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The Bone & Joint Journal
Vol. 104-B, Issue 11 | Pages 1234 - 1241
1 Nov 2022
Park JH Park KT Kim SC Bukhary HA Lee SM Yoo JC

Aims. This study compared patients who underwent arthroscopic repair of large to massive rotator cuff tears (LMRCTs) with isolated incomplete repair of the tear and patients with incomplete repair with biceps tendon augmentation. We aimed to evaluate the additional benefit on clinical outcomes and the capacity to lower the re-tear rate. Methods. We retrospectively reviewed 1,115 patients who underwent arthroscopic rotator cuff repair for full-thickness tears between October 2011 and May 2019. From this series, we identified 77 patients (28 male, 49 female) with a mean age of 64.1 years (50 to 80). Patients were classified into groups A (n = 47 incomplete) and B (n = 30 with biceps augmentation) according to the nature of their reconstruction. Clinical scores were checked preoperatively and at six months, one year, and two years postoperatively. In preoperative MRI, we measured the tear size, the degree of fatty infiltration, and muscle volume ratio of the supraspinatus. In postoperative MRI, the integrity of the repaired rotator cuff tendon was assessed using the Sugaya classification. Tendon thickness at the footprint was evaluated on T2-weighted oblique coronal view. Results. There were no significant differences in the initial preoperative demographic characteristics. In both groups, there were significant improvements in postoperative clinical scores (p < 0.001). However, most clinical outcomes, including range of motion measurements (forward elevation, external rotation, internal rotation, and abduction), showed no differences between the pre- and postoperative values. Comparing the postoperative outcomes of both groups, no further improvement from biceps augmentation was found. Group B, although not reaching statistical significance, had more re-tears than group A (30% vs 15%; p = 0.117). Conclusion. In LMRCTs, biceps augmentation provided no significant improvement of an incomplete repair. Therefore, biceps augmentation is not recommended in the treatment of LMRCTs. Cite this article: Bone Joint J 2022;104-B(11):1234–1241


The Bone & Joint Journal
Vol. 104-B, Issue 1 | Pages 97 - 102
1 Jan 2022
Hijikata Y Kamitani T Nakahara M Kumamoto S Sakai T Itaya T Yamazaki H Ogawa Y Kusumegi A Inoue T Yoshida T Furue N Fukuhara S Yamamoto Y

Aims. To develop and internally validate a preoperative clinical prediction model for acute adjacent vertebral fracture (AVF) after vertebral augmentation to support preoperative decision-making, named the after vertebral augmentation (AVA) score. Methods. In this prognostic study, a multicentre, retrospective single-level vertebral augmentation cohort of 377 patients from six Japanese hospitals was used to derive an AVF prediction model. Backward stepwise selection (p < 0.05) was used to select preoperative clinical and imaging predictors for acute AVF after vertebral augmentation for up to one month, from 14 predictors. We assigned a score to each selected variable based on the regression coefficient and developed the AVA scoring system. We evaluated sensitivity and specificity for each cut-off, area under the curve (AUC), and calibration as diagnostic performance. Internal validation was conducted using bootstrapping to correct the optimism. Results. Of the 377 patients used for model derivation, 58 (15%) had an acute AVF postoperatively. The following preoperative measures on multivariable analysis were summarized in the five-point AVA score: intravertebral instability (≥ 5 mm), focal kyphosis (≥ 10°), duration of symptoms (≥ 30 days), intravertebral cleft, and previous history of vertebral fracture. Internal validation showed a mean optimism of 0.019 with a corrected AUC of 0.77. A cut-off of ≤ one point was chosen to classify a low risk of AVF, for which only four of 137 patients (3%) had AVF with 92.5% sensitivity and 45.6% specificity. A cut-off of ≥ four points was chosen to classify a high risk of AVF, for which 22 of 38 (58%) had AVF with 41.5% sensitivity and 94.5% specificity. Conclusion. In this study, the AVA score was found to be a simple preoperative method for the identification of patients at low and high risk of postoperative acute AVF. This model could be applied to individual patients and could aid in the decision-making before vertebral augmentation. Cite this article: Bone Joint J 2022;104-B(1):97–102


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_13 | Pages 24 - 24
7 Aug 2023
Myers P Goldberg M Davies P
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Abstract. Introduction. Augmentation of meniscus repairs with fibrin clot may enhance the healing capacity. Pulling the clot into the tear with a suture ensures that it stays in position. This paper aims to assess the outcome of this technique. Methods. 52 patients over 4 years undergoing suture repair of a meniscus tear with blood clot augmentation were collected from a prospective database. Follow up included outcome scores and a questionnaire. Failure was defined as pain or further surgery secondary to meniscal pathology. Results. There were 32 males and 20 females, mean age of 35 (14–70). The medial meniscus was repaired in 32 knees and the lateral in 20. Complete radial tears were the most common type. Only 2% of tears were in the red-red zone. Follow-up ranged from 12 months to 7 years. Only 1 patient is known to have come to subsequent arthroscopy. Lysholm scores improved from 53.97 (SD 18.14) to 92.08 (SD 8.97), Oxford Knee Scores from 29.84 (SD 9.65) to 45.79 (SD 2.66), KOOS pain scores from 61.49 (SD 22.76) to 93.54 (SD 8.06) and Tegner scores from 4.56 (SD 3.35) to 6.05 (SD 2.41). Conclusions. Pulling a fibrin blood clot into a meniscus tear with a suture ensures that the clot remains in place while the meniscus is repaired. Patients have shown excellent outcomes with 98% survivorship at 45 months. This is a reliable technique for augmenting meniscus repairs especially for tears which otherwise may not have been repaired


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_9 | Pages 82 - 82
17 Apr 2023
Kale S Deore S Singh S Gunjotikar A Agrawal P Ghodke R
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This study was proposed to evaluate the efficacy of fibrin clot augmentation in meniscal tear using inside-out meniscal repair. A total of 35 patients with meniscus tears were operated on with inside-out meniscus repair and fibrin clot augmentation. Patients were evaluated preoperatively and postoperatively with clinical criteria, Lysholm knee scoring system, and MRI. Out of the total 35 cases, 5 cases were lost to follow up. Clinical improvement was observed in 29 out of 30 patients (96.6%). The mean Lysholm score improved significantly from 67.63 ± 6.55 points preoperatively to 92.0 ± 2.9 points postoperatively (P < 0.05) in 2 years follow-up. Follow-up MRI in all patients revealed complete healing except in 1 case where the patient presented with recurrence of symptoms such as pain and locking which resolved with partial meniscectomy. Paraesthesia in the anterior part of the knee was observed in 2 cases. (6.6%). We conclude that fibrin clot augmentation is a good cost-effective modality of treatment for repairable meniscus tears to preserve the meniscus and decrease the point contact pressure on the condyles which may prevent the early occurrence of osteoarthritis


The Bone & Joint Journal
Vol. 96-B, Issue 10 | Pages 1325 - 1332
1 Oct 2014
Nakamae A Ochi M Deie M Adachi N Shibuya H Ohkawa S Hirata K

We report the clinical outcome and findings at second-look arthroscopy of 216 patients (mean age 25 years (11 to 58)) who underwent anterior cruciate ligament (ACL) reconstruction or augmentation. There were 73 single-bundle ACL augmentations (44 female, 29 male), 82 double-bundle ACL reconstructions (35 female, 47 male), and 61 single-bundle ACL reconstructions (34 female, 27 male). In 94 of the 216 patients, proprioceptive function of the knee was evaluated before and 12 months after surgery using the threshold to detect passive motion test. Second-look arthroscopy showed significantly better synovial coverage of the graft in the augmentation group (good: 60 (82%), fair: 10 (14%), poor: 3 (4%)) than in the other groups (p = 0.039). The mean side-to-side difference measured with a KT-2000 arthrometer was 0.4 mm (-3.3 to 2.9) in the augmentation group, 0.9 mm (-3.2 to 3.5) in the double-bundle group, and 1.3 mm (-2.7 to 3.9) in the single-bundle group: the result differed significantly between the augmentation and single-bundle groups (p = 0 .013). No significant difference in the Lysholm score or pivot-shift test was seen between the three groups (p = 0.09 and 0.65, respectively). In patients with good synovial coverage, three of the four measurements used revealed significant improvement in proprioceptive function (p = 0.177, 0.020, 0.034, and 0.026). We conclude that ACL augmentation is a reasonable treatment option for patients with favourable ACL remnants. Cite this article: Bone Joint J 2014;96-B:1325–32


Bone & Joint 360
Vol. 12, Issue 6 | Pages 46 - 47
1 Dec 2023

The December 2023 Research Roundup. 360. looks at: Tissue integration and chondroprotective potential of acetabular labral augmentation with autograft tendon: study of a porcine model; The Irish National Orthopaedic Register under cyberattack: what happened, and what were the consequences?; An overview of machine learning in orthopaedic surgery: an educational paper; Beware of the fungus…; New evidence for COVID-19 in patients undergoing joint replacement surgery


The Bone & Joint Journal
Vol. 106-B, Issue 9 | Pages 978 - 985
1 Sep 2024
Savoie III FH Delvadia BP Tate JP Winter JE Williams GH Sherman WF O’Brien MJ

Rotator cuff tears are common in middle-aged and elderly patients. Despite advances in the surgical repair of rotator cuff tears, the rates of recurrent tear remain high. This may be due to the complexity of the tendons of the rotator cuff, which contributes to an inherently hostile healing environment. During the past 20 years, there has been an increased interest in the use of biologics to complement the healing environment in the shoulder, in order to improve rotator cuff healing and reduce the rate of recurrent tears. The aim of this review is to provide a summary of the current evidence for the use of forms of biological augmentation when repairing rotator cuff tears. Cite this article: Bone Joint J 2024;106-B(9):978–985


Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_6 | Pages 6 - 6
2 May 2024
Langdown A Goriainov V Watson R
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Gluteal Tendinopathy is a poorly understood condition that predominantly affects post-menopausal women. It causes lateral hip pain, worse when lying on the affected side or when walking up a hill or stairs. It has been labelled ˜Greater Trochanteric Pain Syndrome” a name that recognises the lack of understanding of the condition. Surgical reconstruction of the gluteal cuff is well established and has been undertaken numerous times over the last 16 years by the senior author (AJL). However, the quality of collagen in the tendons can be very poor and this leads to compromised results. We present the results of gluteal cuff reconstruction combined with augmentation using a bioinductive implant. 14 patients (11 female, 3 male; mean age 74.2 ± 6.3 years) with significant symptoms secondary to gluteal tendinopathy that had failed conservative treatment (ultrasound guided injection and structured physiotherapy) underwent surgical reconstruction by the senior author using an open approach. In all cases the iliotibial band was lengthened and the trochanteric bursa excised. The gluteal cuff was reattached using Healicoil anchors (3–5×4.75mm anchors; single anchors but double row repair) and then augmented using a Regeneten patch. Patients were mobilised fully weight bearing post-operatively but were asked to use crutches until they were no longer limping. All had structured post-surgery rehabilitation courtesy of trained physiotherapists. There were no post-operative complications and all patients reported an improvement in pain levels (Visual Analogue Scale 7.8 pre-op; 2.6 post-op) and functional levels (UCLA Activity Score 3.5 pre-op; 7.1 post-op) at 6 months post surgery. Surgery for gluteal tendinopathy produces good outcomes and the use of Regeneten as an augment for poor quality collagen is seemingly a safe, helpful addition. Further comparative studies would help clarify this


The Bone & Joint Journal
Vol. 105-B, Issue 5 | Pages 474 - 480
1 May 2023
Inclan PM Brophy RH

Anterior cruciate ligament (ACL) graft failure from rupture, attenuation, or malposition may cause recurrent subjective instability and objective laxity, and occurs in 3% to 22% of ACL reconstruction (ACLr) procedures. Revision ACLr is often indicated to restore knee stability, improve knee function, and facilitate return to cutting and pivoting activities. Prior to reconstruction, a thorough clinical and diagnostic evaluation is required to identify factors that may have predisposed an individual to recurrent ACL injury, appreciate concurrent intra-articular pathology, and select the optimal graft for revision reconstruction. Single-stage revision can be successful, although a staged approach may be used when optimal tunnel placement is not possible due to the position and/or widening of previous tunnels. Revision ACLr often involves concomitant procedures such as meniscal/chondral treatment, lateral extra-articular augmentation, and/or osteotomy. Although revision ACLr reliably restores knee stability and function, clinical outcomes and reoperation rates are worse than for primary ACLr. Cite this article: Bone Joint J 2023;105-B(5):474–480


Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_12 | Pages 4 - 4
10 Jun 2024
Sethi M Limaye R Limaye N
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Introduction. Acute ankle injuries are commonly seen in musculoskeletal practice. Surgical management is the gold standard for lateral ligament injury in those with failed conservative treatment for a minimum of six months. Several studies have shown good functional outcome and early rehabilitation after MBG repair with an internal brace augmentation which is a braided ultrahigh molecular weight polyethylene ligament used to enhance the repair that acts as a secondary stabiliser. Hence the aim of the study was to compare the results with and without augmentation. Methods. A single centre retrospective review conducted between November 2017 and October 2019 and this included 172 patients with symptomatic chronic lateral ligament instability with failed conservative management. The diagnosis was confirmed by MRI. All patients had an ankle arthroscopy followed by open ligament repair. Patients were grouped into isolated MBG and internal brace groups for analyses and all had dedicated rehabilitation. Results. A total of 148 patients were available for final follow up with 87 patients in the MBG group and 61 patients in the IBA group. Mean Age was 38 years and mean follow up was 22 months. The internal brace group showed better Manchester Oxford foot and ankle score (19.7 vs 18.2) and more patients returning to preinjury activity levels (73 vs 55) as compared to isolated repair. Conclusion. Internal brace augmentation with MBG repair facilitated early rehabilitation and return to pre injury activity level in majority of patients compared to isolated MBG repair


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_7 | Pages 23 - 23
1 Jul 2022
Frame M Hauck O Newman M
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Abstract. Introduction. Tibial tubercle osteotomy (TTO) is a complex surgical procedure with a significant risk of complications, which include nonunion and tibial fracture. To determine whether an additional suture tape augmentation can provide better biomechanical stability compared with standard screw fixation. Methods. Five matched pairs of human cadaveric knees were divided into 2 groups: the first group underwent standard TTO fixation with 2 parallel screws. The second group underwent a novel fixation technique, in which a nonabsorbable suture tape (FiberTape) in a figure-of-8 construct was added to the standard screw fixation. Tubercular fragment migration of >50% of the initial distalization length was defined as clinical failure Tubercular fragment displacement during cyclic loading and pull-to-failure force were recorded and compared between the 2 groups. Results. The augmented group showed less cyclic tubercular fragment displacement after every load level compared with the standard group, with statistically significant differences starting from 500 N (P < .05; power > 0.8). Mean ± standard deviation tubercular fragment displacement at the end of cyclic loading was 2.56 ± 0.82 mm for the augmented group and 5.21 ± 0.51 mm for the standard group. Mean ultimate failure load after the pull-to-failure test was 2475 ± 554 N for the augmented group and 1475 ± 280 N for the standard group. Conclusion. The specimens that underwent suture tape augmentation showed less tubercular fragment displacement during cyclic loading and higher ultimate failure forces compared with those that underwent standard screw fixation


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_14 | Pages 11 - 11
1 Dec 2022
Bergomi A Adriani M De Filippo F Manni F Motta M Saccomanno M Milano G
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Rotator cuff repair has excellent clinical outcomes but continues to be a challenge when it comes to large and massive tears as well as revision procedures. Reported symptomatic retear rates are still too high to be acceptable. The purpose of the present study was to evaluate the effectiveness of a combination of augmentation techniques consisting of microfractures of the greater tuberosity, extracellular matrix (ECM) patch graft and subsequent platelet concentrate (PC) subacromial injections in revision rotator cuff repair. The study was designed as a retrospective comparative study on prospectively collected data from a consecutive cohort of patients. All patients who underwent arthroscopic revision rotator cuff repair for symptomatic failure of previous posterosuperior rotator cuff repair were considered eligible for the study. Symptomatic failure had been diagnosed according to clinical examination and confirmed by magnetic resonance imaging (MRI). Structural integrity had been assessed on MRI and classified according to Sugaya classification. Only patients affected by stage IV-V were considered eligible. Tear reparability was confirmed during arthroscopy. Only patients with a minimum 2 years follow-up were included. Patients were divided in two groups. In group 1 (control group) a standard arthroscopic revision and microfractures of the greater tuberosity were performed; in group 2 (experimental group), microfractures of the greater tuberosity and a ECM patch graft were used to enhance tendon repair, followed by postoperative PC injections. Minimum follow-up was 12 months. Primary outcome was the Constant-Murley score (CMS) normalized for age and gender. Subjective outcome was assessed with the Disabilities of the Arm, Shoulder and Hand (DASH) score in its short version (Quick-DASH). Tendon integrity was assessed with MRI at 6 months after surgery. Comparison between groups for all discrete variables at baseline and at follow-up was carried out with the Student's t-test for normally distributed data, otherwise Mann-Whitney U-test was used. Within-group differences (baseline vs follow-up) for discrete variables were analyzed by paired t-test, or by Wilcoxon signed-rank test in case of data with non-normal distribution. Differences for categorical variables were assessed by chi-squared test. Significance was considered for p values < 0.05. Forty patients were included in the study (20 patients for each group). The mean follow-up was 13 ± 1.6 months. No patients were lost at the follow up. Comparison between groups did not show significant differences for baseline characteristics. At follow-up, mean CMS was 80.7 ± 16.6 points in group 1 and 91.5 ± 11.5 points in group 2 (p= 0.022). Mean DASH score was 28.6 ± 21.6 points in group 1 and 20.1 ± 17.4 points in group 2 (p= 0.178). Post-operative MRI showed 6 healed shoulders in Group 1 and 16 healed shoulders in Group 2 (p<0.004). No postoperative complications were reported in both groups. The combination of microfractures of the greater tuberosity, ECM patch graft, and subsequent PC subacromial injections is an effective strategy in improving tendon healing rate


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 1 | Pages 32 - 35
1 Jan 2005
Diab M Clark JM Weis MA Eyre DR

In developmental dysplasia of the hip, a deficient acetabulum may be augmented by placing local autogenous iliac osseous graft, or the ilium itself, over the head of the femur with the expectation that the added bone will function as a bearing surface. We analysed this bone obtained en bloc during subsequent surgery which was performed for degenerative osteoarthritis in three patients at 6, 25 and 30 years after the initial augmentation procedure. In each patient, the augmentation comprised of red cancellous bone covered on its articulating surface by a distinct layer of white tissue. Microscopy of this tissue showed parallel rows of spindle-shaped cells lying between linearly arranged collagen bundles typical of joint capsule. Biochemical analysis showed type I collagen, the principal collagen of joint capsule and bone, with no significant quantity of type II collagen, the principal collagen of cartilage. While the added bone produced by acetabular augmentation was durable, histological and biochemical analyses suggested that it had not undergone cartilage metaplasia. The augmented acetabulum articulates with the head of the femur by means of an interposed hip joint capsule


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_8 | Pages 62 - 62
1 Apr 2017
Inzana J Münch C Varga P Hofmann-Fliri L Südkamp N Windolf M
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Background. Osteoporotic fracture fixation in the proximal humerus remains a critical challenge. While the biomechanical benefits of screw augmentation with bone cement are established, minimising the cement volume may help control any risk of extravasation and reduce surgical procedure time. Previous experimental studies suggest that it may be sufficient to only augment the screws at the sites of the lowest bone quality. However, adequately testing this hypothesis in vitro is not feasible. Methods. This study systematically evaluated the 64 possible strategies for augmenting six screws in the humeral head through finite element simulations to determine the relative biomechanical benefits of each augmentation strategy. Two subjects with varying levels of local bone mineral density were each modeled with a 2-part and 3-part fracture that was stabilised with a PHILOS plate. The biomechanical fixation was evaluated under physiological loads (muscle and joint reaction forces) that correspond to three different motions: 45 degrees abduction, 45 degrees abduction with 45 degrees internal rotation, and 45 degrees flexion. Results. The higher risk cases (low bone quality or 3-part fracture) exhibited greater peri-implant bone strains and derived greater benefits from screw augmentation. When selecting four screws to augment, the biomechanical benefits ranged from a 25% reduction in bone strain to a 59% reduction in bone strain, depending on the choice of screws. Further, the relative benefits of each augmentation strategy varied between patients and under different loading conditions. Correlations between local bone mineral density and benefits of augmentation were not significant. Conclusions. An optimal augmentation strategy is likely patient-specific and a larger cohort, modeled under a variety of conditions, would be required to elucidate any patient-specific factors (e.g. morphology or bone quality) that may dictate the relative benefits of each augmentation strategy


Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_11 | Pages 9 - 9
4 Jun 2024
Gilsing G De Kort J Van der Weegen W
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Objective. To evaluate early mobilization with the ‘STRONG regime’ is safe after lateral ankle ligament repair with suture tape augmentation. Background. The ESSKA-AFAS ankle instability group presented in 2016 evidence-based guidelines for rehabilitation and return to activity after lateral ankle ligament repair. Early mobilization is considered an important element of postoperative rehabilitation. Patients have to be immobilized for approximately six weeks to protect the delicate repair. Lateral ankle ligament repair with suture tape augmentation results in greater strength compared with standard repairs and early mobilization proved to be successful in small sample size studies. Augmented surgery technique is getting increasingly popular. However, it is unknown which rehabilitation regimes are used. It is essential to establish a clear evidence-based guideline for rehabilitation after surgery. Methods. A systematic literature search was performed to obtain the best evidence research regarding this surgery. In cooperation between the orthopaedic- and physical therapy department a post-operative rehabilitation protocol with early mobilization was established. This STRONG protocol (figure 1) is based on milestones and three stages. Results. In February 2016 the first patients were selected for the early mobilization regime. In total 102 patients with a lateral ankle ligament repair were treated with the STRONG protocol. No re-ruptures were observed with a follow up of a year. In a subgroup of athletes hop tests showed a symmetry index of 100,5% for triple hop, 98,6 for side hop and 103,6 for figure of 8 hop. First return to sport was achieved between 9–12 weeks, with full return to competition after a mean of 4 months. Conclusions. An early postoperative mobilization regime based on supervised exercises seems to be a safe intervention after a lateral ankle ligament reconstruction. Clinical implications. Augmented ankle ligament surgery with early mobilization could be an important advancement in treating patients with chronic ankle injuries. For any figures or tables, please contact authors directly


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_2 | Pages 4 - 4
1 Jan 2019
Coe R Warren J Sikora S Miles DE Mengoni M Wilcox RK
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Intervertebral disc (IVD) degeneration is one of the major causes of back pain. A number of emerging treatments for the condition have failed during clinical trial due to the lack of robust biomechanical testing during product development. The aim of this work was to develop improved in-vitro testing methods to enable new therapeutic approaches to be examined pre-clinically. It forms part of a wider programme of research to develop a minimally invasive nucleus augmentation procedure using self-assembling hydrogels. Previous static testing on extracted IVDs have shown large inter-specimen variation in the measured stiffness when specimen hydration and fluid flow were not well controlled. In this work, a method of normalising the hydration state of IVDs prior-to and during compressive testing was developed. Excised adult bovine IVDs underwent water-pik treatment and a 24-hour agitated bath in monosodium citrate solution to maximise fluid mobility. Specimens were submerged in a saline bath and held under constant pressure for 24 hours, after which the rate of change of displacement was low. Specimens were then cyclically loaded, from which the normalised specimen stiffness was determined. A degenerate disc model was developed with the use of enzymatic degeneration, allowing specimens to be tested sequentially in a healthy, degenerate, and then treated state. Self-assembling peptide-GAG hydrogels were tested using the developed method and the effect of treatment on stiffness and disc height were assessed. Compared to previous static tests, the improved method reduced the variation in the normalised specimen stiffness. In addition, statistically significant differences were seen before and after enzymatic degradation to simulate degeneration, thus providing controls against which to evaluate treatments. The augmentation of the nucleus with the hydrogel intervention reduces the stiffness of the degenerate disc towards that of the healthy disc. This method is now being used to further investigate nucleus augmentation devices


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 11 | Pages 1493 - 1496
1 Nov 2011
Lee JK Choi CH

Bone defects are occasionally encountered during primary total knee replacement (TKR) and cause difficulty in establishing a stable well-aligned bone-implant interface. Between March 1999 and November 2005, 59 knees in 43 patients underwent primary TKR with a metal block augmentation for tibial bone deficiency. In all, six patients (eight knees) died less than four years post-operatively, and four patients (five knees) were lost to follow-up leaving 46 knees in 33 patients available for review at a mean of 78.6 months (62 to 129). The clinical results obtained, including range of movement, American Knee Society and Oxford knee scores, and the Western Ontario and McMaster Universities osteoarthritis index, were good to excellent, with no failures. Radiolucent lines at the block-cement-bone interface were noted in five knees (11%) during the first post-operative year, but these did not progress. . Modular rectangular metal augmentation for tibial bone deficiency is a useful option. No deterioration of the block-prosthesis or block-cement-bone interface was seen at minimum of five years follow-up


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_10 | Pages 31 - 31
1 Oct 2015
Sabat D
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The purpose of this study was to evaluate the results of selective anatomic augmentation of partial anterior cruciate (ACL) ligament tears in 36 consecutive patients with mean 3years follow-up. Our hypothesis is that this selective augmentation of partial ACL tears could restore knee stability and function. In a consecutive series of 314 ACL reconstructions, 40 patients in which intact ACL fibers remained in the location corresponding to the anteromedial or posterolateral bundle were diagnosed perioperatively. All patients underwent selective augmentation of the torn bundle, while keeping the remaining fibers intact using autogenous hamstring graft. 38 patients (28 males, 10 females) were available with minimum 3 year follow- up. 26 cases had AM bundle tears and 12 cases had PL bundle tears respectively. Patients were assessed with International Knee Documentation Committee (IKDC) 2000 Knee Evaluation Form, Lysholm score; instrumented knee testing was performed with the arthrometer (KT 2000). Statistical analysis was performed to compare the preoperative and postoperative objective evaluation. At 3 year follow-up, 12 (31.6%) patients were graded A, 25 (65.8%) graded B and 1 C (2.6%) at IKDC objective evaluation. Lysholm's score and mean side to side instrumental laxity improved significantly. The results of anatomic single bundle augmentation in partial ACL tears are encouraging with excellent side to side laxity


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 136 - 136
1 Mar 2010
Kim H Kim J Seol Y
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Uncontained peripheral bone defect in posteromedial tibial plateau is not an infrequent problem even in primary total knee arthroplasty, especially in Korean patients some of those have large angular deformities preoperatively. We reviewed the clinical and radiological results of primary total knee replacements of 33 osteoarthritic knees in 28 patients with the use of metal block augmentation for uncontained peripheral tibial bone defects more than 5 millimeters in depth and more than a quarter of medial tibial plateau in width. Those defects were encountered in 75 knees (9.6%) during 779 primary total knee arthroplasties performed by single surgeon between January 2002 and December 2004 at our institution. Modular metal block augmentation was reserved for 42 knees, while the other knees were managed with bone-grafting or cement-filling techniques. Clinical and radiological follow-up more than 12 months were available from 33(78.6%) of 42 knees. At a mean of 32.2 months (range:12~75 months), 31 knees (93.9%) except two cases of failure were evaluated as good or excellent. The average pre-operative American Knee Society Knee and Function scores were 32.5 and 38.6 respectively, which increased to 82.9 and 79.8 respectively at the latest follow-up. There were no radiolucent lines (RLLs) beneath the metallic block or tibial tray, which were progressive or more than 2 millimeters on radiographs, in those knees. Revisions were required for one delayed infection and another aseptic loosening of tibial component. Non-progressive RLLs less than 2 millimeters at the cement-bone interface beneath the metallic block were noted in 10 (32.3%) of 31 knees. The RLLs appeared in 5 (41.7%) of 12 knees with metallic block augmentation alone and 5 (26.3%) of 19 knees which had been treated with the use of additional intramedullary stem augmentation, although this difference was not statistically significant. Since these radiolucent lines were not progressive or symptomatic at all, their clinical meanings or long-term consequences are not determined yet. All knees managed with the additional intramedullary stem augmentation revealed to have radiopaque lines adjacent to the stem on follow-up radiographs. The sclerotic halo around the tip of stem could be interpreted as evidence of the stem’s function in load sharing and might reflect secure fixation of tibial tray to bony interface. We concluded that the use of modular metal block augmentation devices for peripheral tibial defects measuring more than 5 millimeters could provide a simple, rapid and dependable technique that provides predictable results. The observation that all knees managed with additional intramedullary stem augmentation would have sclerotic halo adjacent to the stem on follow-up radiographs may reflect an intramedullary stem is an important adjunct to bone defect management


The Bone & Joint Journal
Vol. 100-B, Issue 3 | Pages 271 - 284
1 Mar 2018
Hexter AT Thangarajah T Blunn G Haddad FS

Aims. The success of anterior cruciate ligament reconstruction (ACLR) depends on osseointegration at the graft-tunnel interface and intra-articular ligamentization. Our aim was to conduct a systematic review of clinical and preclinical studies that evaluated biological augmentation of graft healing in ACLR. . Materials and Methods. In all, 1879 studies were identified across three databases. Following assessment against strict criteria, 112 studies were included (20 clinical studies; 92 animal studies). . Results. Seven categories of biological interventions were identified: growth factors, biomaterials, stem cells, gene therapy, autologous tissue, biophysical/environmental, and pharmaceuticals. The methodological quality of animal studies was moderate in 97%, but only 10% used clinically relevant outcome measures. The most interventions in clinical trials target the graft-tunnel interface and are applied intraoperatively. Platelet-rich plasma is the most studied intervention, but the clinical outcomes are mixed, and the methodological quality of studies was suboptimal. Other biological therapies investigated in clinical trials include: remnant-augmented ACLR; bone substitutes; calcium phosphate-hybridized grafts; extracorporeal shockwave therapy; and adult autologus non-cultivated stem cells. Conclusion. There is extensive preclinical research supporting the use of biological therapies to augment ACLR. Further clinical studies that meet the minimum standards of reporting are required to determine whether emerging biological strategies will provide tangible benefits in patients undergoing ACLR. Cite this article: Bone Joint J 2018;100-B:271–84


