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Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 256 - 257
1 Jul 2008
LANGLAIS F BELOT N ROPARS M LAMBOTTE J THOMAZEAU H
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Purpose of the study: Revision total knee arthroplasty with major destruction of bone and ligament tissue raises the problem of choosing between a complex reconstruction with a semi-constrained prosthesis or a much more simple procedure using a hinged prosthesis which transmits all of the stress to the bone anchors. The choice is basically one of longevity of the bony fixation of these constrained prostheses (and the deterioration of the articulated pieces). The present work reports the long-term outcome observed with constrained hinged prosthesis with a cemented press-fit stem implanted for bone tumors where the stress is even greater than for revisions.

Material and methods: The series included 32 prostheses implanted in young active subjects (mean age 33 years). A hinged, non-rotating Guepar II revision prosthesis was implanted. The part of the implant corresponding to the reconstruction after tumor resection was custom-made but the part implanted in «healthy» bone (for example the tibial piece in a patient with a femoral tumor) was the same as used for revisions prostheses inserted after loosening. On the healthy side, press-fit quadrangular stems were used, generally adapted to the endosteum by reaming. The prosthesis was fixed by simple mechanical adjustment before cementing, using the French paradox system (JBJS 2003). Before 1993, a metal-polyethylene bearing was used and after 1993 a metal-on-metal bearing without inserts.

Results: Among the 32 patients with a malignant tumor, 19 survived, seven with 2–10 years follow-up and 12 with 10–21 years follow-up. For the overall series, there was only one case of osteolysis on a tibial tumor which was revised at 12 years. There was one infection (hematogeneous) at 21 years (antibiotic cement). Prostheses with polyethylene inserts produced laxities or synovitis with 50% requiring synovectomy and insert replacement. There were no cases of synovitis for the metal-on-metal bearings. Two stems (inserted in adolescents) were too thin and had to be changed because of fracture without loosening.

Discussion: Prosthesis survival was 88% at ten years (1 osteolysis, 2 fractures on tumor), even for the constrained prostheses, even for young and active subjects.

Conclusion: The very good longevity of cemented pressfit stems (and the absence of synovitis and osteolysis with metal-on-metal bearings, and the low rate of infection) should be kept in mind as a possible alternative to very complex and possibly less predictable procedures in the presence of certain very severe loosenings with bone and ligament destruction.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 3 | Pages 335 - 341
1 Mar 2007
Albert J Meadeb J Guggenbuhl P Marin F Benkalfate T Thomazeau H Chalès G

In a prospective randomised trial of calcifying tendinitis of the rotator cuff, we compared the efficacy of dual treatment sessions delivering 2500 extracorporeal shock waves at either high- or low-energy, via an electromagnetic generator under fluoroscopic guidance. Patients were eligible for the study if they had more than a three-month history of calcifying tendinitis of the rotator cuff, with calcification measuring 10 mm or more in maximum dimension. The primary outcome measure was the change in the Constant and Murley Score.

A total of 80 patients were enrolled (40 in each group), and were re-evaluated at a mean of 110 (41 to 255) days after treatment when the increase in Constant and Murley score was significantly greater (t-test, p = 0.026) in the high-energy treatment group than in the low-energy group. The improvement from the baseline level was significant in the high-energy group, with a mean gain of 12.5 (−20.7 to 47.5) points (p < 0.0001). The improvement was not significant in the low-energy group. Total or subtotal resorption of the calcification occurred in six patients (15%) in the high-energy group and in two patients (5%) in the low-energy group.

High-energy shock-wave therapy significantly improves symptoms in refractory calcifying tendinitis of the shoulder after three months of follow-up, but the calcific deposit remains unchanged in size in the majority of patients.


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 8 | Pages 1022 - 1026
1 Aug 2006
Langlais F Belot N Ropars M Lambotte JC Thomazeau H

We evaluated the long-term fixation of 64 press-fit cemented stems of constrained total knee prostheses in 32 young patients with primary malignant bone tumours. Initial stable fixation, especially in rotation, was achieved by precise fit of the stem into the reamed endosteum, before cementation. Complementary fixation, especially in migration and rotation, was obtained by pressurised antibiotic-loaded cement. The mean age at operation was 33 years (13 to 61). No patient was lost to follow-up; 13 patients died and the 19 survivors were examined at a mean follow-up of 12.5 years (4 to 21). Standard revision press-fit cemented stems were used on the side of the joint which was not involved with tumour (26 tibial and six femoral), on this side there was no loosening or osteolysis and stem survival was 100%. On the reconstruction side, custom-made press-fit stems were used and the survival rate, with any cause for revision as an end point, was 88%, but 97% for loosening or osteolysis. This longevity is similar to that achieved at 20 years with the Charnley-Kerboull primary total hip replacement with press-fit cemented femoral components.

