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Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_12 | Pages 8 - 8
10 Jun 2024
Airey G Aamir J Chapman J Tanaka H Elbannan M Singh A Mangwani J Kyaw H Jeyaseelan L Mason L
Full Access

Background

Research on midfoot injuries have primarily concentrated on the central column and the Lisfranc ligament without amassing evidence on lateral column injuries. Lateral column injuries have historically been treated with Kirschner wire fixation when encountered.

Objective

Our aim in this study was to analyse lateral column injuries to the midfoot, their method of treatment and the radiological lateral column outcomes. Our nul hypothesis being that fixation is required to obtain and maintain lateral column alignment.


Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_11 | Pages 8 - 8
4 Jun 2024
Safdar NZ Chapman G Hopwood J Brockett C Redmond A
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Ankle fusion (AF), a durable intervention for ankle arthritis, has been the management of choice but restricts mobility. Recently, total ankle replacement (TAR) has been offered to patients looking to maintain mobility. The aim was to compare the biomechanics of AF and TAR while walking on inverted and everted slopes which create a greater demand for complex foot mobility than level walking. A ten-camera motion detection setup captured trials as patients walked in both directions over a 5⁰ lateral slope with embedded force plates. Moments (Nm/Kg) across the knee and ankle were exported from Visual 3D in the sagittal and frontal plane, and data were reported as means with 95% confidence intervals. 15 patients were recruited (6 TAR, 9 AF). The median age, follow-up and BMI was 67 years, 4 years and 35.8 kg/m² in AF, and 73 years, 7 years and 28.1 kg/m² in TAR, respectively. During inverted slope walking (4 TAR, 7 AF), abduction moments across (i) the knee: TAR 0.38 (0.37–0.39) vs AF 0.37 (0.27–0.52) and (ii) the ankle: TAR 0.20 (0.13–0.27) vs AF 0.25 (0.18–0.32), and extension moments across (i) the knee: TAR 0.68 (0.38–0.97) vs AF 0.85 (0.69–1.01) and (ii) the ankle: TAR 1.46 (1.30–1.62) vs AF 1.30 (1.08–1.52). During everted walking (5 TAR, 7 AF), abduction moments across (i) the knee: TAR 0.41 (0.30–0.52) vs AF 0.46 (0.27–0.66) and (ii) the ankle: TAR 0.24 (0.11–0.38) vs AF 0.26 (0.18–0.33), and extension moments across (i) the knee: TAR 0.76 (0.54–0.99) vs AF 0.93 (0.72–1.14) and (ii) the ankle: TAR 1.39 (1.19–1.59) vs AF 1.26 (1.04–1.48). There were no differences in abduction moments during inverted or everted slope walking. However, patients with AF had increased extension moments across the knee, particularly on inverted slopes, suggesting that AF creates a greater demand for knee compensation than TAR.


Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_11 | Pages 12 - 12
4 Jun 2024
Chapman J Choudhary Z Gupta S Airey G Mason L
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Introduction

Treatment pathways of 5th metatarsal fractures are commonly directed based on fracture classification, with Jones types for example, requiring closer observation and possibly more aggressive management.

Primary objective

To investigate the reliability of assessment of subtypes of 5th metatarsal fractures by different observers.


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_10 | Pages 34 - 34
1 Jun 2023
Airey G Chapman J Mason L Harrison W
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Introduction

Open fragility ankle fractures involve complex decision making. There is no consensus on the method of surgical management. Our aim in this study was to analyse current management of these patients in a major trauma centre (MTC).

Materials & Methods

This cohort study evaluates the management of geriatric (≥65years) open ankle fractures in a MTC (November 2020–November 2022). The method, timing(s) and personnel involved in surgical care were assessed. Weightbearing status over the treatment course was monitored. Patient frailty was measured using the clinical frailty score (CFS).


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_8 | Pages 98 - 98
11 Apr 2023
Williams D Chapman G Esquivel L Brockett C
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To be able to assess the biomechanical and functional effects of ankle injury and disease it is necessary to characterise healthy ankle kinematics. Due to the anatomical complexity of the ankle, it is difficult to accurately measure the Tibiotalar and Subtalar joint angles using traditional marker-based motion capture techniques. Biplane Video X-ray (BVX) is an imaging technique that allows direct measurement of individual bones using high-speed, dynamic X-rays.

The objective is to develop an in-vivo protocol for the hindfoot looking at the tibiotalar and subtalar joint during different activities of living.

A bespoke raised walkway was manufactured to position the foot and ankle inside the field of view of the BVX system. Three healthy volunteers performed three gait and step-down trials while capturing Biplane Video X-Ray (125Hz, 1.25ms, 80kVp and 160 mA) and underwent MR imaging (Magnetom 3T Prisma, Siemens) which were manually segmented into 3D bone models (Simpleware Scan IP, Synopsis). Bone position and orientation for the Talus, Calcaneus and Tibia were calculated by manual matching of 3D Bone models to X-Rays (DSX Suite, C-Motion, Inc.). Kinematics were calculated using MATLAB (MathWorks, Inc. USA).

Pilot results showed that for the subtalar joint there was greater range of motion (ROM) for Inversion and Dorsiflexion angles during stance phase of gait and reduced ROM for Internal Rotation compared with step down. For the tibiotalar joint, Gait had greater inversion and internal rotation ROM and reduced dorsiflexion ROM when compared with step down.

The developed protocol successfully calculated the in-vivo kinematics of the tibiotalar and subtalar joints for different dynamic activities of daily living. These pilot results show the different kinematic profiles between two different activities of daily living. Future work will investigate translation kinematics of the two joints to fully characterise healthy kinematics.


Bone & Joint Open
Vol. 2, Issue 11 | Pages 1004 - 1016
26 Nov 2021
Wight CM Whyne CM Bogoch ER Zdero R Chapman RM van Citters DW Walsh WR Schemitsch E

Aims

This study investigates head-neck taper corrosion with varying head size in a novel hip simulator instrumented to measure corrosion related electrical activity under torsional loads.

Methods

In all, six 28 mm and six 36 mm titanium stem-cobalt chrome head pairs with polyethylene sockets were tested in a novel instrumented hip simulator. Samples were tested using simulated gait data with incremental increasing loads to determine corrosion onset load and electrochemical activity. Half of each head size group were then cycled with simulated gait and the other half with gait compression only. Damage was measured by area and maximum linear wear depth.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_2 | Pages 38 - 38
1 Mar 2021
Vasiljeva K Lunn D Chapman G Redmond A Wang L Thompson J Williams S Wilcox R Jones A
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Abstract

Objectives

The importance of cup position on the performance of total hip replacements (THR) has been demonstrated in in vitro hip simulator tests and clinically. However, how cup position changes during gait has not been considered and may affect failure scenarios. The aim of this study was to assess dynamic cup version using gait data.

Methods

Pelvic movement data for walking for 39 unilateral THR patients was acquired (Leeds Biomedical Research Centre). Patient's elected walking speed was used to group patients into high- and low-functioning (mean speed, 1.36(SD 0.09)ms−1 and 0.85(SD 0.08)ms−1 respectively). A computational algorithm (Python3.7) was developed to calculate cup version during gait cycle. Inputs were pelvic angles and initial cup orientation (assumed to be 45° inclination and 7° version, anterior pelvic plane was parallel to radiological frontal plane). Outputs were cup version angles during a gait cycle (101 measurements/cycle). Minimum, maximum and average cup version during gait cycle were measured for each patient. Two-sample t-test (p=0.05) was used to compare groups.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_2 | Pages 31 - 31
1 Mar 2021
Hopwood J Redmond A Chapman G Richards L Collins S Brockett C
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Abstract

Objectives

Implant loosening remains a common cause of total ankle replacement (TAR) revision, and has been associated with wear-mediated osteolysis. Limited pre-clinical studies for TARs have been reported and the variety of experiment settings make it difficult to compare wear rates. Factors such as simulator control mechanism; whether pneumatic or electromechanical, may influence the integrity of the simulator outputs with respect to input profiles. This study compares the wear of a TAR, tested in electromechanical and pneumatic experimental simulators under identical input conditions.