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_8 | Pages 81 - 81
1 May 2016
Kang K Trinh T Jang Y Yoo O Lee M Lim D
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Introduction. Revision total knee arthroplasy (TKA) has been often used with a metal block augmentation for patients with poor bone quality. However, bone resorption beneath metal block augmentation has been still reported and little information about the reasons of the occurrence of bone resorption is available. The aim of the current study is to identify a possibility of the potential occurrence of bone resorption beneath metal block augmentation, through evaluation of strain distribution beneath metal block augmentation in revision TKA with metal block augmentation, during high deep flexion. Materials and Method. LOSPA, revision TKA with a metal block augmentation (Baseplate size #5, Spacer size #5, Stem size Φ9, L30, Augment #5 T5) was considered in this study. For the test, the tibia component of LOSPA was implanted to the tibia sawbone (left, #3401, Sawbones EuropeAB, Malmö, Sweden), which was corresponded to a traditional TKR surgical guideline. The femoral component of LOSPA was mounted to a customized jig attached to the Instron 8872 (Instron, Norwood, MA, USA), which was designed specially to represent the angles ranged from 0° to 140° with consideration of a rollback of knee joint (Figure. 1). Here, a compressive load of 1,600N (10N/s) was applied for each angle. Strain distribution was then measured from rossete strain gauge (Half Bridge type, CAS, Seoul, Korea) together (Figure 1). Results and Discussions. The strain distribution on the cortical bone of the tibia was shown in Figure 2. The results showed that the strains on the posterior region were gradually increased from extension to high deep of the knee joint and generally larger than the other regions. In contrast to the results on the posterior region, the strains on the medial region were gradually decreased after 60° or 90° flexion position and relatively lower than the other regions. Particularly, the strains on the medial region were generally lower than 50–100 µstrain, which is known as critical value range able to inducing bone resorption, during high deep flexion. This fact indicate that a possibility of the potential bone resorption occurrence in revision TKA used with a metal block augmentation may be relatively increased in patients who are frequently exposed to a personal lifestyle history with the loading conditions of the high flexion. This study may be valuable by identifying for the first time a possibility of the potential bone resorption occurrence through evaluation of the strain distribution beneath metal block augmentation in revision TKA used with a metal block augmentation during high deep flexion. Conclusion. A possibility of the potential bone resorption occurrence in revision TKA used with a metal block augmentation may be dependent on loading patterns applied on the knee joint related to personal lifestyle history. Particularly, it may be relatively increased in patients who are frequently exposed to a personal lifestyle history with the loading conditions of the high flexion. Acknowledgements. This study was supported by a grant from the New Technology Product Evaluation Technical Research project, Ministry of Food and Drug Safety (MFDS), Republic of Korea


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_2 | Pages 49 - 49
1 Mar 2021
Dixon A Wareen J Mengoni M Wilcox R
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Abstract. Objectives. Develop a methodology to assess the long term mechanical behavior of intervertebral discs by utilizing novel sequential state testing. Methods. Bovine functional spinal units were sequentially mechanically tested in (1) native (n=8), (2) degenerated (n=4), and (3) treated states (n=4). At stage (2), artificial degeneration was created using rapid enzymatic degeneration, followed by a 24 hour hold period under static load at 42°C. At stage (3), nucleus augmentation treatments were injected with a hydrogel or a ‘sham’ (water, chondroitin sulfate) injection. The mechanical protocol employed applied a static load hold period followed by cyclic compressive loading between ∼350 and 750 N at 1 Hz. 1000 cycles were applied at each stage, and the final test on each specimen was extended up to 20000 cycles. To verify if test time can be reduced, functions were fitted using stiffness data up to 100, 1000, 2500, 5000, 10000 and 20000 cycles. Linear regression for the native specimens comparing the stiffness at various cycles to the stiffness at 20000 cycles was completed. Results. Independent of the disc state, as the number of cycles increased, the hysteresis decreased and the stiffness increased. The degenerated specimen stiffness was greater than the healthy and treated stiffness and the degenerate hysteresis loops were smaller. A mathematical model was found to successfully predict the high cycle behaviour of the disc reaching a root mean squared (RMS) error below 10% when using 5000 or more cycles. The linear regression gave a RMS error below 7.5% at 1000 cycles. Conclusions. A method was developed to consistently determine intervertebral disc mechanics through sequential testing. A shortened cyclic testing period was shown to be viable as a method to reduce preliminary test time for novel hydrogels, compared to currently literature. The methodology permits rapid preliminary assessment of intervertebral disc mechanics and treatments. Declaration of Interest. (b) declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported:I declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project


Bone & Joint Open
Vol. 3, Issue 8 | Pages 607 - 610
1 Aug 2022
Wellington IJ Hawthorne BC Dorsey C Connors JP Mazzocca AD Solovyova O

Aims. Tissue adhesives (TAs) are a commonly used adjunct to traditional surgical wound closures. However, TAs must be allowed to dry before application of a surgical dressing, increasing operating time and reducing intraoperative efficiency. The goal of this study is to identify a practical method for decreasing the curing time for TAs. Methods. Six techniques were tested to determine which one resulted in the quickest drying time for 2-octyle cyanoacrylate (Dermabond) skin adhesive. These were nothing (control), fanning with a hand (Fanning), covering with a hand (Covering), bringing operating room lights close (OR Lights), ultraviolet lights (UV Light), or prewarming the TA applicator in a hot water bath (Hot Water Bath). Equal amounts of TA were applied to a reproducible plexiglass surface and allowed to dry while undergoing one of the six techniques. The time to complete dryness was recorded for ten specimens for each of the six techniques. Results. Use of the Covering, OR Lights, and Hot Water Bath techniques were associated with a 25- (p = 0.042), 27- (p = 0.023), and 30-second (p = 0.009) reduction in drying time, respectively, when compared to controls. The UV Light (p = 0.404) and Fanning (p = 1.000) methods had no effect on drying time. Conclusion. Use of the Covering, OR Lights, and Hot Water Bath techniques present a means for reducing overall operating time for surgeons using TA for closure augmentation, which can increase intraoperative efficiency. Further studies are needed to validate this in vivo. Cite this article: Bone Jt Open 2022;3(8):607–610


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 79 - 79
1 Mar 2008
Mountney J Paice M Greidanus N Wilson D Masri B
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We have evaluated the function of a trabecular metal augmentation patella to restore knee kinetics and kinematics after revision total knee arthroplasty. An “Oxford type” rig was used with fresh frozen cadaveric knees, for an active model that maximally retained the soft tissue envelope. Investigating the force through the extensor mechanism, we found a statistically significant difference between the TKA before and after patelloplasty, which was abolished by the insertion of the augmentation patella. Investigation patella tracking, we found a statistically significant difference between the TKA before and after patelloplasty, that was rectified by the insertion of the augmentation patella. The purpose of this study is to evaluate the kinetic and kinematic function of a new trabecular metal augmentation patella. Investigating the force through the extensor mechanism, we found a statistically significant difference between the TKA before and after patelloplasty, which was abolished by the insertion of the augmentation patella. Investigation patella tracking, we found a statistically significant difference between the TKA before and after patelloplasty, that was rectified by the insertion of the augmentation patella. This study demonstrates that the augmentation patella restorers the abnormal tracking and higher extensor mechanism forces seen after patelloplasty in revision TKA to those normal after a TKA. The mean, maximum extensor mechanism force in extension for the TKA group as compared to the patelloplasty group (p=0.0000032), reduced to near normal with the augmentation patella (p=0.198). The mean, maximum patella maltracking in extension for the TKA group as compared to the patelloplasty group (p=0.025), reduced to near normal with the augmentation patella (p=0.301). Eight frozen human cadaveric knees (mean age sixty-eight years) were prepared for an “Oxford type” knee rig. Alignment ands offset were addressed and the soft tissue envelope kept as intact as possible. A load cell was introduced into the extensor mechanism. Femoral, patella and tibial motion were assessed using the Optotrak system. Patella bone loss at revision TKA remains an unsolved problem, with the patella often too thin to accept a new prosthesis. Leaving the patella shell to articulate against the femoral component can lead to disappointing results. Funding - Zimmer


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 75 - 75
1 Mar 2008
Mountney J Paice M Greidanus N Wilson D Masri B
Full Access

We have evaluated the function of a trabecular metal augmentation patella to restore knee kinetics and kinematics after revision total knee arthroplasty. An “Oxford type” rig was used with fresh frozen cadaveric knees, for an active model that maximally retained the soft tissue envelope. Investigating the force through the extensor mechanism, we found a statistically significant difference between the TKA before and after patelloplasty, which was abolished by the insertion of the augmentation patella. Investigation patella tracking, we found a statistically significant difference between the TKA before and after patelloplasty, that was rectified by the insertion of the augmentation patella. The purpose of this study is to evaluate the kinetic and kinematic function of a new trabecular metal augmentation patella. Investigating the force through the extensor mechanism, we found a statistically significant difference between the TKA before and after patelloplasty, which was abolished by the insertion of the augmentation patella. Investigation patella tracking, we found a statistically significant difference between the TKA before and after patelloplasty, that was rectified by the insertion of the augmentation patella. This study demonstrates that the augmentation patella restorers the abnormal tracking and higher extensor mechanism forces seen after patelloplasty in revision TKA to those normal after a TKA. The mean, maximum extensor mechanism force in extension for the TKA group as compared to the patelloplasty group (p=0.0000032), reduced to near normal with the augmentation patella (p=0.198). The mean, maximum patella maltracking in extension for the TKA group as compared to the patelloplasty group (p=0.025), reduced to near normal with the augmentation patella (p=0.301). Eight frozen human cadaveric knees (mean age sixty-eight years) were prepared for an “Oxford type” knee rig. Alignment ands offset were addressed and the soft tissue envelope kept as intact as possible. A load cell was introduced into the extensor mechanism. Femoral, patella and tibial motion were assessed using the Optotrak system. Patella bone loss at revision TKA remains an unsolved problem, with the patella often too thin to accept a new prosthesis. Leaving the patella shell to articulate against the femoral component can lead to disappointing results. Funding - Zimmer


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 4 | Pages 535 - 541
1 Apr 2008
Pendegrass CJ Sundar S Oddy MJ Cannon SR Briggs T Blunn GW

We used an in vivo model to assess the use of an autogenous cancellous bone block and marrow graft for augmenting tendon reattachment to metallic implants. We hypothesised that augmentation of the tendon-implant interface with a bone block would enable retention of the graft on the implant surface, enhance biological integration, and result in more consistent functional outcomes compared with previously reported morcellised graft augmentation techniques. A significant improvement in functional weight-bearing was observed between six and 12 weeks. The significant increase in ground reaction force through the operated limb between six and 12 weeks was greater than that reported previously with morcellised graft augmented reconstructions. Histological appearance and collagen fibre orientation with bone block augmentation more closely resembled that of an intact enthesis compared with the morcellised grafting technique. Bone block augmentation of tendon-implant interfaces results in more reliable functional and histological outcomes, with a return to pre-operative levels of weight-bearing by 24 weeks


