014
Grammatopoulos G Pandit HG da Assunção R McLardy-Smith P De Smet KA Gill HS Murray DW

There is great variability in acetabular component orientation following hip replacement. The aims of this study were to compare the component orientation at impaction with the orientation measured on post-operative radiographs and identify factors that influence the difference between the two. A total of 67 hip replacements (52 total hip replacements and 15 hip resurfacings) were prospectively studied. Intra-operatively, the orientation of the acetabular component after impaction relative to the operating table was measured using a validated stereo-photogrammetry protocol. Post-operatively, the radiographic orientation was measured; the mean inclination/anteversion was 43° (sd 6°)/ 19° (sd 7°). A simulated radiographic orientation was calculated based on how the orientation would have appeared had an on-table radiograph been taken intra-operatively. The mean difference between radiographic and intra-operative inclination/anteversion was 5° (sd 5°)/ -8° (sd 8°). The mean difference between simulated radiographic and intra-operative inclination/anteversion, which quantifies the effect of the different way acetabular orientation is measured, was 3°/-6° (sd 2°). The mean difference between radiographic and simulated radiographic orientation inclination/anteversion, which is a manifestation of the change in pelvic position between component impaction and radiograph, was 1°/-2° (sd 7°).

This study demonstrated that in order to achieve a specific radiographic orientation target, surgeons should implant the acetabular component 5° less inclined and 8° more anteverted than their target. Great variability (2 sd about ± 15°) in the post-operative radiographic cup orientation was seen. The two equally contributing causes for this are variability in the orientation at which the cup is implanted, and the change in pelvic position between impaction and post-operative radiograph.

Cite this article: Bone Joint J 2014;96-B:1290–7


The Bone & Joint Journal
Vol. 96-B, Issue 7 | Pages 876 - 883
1 Jul 2014
Grammatopoulos G Pandit HG da Assunção R Taylor A McLardy-Smith P De Smet KA Murray DW Gill HS

The orientation of the acetabular component is influenced not only by the orientation at which the surgeon implants the component, but also the orientation of the pelvis at the time of implantation. Hence, the orientation of the pelvis at set-up and its movement during the operation, are important. During 67 hip replacements, using a validated photogrammetric technique, we measured how three surgeons orientated the patient’s pelvis, how much the pelvis moved during surgery, and what effect these had on the final orientation of the acetabular component. Pelvic orientation at set-up, varied widely (mean (± 2, standard deviation (sd))): tilt 8° (2sd ±32), obliquity –4° (2sd ±12), rotation –8° (2sd ±14). Significant differences in pelvic positioning were detected between surgeons (p < 0.001). The mean angular movement of the pelvis between set-up and component implantation was 9° (sd 6). Factors influencing pelvic movement included surgeon, approach (posterior >  lateral), procedure (hip resurfacing > total hip replacement) and type of support (p < 0.001). Although, on average, surgeons achieved their desired acetabular component orientation, there was considerable variability (2sd ±16) in component orientation. We conclude that inconsistency in positioning the patient at set-up and movement of the pelvis during the operation account for much of the variation in acetabular component orientation. Improved methods of positioning and holding the pelvis are required.

Cite this article: Bone Joint J 2014; 96-B:876–83.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 9 | Pages 1180 - 1186
1 Sep 2012
Murray DW Grammatopoulos G Pandit H Gundle R Gill HS McLardy-Smith P

Recent events have highlighted the importance of implant design for survival and wear-related complications following metal-on-metal hip resurfacing arthroplasty. The mid-term survival of the most widely used implant, the Birmingham Hip Resurfacing (BHR), has been described by its designers. The aim of this study was to report the ten-year survival and patient-reported functional outcome of the BHR from an independent centre.

In this cohort of 554 patients (646 BHRs) with a mean age of 51.9 years (16.5 to 81.5) followed for a mean of eight years (1 to 12), the survival and patient-reported functional outcome depended on gender and the size of the implant. In female hips (n = 267) the ten-year survival was 74% (95% confidence interval (CI) 83 to 91), the ten-year revision rate for pseudotumour was 7%, the mean Oxford hip score (OHS) was 43 (sd 8) and the mean UCLA activity score was 6.4 (sd 2). In male hips (n = 379) the ten-year survival was 95% (95% CI 92.0 to 97.4), the ten-year revision rate for pseudotumour was 1.7%, the mean OHS was 45 (sd 6) and the mean UCLA score was 7.6 (sd 2). In the most demanding subgroup, comprising male patients aged < 50 years treated for primary osteoarthritis, the survival was 99% (95% CI 97 to 100).

This study supports the ongoing use of resurfacing in young active men, who are a subgroup of patients who tend to have problems with conventional THR. In contrast, the results in women have been poor and we do not recommend metal-on-metal resurfacing in women. Continuous follow-up is recommended because of the increasing incidence of pseudotumour with the passage of time.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 11 | Pages 1527 - 1534
1 Nov 2010
Grammatopoulos G Pandit H Murray DW Gill HS

Pseudotumour is a rare but important complication of metal-on-metal hip resurfacing that occurs much more commonly in women than in men. We examined the relationship between head-neck ratio (HNR) and pseudotumour formation in 18 resurfaced hips (18 patients) revised for pseudotumour and 42 asymptomatic control resurfaced hips (42 patients).

Patients in whom pseudotumour formation had occurred had higher pre-operative HNR than the control patients (mean 1.37 (sd 0.10) vs mean 1.30 (sd 0.08) p = 0.001). At operation the patients with pseudotumours had a greater reduction in the size of their femoral heads (p = 0.035) and subsequently had greater neck narrowing (mean 10.1% (sd 7.2) vs mean 3.8% (sd 3.2) p < 0.001). No female patient with a pre-operative HNR ≤ 1.3 developed a pseudotumour.

We suggest that reducing the size of the femoral head, made possible by a high pre-operative HNR, increases the risk of impingement and edge loading, and may contribute to high wear and pseudotumour formation. As the incidence of pseudotumour is low in men, it appears safe to perform resurfacing in men. However, this study suggests that it is also reasonable to resurface in women with a pre-operative HNR ≤ 1.3.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 8 | Pages 1072 - 1078
1 Aug 2010
Grammatopoulos G Pandit H Glyn-Jones S McLardy-Smith P Gundle R Whitwell D Gill HS Murray DW

Pseudotumours are a rare complication of hip resurfacing. They are thought to be a response to metal debris which may be caused by edge loading due to poor orientation of the acetabular component. Our aim was to determine the optimal acetabular orientation to minimise the risk of pseudotumour formation.

We matched 31 hip resurfacings revised for pseudotumour formation with 58 controls who had a satisfactory outcome from this procedure. The radiographic inclination and anteversion angles of the acetabular component were measured on anteroposterior radiographs of the pelvis using Einzel-Bild-Roentgen-Analyse software. The mean inclination angle (47°, 10° to 81°) and anteversion angle (14°, 4° to 34°) of the pseudotumour cases were the same (p = 0.8, p = 0.2) as the controls, 46° (29° to 60°) and 16° (4° to 30°) respectively, but the variation was greater. Assuming an accuracy of implantation of ± 10° about a target position, the optimal radiographic position was found to be approximately 45° of inclination and 20° of anteversion. The incidence of pseudotumours inside the zone was four times lower (p = 0.007) than outside the zone.

In order to minimise the risk of pseudotumour formation we recommend that surgeons implant the acetabular component at an inclination of 45° (± 10) and anteversion of 20° (± 10) on post-operative radiographs. Because of differences between the radiographic and the operative angles, this may be best achieved by aiming for an inclination of 40° and an anteversion of 25°.