Methods

Twelve medium BOX® (MatOrtho Ltd) TARs (n=6 for each simulator) were tested in an electromechanical and pneumatic knee simulator (Simulation Solutions, UK) for 3 million cycles (Mc). Standard ‘Leeds’ displacement-controlled inputs were used. Kinematic performance was investigated by comparing the output profiles against the maximum demanded input values. The lubricant used was 25% new-born calf serum and wear was determined gravimetrically.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_2 | Pages 64 - 64
1 Mar 2021
Esquivel L Chapman G Holt C Brockett C Williams D
Full Access

Abstract

Skeletal kinematics are traditionally measured by motion analysis methods such as optical motion capture (OMC). While easy to carry out and clinically relevant for certain applications, it is not suitable for analysing the ankle joint due to its anatomical complexity. A greater understanding of the function of healthy ankle joints could lead to an improvement in the success of ankle-replacement surgeries. Biplane video X-ray (BVX) is a technique that allows direct measurement of individual bones using highspeed, dynamic X-Rays.

Objective

To develop a protocol to quantify in-vivo foot and ankle kinematics using a bespoke High-speed Dynamic Biplane X-ray system combined with OMC.

Methods

Two healthy volunteers performed five level walks and step-down trials while simultaneous capturing BVX and synchronised OMC. participants undertook MR imaging (Magnetom 3T Prisma, Siemens) which was manually segmented into 3D bone models (Simpleware Scan IP, Synopsis). Bone position and orientation for the Talus, Tibia and Calcaneus were calculated by manual matching of 3D Bone models to X-Rays (DSX Suite, C-Motion, Inc.). OMC markers were tracked (QTM, Qualisys) and processed using Visual 3D (C-motion, Inc.).


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_9 | Pages 52 - 52
1 Oct 2020
Dalury DF Chapman DM
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Introduction

One of the main considerations in the revision TKR setting is deciding on the level of constraint to be utilized once the bone defects have been reconstructed. There is a fear that employing a maximally constrained insert could compromise long term results. We report on a consecutive series of full tibial and femoral component revisions all treated with a maximally conforming insert and followed for a minimum of 5 years.

Materials and Methods

The study group consisted of 76 consecutive revision TKR in 76 patients where both the femur and the tibia were revised. 4 patients died and 6 were lost to follow up. Final cohort had an average age of 70 years, average BMI of 31 and there were 39 males in the group. Average time to revision was 7 years (range 1–10 years) and the reasons for revision included infection in 28, aseptic loosening 26, osteolysis and poly wear in 9 and 13 other. All were treated with the same revision system and an identical maximally conforming tibial rotating platform insert and followed for an average of 7 years (range 5–14 years).


Aims

Enhanced perioperative protocols have significantly improved patient recovery following primary total knee arthroplasty (TKA). Little has been investigated the effectiveness of these protocols for revision TKA (RTKA). We report on a matched group of aseptic revision and primary TKA patients treated with an identical pain and rehabilitation programmes.

Methods

Overall, 40 aseptic full-component RTKA patients were matched (surgical date, age, sex, and body mass index (BMI)) to a group of primary cemented TKA patients. All RTKAs had new uncemented stemmed femoral and tibial components with metaphyseal sleeves. Both groups were treated with an identical postoperative pain protocol. Patients were followed for at least two years. Knee Society Scores (KSS) at six weeks and at final follow-up were recorded for both groups.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 64 - 64
1 Feb 2020
Hopwood J Redmond A Chapman G Richards L Collins S Brockett C
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Background

Total ankle arthroplasty (TAA) is an alternative to ankle arthrodesis, replacing the degenerated joint with a mechanical motion-preserving alternative. Implant loosening remains a primary cause of TAA revision, and has been associated with wear-mediated osteolysis. Differing implant designs have a major influence on the wear performance of joint replacements. Providing a range of implant sizes allows surgeons a greater intra-operative choice for varying patient anatomy and potential to minimise wear. Minimal pre-clinical testing exists in the literature that investigates the effect of implant size on the wear behaviour. The aim of this study therefore was to investigate the effect of two different implant sizes on the wear performance of a TAA.

Materials & Methods

Six ‘medium’ and six ‘extra small’ BOX® (MatOrtho Ltd, UK) TAA implants, of the same conceptual design and polyethylene insert thickness, were tested in a modified 6 station pneumatic knee simulator. 5 million cycles (Mc) of wear simulation were completed for each implant size, under kinematics aiming to replicate an ankle gait cycle (Figure 1) [1]. The simulator used had six degrees of freedom, of which four were controlled. The maximum axial load was 3150N, equivalent to 4.5 times body weight of a 70kg individual. The flexion profile ranged from −15° plantarflexion to 15° dorsiflexion. Rotation about the tibial component ranged from −2.3° of internal rotation to 8° external rotation, and anterior/posterior (AP) displacement ranged from 3.1 mm anterior to −0.9 mm posterior displacement. The lubricant used was 25% bovine serum supplemented with 0.04% sodium azide to prevent bacterial degradation. The wear of the TAA polyethylene inserts were determined gravimetrically after each Mc, with unloaded soak controls used to compensate for the uptake of moisture by the polyethylene.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_2 | Pages 51 - 51
1 Feb 2020
Chapman R Moschetti W Van Citters D
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Introduction

Total knee arthroplasty (TKA) is highly successful due to pain reduction, patient satisfaction, and increased range of motion (ROM) during activities of daily living (ADL). ROM recovery is critical for successful outcomes, however ROM values are typically captured during routine physical therapy (PT) appointments via simplified measures (e.g. goniometric maximum passive ROM). These measures are imprecise, potentially neglecting patients’ home experiences. Accordingly, improved measurement methods are necessary to realistically represent ROM recovery. A validated inertial measurement unit (IMU) method continuously capturing knee ROM was deployed assessing knee ROM recovery during PT appointments and during patients’ routine daily experiences. Our objectives were to 1) continuously capture knee ROM pre-/post-TKA via IMUs and 2) divide each day's data to PT/non-PT segments comparing ‘gold standard’ ROM measurements (PT periods) with non-invasive home measurements (non-PT periods). Given patients are verbally/physically encouraged during PT, we hypothesized PT and non-PT metrics would be significantly different including 1) greater kinematics, 2) shorter times, and 3) greater activity level during PT compared to non-PT.

Methods

Following IRB approval, IMUs captured long duration, continuous (8–12 hours/day, ∼50 days) knee ROM pre-/post-TKA. Post-TKA metrics were subdivided to PT/non-PT time periods including maximum ROM, gait phase ROMs (stance/swing), gait times (stride/stance/swing), and activity level. Clinical ROM and patient reported outcome measures (PROMs) were also captured before/after TKA. Statistical comparisons were completed between pre-TKA, post-TKA PT, and post-TKA non-PT metrics. Correlation analyses were completed between IMU, clinical ROM, and PROMs.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_2 | Pages 49 - 49
1 Feb 2020
Chapman R Moschetti W Van Citters D
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Introduction

With many stakeholders, healthcare decisions are complex. However, patient interests should be prioritized. This maximizes healthcare value (quality divided by cost), simultaneously minimizing costs (objective) and maximizing quality (subjective). Unfortunately, even ‘high value’ procedures like total knee arthroplasty (TKA) suffer from recovery assessment subjectivity (i.e. high assessment variability) and increasing costs. High TKA costs and utilization yield high annual expenditures (∼$22B), including postoperative physical therapy (PT) accounting for ∼10% of total costs (∼$2.3B annually). Post-TKA PT is typically homogenous across subjects ensuring most recover, however recent work shows outcomes unimpacted by PT. Accordingly, opportunities exist improving healthcare value by simultaneously reducing unnecessary PT expenditures and improving outcomes. However, discerning recovery completion relies on discrete ROM measures captured clinically and subjective clinician experience (i.e. intuition about recovery). Accordingly, our goal was developing objective post-TKA performance assessment methods utilizing gait knee ROM and statistical analyses to categorize patient recovery (‘accelerated,’ ‘delayed,’ or ‘normal’).