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 9 | Pages 1203 - 1209
1 Sep 2005
Mattsson P Alberts A Dahlberg G Sohlman M Hyldahl HC Larsson S

We undertook a multicentre, prospective study of a series of 112 unstable trochanteric fractures in order to evaluate if internal fixation with a sliding screw device combined with augmentation using a calcium phosphate degradable cement (Norian SRS) could improve the clinical, functional and radiological outcome when compared with fractures treated with a sliding screw device alone. Pain, activities of daily living, health status (SF-36), the strength of the hip abductor muscles and radiological outcome were analysed. Six weeks after surgery, the patients in the augmented group had significantly lower global and functional pain scores (p < 0.003), less pain after walking 50 feet (p < 0.01), and a better return to the activities of daily living (p < 0.05). At follow-up at six weeks and six months, those in the augmented group showed a significant improvement compared with the control group in the SF-36 score. No other significant differences were found between the groups. We conclude that augmentation with calcium phosphate cement in unstable trochanteric fractures provides a modest reduction in pain and a slight improvement in the quality of life during the course of healing when compared with conventional fixation with a sliding screw device alone


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_7 | Pages 5 - 5
1 Jul 2022
Smith J Stephens T Paulson K Schneider P Martin CR
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Abstract. Introduction. All-tissue quadriceps tendon (QT) is becoming an increasingly popular alternative to hamstrings tendon (HT) and bone-tendon-bone (BTB) autograft for anterior cruciate ligament (ACL) reconstruction. The relatively short graft length however dictates that one, or both, ends rely on suture fixation. The strength of this construct is therefore extremely important. This study evaluates whether the use of a novel fixation technique can improve the tensile properties of the construct compared to a Krackow suture, and a looped tendon (suture free) gold standard. Methods. Eighteen porcine flexor tendons were tested, across three groups; suture-tape Krackow, looped tendon, and the novel ‘strain suture’. Biomechanical testing simulated the different stages of ACL graft preparation and loading (60N preload for 10 minutes, 10 cycles from 10N to 75N, and 1000 cycles from 100N to 400N). Elongation and load to failure were recorded, and stiffness calculated for each construct. Results. The mean elongation was significantly improved for the strain suture compared to the suture tape Krackow for preload, 10 cycle and 1000 cycle testing protocols respectively (1.36mm vs 4.93mm, p<001; 0.60mm vs 2.72mm, p<0.001; 2.95mm vs 29.08mm, p<0.001). Compared with the looped tendon, the strain suture demonstrated similar results for preload and 10 cycle elongation, but greater elongation during the 1000 cycle stage. Stiffness of the latter two constructs was similar. Conclusions. Augmentation of the suture fixation using this novel technique provides a construct that is significantly superior to currently practised suture techniques, and similar in elongation and stiffness to a looped graft


The Bone & Joint Journal
Vol. 104-B, Issue 1 | Pages 8 - 11
1 Jan 2022
Wright-Chisem J Elbuluk AM Mayman DJ Jerabek SA Sculco PK Vigdorchik JM

Dislocation following total hip arthroplasty (THA) is a well-known and potentially devastating complication. Clinicians have used many strategies in attempts to prevent dislocation since the introduction of THA. While the importance of postoperative care cannot be ignored, particular emphasis has been placed on preoperative planning in the prevention of dislocation. The strategies have progressed from more traditional approaches, including modular implants, the size of the femoral head, and augmentation of the offset, to newer concepts, including patient-specific component positioning combined with computer navigation, robotics, and the use of dual-mobility implants. As clinicians continue to pursue improved outcomes and reduced complications, these concepts will lay the foundation for future innovation in THA and ultimately improved outcomes. Cite this article: Bone Joint J 2022;104-B(1):8–11


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_10 | Pages 84 - 84
1 May 2016
Trinh T Kang K Lim D Yoo O Lee M Jang Y
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Introduction. Revision total knee arthroplasty (TKA) has been often used with a metal block augmentation for patients with poor bone quality. However, bone defects are frequently detected in revision TKA used with metal block augmentation. This study focused on identification of a potential possibility of the bone defect occurrence through the evaluation of the strain distribution on the cortical bone of the tibia implanted revision TKA with metal block augmentation, during high deep flexion. Materials and Methods. Composite tibia finite element (FE) model was developed and revision TKA FE model with a metal block augmentation (Baseplate size #5 44AP/67ML, Spacer size #5 44AP/67ML, Stem size Φ9, L30, Augment #5 44AP/67ML thickness 5mm) was integrated with the composite tibia FE model. 0°, 30° 60°, 90°, 120° and 140° flexion positions were then considered with femoral rollback phenomenon [Fig 1.A]. A compressive load of 1,600N through the femoral component was applied to the composite tibia FE model integrated with the tibia component, sharing by the medial and lateral condyles, simulating a stance phase before toe-off [Fig 1.B]. Results and Discussions. The strain distribution on the cortical bone of the tibia was shown in [Fig 2]. The results showed that the strains on the posterior region were gradually increased from extension to high deep of the knee joint and generally larger than the other regions. This fact was favorably corresponded to the femoral rollback phenomenon in the knee joint, showing a good accuracy of our FE model. In contrast to the results on the posterior region, the strains on the medial region were gradually decreased after 60° or 90° flexion position and relatively lower than the other regions. Particularly, the strains on the medial region were generally lower than 50–100 µstrain, which is known as critical value range able to inducing bone loss, during high deep flexion. This fact indicate that a potential possibility of bone defect occurrence in revision TKA used with a metal block augmentation may be relatively increased in patients who are frequently exposed to a personal lifestyle history with the loading conditions of the high flexion. This study may be valuable by identifying for the first time a potential possibility of the bone defect occurrence through evaluation of the strain distribution beneath metal block augmentation in revision TKA used with a metal block augmentation during high deep flexion. Conclusions. A potential possibility of bone defect occurrence in revision TKA used with a metal block augmentation may be dependent on loading patterns applied on the knee joint related to personal lifestyle history. Particularly, it may be relatively increased in patients who are frequently exposed to a personal lifestyle history with the loading conditions of the high flexion. Acknowledgements. This study was supported by a grant from the New Technology Product Evaluation Technical Research project, Ministry of Food and Drug Safety (MFDS), Republic of Korea


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_4 | Pages 47 - 47
1 Apr 2018
Hughes E Williams R Cooke M Hall T Cox S Grover L
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Background. Bone is a hierarchically structured hard tissue that consists of approximately 70 wt% low-crystallinity hydroxyapatite. Intricate tubular channels, such as Haversian canals, Volkman's canals, and canaliculi are a preserved feature of bone microstructure. These structures provide pathways for vasculature and facilitate cell-to-cell communication processes, together supporting viability of cellular components and aiding in remodeling processes. Unfortunately, many commercial bone augmentation materials consist of highly crystalline phases that are absent of the structuring present within the native tissue they are replacing. This work reports on a the development of a novel bone augmentation material that is able to generate biologically analogous tubular calcium phosphate mineral structures from hydrogel-based spheres that can be packed into defects similar to those encountered in vivo. Experimental. Calcium loaded spheres were made by adding 5 wt% agar powder to 1 M calcium nitrate solutions, before heating the mixture to 80–90 oC and feeding droplets of gel into a reservoir of liquid nitrogen. Deposition of tubular mineral was initiated by exposure to ammonium phosphate solutions at concentrations between 500 mM and 1 M, and was characterized by micro-XRF mapping, XRD and SEM techniques. For an ex vivo model, human bone tissue was collected from patients undergoing elective knee replacement surgery. The United Kingdom National Research Ethics Service (East of Scotland Research Ethics Service) provided ethical approval (11/ES/1044). The augmented defect of the model was characterised by micro-XRF mapping and micro-CT techniques. Results and Discussion. Immersion of calcium-loaded hydrogel spheres in physiological solutions rich in phosphate promotes the release of calcium rich streams from the sphere surface, resulting in the precipitation of tubule structures. Micro-XRF mapping, XRD and SEM, revealed tubules possessed hierarchically structuring and consisted of low-crystallinity hydroxyapatite, making them analogous in composition and structure to incritate features of bone microstructure. When brought into close proximity with one another, spheres become fused in a matter of minutes by the entanglement and subsequent interstitial mineralisation of the mineral tubules. Micro-XRF mapping and micro-CT analysis of an augmented ex vivo human tissue defect model demonstrated the extensive deposition of low-crystallinity tubular mineral throughout a tissue defect. Conclusions. This is possibly the first example of a bone augmentation material that is able to generate biologically analogous structures in situ, and therefore may serve as a better scaffold for bone formation over synthetic alternatives. Moreover, the formation of structured mineral aids in achieving rapid hardening of the augmenting calcium-loaded hydrogel shperes within the defect space


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 10 | Pages 1397 - 1402
1 Oct 2010
Nada AN Debnath UK Robinson DA Jordan C

We describe the clinical outcome of a technique of surgical augmentation of chronic massive tears of the rotator cuff using a polyester ligament (Dacron) in 21 symptomatic patients (14 men, seven women) with a mean age of 66.5 years (55.0 to 85.0). All patients had MRI and arthroscopic evidence of chronic massive tears. The clinical outcome was assessed using the Constant and Murley and patient satisfaction scores at a mean follow-up of 36 months (30 to 46). The polyester ligament (500 mm × 10 mm) was passed into the joint via the portal of Neviaser, medial to the tear through healthy cuff. The two ends of the ligament holding the cuff were passed through tunnels made in the proximal humerus at the footprint of the insertion of the cuff. The ligament was tied with a triple knot over the humeral cortex. All the patients remained free from pain (p < 0.001) with improvement in function (p < 0.001) and range of movement (p < 0.001). The mean pre-operative and post-operative Constant scores were 46.7 (39.0 to 61.0) and 85.4 (52.0 to 96.0), respectively (p < 0.001). The mean patient satisfaction score was 90%. There were two failures, one due to a ruptured ligament after one year and the other due to deep-seated infection. The MR scan at the final follow-up confirmed intact and thickened bands in 15 of 17 patients. This technique of augmentation gives consistent relief from pain with improved shoulder movement in patients with symptomatic massive tears of the rotator cuff