We recommend this type of fixation when extensive reconstruction of the knee is required. It may also be suitable for older patients requiring revision of a total knee replacement or in difficult situations such as severe deformity and complex articular fractures.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 137 - 137
1 Apr 2005
Langlais F Portillo M Lambotte J Ropars M Thomazeau H
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Purpose: A consecutive series of 32 metaphyseal locked hydroxyapatite coated stems were reviewed at a maximum 5 years to analyse the effect of the type of distal (diaphyseal) and proximal (metaphyseal) fixation on clinical and radiological outcome (distal shaft fixation: tight or moderate; hydroxyapatite coating: complete or limited to metaphysic; approach: window or endofemoral).

Material and methods: Stems were used to treat femoral osteolysis (35% SOFCOT stage III and IV femoral loosening) with significant acetabular osteolysis (59% segmentary osteolysis and 47% revisions with structural allografts). Nineteen stems were implanted with a femoral window and 13 via endofemoral access. Twenty-six were screw locked. To study the effect of the type of fixation on clinical and radiographic outcome, we studied metaphyseal “regeneration”, and intraoperative diaphyseal anchorage. Anchorage was considered tight when the endosteum and the stem were in contact over at least 40 mm, and the difference in diameter between the stem and the endosteum was 1 mm or less. Anchorage was considered moderate when the height of contact was less than 40 mm and the endosteumstem difference in diameter was greater than 2 mm.

Results: The results were encouraging, with a clinical score (PMA) of 15/18, and stable diaphyseal fixation of the prosthesis in 31 hips (one migration of about 1 cm with secondary blockage in one non-locked stem). There were few complications: no infections, one isolated dislocation, one screw fracture, but three replacements of overly long stems, one trochanteric non-union which was not reoperated. In 22 hips with more than one year follow-up, shaft fixation of the stem was complete (no osteolytic lucent line), and a line of bone densification (particularly in hips with less solid anchorage) was seen in ten hips. There appeared to be bone regeneration around the hydroxy-apatite metaphysis in 50% of the cases. There were no cases of secondary osteolysis. This “regeneration” did not appear to be different after window or endofemoral replacement. It was the same with tight (63% of hips) or moderate anchorage. There was no stress shielding even when the distal stem was coated with hydroxyapatite.

Conclusion: It appears that good results can be obtained at mid-term with this type of prosthesis using a short distal (60 mm) fixation, limiting the diaphyseal escalation and requirement for femoral window.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 66 - 66
1 Jan 2004
Langlais F Dréano T Sevestre F Thomazeau H Collin P Aillet S
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Purpose: Reconstruction using a revascularised fibula has advantages in terms of remodelling the transplant to the stress forces and of better resistance against infections. Osteosynthesis offers mechanical advantages (stabilisaton facilitating primary and stress fracture healing) but with the risk of preventing hypertrophy of the fibula which is not exposed to the stress forces.

Material and methods: Our series of 25 vascularised fibular transfers (maximum follow-up 15 years) concerned post-trauma tissue loss (11 cases) and tumour resections (14 cases). For this study of remodelling, we retained only oncological reconstructions because in the event of trauma sequelae, many factors can interfer (infection, preservation of the homolateral fibula with tibial tissue loss). None of the patients were lost to follow-up and remodelling was assessed at two years or more.

Results: There was one failure requiring leg amputation (infected nonunion of the distal tibia on a radiated osteo-sarcoma). All the other fibulae healed. Three metaphyseal resections of the distal femur were assembled with a lateral plate using the fibula as a medial strut under compression. This type of assembly favours remodelling and excellent results were obtained in three cases. Five arthrodeses of the knee were performed using a fibula with a femorotibial nail. Healing was slow and the fibula thickened little, particularly when it was simply apposed on the tutor (three cases) rather than encased under compression (two cases). For five proximal humeri, use of a thin plate in three cases (forearm plate) was sufficient to allow healing without inhibiting remodelling.

Discussion: For the lower limb, good remodelling is obtained with an assembly allowing compression of the fibula placed medially to the shaft alignment. For metaphyseal loss, we advise a lateral plate with a fibular strut medially. For arthrodesis, a nail is probably more prudent. The position of the lateral tutor decreases the stress on the fibula and is recommended less than the medial strut position. For the humerus, synthesis is required but may be minimal to allow optimal remodelling.

Conclusion: Vascularised fibula transfer is a reliable technique which can be recommended for major resections (mean 160 mm) in active subjects. Axial compression forces applied to the graft and use of light osteosynthesis appear to favour healing and remodelling.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 38 - 38
1 Jan 2004
Collin P Brasseur P Lambotte J Thomazeau H Nguyen Q Langlais F
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Purpose: A spacer can be used for two-phase replacement of an infected total hip prosthesis. The goal is to facilitate reimplantation by avoiding soft tissue retraction. Several types of spacers can be used. We searched for a spacer which avoids wear debris due to methacrylate friction against bone, delivers a local antibiotic, is easily removed, and does not worsen bone damage. Since 1995, we have used a Charnley Kerboull type prosthesis as a spacer. The purpose of the present study was to 1) verify the absence of spacer-related complications, 2) assess outcome in terms of cure of infection and improved function.