Methods

We first established statistical reasons for current post-TKA rehabilitation including risk-reward tradeoffs between incorrectly ascribing ‘poor recovery’ to well-recovering patients (T1 error) or ‘good recovery’ to poorly-recovering patients (T2 error) using methods described by Mudge et al. and known TKA volumes/rehabilitation costs. Next, previously captured gait ROM data from well-healed patients was utilized establishing standard recovery curves. These were then utilized to assess newly captured patient recovery. Following IRB approval, we prospectively captured gait ROM from 10 TKA patients (3M, 69±13 years) 1-week pre-TKA and 6-weeks immediately post-TKA. Performance was compared to recovery curves via control charts/Shewhart rules (daily performance) as well as standard deviation thresholds (weekly performance) establishing recovery as ‘accelerated,’ ‘delayed,’ or ‘normal.’ The categorization was extrapolated to US TKA population and savings/expenses quantified. Statistical analyses were performed in Minitab with statistical significance set to α<0.05.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_11 | Pages 26 - 26
1 Oct 2019
Dalury DF Chapman DM Miller MJ
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Introduction

Enhanced pain and rehabilitation protocols have significantly improved patient recovery following primary TKR. Little has been written on how the protocols have affected the revision TKR patient. We report on a matched group of revision and primary TKR patients treated with the identical pain and rehab program.

Materials and Methods

40 aseptic RTKR patients who underwent a full femoral and tibial revision were matched by age, sex, and BMI to a group of patients who underwent a cemented tri-compartmental primary TKR. All revision knees had uncemented stemmed femurs and tibias. All 40 patients had either a metaphyseal sleeve on either the femur or tibia or both. Patients in both groups were treated with an identical post op pain protocol (Spinal anesthetic, local infiltrative analgesia and multimodal oral pain management along with rapid rehabilitation). All patients were mobilized on POD1 and allowed weight bearing as tolerated. Patients were followed for a minimum of 1 year. KSS at 6 weeks and 1 year were recorded for both groups.


The Bone & Joint Journal
Vol. 101-B, Issue 7_Supple_C | Pages 104 - 107
1 Jul 2019
Greenwell PH Shield WP Chapman DM Dalury DF

Aims

The aim of this study was to establish the results of isolated exchange of the tibial polyethylene insert in revision total knee arthroplasty (RTKA) in patients with well-fixed femoral or tibial components. We report on a series of RTKAs where only the polyethylene was replaced, and the patients were followed for a mean of 13.2 years (10.0 to 19.1).

Patients and Methods

Our study group consisted of 64 non-infected, grossly stable TKA patients revised over an eight-year period (1998 to 2006). The mean age of the patients at time of revision was 72.2 years (48 to 88). There were 36 females (56%) and 28 males (44%) in the cohort. All patients had received the same cemented, cruciate-retaining patella resurfaced primary TKA. All subsequently underwent an isolated polyethylene insert exchange. The mean time from the primary TKA to RTKA was 9.1 years (2.2 to 16.1).


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_5 | Pages 75 - 75
1 Apr 2019
Lunn D Chapman G Redmond A
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Introduction

Total hip replacement (THR) patients are often considered a homogenous group whereas in reality, patients are heterogeneous. Variation in revision rates between patient groups suggest that implants are exposed to different environmental conditions in different patients [1]. Previous reports suggest that for every unit increase of BMI, there is a 2% increased risk of revision of a THR [2]. The aim of this study was to better understand the effect of patient-specific characteristics such as BMI on hip motions and to explore the possible impact on wear.

Methods

137 THR patients, at least 12 months post-surgery, underwent 3D kinematic (Vicon, Oxford, UK) and kinetic (AMTI, USA) analysis whilst walking at self-selected walking speed. 3D kinematic data were then mapped onto a modelled femoral cup at 20 pre-determined points to create pathways for femoral head contact, which were then quantified by deriving the aspect ratio (AR). Patients were stratified into three groups determined by BMI scores; healthy weight (BMI ≤25 kg/m2) (n=34); overweight (BMI >25kg/m2 to ≤ 30 kg/m2) (n=66) and obese patients (BMI > 30 kg/m2) (n=37). Comparisons were made using 95% confidence intervals (CI) and one way ANOVAs.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_5 | Pages 76 - 76
1 Apr 2019
Vasiljeva K Al-Hajjar M Lunn D Chapman G Redmond A Flatters I Thompson J Jones A
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Introduction

One of the known mechanisms which could contribute to the failure of total hip replacements (THR) is edge contact. Failures associated with edge contact include rim damage and lysis due to altered loading and torques. Recent study on four THR patients showed that the inclusion of pelvic motions in a contact model increased the risk of edge contact in some patients. The aim of current study was to determine whether pelvic motions have the same effect on contact location for a larger patient cohort and determine the contribution of each of the pelvic rotations to this effect.

Methods

Gait data was acquired from five male and five female unilateral THR patients using a ten camera Vicon system (Oxford Metrics, UK) interfaced with twin force plates (AMTI) and using a CAST marker set. All patients had good surgical outcomes, confirmed by patient-reported outcomes and were considered well-functioning, based on elective walking speed. Joint contact forces and pelvic motions were obtained from the AnyBody modelling system (AnyBody Technologies, DK). Only gait cycle regions with available force plate data were considered. A finite element model of a 32mm head on a featureless hemispherical polyethylene cup, 0.5mm radial clearance, was used to obtain the contact area from the contact force. A bespoke computational tool was used to analyse patients' gait profiles with and without pelvic motions. The risk of edge contact was measured as a “centre proximity angle” between the cup pole and centre of the contact area, and “edge proximity angle” between the cup pole and the furthest contact area point away from the pole. Pelvic tilt, drop and internal-external rotation were considered one at a time and in combinations.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_2 | Pages 15 - 15
1 Jan 2019
Rochelle D Herbert A Ktistakis I Redmond AC Chapman G Brockett CL
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Whilst lateral ankle sprain is often considered a benign injury it represents between 3–5% of all A&E visits in the UK. The mechanical characteristics of ankle ligaments under sprain-like conditions are scarcely reported.

The lateral collateral ankle ligaments were dissected from n=6 human cadaveric specimens to produce individual bone-ligament-bone specimens. An Instron Electropuls E10000 was used to uni-axially load the ankle ligaments in tension. The ligaments were first preconditioned between 2 N and a load value corresponding to 3.5% strain for 15 cycles and then strained to failure at a rate of 100%/s.

The mean ultimate failure loads and their standard deviations for the anterior talofibular (ATFL), calcaneofibular (CFL) and posterior talofibular (PTFL) ligaments are 351.4±105.6 N, 367.8±76.1 N and 263.6±156.6 N, respectively. Whilst the standard deviation values are high they align with those previously reported for ankle ligament characterisation. The large standard deviations are partly due to the inherent variability of human cadaveric tissue but could also be due to varying previous activity levels of participants or a prior unreported ankle sprain. Although the sample size is relatively small the results were stratified to identify any potential correlations of age, BMI and weight with ultimate load. A strong Pearson correlation (r=0.919) was found between BMI and ultimate load of the CFL but a larger sample size is required to confirm a link. The ligament failure modes were observed and categorised as avulsion or intra-ligamentous failure. The ATFL avulsed from the fibula in five instances and intra-ligamentous failure occurred once. The CFL avulsed from the fibula twice and failed four times through intra-ligamentous failure. Finally, the PTFL avulsed from the fibula once, avulsed from the talus once and failed through intra-ligamentous failure in four instances.

The results identify the forces required to severely sprain the lateral collateral ankle ligaments and their failure modes.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_2 | Pages 33 - 33
1 Jan 2019
Hopwood J Chapman G Redmond A Richards L Brockett C
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Total ankle replacement (TAR) is a substitute to ankle fusion, replacing the degenerated joint with a mechanical motion-conserving alternative. Compared with hip and knee replacements, TARs remain to be implanted in much smaller numbers, due to the surgical complexity and low mid-to-long term survival rates. TAR manufacturers have recently explored the use of varying implant sizes to improve TAR performance. This would allow surgeons a wider scope for implanting devices for varying patient demographics. Minimal pre-clinical testing has been demonstrated to date, while existing wear simulation standards lack definition. Clinical failure of TARs and limited research into wear testing defined a need for further investigation into the wear performance of TARs to understand the effects of the kinematics on varying implant sizes.

Six medium and six extra small BOX® (MatOrtho) TARs will be tested in a modified knee simulator for 5 million cycles (Mc). The combinations of simulator inputs that mimic natural gait conditions were extracted from ankle kinematic profiles defined in previous literature. The peak axial load will be 3.15 kN, which is equivalent to 4.5 times body weight of a 70kg individual. The flexion profile ranges from 15° plantarflexion to 15° dorsiflexion. Rotation about the tibial component will range from −2.3° of internal rotation to 8° external rotation, while the anterior/posterior displacement will be 7mm anterior to −2mm posterior throughout the gait cycle. The components will be rotated through the simulation stations every Mc to account for inter-station variability. Gravimetric measurements of polyethylene wear will be taken at every Mc stage. A contact profilometer will also be used to measure average surface roughness of each articulating surface pre-and-post simulation.