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_7 | Pages 9 - 9
1 Apr 2014
Marsh A Nisar A El Refai M Meek R Patil S
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When performing total hip replacements in patients with hip dysplasia, acetabular augmentation may be required to prevent early component failure. Preoperative radiographic templating may help estimate acetabularcomponent coverage but has not previously been shown to predict the need for augmentation. We developed a simple method to estimate the percentage of acetabular component coverage from pre-operative radiographs (True: False cup ratio). We aimed to evaluate whether this couldpredict the need foracetabular augmentation at primary total hip replacement for patients with dysplastic hips. We reviewed all patients with hip dysplasia who underwent a primary total hip replacement from 2005–2012. Classification of hip dysplasia (Crowe), centre edge angle (CEA), Sharp and Tonnis angles were determined on pre-operative radiographs for each patient. Templating was performed on anteroposteriorand lateral view hip radiographs to determine the likely percentage of acetabular component coverage using the True: False cup ratio. Patients requiring acetabular augmentation at time of primary total hip arthroplasty were noted. 128 cases were reviewed, 31 (24%) required acetabularaugmentation. Comparison between augmented and non-augmented cases revealed no difference in the mean CEA (p = 0.19), Sharp angles (p = 0.76) or Tonnis angles (p = 0.32). A lower True Cup: False Cup ratio was observed in the augmented groupcompared to the non-augmented group(median = 0.68 vs 0.88, p < 0.01). Preoperative templating can help predict which dysplastic hips are likely to require acetabular augmentation at primary total hip replacement


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 36 - 36
1 Mar 2008
Tan J Kwon B Dvorak M Fisher C Oxland T
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A biomechanical study assessing pedicle screw fixation with three different augmentation methods was performed in human cadaveric vertebrae. Precision opto-electronic measurement of screw motion assessed motion magnitude and patterns, ie translation and/or rotation. Physiological cyclic loads were applied as opposed to the simple pull out test. Augmentation with wires, hook or cement decreased overall motion. There were no significant differences in motion magnitude between the three augmentation methods. Motion patterns for screws with cement augmentation were mainly rotational and differed from the other two methods. Rigid body translations were observed with wires or hook augmentation, suggesting a loosening behaviour. Augmentation with cement resulted in better fixation than wires or hook. Augmentation of loosened pedicle screws in poor quality bone is often necessary. The purpose of this study was to contrast the kinematics of loosened pedicle screws augmented with laminar hooks, sublaminar wires or calcium phosphate cement. Cyclic tests of pedicle screws with compressive force and bending moment were carried out on forty-eight screws in twenty-four cadaveric vertebrae (L3-L5) augmented with hooks, wires or cement. Motion at the screw tip and screw head were measured using an optoelectronic camera system and the magnitudes compared in a paired manner using non-parametric statistics. Motion patterns of the screws were determined for each augmentation method. Augmentation with hook, wire or cement decreased screw motion. There was no significant difference between augmentation methods when the magnitudes of motion, described as ranges and offsets, were compared. Augmentation with cement resulted in mainly rotations of the screws while there were rigid body translations with wires or hooks. Comparing magnitudes of motion at the screw head and screw tip were insufficient. The screw head and screw tip could be moving in synchronous, indicating rigid body translations. Using simple pull out tests would not detect such differences. The method used in this study contrasted pedicle screws motion with different augmentations. While there was no detected significant difference in motion magnitude of the pedicle screws, the motion pattern of the screws suggested better augmentation with cement. Motion of pedicle screws in situ had not been described in the literature. Previous work comparing pedicle screws fixation used the pull out test, while the current method applied physiological loads. Funding: Funding from the Canadian Institutes for Health Research, Funding from Synthes. Spine Please contact author for diagrams and/or graphs


The Bone & Joint Journal
Vol. 99-B, Issue 4 | Pages 445 - 450
1 Apr 2017
Marsh AG Nisar A El Refai M Patil S Meek RMD

Aims. The purpose of this study was to evaluate whether an innovative templating technique could predict the need for acetabular augmentation during primary total hip arthroplasty for patients with dysplastic hips. Patients and Methods. We developed a simple templating technique to estimate acetabular component coverage at total hip arthroplasty, the True Cup: False Cup (TC:FC) ratio. We reviewed all patients with dysplastic hips who underwent primary total hip arthroplasty between 2005 and 2012. Traditional radiological methods of assessing the degree of acetabular dysplasia (Sharp’s angle, Tönnis angle, centre-edge angle) as well as the TC:FC ratio were measured from the pre-operative radiographs. A comparison of augmented and non-augmented hips was undertaken to determine any difference in pre-operative radiological indices between the two cohorts. The intra- and inter-observer reliability for all radiological indices used in the study were also calculated. Results. Of the 128 cases reviewed, 33 (26%) needed acetabular augmentation. We found no difference in the median Sharp’s angle (p = 0.10), Tönnis angle (p = 0.28), or centre-edge angle (p = 0.07) between the two groups. A lower TC:FC ratio was observed in the augmented group compared with the non-augmented group (median = 0.66 versus 0.88, p <  0.001). Intra-observer reliability was found to be high for all radiological indices analysed (interclass correlation coefficient (ICC) > 0.7). However, inter-observer reliability was more variable and was only high for the TC: FC ratio (ICC > 0.7). Conclusion. The TC: FC ratio gives an accurate estimate of acetabular component coverage. It can help predict which dysplastic hips are likely to need acetabular augmentation at primary total hip arthroplasty. It has high intra- and inter-observer reliability. Cite this article: Bone Joint J 2017;99-B:445–50


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 156 - 157
1 Apr 2005
Mountney J Paice M Greidanus N Wilson D Masri B
Full Access

Purpose To evaluate the kinetic and kinematic function of a new trabecular metal augmentation patella. Method Eight frozen human cadaveric knees (mean age 68 years) were prepared for an “Oxford type” knee rig. Alignment ands offset were addressed and the soft tissue envelope kept as intact as possible. A load cell was introduced into the extensor mechanism. Femoral, patella and tibial motion were assessed using the Optotrak system. Summary of Results The mean, maximum extensor mechanism force in extension for the TKA group as compared to the patelloplasty group (p=0.0000032), reduced to near normal with the augmentation patella (p=0.198). The mean, maximum patella maltracking in extension for the TKA group as compared to the patelloplasty group (p=0.025), reduced to near normal with the augmentation patella (p=0.301). Conclusion Investigating the force through the extensor mechanism, we found a statistically significant difference between the TKA before and after patelloplasty, which was abolished by the insertion of the augmentation patella. Investigation patella tracking, we found a statistically significant difference between the TKA before and after patelloplasty, that was rectified by the insertion of the augmentation patella


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_1 | Pages 58 - 58
1 Jan 2017
Varga P Jenni D Inzana J Gueorguiev B Blauth M Windolf M
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The high risk and the associated high mortality of secondary, contralateral hip fractures [1,2] could justify internal, invasive prophylactic reinforcement of the osteoporotic proximal femur to avoid these injuries in case of a low energy fall. Previous studies have demonstrated high potential of augmentation approaches [3,4,5], but to date there has no ideal solution been found. The development of optimized reinforcement strategies can be aided with validated computer simulation tools that can be used to evaluate new ideas. A validated non-linear finite element (FE) simulation tool was used here to predict the yield and fracture load of twelve osteoporotic or osteopenic proximal femora in sideways fall based on high resolution CT images. Various augmentation strategies using bone cement or novel metal implants were developed, optimized and virtually performed on the bone models. The relative strengthening compared to the non-augmented state was evaluated using case-specific FE analyses. Strengthening effect of the cement-based augmentation was linearly proportional to cement volume and was significantly affected by cement location. With the clinically acceptable 12.6 ± 1.2 ml volume and optimized location of the cement cloud, compared to the non-augmented state, 71 ± 26% (42 – 134%) and 217 ± 166% (83 – 509%) increase in yield force and energy was reached, respectively. These were significantly higher than previously published experimental results using the “central” cement location [5], which could be well predicted by our FE models. The optimized metal implant could provide even higher strengthening effect: 140 ± 39% (76 – 194%) increase in yield force and +357 ± 177% (132 – 691%) increase in yield energy. However, for metal implants, a higher risk of subcapital fractures was indicated. For both cement and metal, the originally weaker bones were strengthened exponentially more compared to the stronger ones. The ideal solution for prophylactic augmentation should provide an appropriate balance between the requirements of being clinically feasible, ethically acceptable and mechanically sufficient. Even with the optimized location, the cement-based approach may not provide enough strengthening effect and adequate reproducibility of the identified optimal cement cloud position may not be achieved clinically. While the metal implant based strategy appears to be able to deliver the required strengthening effect, the ethical acceptance of this more invasive option is questionable. Further development is therefore required to identify the ideal, clinically relevant augmentation strategy. This may involve new cement materials, less invasive metal implants, or a combination of both. The FE simulation approach presented here could help to screen the potential ideas and highlight promising candidates for experimental evaluation


The Bone & Joint Journal
Vol. 98-B, Issue 5 | Pages 703 - 709
1 May 2016
Kim Y Kang HG Kim JH Kim S Lin PP Kim HS

Aims. The purpose of the study was to investigate whether closed intramedullary (IM) nailing with percutaneous cement augmentation is better than conventional closed nailing at relieving pain and suppressing tumours in patients with metastases of the femur and humerus. Patients and Methods. A total of 43 patients (27 men, 16 women, mean age 63.7 years, standard deviation (. sd. ) 12.2; 21 to 84) underwent closed IM nailing with cement augmentation for long bone metastases. A further 27 patients, who underwent conventional closed IM nailing, served as controls. Pain was assessed using a visual analogue scale (VAS) score pre-operatively (pre-operative VAS), one week post-operatively (immediate post-operative VAS), and at six weeks post-operatively (follow-up post-operative VAS). Progression of the tumour was evaluated in subgroups of patients using F-18-fludeoxyglucose (F-18-FDG) positron emission tomography (PET)/computed tomography (CT) and/or bone scintigraphy (BS), at a mean of 8.8 and 7.2 months post-operatively, respectively. Results. The mean pain scores of patients who underwent closed nailing with cement augmentation were significantly lower than those of the control patients post-operatively (immediate post-operative VAS: 3.8, . sd. 0.9 versus 6.0, . sd. 0.9; follow-up post-operative VAS: 3.3, . sd. 2.5 versus 6.6, . sd. 2.2; all p < 0.001). The progression of the metastasis was suppressed in 50% (10/20) of patients who underwent closed nailing with augmentation, but in only 8% (1/13) of those in the control group. Conclusion. Percutaneous cement augmentation of closed IM nailing improves the relief of pain and limits the progression of the tumour in patients with metastases to the long bones. Take home message: Percutaneous cement augmentation while performing closed IM nailing has some advantages for long bone metastases. Cite this article: Bone Joint J 2016;98-B:703–9