Material and methods: We used 14 articulated spacers for two-phasee prosthesis replacement in nine men and five women, mean age 64 years. Erythrocyte sedimentation rate was 32 and C-reactive protein was 17. The mean Postel-Merle d’Aubigné (PMA) score was 3+5+2. All patients were reviewed at a minimum 37 months follow-up. Technique: The approach was generally a digastric trochanterotomy, associated with a more or less extensive femoral procedure (depending on the length of the plug to remove) to achieve removal of all implants and cement. A small-size polyethylene cup was inserted with cement delivering at least one antibiotic on a Surgicel bed to facilitate later extraction. A long small-diameter femoral stem was then inserted (bridging the femoral window) and blocked with cement, also on a Surgicel bed. Partial then total weight bearing was authorised between the phases.

Results: There were no dislocations. All patients achieved total weight bearing between the two phases. The same germ identified at the first operation was also identified at the second in two patients, requiring prolonged antibiotic therapy. There was one septic failure, in a different patient. The mean PMA score was 5.7+5.8+5.2.

Conclusion: This technique avoids methacrylate wear induced by classical spacers and does not modify polymorphonuclear chemotactism, facilitating the efficacy of medical treatment. Patient comfort is also improved between the two phases and muscle atrophy, which could compromise long-term function, is avoided.


The Journal of Bone & Joint Surgery British Volume
Vol. 85-B, Issue 4 | Pages 510 - 516
1 May 2003
Langlais F Lambotte JC Collin P Langlois F Fontaine JW Thomazeau H

We used a trochanteric slide osteotomy (TSO) in 94 consecutive revision total hip arthroplasties (90 with replacement of both the cup and stem). This technique proved to be adequate for removing the components, with few complications (two minor fractures), and for implanting acetabular allografts (18%) and reinforcement devices (23%). Trochanteric union was obtained in most patients (96%), even in those with septic loosening (18/19), major femoral osteolysis (32/32), or previous trochanteric osteotomy (17/18). TSO is versatile, since it can be extended by a femoral flap (four cases) or a distal femoral window (eight cases). Despite significant bone loss, in 24% of the femora and 57% of the acetabula, favourable midterm results were achieved and only six reoperations were required, including two for trochanteric nonunion and two for loosening. It leaves the lateral femoral cortex intact so that a stem longer than 200 mm was needed in only 25% of patients. This is a considerable advantage compared with the extended trochanteric osteotomy in which the long lateral flap (12 to 14 cm) requires an average length of stem of 220 mm beyond the calcar.

TSO provides an approach similar in size to the standard trochanteric osteotomy but with a rate of nonunion of 4% versus 15%. It reduces the risk of difficulties with removal of the stem, and removes the need for routine distal anchoring of long revision stems. The limited distal femoral compromise is very important in patients with a long life expectancy.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages - 23
1 Mar 2002
Gleyze P Thomazeau H Flurin P Lafosse L Gazielly D Allard M
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Purpose of the study: The aim of this study was to evaluate the anatomical and technical limits of endoscopic rotator cuff repair. Anatomical results were also compared with functional assessment of the shoulder.

Material and methods: A multicentric serie of 87 patients presenting a full thickness rotator cuff tear repaired endoscopically was retrospectively reviewed at 25.4 months (mean) post surgery. Limits of the surgical technique were studied in correlation with functional results and anatomic radiographic evaluation (arthroscans in 93 p. 100).

Results: Anatomical repair (normal thickness and no contrast in the subacromial space on arthroscan) was achieved in 83 p. 100 of the rotator cuffs with limited damage to the frontal part of the supra spinatus tendon. This percentage fell to 57.8 p. 100 in case of posterior extension of the tear to the supra spinatus tendon and further dropped to 40.8 p. 100 in case of retraction to the apex of the humeral head. Functional outcome evaluated with the Constant score was strongly related to the radiographic cuff condition (p < 0.05). For distal and anterior tears of the supra spinatus tendon, the Constant score at revision was 89.8 points in cases with anatomic repair at revision. This score fell to 75 when the rotator cuff tear was evidenced radiographically (p < 0.0001). For tears involving the entire supra spinatus tendon repaired by arthroscopy, the functional difference at revision was 8 points on the Constant scale. Objective and subjective analysis of the surgical procedure identified significant peroperative elements predictive of clinical and anatomical outcome (difficult reduction, p < 0.05; subjective degree of solidity, p < 0.0001; anatomical aspect of the repaired cuff, p < 0.05).

Discussion: A comparison of our findings with data on equivalent lesions reported in the literature suggests that endoscopic surgery for rotator cuff tears offers both functional and anatomic results equivalent to those achieved with conventional open surgery. This assumes that the surgical procedure is carried out by surgeons experienced in shoulder arthroscopy who can precisely gauge the posterior/anterior extension of the tears and the limits of the surgical technique.