The development of such methods will be crucial in the ongoing improvement of TARs, and in enhancing clinical functionality, through understanding the envelope of TAR performance.


The Bone & Joint Journal
Vol. 100-B, Issue 12 | Pages 1609 - 1617
1 Dec 2018
Malhas AM Granville-Chapman J Robinson PM Brookes-Fazakerley S Walton M Monga P Bale S Trail I

Aims

We present our experience of using a metal-backed prosthesis and autologous bone graft to treat gross glenoid bone deficiency.

Patients and Methods

A prospective cohort study of the first 45 shoulder arthroplasties using the SMR Axioma Trabecular Titanium (TT) metal-backed glenoid with autologous bone graft. Between May 2013 and December 2014, 45 shoulder arthroplasties were carried out in 44 patients with a mean age of 64 years (35 to 89). The indications were 23 complex primary arthroplasties, 12 to revise a hemiarthroplasty or resurfacing, five for aseptic loosening of the glenoid, and five for infection.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_12 | Pages 58 - 58
1 Oct 2018
Dalury D Chapman DM
Full Access

Introduction

The causes of revision total knee replacement are varied. There is a subset of these revision cases (poly wear and some cases of instability for example) where the ability to retain the metal femoral and tibial components and replacing just the polyethylene is an appealing option. We report on a series of RTKR where only the poly insert was replaced and the patients were followed for a minimum of ten years.

Materials and Methods

Our study group consisted of 64 consecutive non infected RTKR patients who underwent a revision of the polyethylene alone between 1998 and 2006. All patients had been treated originally with the same cemented, CR, patella resurfaced primary TKR. Reasons for revision were 51 poly wear and/or osteolysis, 7 instability, and 6 other. The average time from the primary to the revision surgery was 9.1 years (range 2.2 to 16.1 years). All patients had an isolated poly liner change. No femurs or tibial trays were revised. Average age of the cohort at revision was 72.2 (range 48 to 88). Average BMI was 31.9 (range 23.6 to 43.9). There were 36 female patients. Of the group, 42 were ASA 1 or 2 and 22 were ASA 3. Pre-op alignment averaged 6.0 (range 2 varus to 8 valgus). Patients were followed for a minimum of 10 years (range 10 to 19 years).


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 22 - 22
1 Jun 2017
Tadross D Lunn D Redmond A Macdonald D Stone M Chapman G
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In the UK, the posterior approach (PA) and direct lateral approach (DLA) are the most common total hip arthroplasty (THA) procedures. Few studies however, have compared the subsequent functional outcomes. This exploratory study aimed to examine the effect of PA and DLA approaches on post-operative hip kinematics, strength and hip muscle cross-sectional area (CSA), compared to healthy controls.

Participants comprised of 15 cases in the DLA group, > 12 month post-operatively, (ten male, age 68.9+/-5.5 years, BMI 26.9+/-3.0), 13 cases in the PA group (six male; age 72.9+/-6.9 years, BMI 27.1+/-3.6) and 11 age/BMI-matched healthy control participants. All participants underwent 3D kinematic (Vicon, Oxford, UK) and kinetic (AMTI, USA) analysis whist performing self-selected and fast walking as well as sit-to-stand and stand-to-sit. Isometric dynamometry was performed (Biodex Medical systems, USA) for all major muscle groups around the operated hip, and a subset of five participants (three DLA v two PA) underwent “slice encoding for metal artefact correction” (SEMAC) MRI imaging to measure muscle CSA. Patient-reported outcome measures were collected.

Both post-operative surgical groups exhibited altered gait, particularly in limited hip extension, compared to the control participants. The DLA group demonstrated forced hip extension matching controls only under fast walking conditions while the PA group did not achieve hip extension. Both surgical approaches achieved high PROMs scores.

The PA group were weaker for all strength activities tested, whereas the DLA cases demonstrated similar hip strength to controls. SEMAC imaging revealed reduced CSA for those muscles dissected during surgery, compared to the contralateral side.

This exploratory study demonstrated small but measurable differences between surgical approaches for muscle CSA, hip strength of major hip muscle groups and a number of gait variables, although both approaches produce satisfactory functional outcomes for patients after surgery.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_3 | Pages 64 - 64
1 Feb 2017
Chapman R Kokko M Goodchild G Roche M Van Citters D
Full Access

Introduction

For nearly 58% of total knee arthroplasty (TKA) revisions, the reason for revision is exacerbated by component malalignment. Proper TKA component alignment is critical to functional outcomes/device longevity. Several methods exist for orthopedic surgeons to validate their cuts, however, each has its limitations. This study developed/validated an accurate, low-cost, easy to implement first-principles method for calculating 2D (sagittal/frontal plane) tibial tray orientation using a triaxial gyroscope rigidly affixed to the tibial plateau of a simulated leg jig and validated 2D tibial tray orientation in a human cadaveric model.

Methods

An initial simulation assessed error in the sagittal/frontal planes associated with all geometric assumptions over a range of positions (±10°, ±10°, and −3°/0°/+3° in the sagittal, frontal, and transverse planes, respectively). Benchtop experiments (total positions - TP, clinically relevant repeated measures - RM, novice user - NU) were completed using a triaxial gyroscope rigidly affixed to and aligned with the tibial tray of the fully adjustable leg-simulation jig. Finally, two human cadaveric experiments were completed. A similar triaxial gyroscope was mounted to the tibial tray of a fresh frozen human cadaver to validate sagittal and frontal plane tibial tray orientation. In cadaveric experiment one, three unique frontal plane shims were utilized to measure changes in frontal plane angle. In cadaveric experiment two, measurements using the proprosed gyroscopic method were compared with computer navigation at a series of positions. For all experiments, one rotation of the leg was completed and gyroscopic data was processed through a custom analysis algorithm.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_3 | Pages 63 - 63
1 Feb 2017
Chapman R Van Citters D Dalury D
Full Access

Introduction

Subluxation and dislocation are frequently cited reasons for THA revision. For patients who cannot accommodate a larger femoral head, an offset liner may enhance stability. However, this change in biomechanics may impact the mechanical performance of the bearing surface. To our knowledge, no studies have compared wear rates of offset and neutral liners. Herein we radiographically compare the in-vivo wear performance of 0mm and 4mm offset acetabular liners.

Methods

Two cohorts of 40 individuals (0mm, 4mm offset highly crosslinked acetabular liners, respectively) were selected from a single surgeon's consecutive caseload. All patients received the same THA system via the posterior approach. AP radiographs were taken at 6-week (‘pre’) and 5-year (‘post’) postoperative appointments. Patients with poor radiograph quality were excluded (n0mm=5, n4mm=4). Linear and volumetric wear were quantified according to Patent US5610966A. Briefly, images were processed in computer aided design (CAD) software. Differences in vector length between the center of the femoral head and the acetabular cup (pre- and post-vector, Figure 1) allow for calculation of linear wear and wear rate. The angle (β) between the linear wear vector and the cup inclination line was quantified (Figure 1). Patients with negative β were excluded from volumetric analyses (n0mm=11, n4mm=7). Volumetric wear was accordingly calculated accounting for wear vector direction. The results from three randomly selected patients were compared to results achieved using the “Hip Analysis Suite” software package (UChicagoTech).


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 21 - 21
1 Nov 2015
Barbur S Gallespie-Gallery H Chapman P Griffiths H Conn K Britton J Briant-Evans T
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Introduction

The prevalence of adverse reactions to metal debris (ARMD) associated with metal on metal (MoM) hip arthroplasty has been reported to be as high as 69%. Such findings promoted the development of metal-artefact reducing sequence (MARS)-magnetic resonance imaging (MRI) classifications, with the aim of stratifying soft lesions by severity of disease. The Modified Oxford Classification is a straightforward system that has been shown to correlate with disease progression.