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_1 | Pages 107 - 107
1 Jan 2017
Danesi V Tozzi G Soffiatti R Cristofolini L
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Prophylactic augmentation is meant to reinforce the vertebral body (VB), but in some cases it is suspected to actually weaken it. To elucidate the biomechanical efficacy of prophylactic augmentation, the full-field three-dimensional strain distributions were measured for the first time inside prophylactic-augmented vertebrae. Twelve thoracic porcine vertebrae were assigned to three groups: 4 were augmented with bone cement for vertebroplasty (Mendec-Spine, Tecres), 4 were treated with another bone cement for vertebroplasty (Calcemex-Spine, Tecres) while the other 4 were tested untreated as a control. Destructive tests were carried out under axial compression, in a step-wise fashion (unloaded, 5%, 10% and 15% compression). At each loading step, μCT-images were acquired. The internal strain distribution was investigated by means of DVC analysis. Some augmented specimens were stronger than the respective control, while others were weaker. In most of the specimens, the strain distribution in the elastic regime (5% compression) seemed to predict the location of the micro-damage initiation before it actually became identifiable (at 10% and 15% compression). The measured strain had the same order of magnitude for all groups. However, in the control vertebrae, the highest strain would unpredictably appear at any location inside the VB. Conversely, for both augmentation groups, the highest strains were measured in the regions adjacent to the injected cement mass, whereas the cement-interdigitated-bone was less strained. Localization of high strains and failure was consistent between specimens, but different between the two cement types: with Mendec-Spine failure the highest strains were mainly localized at mid-height and at the same level where the cement mass was localized; with Calcemex-Spine failure the highest strains were mainly cranial and caudal to the cement mass. Both the micro-CT images, and the DVC strain analysis highlighted that:. The cement mass was less strained than any other regions in the vertebra. Failure never started inside the cement mass. This can be explained with the additional stiffening and reinforcement associated with the infiltration of the cement inside the trabecular bone. The highest strains and failure were localized in the bone adjacent to the cement-bone interdigitated region. This can be explained by the strain concentration between the cement-interdigitated bone (stiffer and stronger), and the adjacent non-augmented trabecular bone. The strain maps in the elastic regime and the localization of failure was different in the augmented vertebrae, when compared to the natural controls. This suggests an alteration of the load sharing in the augmented structure where the load is mostly carried by the cement region. The different localization of failure initiation between the two augmented groups could be explained by the different mechanical properties of the two cements. This study has demonstrated the potential of DVC in measuring the internal strain and failure in prophylactic-augmented vertebrae. It has been shown that failure starts inside the augmented VB, next to the injected cement mass. This can help establishing better criteria (in terms of localization of the cement mass) in order to improve clinical protocols for vertebroplasty surgical procedures


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_20 | Pages 1 - 1
1 Apr 2013
Velpula J Thibbaiah M Ferandez R Anand Pimpalnerkar A
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Treatments of Chronic Acromioclavicular joint dislocation are controversial. Many procedures have been described in the past for the management of them. Treatment modalities have changed with increasing understanding of the nature of the problem, patient expectations and the biomechanics of the joint. Aim. To assess the functional outcome of the chronic AC joint dislocations treated by modified Weaver-Dunn procedure combined with Acromioclavicular joint augmentation. Material and methods. We treated 54 patients with chronic AC joint dislocation by modified Weaver-Dunn procedure with additional AC joint augmentation. We used tight rope system in 20 patients, Mersilene tape in 22 patients and no 5 Ethibond in 12 patients. Results. This Study was done between Jan 2003 to Jan 2012. Mean follow up was 20 months, mean age of the patients was 35, and male to female distribution was 48:6. We assessed them clinically and radio logically during their follow up. All patients were back to their occupation. 80% are back to their pre injury sporting activity level. The mean Disabilities of the Arm, Shoulder, and Hand (DASH) score was 10.2 points. One patient had a failure of augmentation device. Conclusion. Our study shows that chronic symptomatic AC joint dislocations, (Rockwood types III to V) Managed with modified modified Weaver-Dunn procedure with augmentation are showing good short term results. Significant improvement in the patient satisfaction, early return to work and radiological appearance


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_12 | Pages 8 - 8
1 Mar 2013
Velpula J Gajula P Thibbaiah M Ferandez R Anand A Pimpalnerkar A
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Treatments of Chronic Acromioclavicular joint dislocation are controversial. Many procedures have been described in the past for the management of them. Treatment modalities have changed with increasing understanding of the nature of the problem, patient expectations and the biomechanics of the joint. To assess the functional outcome of the chronic AC joint dislocations treated by modified Weaver-Dunn procedure combined with Acromioclavicular joint augmentation. We treated 54 patients with chronic AC joint dislocation by modified Weaver-Dunn procedure with additional AC joint augmentation. We used tight rope system in 20 patients, Mersilene tape in 22 patients and no 5 Ethibond in 12 patients. This Study was done between Jan 2003 to Jan2012. Mean follow up was 20 months, mean age of the patients was 35, and male to female distribution was 48:6. We assessed them clinically and radio logically during their follow up. All patients were back to their occupation. 80% are back to their pre injury sporting activity level. The mean Disabilities of the Arm, Shoulder, and Hand (DASH) score was 10.2 points. One patient had a failure of augmentation device. Our study shows that chronic symptomatic AC joint dislocations, (Rockwood types III to V,) Managed with modified modified Weaver-Dunn procedure with augmentation are showing good short term results. Significant improvement in the patient satisfaction, early return to work and radiological appearance


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_15 | Pages 67 - 67
1 Nov 2018
Juhdi A Abdulkarim A Harrington P
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The treatment of massive chronic tears is problematic. The re-tear rate following surgery for extensive cuff tears remains high, and there is little consensus regarding optimum treatment. To investigate the outcome of a cohort of patients who had open repair of an extensive cuff tear using the Leeds Kuff patch as an augment. A retrospective cohort study of consecutive patients with a massive cuff tear who had surgery in our regional elective orthopaedic centre over a two year period from January 2015 to Dec 2016. All patients followed identical rehabilitation protocols, supervised by physiotherapists with an interest in the shoulder. Outcomes assessment was undertaken at a minimum of 12 months by a registrar or physiotherapist who was not part of the treating team. Pre-op data collection included; range of motion, pain score, Oxford shoulder score (OSS), assessment of muscle atrophy on MRI. Data collection was completed in 15 patients. The mean age was 62 yrs (56 – 75). The mean pre-op OSS was 22, improving to a mean of 43. The range of motion and pain score improved. There were no intra-operative complications. One patient required a second surgery for evacuation of a haematoma at 10 days post op. One patient had an obvious re-tear at 4 months. Open rotator cuff repair with synthetic Kuff patch augmentation for chronic degenerative tears appears worthwhile when assessed at 12 months and they continuous to improve even at 18 months. This treatment method may be a useful option for patients > 70 years old


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 412 - 413
1 Sep 2009
Kwong Y Desai V
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Introduction: The indications for patellectomy have been considerably narrowed in recent years, but there remains a cohort of patients with previous patellectomies that remain symptomatic. In addition, these patients can develop osteoarthrosis or instability, and their treatment is challenging. We report our experience of the use of a novel implant to substitute for the absent native patella. Materials and Methods: Six patients were treated with the Augmentation Patella (Zimmer, Allendale, USA), which was sutured to the patellar tendon. All 6 patients had previously had a patellectomy for anterior knee pain syndrome or chondromalacia patellae, between 5 and 22 years previously. They all had an arthroscopy to document the extent of degenerative changes. Patients with trochlear changes only had the trochlea resurfaced (4 cases) and those with tibio-femoral changes as well had a total knee replacement (2 cases). Results: One patient reported excellent relief of pain, with no evidence of radiological loosening. Two patients continued to complain of pain despite the implant being solidly fixed. One patient developed wound complications secondary to difficult closure due to the bulk of the implant. In two patients, the implant loosened within 15 months necessitating further surgery to retrieve the Augmentation Patella. Discussion: The results of the Augmentation Patella in our series of patients with previous patellectomies have been disappointing. Previous studies, where this implant has been used with a remaining shell of patella, has yielded better results. This suggests that bony ingrowth is important for a successful outcome. We recommend that this device should only be implanted if bony contact is possible


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 255 - 255
1 Sep 2012
Moroni A Hoque M Micera G Sinapi F Calbucci L Maccagnan E Giannini S
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Introduction. Metal-on-metal hip resurfacing (MOMHR) is a good surgical indication for young active patients. However, it cannot be used in patients with an excessively short femoral head/neck. To address these cases, a new surgical technique has been developed comprising femoral head augmentation using impacted morcellized bone grafts. Methods. 32 osteoarthritis patients who had severe congenital insufficiency of the femoral head/neck were treated with MOMHR combined with femoral head augmentation. Mean patient age was 49 ± 9 years (18–66). The required amount of augmentation was calculated on preoperative X-rays and confirmed during surgery. Using specially designed instrumentation, bone chips produced while reaming the socket and trimming the head were impacted onto the head to achieve the desired reconstruction and lengthening. Finally, the femoral component was cemented. Results. Mean head lengthening was 12 ± 2mm. Mean follow-up was 4.2 years (3–6). Mean preoperative Harris hip score was 58, increasing to 95 at follow-up (p<0.05). Mean leg lengthening was 2.2cm (p=0.001). In all Gruen zones, bone mineral density (BMD) decreased during the first 3 months. At 2 years, in zone 1, mean BMD increased to 96.8% (p=0.009) and to 102.1% in zone 7 (p=0.05). A correlation was found between valgus positioning of the femoral components and increased BMD (p=0.005). To date, only 1 patient has been revised due to socket loosening. Discussion and conclusions. This bone grafting technique expands the use of MOMHR to patients with severe deficiencies of the femoral head, thereby leading to a more anatomical reconstruction with a full recovery of function and BMD of the proximal femur


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 172 - 172
1 May 2011
Moroni A Hoque M Micera G Orsini R Samy A Giannini S
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Metal-on-metal hip resurfacing (MOMHR) is a good surgical indication for young active patients. However, it cannot be used in patients with severe CDH and in particular a too short head/neck. To address these cases, a new surgical technique consisting of augmentation of the femoral head with impacted morcellized bone grafts has been developed. 32 osteoarthritis patients following severe congenital insufficiency of the femoral head/neck were treated with MOMHR combined with femoral head augmentation. The required amount of augmentation was calculated on preoperative X-rays and confirmed during surgery. Using special instrumentation, bone chips produced while reaming the socket and trimming the head were impacted on the head to achieve the desired reconstruction and lengthening. Finally, the femoral component was cemented. Mean patient age was 49+ 9 years (18–66). Median head lengthening was 12+ 2 mm. Mean follow up is 4.2 years (3–6). Mean preoperative Harris hip score (HHS) was 58 and at follow-up 95 (p < 0.05). Mean leg lengthening was 2.2 cm (p = 0.001). In all Gruen zones, bone mineral density (BMD) decreased during the first 3 months. At 2 years in zone 1 mean BMD increased to 96.8% (p = 0.009) and in zone 7 to 102.1% (p = 0.05). A correlation was found between valgus positioning of the femoral components and increased BMD (p = 0.005). This impaction bone grafting technique expands the use of MOMHR to patients with severe congenital hip dysplasia leading to a more anatomical reconstruction with a full recovery of function and BMD


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLII | Pages 2 - 2
1 Sep 2012
Piper D Halliday R Murray J Porteous A Robinson J
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Separation of the ACL into anteromedial (AM) and posterolateral (PL) fibre bundles has been widely accepted. The bundles act synergistically to restrain anterior laxity throughout knee flexion, with the PL bundle providing the more important restraint near extension and its obliquity better restraining tibial rotational laxity. 10% of ACL injuries involve isolated rupture to one of these bundles causing patients to present with instability symptoms or pain. As knowledge about the influence of the ACL bundles on knee kinematics has increased, isolated reconstruction of either PL or AM bundle has been advocated. However only one cohort study of 17 patients has been presented in the clinical literature. KOOS (Knee Injury and Osteoarthritis Outcome Score) and IKDC (International Knee Documentation Committee Form) scores at 1yr post op were obtained for 12 patients who had undergone isolated ACL augmentation between 2007 and 2009. These were compared with previously published outcome scores for standard ACL reconstruction procedures. In addition examination under anaesthesia (EUA) assessments were analysed to see if a pattern of laxity for isolated AM and PL rupture could be determined. There were 5 patients with isolated AM bundle rupture and 7 with isolated PL bundle rupture. EUA analysis demonstrated that patients with isolated PL bundle rupture had increased pivot shift and Lachman test laxity, whereas the AM bundle rupture group had increased laxity with the anterior drawer test. Compared to previously published IKDC scores, there were no difference between isolated bundle augmentation and standard ACL reconstruction. However the KOOS scores showed significantly increased Sports function scores which was significantly better in the isolated bundle augmentations (93/100 v's 74/100). Differences between isolated AM and PL bundle reconstructions were not distinguishable. Isolated ACL bundle tears make up a significant proportion ACL injuries. Although technically more difficult than standard ACL reconstruction, isolated bundle augmentation appears to result in improved sports function when compared to standard ACL reconstruction


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_8 | Pages 29 - 29
1 Aug 2020
Wong I Oldfield M
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The primary objective of this study was to establish a safety profile for an all-arthroscopic anatomic glenoid reconstruction via iliac crest autograft augmentation for the treatment of shoulder instability with glenoid bone loss. Short-term clinical and radiological outcomes were also evaluated. This study involved a retrospective analysis of prospectively collected data for 14 patients (male 8, female 6) who were treated for shoulder instability with bone loss using autologous iliac crest bone graft between 2014 and 2018. Of 14 patients, 11 were available for follow-up. The safety profile was established by examining intra-operative and post-operative complications such as neurovascular injuries, infections, major bleeding, and subluxations. Assessment of pre-operative and post-operative Western Ontario Shoulder Instability (WOSI) index, radiographs, and CT scans comprised the evaluation of clinical and radiological outcomes. A good safety profile was observed. There was no occurrence of intraoperative complications, neurovascular injuries, adverse events, or major bleeding. One patient did develop an infection in the neurovascular injuries, adverse events, or major bleeding. One patient did develop an infection in the treated shoulder post-surgery. There were no subluxations or positive apprehension tests on clinical examination post-operatively. Short-term clinical outcomes were seen to be favorable WOSI scores at the most recent follow-up were significantly higher than pre-operative scores, with a mean increase of 39.6 ± 10.60 (p = 0.00055). The average follow-up for CT scan was 4.66 (SD± 2.33) months, where all patients showed bone graft union. Arthroscopic treatment of shoulder instability with bone loss via autologous iliac crest bone graft is shown to be a safe operative procedure that results in favorable short-term clinical and radiological outcomes. Further investigations must be done to evaluate the longevity of these positive health outcomes


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 460 - 460
1 Oct 2006
Goss B Aebli N Ferguson S Williams R Krebs J
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Introduction Reported clinical results suggest that vertebroplasty is a safe and effective technique for providing pain relief. However, information about the long-term effect of PMMA on the adjacent intervertebral discs and the augmented bone is lacking. Adjacent intervertebral discs may be at higher risk of degeneration due to nutritional constraints. Bone loss in augmented vertebrae may occur due to mechanical stress-shielding or toxicological effects. The aim of the present study was therefore to investigate the effect of PMMA augmentation on intervertebral disc and bone tissue after 6 and 12 months, using an animal model. Methods In 12 skeletally mature sheep, 2.0ml PMMA (Simplex P) was injected into three lumbar vertebrae (approved by Animal Ethics Committee). Two injection holes were drilled into the middle of three vertebrae at a distance of 5.0mm from the cranial and caudal endplate and 1.0ml PMMA was injected into each hole. Four weeks before euthanasia, animals received an injection of tetracycline for bone labeling. Postmortem, T1- and T2-weighted sagittal and axial MR images were taken prior to fixation in 80% ethanol. Spines were cut into specimens containing one intervertebral disc and half of the two adjacent vertebrae. The discs which were two levels above the first augmented vertebra served as controls. Microsections were stained with H& E, Goldner, Alcian blue-PAS and Safranin O. MRI signal intensity and morphology of discs were evaluated qualitatively. Histomorphological analysis of discs and endplates was conducted using published criteria [. 1. ]. Presence of bone remodeling, fibrous tissue and foreign body reaction in the vertebrae was also recorded. Results There was no distinguishable loss of MRI signal intensity in the discs in between augmented vertebrae. Cement injection resulted in blocking 50–75% of the endplate lengths. Most discs that were in between augmented vertebrae showed signs of degeneration (chondrocyte proliferation, necrosis) after 6 (80%) and 12 months (88%). Inflammatory reaction to PMMA was observed in some specimens (approximately 25%). Cement had been covered with fibrous tissue in all augmented vertebrae, but tetracycline labeling revealed new bone formation in the vicinity of PMMA. Discussion Augmentation of three adjacent vertebrae initiated degenerative changes of intervertebral discs in between two augmented vertebrae. This is in contrast to previous animal studies [. 2. ] where no degenerative changes after cementing endplates were observed. Current investigations were performed with the specific aim to block the endplates. Clinically, endplates may not get blocked as effectively. On the other hand, discs in older patients are nutritionally constrained due to end-plate calcification and even partial blockage may lead to degenerative changes as documented presently. The risk of degenerative changes of intervertebral discs should be considered in patients undergoing vertebroplasty


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 20 - 20
1 Dec 2016
Amar E Dillman D Smith B Coady C Wong I
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Background: The results of arthroscopic anterior labral (Bankart) repair have been shown to have high failure rate in patients with significant glenoid bone loss. Several reconstruction procedures using bone graft have been described to overcome the bone loss, including autogenous coracoid transfer to the anterior glenoid (Latarjet procedure) as well as iliac crest autograft and tibial allografts. In recent years, trends toward minimally invasive shoulder surgery along with improvements in technology and technique have led surgeons to expand the application of arthroscopic treatment. Purpose: This study aims to perform a retrospective analysis of prospectively collected data to evaluate the clinical and radiological follow up of patient who underwent anatomic glenoid reconstruction using distal tibia allograft for the treatment of shoulder instability with glenoid bone loss at 1-year post operation time point. Between December 2011 and January 2015, 55 patients underwent arthroscopic stabilisation of the shoulder by means of capsule-labral reattachment to glenoid ream and bony augmentation of glenoid bone loss with distal tibial allograft for recurrent instability of the shoulder. Preoperative and postoperative evaluation included general assessment by the western Ontario shoulder instability index (WOSI) questionnaire, preoperative and postoperative radiographs and CT scans. Fifty-five patients have been evaluated with mean age of 29.73 years at time of the index operation. There were 40 males (mean age of 29.66) and 15 female (mean age of 29.93). Minimum follow up time was 12 months. The following adverse effects were recorded: none suffered from recurrent dislocation, 2 patients suffered from bone resorption but without overt instability, 1 patient had malunion due to screw fracture, None of the patients had nonunion. The mean pre-operative WOSI score was 36.54 and the mean postoperative WOSI score was 61.0. Arthroscopic stabilisation of the shoulder with distal tibia allograft augmentation demonstrates promising result at 1year follow up


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLIV | Pages 76 - 76
1 Oct 2012
Song E Seon J Kang K Park C Yim J
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This prospective study was undertaken to compare the clinical and radiological results and the in vivo stabilities of anteromedial (AM) and posterolateral (PL) bundle augmentation during anterior cruciate ligament (ACL) reconstruction. Forty-two ACL partial tears that underwent isolated bundle augmentation (22 AM and 20 PL bundles) were evaluated with a minimum follow-up of 1 year. For in vivo intraoperative stability testing, anteroposterior and external/internal rotation stabilities were measured at 0, 30, 60, and 90° of flexion using a navigation system. Ranges of motion, Lachman and pivot shift test results, Tegner activity scores, and Lysholm knee scores of the AM and PL bundle groups were compared. In addition, Telos arthrometer determined stabilities were compared. In-vivo intraoperative stability testing showed that mean preoperative anterior translation at 30° of flexion was greater in the AM group (8.7 vs. 6.5, p = 0.04), whereas mean rotational amount was larger in the PL group (by 2.9 at 0° and 3.6 at 30° of flexion). After ACL reconstruction, no significant differences were found between the two groups in terms of anterior and rotational stabilities at any flexion angle. Furthermore, clinical outcomes in the two groups were not significantly different. Lachman and pivot shift test results and instrumented laxity findings were similar for the two groups at final follow up. In this study, the authors carefully preserved the remnant injured ACL, and achieved excellent anterior stability recoveries and good rotatory stabilities. No significant intergroup difference was found in terms of intraoperative stability or clinical parameters after ACL reconstruction