Methods

The aim of this study was to test the reliability of this classification between observers. Seven observers were recruited, all with a musculoskeletal background. Using the PACS image analysis system, 20 MARS-MRI scans were provided for interpretation. Observers reviewed these scans in random order at two separate intervals over the course of five weeks. They classified them according to the Modified Oxford Classification as: ‘normal’, ‘trochanteric fluid, ‘effusion’, ‘ARMD type 1’, ‘ARMD type 2’ and ‘ARMD type 3’.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_11 | Pages 21 - 21
1 Oct 2015
Gumbs J Chapman N Young D Clegg P Canty-Laird E
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Introduction

Tendons are critical to mobility, and are susceptible to degeneration through injury and ageing. Type I collagen is the most abundant protein in vertebrates; it is the main structural protein of the extracellular matrix in numerous musculoskeletal tissues, including tendons. Type I collagen predominantly is a heterotrimer, which consists of two alpha-1 chains and one alpha-2 chain (α1)2(α2) encoded by the COL1A1 and COL1A2 genes, respectively. However, type I collagen can form homotrimers (α1)3 which are protease-resistant, and are associated with age-related musculoskeletal diseases, fibrotic and connective tissue pathologies. Transforming growth factor beta (TGFβ) enhances collagen (I) gene expression, is involved in tendon mechanobiology and repair processes, while its effect on homotrimer formation is unknown. Our aim is to investigate the relative expressions of collagen (I) α1 and α2 polypeptide chains in tenocytes (tendon fibroblasts) stimulated with TGFβ.

Materials and Methods

Included RT-qPCR to measure the relative expression of COL1A1 and COL1A2 genes. [14C]-proline metabolic labelling was used to measure the expression of the collagen (I) α1 and α2 polypeptide chains. These techniques were performed in equine superficial digital flexor tendon (SDFT) tenocytes (n=3) and murine tail tendon tenocytes (n=3) with different concentrations of TGFβ (0.01 ng/ml-100 ng/ml).


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_7 | Pages 22 - 22
1 May 2015
Mathews J Ward J Chapman T Khan U Kelly M
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Grade III Open fractures of the tibia represent a serious injury. It is recognised that combined management of these cases by experienced orthopaedic and plastic surgeons improves outcomes. Previous studies have not considered the timing of definitive soft tissue cover in relation to the definitive orthopaedic management. We reviewed medical notes of 73 patients with 74 Grade III Open tibia fractures (minimum 1 year follow up), to compare deep infection rates in patients who had a) a single-stage definitive fixation and soft tissue coverage vs. those who had separate operations, and b) those who had definitive treatment completed in < 72 hours vs. > 72 hours.

Of subjects that underwent definitive fixation and coverage in a single procedure, 4.2% developed deep infections, compared with 34.6 % deep infection(p<0.001) in those who underwent definitive treatment at separate operations. Of patients who had definitive treatment completed in < 72-hours, 20.0% developed deep infections a compared with 12.2%(p=0.4919) in the >72-hour group.

Patients with Gustilo III open tibial fractures have lower rates of deep infection if definitive fixation and coverage are performed in a single-stage procedure. Emphasis should be placed on timely transfer to a specialist centre, aiming for a single-stage combined orthoplastic surgery.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 180 - 180
1 Jul 2014
Sultan J Chapman G Jones R
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Summary

This study shows a significant reduction in knee adduction moment in patients with medial compartment osteoarthritis, in both the symptomatic and asymptomatic knees. Long-term follow-up studies are required to confirm the effect of treating the asymptomatic side on disease progression.

Background

The knee is the commonest joint to be affected by osteoarthritis, with the medial compartment commonly affected. Knee osteoarthritis is commonly bilateral, yet symptoms may initially present unilaterally. Higher knee adduction moment has been associated with the development and progression of medial compartment knee osteoarthritis. The aim of this study was to assess the effect of lateral wedge insoles on the asymptomatic knee of patients with unilateral symptoms of medial compartment knee osteoarthritis.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_9 | Pages 3 - 3
1 May 2014
Wood R Granville-Chapman J Clasper J
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Surgical planning is the first step in operative fracture management. Complex situations are often faced which pose difficulties on both technical and logistic fronts. Surgical planning is the first step in operative fracture management. The degree of planning that is required is therefore determined by a number of factors including: the nature of the injury mechanism and its concomitant physiological insult, complexity of the fracture and region, expertise of the surgical team and equipment limitations. This paper explores a novel planning process in orthopaedic trauma surgery based upon British Military Doctrine. The seven questions of surgical planning represent a novel method that draws inspiration from the combat estimate process. It benefits from a global approach that encompasses logistic as well as surgical constraints. This, in turn, allows the surgical team to form an understanding of the nature of the fracture in order to develop, document and deliver a surgical plan. This has benefits for the operating surgeon, operating room practitioners and trainees alike and ultimately can result in improved patient care.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_5 | Pages 5 - 5
1 Mar 2014
Hassaballa M Artz N Mihok P Chapman L Robinson J Porteous A Murray J
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This is a prospective review of consecutive patients who underwent knee revision surgery using the Legion knee system.

Clinical and functional assessments (American Knee Scores-AKS, WOMAC and Oxford knee score-OKS) were carried out preoperatively, one year and 2 years post op. Radiographic evaluation was done at 1 and 2 years included review of standing AP, lateral and skyline views. Figgie's method was used to measure the joint line reproduction.

210 patients underwent revision knee system 103 male: 107 females with a mean age of 66.4 (44–87) yrs. Mean BMI-26.03 (21–50). We had a 2-year follow up for 110 patients. Surgery was carried out at a single centre and performed by Bristol knee specialists.

Indications for surgery were aseptic loosening (84), infection (27) instability (47), pain and stiffness (31), progression of disease (6), peri-prosthetic fractures (15)

The AKS and WOMAC scores at, 1 year and 2 years follow up showed significant improvements in pain and function. The mean total AKS improved from 75.7/200 pre-operatively to 140.5/200 at 2 yrs. Radiographic assessment showed a mean AP coronal femoral angle of 95.3 degrees (89.6–99.9), coronal tibial angle of 90.1 degrees (88–92). The mean sagittal femoral and tibial angles were 88.4 and 90.4 degrees respectively.

The short-term results showed significant improvement in functional and pain scores irrespective of indications for revision surgery. The Legion system has showed good outcome scores that match or beat published series on revisions. It also showed a good ability to restore joint line.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_2 | Pages 21 - 21
1 Jan 2014
Ribee H Bhalla A Patel A Johnson B Leah J Bailey A Chapman C Bing A Hill S Laing P Makwana N Thomason K Marquis C
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Introduction:

Plantar Fasciitis is an extremely common and challenging problem that presents itself to foot and ankle practitioners. Many different treatment modalities are available for this condition, with little proven benefit. ECSWT was approved for use by the FDA for the treatment of chronic proximal plantar fasciitis in 2002 and NICE published guidance in 2009 recommending its use in refractory cases.

Methods:

Patients who diagnosed with ultrasound scan, and for whom other treatments were unsuccessful, underwent treatment on an outpatient basis. They had three 4–5 minute sessions, once a week. A Spectrum machine was used delivering 10 Hz waves in 500 preset pulses at 2 bar pressure, followed by 2000 preset pulses at 2.5 bar pressure. Pre- and 3 month post-treatment pain levels were recorded using a 10 point Visual Analogue Scale.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_2 | Pages 19 - 19
1 Jan 2014
Kelsall N Chapman A Sangar A Farrar M Taylor H
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Introduction:

The dorsal closing wedge calcaneal osteotomy has been described for the treatment of insertional pathology of the tendo-achilles. The aim of this study was to evaluate the efficacy of the technique using outcome measures.

Method:

This was a prospective case series. Patients were included if they had tendo-achilles insertional pathology (calcific tendonitis, bursitis or Haglund's deformity). A short extended lateral approach was used and a 1 cm dorsally based closing wedge osteotomy of the calcaneus performed. Fixation was with 2 staples. Patients were scored pre-operatively and at 6 and 12 months post-operatively using the VISA-A and AOFAS ankle-hindfoot scores. Results were analysed with the paired student t-test.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_8 | Pages 6 - 6
1 Feb 2013
Granville-Chapman J Nawaz S Trompeter A Newman K Elliott D
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Intramedullary nailing of tibial fractures is commonplace and freehand techniques are increasingly popular. The standard freehand method has the knee of the injured leg flexed over a radio-lucent bolster. This requires the imaging C-arm to swing from antero-posterior to lateral position several times. Furthermore, guide wire placement; reaming and nail insertion are all performed well above most surgeons' shoulder height. If instead the leg is hung over the edge of the table, the assistant must crouch and hold the leg until the nail is passed beyond the fracture.

We describe a method of nailing which is easier both for the surgeons and the (often inexperienced) radiographer and present a series of 87 consecutive cases managed with this technique.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 65 - 65
1 Jan 2013
Sultan J Chapman G Jones R
Full Access

Background

The knee is the commonest joint to be affected by osteoarthritis, with the medial compartment commonly affected. Knee osteoarthritis is commonly bilateral, yet symptoms may initially present unilaterally. Higher knee adduction moment has been associated with the development and progression of medial compartment knee osteoarthritis.

Objectives

To assess the effect of lateral wedge insoles on the asymptomatic knee of patients with unilateral symptoms of medial compartment knee osteoarthritis.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXII | Pages 31 - 31
1 Jul 2012
Wood A Hales R Bakker-Dyos J Chapman M Keenan A
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Previous Anterior Cruciate Ligament (ACL) reconstruction is currently a bar from entry to the Royal Marines and Royal Navy, whilst the British Army allows recruits to join if asymptomatic 18 months post ACL reconstruction. However current Royal Marines policy is to rehabilitate recruits who sustain an ACL disruption in training. We retrospectively analysed the rehabilitation times and pass out rate of Royal Marines who had an ACL disruption during recruit training over an 8 year period.

12 recruits sustained an ACL disruption during recruit training in the study period, giving an incidence of around 1.5/1000 recruits. 9 Patients underwent ACL repairs in training, with 1 patient leaving and rejoining post repair and later successfully passed out. 2 patients were treated conservatively. Of the 12 ACL sustained in training 8/12 (67%) passed out. None of the patients treated conservatively passed out. The mean time out of training for successful recruits was 51.6 weeks (95% CI 13.1) mean rehabilitation time post ACL reconstruction for successful recruits was 36.7 weeks (95% CI 12.5). Mean time to discharge for unsuccessful recruits 63.2 weeks (95% CI 42.4). In the operative group 1/10 left due to failure to return to training and 1/10 left through unrelated reasons. Current costing for recruit training is £1800 per week per recruit.

ACL injuries are not common in Royal Marine Training, and reconstruction is not a bar to completing Royal Marine basic training. We estimate that it costs around £100,000 per-injured recruit, to maintain a policy of rehabilitating ACL injured recruits in Royal Marines training. Further research into the long-term employability or Royal Marines sustaining an ACL injury in training is required.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXII | Pages 16 - 16
1 Jul 2012
Granville-Chapman J Hacker A Keightley A Sarkhel T Monk J Gupta R
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Extensor tendon ruptures have been reported in up to 8.8% of patients after volar plating and long screws have been implicated. The dihedral dorsal surface of the distal radius hinders accurate screw length determination using standard radiographic views (lateral; pronation and supination). A ‘dorsal tangential’ view has recently been described, but has not been validated.

To validate this view, we mounted a plate-instrumented sawbone onto a jig. Radiographs at different angles were reviewed independently by 11 individuals. Skyline views clearly demonstrated all screw tips, whereas only 69% of screw tips were identifiable on standard views.

With screws 2mm proud of the dorsal surface, skyline views detected 67% of long screws (sensitivity). The best of the standard views achieved only 11% sensitivity. At 4mm long, skyline sensitivity was 85%, compared with 25% for standard views. At 6mm long, 100% of long screws were detected on skylines, but only 50% of 8mm long screws were detected by standard views. Inter and intra-observer variability was 0.97 (p=0.005).

For dorsal screw length determination of the distal radius, the skyline view is superior to standard views. It is simple to perform and its introduction should reduce the incidence of volar plate-related extensor tendon rupture.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVI | Pages 55 - 55
1 Jun 2012
Sharma H Breakwell L Chiverton N Michael A Townsend R Highland A Chapman A Cole A
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Introduction

Spinal infections constitute a spectrum of disease comprising pyogenic, tuberculous, nonpyogenic-nontuberculous and postoperative spinal infections. The aim of this study was to review the epidemiology, diagnostic yield of first and second biopsy procedures and microbiology trends from Sheffield Spinal Infection Database along with analysing prognostic predictors in spinal infections.

Materials and Methods

Sheffield Spinal Infection Database collects data prospectively from regularly held Spinal infection MDTs. We accrued 125 spinal infections between September 2008 and October 2010. The medical records, blood results, radiology and bacteriology results of all patients identified were reviewed. In patients with negative first biopsy, second biopsy is contemplated and parenteral broad spectrum antibiotic treatment initiated.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIII | Pages 223 - 223
1 May 2012
Petterwood J Fettke G Chapman N
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All children with a fracture of both bones of the forearm who underwent general anaesthetic manipulation and plaster (GAMP) at the Launceston General Hospital over a four-year period from 2005–2008 were reviewed. Casting technique was determined according to the treating surgeon, with three casting techniques used: flexion, extension and a mid-flexed position.

The primary end-point was defined as re-manipulation or progression to open reduction and internal fixation. The secondary end-point of residual angulation was also assessed.

A total of 123 patients with 124 fractures were treated with GAMP. Seventy-seven cases were treated in a traditional flexion cast, 28 in extension and 19 were treated in a dorsoradial slab in a mid-flexed position. Ten patients required repeat intervention. Six failures were initially cast in flexion, four were in the mid flexed position and none of the fractures in the extension group required re-manipulation. The difference between the groups was statistically significant (p<0.001).

There was significantly greater residual angulation at follow up in the flexed group compared to the extension group for both the radius (p=0.049) and the ulna (p=0.046)

Closed reduction and cast immobilisation with the elbow extended is a safe and more effective technique in maintaining position in both bone forearm fractures in children.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XVIII | Pages 7 - 7
1 May 2012
Shu K Kendall D Chapman V Barrett D Jeffcoate W Bennett A Scammell B
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Introduction

Both the RANK/RANKL system and the endocannabinoid system have roles in bone remodelling. Activation of CB1 receptors on sympathetic nerve terminals in trabecular bone modulates bone remodelling by attenuating adrenergic inhibition over bone formation. CB2 receptors are involved in the local control of bone cell differentiation and function. Osteoblastic CB2 receptor activation negatively regulates RANKL mRNA expression indicating an interaction between the two systems and that efficient bone remodelling requires a balance between these two systems. The aim of the study was to establish the presence of the different components of the endocannabinoid system and the RANK/RANKL signalling pathway in human bone and osteoclast culture.

Methods

Levels of endocannabinoids (AEA, 2-AG) and their related compounds (OEA, PEA) in human trabecular bone, obtained from patients undergoing elective orthopaedic surgery, were measured using Liquid Chromatography Mass Spectrometry (LC-MS-MS). mRNA for the endocannabinoid synthetic and catabolic enzymes (NAPE-PLD, DAGLa, FAAH, MAGL), cannabinoid-activated receptors (CB1, CB2, PPARs, TRPV1), and RANK, RANKL and NFkB were determined using Taqman Real-Time PCR. Osteoclasts were differentiated from U-937 cells (Human leukaemic monocyte lymphoma cell line), following the sequential treatment using TPA (0.1μg/ml) followed by either TNF-a (3ng/ml) or calcitriol (10−8M), cultured for up to 30 days. Osteoclasts were identified by positive staining with tartrate resistant acid phosphatase (TRAP), multinucleation and the ability to form resorption pits on calcium phosphate coated discs. Taqman Real-Time PCR was performed to detect the expression of the osteoc!

last marker genes TRAP and cathepsin K, together with genes of the endocannabinoid and RANK/RANKL signalling pathways.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 63 - 63
1 Mar 2012
Fetherston CR Chapman-Sheath P Tice JW
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This study looks at the use of rotating hinge Total Knee Replacement (TKR) as a treatment option when dealing with fractures involving the knee.

The treatment of complex intra-articular fractures involving the knee has always proved challenging. Studies have investigated the outcome of various forms of treatment for such injuries, including internal fixation and primary knee arthroplasty. Recent advances in technology have brought about more sophisticated implants for both internal fixation and arthroplasty, including rotating hinge TKR.

The initial non-rotating hinged prostheses for total knee arthroplasty did not enjoy a good reputation. The cumulative survival rate has been quoted as 65% at 6 years, significantly lower than that of conventional prostheses. Therefore the use of such implants was restricted to complex primary or revision arthroplasty, and tumour surgery. Studies have been published advocating the use of hinged prostheses for distal femoral fractures in elderly patients. The average age in the most recent study was 82, of whom 42% had died within the first post-operative year.

This study is a case series of 16 patients with fractures who were treated with rotating hinge TKR. The age range is 36 to 92, with a mean of 69, lower than that of earlier studies. Outcome data as measured by the Oxford knee scoring system has been retrospectively collected. At follow up the range of Oxford knee scores was 14 to 52, with a mean of 36. We discuss the indications, experiences and outcomes in the management of these patients, and conclude that this is a valid treatment option in certain circumstances.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 301 - 301
1 Jul 2011
Johnston P Getgood A McKee A Larson D Chapman P Chojnowski A
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Long-term follow up after replacement arthroplasty has become established as a “Gold Standard”, providing information that can aid optimisation in future prosthetic design and use. In less mainstream joint replacements however, the evidence for use of prostheses, and in particular long-term outcome, is scarce.

A cohort of 71 patients (93 implants) was reviewed in 1997 having had a De la Caffinière prosthesis implanted between 1980 and 1989. The conclusions of the study included the findings that the replacement was generally well regarded by recipients, pain was improved and survivorship was comparable with data from the best hip replacements.

Ethical permission was obtained to review the same cohort ten years on (16 – 26 years post-op). Similar outcome measures were employed as in the original study but in addition formal grip strength measurements were taken, along with newer outcome scores including the DASH (Disability of arm, shoulder and hand) and EQ-5D (a European quality of life measure). Radiographs allowed assessment of radiological failure using the criteria from the original study.

We found a significant mortality rate in the interim period since the original review (27 patients, 36 implants). A further 8 implants in 8 patients had been removed and were not clinically reviewed as per patients’ wishes. However, 39 implants in 26 patients were available for follow up at a mean 19 years (SD 6.3) leaving a “lost to follow up” rate of 10 patients (10 implants). Survivorship at 26 years was 73.9% (95% CI 61.2, 86.6) with the end-point as revision. Our data also demonstrated continued patient satisfaction without pain, satisfactory power and thumb mobility.

Such information may be used to counsel future patients requiring surgery that there is a functional alternative to excision arthroplasty (trapeziectomy).


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 55 - 55
1 Jan 2011
Fetherston C Tice J Chapman-Sheath P
Full Access

The treatment of complex intra-articular fractures involving the knee has always proved challenging. The goals are to achieve satisfactory reduction, bony union and good functional outcome. Studies have investigated the outcome of various forms of treatment, including internal fixation and primary knee arthroplasty. In recent years there have been advances in technology bringing about more sophisticated implants such as pre-contoured peri-articular locking plates. Similar advances have been made in the production of constrained knee arthroplasty prostheses with the introduction of the Rotating Hinge Knee (RHK).

The initial non-rotating hinged prostheses for total knee arthroplasty did not enjoy a good reputation. The cumulative survival rate has been quoted as 65% at 6 years, significantly lower than that of conventional stabilised prostheses. Therefore the use of such implants was restricted to complex primary or revision arthroplasty, and tumour surgery. Studies have been published advocating the use of hinged prostheses for distal femoral fractures in elderly patients. The average age in the most recent study was 82, of whom 42% had died within the first post-operative year.

This study is a case series of 16 patients with fractures who were treated with hinged knee replacements, a subgroup of whom were treated with RHK. Demographic and outcome data has been retrospectively collected. We discuss the indications, experiences and outcomes in the management of these patients. This study also stimulates debate about the use of RHK to treat fractures in a younger population.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 31 - 31
1 Jan 2011
Cohen D Chapman E Sarkar S Manning M
Full Access

Over 200,000 osteoporotic fractures occur in the UK annually. Patients with fragility fractures are at highest risk of further fracture, though preventative treatment has been shown to reduce subsequent fracture incidence. In 2005, the National Institute for Health & Clinical Excellence (NICE) recommended bisphosphonates as a treatment option in women over 75 years without the need for prior DEXA scanning (Technology Appraisal Guidance 87). We prospectively reviewed the medication of such patients who were admitted to our Trauma Unit to identify if the NICE guidance was being followed.

Over a three month period between May and July 2007, 54 women over 75 years old were discharged from our Trauma Unit having sustained an osteoporotic fracture. We prospectively reviewed their medication to identify if a bisphosphonate had been commenced by the General Practitioner and their discharge letters to their General Practitioners to see if it had been suggested to start one. 7 of the 54 women (13%) were already on a bisphosphonate and were therefore excluded.

Only one (2%) of the discharge letters (written by the Orthopaedic doctor to the General Practitioner) recommended commencing a bisphosphonate. 6 of the 47 patients (13%) had been started on a bisphosphonate by the General Practitioner.

Nice guidance from 2005 is clearly not being implemented in our area. A minority of patients will have contraindications or allergies to bisphosphonates (up to 1 in 4 patients as highlighted recently by the National Osteoporosis Society). Important deficiencies in local services have been identified, particularly with respect to communication between secondary and primary care. This study lead to an education initiative to ensure the Trauma department and our local General Practitioners were aware of the NICE guidance. A second prospective audit is currently being undertaken to assess the effect on our service.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 331 - 331
1 May 2010
Cohen D Chapman E Sarkar S Manning M
Full Access

Introduction: Over 200,000 osteoporotic fractures occur in the UK annually. Patients with fragility fractures are at highest risk of further fracture, though preventative treatment has been shown to reduce subsequent fracture incidence. In 2005, the National Institute for Health & Clinical Excellence (NICE) recommended bisphosphonates as a treatment option in women over 75 years without the need for prior DEXA scanning (Technology Appraisal Guidance 87).

We prospectively reviewed the medication of such patients who were discharged from our Trauma Unit to identify if the NICE guidance was being followed.

Method: Over a three month period between May and July 2007, 54 women over 75 years old were discharged from our Trauma Unit having sustained an osteoporotic fracture.

We prospectively reviewed their medication to identify if a bisphosphonate had been commenced by the General Practitioner and their discharge letters to their General Practitioners to see if it had been suggested to start one.

Results: 7 of the 54 women (13%) were already on a bisphosphonate and were therefore excluded.

Only one (2%) of the discharge letters (written by the Orthopaedic doctor to the General Practitioner) recommended commencing a bisphosphonate.

6 of the 47 patients (13%) had been started on a bisphosphonate by the General Practitioner.

Conclusions: Nice guidance from 2005 is clearly not being implemented in our area. Some patients will have contraindications or allergies to bisphosphonates, however, they will be a minority (up to 1 in 4 patients as highlighted recently by the National Osteoporosis Society).

We believe the results demonstrate a lack of health promotion opportunities to prevent future fracture. Although there is clear focus and impetus for developing falls prevention services nationwide, this enthusiasm has not been translated across to bone health, despite the potential savings in terms of morbidity, mortality and healthcare costs.

Important deficiencies in local services have been identified, particularly with respect to communication between secondary and primary care.

This study lead to an education initiative to ensure the Trauma department and our local General Practitioners were aware of the NICE guidance. A second prospective audit is currently being undertaken to assess the effect on our service.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 461 - 461
1 Aug 2008
Walsh G Das K Siddique A Flood B Chapman J Halder S
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The results of displaced three part fracture of the proximal humerus treated by retro grade nailing +/− cannulated cancellous screws for fixation of the greater tuberosity was analysed.

Displaced three part fractures of the humerus are unstable and difficult to fix. Different methods of operative treatment available for this type of fracture are Kirschner wires, tension band wiring, hemiarthroplasty and open reduction and internal fixation with plate and screws.

The Halder Humeral Nail was introduced through the olecranon fossa into the head of the humerus, to stabilize the neck of humerus fracture. The displaced greater tuberosity was reduced with a minimal stab incision and fixed with cannulated screws. Compared to other open procedures the proximal exposure was minimal.

47 Patients with displaced three part proximal humeral fractures have been surgically treated since January 1995. 22 Were treated with proximal screws and 25 without proximal screw fixation. There were 32 females and 15 males. The average age was 67.68 years.

Early passive movements were encouraged in the shoulder. Pain was relieved in almost all the patients. 41 Fractures united. 3 Patients had a malunion, 2 had humeral head collapse, and 1 developed AVN of the humeral head.

The authors concluded that displaced three part proximal humeral fractures can be treated using the Halder Humeral Nail, and that this is a simple method of treatment which avoids major surgical exposures.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 68 - 68
1 Mar 2008
Bellabarba C Schildhauer T Mirza S Nork S Routt MC Chapman J
Full Access

Retrospective review of eighteen patients with sacral fracture dislocations and cauda equina deficits treated with posterior sacral decompression and lumbopelvic fixation. At mean nineteen-month follow-up, all fractures healed without loss of alignment despite immediate full weight-bearing. Fifteen patients (83%) improved neurologically, and ten patients (56%) had full bowel/ bladder recovery. Complications consisted mainly of infection (17%) and asymptomatic rod breakage (33%). This series demonstrates the clinical effectiveness of lumbopelvic fixation, allowing the application to sacral injuries of decompression and fixation principles commonly used in fractures with neurologic deficits that occur in more rostral areas of the spine.

To evaluate the results of sacral decompression and lumbopelvic fixation for sacral fracture-dislocations with neurologic deficits.

Lumbopelvic fixation provided the stability necessary for full weight-bearing without loss of fracture reduction despite extensive sacral decompression. The functional neurologic improvement in most patients and complete neurologic recovery in all but one patient with intact lumbosacral roots are encouraging. The effectiveness of lumbopelvic fixation facilitates the application of principles of early decompression and stabilization to sacral fracture-dislocations.

Sacral fractures healed in all eighteen patients without loss of reduction. Average sacral kyphosis improved from forty-one to twenty-four degrees. Fifteen patients (83%) had normalization or improvement of bowel and bladder deficits, although only ten patients (56%) had improved Gibbons scores. Average Gibbons type improved from four to 2.8 at nineteen-month average follow-up. Rod breakage (33%) and infection (17%) were the most common complications. Recovery of bowel and bladder function was less likely in patients with disruption of any lumbosacral root (36% vs. 86%, p=.066) and complete deficits (47% vs. 100%, p=.241) although the small cohort size precluded statistical significance.

Retrospective review of medical records, radiographs, and prospectively collected data of eighteen consecutive patients with sacral fracture-dislocations and cauda equina deficits identified between 1997 and 2002 through institutional databases. Treatment consisted of open reduction, sacral decompression and lumbopelvic fixation. Radiographic and clinical results of treatment were evaluated. Neurologic outcome was measured by Gibbons’ criteria.

Please contact author for figures and diagrams.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 71 - 71
1 Mar 2008
Bellabarba C Mirza S West G Mann F Newell D Chapman J
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Retrospective review of seventeen consecutive survivors of craniocervical dissociation (CCD). Thirteen patients had delay in diagnosis, with associated neurologic deterioration in five. Diagnosis of CCD was entertained after lateral C-spine x-ray in only two patients, and after screening C-spine CT in two others. At fifteen-month average follow-up, mean ASIA motor score improved from fifty preoperatively to seventy-nine postoperatively. One patient had temporary postoperative neurologic decline. There were no pseudarthroses. The diagnosis of CCD is often missed, with potentially severe neurologic consequences. Early diagnosis and stabilization are neuroprotective. A classification that identifies minimally displaced yet unstable injuries may improve diagnostic accuracy.

To identify the timing and method of diagnosis, diagnostic reliability of screening lateral radiographs, effect of delayed diagnosis, complications of treatment, and neurologic outcome of this life-threatening condition.

Diagnosis of craniocervical dissociation (CCD) was frequently delayed, increasing the risk of neurologic decline. Early diagnosis and stabilization protected against worsening spinal cord injury.

This study highlights the importance of disciplined evaluation of the lateral cervical spine radiograph of poly-traumatized patients. Head-injured patients with cranio-facial trauma and asymmetric high cervical spinal cord injuries should heighten clinicians’ suspicion of CCD.

CCD was identified or suspected on two of seventeen (12%) initial lateral cervical spine radiographs, and on screening CT scan in only two additional patients (12%), despite an abnormal dens-basion relationship in 16/17 (94%) patients. Of the thirteen patients with (two-day average) delay in diagnosis, 5/13 (38%) had profound neurologic deterioration. One patient worsened temporarily after fixation. There were no pseudarthroses at fifteen-month average follow-up. Mean ASIA motor score of fifty improved to seventy-nine, and the number of patients with useful motor function (ASIA D or E) increased from seven (41%) preoperatively to thirteen (76%) postoperatively.

Four patients with severe craniocervical instability had < 3 mm displacement. We therefore adopted a classification based on provocative traction testing of minimally displaced injuries.(Table).

Retrospective review of seventeen consecutive CCD survivors identified between 1994–2002 through institutional databases. Radiographic and clinical results were evaluated, emphasizing timing of diagnosis, effect of delayed diagnosis, clinical or radiographic warning signs, and response to treatment.

Please contact author for tables and /or diagrams.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 218 - 218
1 May 2006
Coltman T Chapman-Sheath P Riddell A McNally E Wilson-MacDonald J
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Study design: A prospective comparison of MRI findings with surgical findings in patients presenting to our spinal triage service with a prospective diagnosis of a lumbar disc herniation.

Objective: To investigate consistency between radiologists interpretation of MRI scans, and comparison between MRI and surgical findings, in an attempt to identify those patients suitable for percutaneous treatment.

Background: MRI has assumed a preeminent position in the diagnosis of lumbar disc prolapse.

Methods: 87 consecutive patients presenting with signs and symptoms suggestive of a lumbar disc prolapse that underwent an MRI and based on that a discectomy.

Results: Reliability tests show only fair agreement (k=0.36) between the radiologists and at best only moderate agreement (k=0.41) between the radiologists and surgical findings.

Conclusions: MRI is an excellent tool for diagnosis of a disc prolapse but does not appear to help in classifying discs suitable for percutaneous treatment.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 253 - 253
1 May 2006
Raman R Kandiyil N White W Chapman A Chakrabarty G
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Aim: To report the intermediate clinical and radiological results of a consecutive series of knee arthroplasies using PFC Sigma endoprosthesis.

Methods: 525 total knee replacements (469 patients) were performed from Aug 97 to Jun 01 using the PFC Sigma components. Cruciate retaining femoral component was used in 219 knees. All patients were prospectively followed up at 6 weeks, 3 months and yearly. Pre operative HSS knee scores and Oxford knee scores were compared with annual scores. Quality of life was assessed using SF12 questionnaire. Knee Society scores were used to assess the radiographs. The average follow up was 61 months (36–84). 11 patients lost to follow up.

Results: Of the 469 patients, 64% were females. Mean age was 74.2 yrs (59–90). Pre operative valgus deformity of at least 10 deg was present in 87 (16.5%). Patella resurfacing was performed in 80.5%. A lateral release was performed in 20 patients. Post operative mobilisation was standardised in all patients. 34 patients developed radiologically proven DVT. 24 patients died from unrelated causes. 16 (3%) patients developed superficial and 6 developed deep infection. 4 patients underwent revision surgery (3 for infection, 1- catastrophic failure). The HSS scores improved from 29(16–65) to 86(59–97) at final follow up (p=0.004). Pre operative Oxford knee scores improved from 10(6–31) to 43(37–48) at last follow up (p=0.008). Radiological knee society score for the femur were less than 5 in 477/478 patients and 7 in 1 patient. The scores for the tibia were less than 5 in 475/478 patients and 6 in 3 patients. Average femoral flexion was 1–9.2 deg (3.9), knee valgus angle 0.5–7.4 (3.5) degrees and the tibial slope was 3.1 deg (0–7.1). SF 12 health scores revealed a good functional outcome of both the physical and mental components. With failure defined as repeat revision because of aseptic loosening, the rate of survival at 5 years months was 99.1% and overall survival at 5 years with removal or repeat revision of any component for any reason as the end point was 97.5%.

Conclusion: Our prospective study of patients with primary knee arthroplasties supports the use of PFC sigma total knee endoproshesis. Our results show excellent clinical outcome comparable with other prosthesis. A longer follow up is needed to establish the durability and longevity of this prosthesis given its excellent intermediate term results