Objectives

The aim of this study was to examine whether asymmetric loading influences macrophage elastase (MMP12) expression in different parts of a rat tail intervertebral disc and growth plate and if MMP12 expression is correlated with the severity of the deformity.

Purpose: Fractures of the distal tibia are high energy fractures, associated with marked soft-tissue trauma. Management of these fractures is challenging. The purpose of this study is to present our experience on the treatment of these fractures using hybrid external fixation, with or without open reduction and minimal internal fixation of the fibular fracture.

Patients and Methods: Forty eight patients with a distal tibial fracture were admitted to the authors’ institution since 2005. There were 33 men and 15 women. According to AO there were 24 A, 10 B and 14 C fractures. The mean age of the patients was 45.6 years. Eight patients had an open pilon fracture; according to the Gustilo classification, 1 patient had a grade I, 5 patients had a grade II, and 2 patients had a grade III open fracture. In all patients, the pilon fracture was treated using hybrid external fixation; in 18 patients, open reduction and minimal internal fixation of the fibular fracture using plate and screws was also done.

Results: Mean follow-up was 14 months (range, 9 to 36 months). In all patients, the mean duration of the application of the external fixation was 2.85 months, followed by the application of a below-knee cast. In 42 patients, radiographic evidence of union was observed at 3,6 months (range, 3 to 9 months). Time for union was different between patients with closed and grade I open fractures compared to patients with grade II and grade III open fractures (union at 3.5 and 6 months, respectively). There were 5 non-unions (10,4%) with 3 of them septic (6,25%). All three deep infections were low grade and occurred in open fractures.Delayed union was observed in 3 patients; in these patients, solid union of the fracture was observed at 7 months (range, 6 to 9 months). Pin track infection was observed in 7 patients (14.6%).

Conclusion: Based on the present study, hybrid external is associated with satisfactory results for the management of distal tibial fractures with acceptable complications.

Unstable intertrochanteric fractures present a difficult problem with a high incidence of complications such as mechanical failure of the implants or cut-out. The use of bone cement (PMMA) has been suggested in the past but the application with hand to fill the existing voids has not given good results and also has high incidence of pseudarthrosis and infection.

A new technique is presented in which the PMMA is injected with syringe through the hole opened for the compression screws. The aim is to augment mechanical stability and also to replace the compressed spongiosa.

The study population of 105 patients with unstable intertrochanteric fractures was separated in 2 groups, hi group A (51 patients, 4 male/47 female, mean age 72.3) a conventional sliding nail was performed, while in group B (54 patients, 3 male/51 female, mean age 78.9) the new technique was applied. The two were similar regarding age and gender.

Post-operatively in group A 95% of the patients remain in bed for 1–2 weeks according to the surgeon opinion regarding the stability of osteosynthesis. 45% of them remain in a regime of bed to chair existence for 6 weeks. 72% return to its previous domicile and activity. In group B all patients were sat out the bed in the 1st day post-op and walked in the 2nd day post-op with partial weight bearing where that ability preexisted. 91% return to its previous domicile and activity.

In group A ll cases of cut-out were noted while in group B only 1 cut-out and also 2 cases, where we had screw failure, but fracture went on to union. All the difference are in favor in group B and statistical significant (p< 0,0 5). No infection was noted.

The suggested method appears to give a satisfactory solution to the problem of unstable intertrochanteric fractures, allowing fast and safe mobilization of the patient, reducing thus morbidity. Technically it is simple, easy to apply and does not require instrumentation while the extra cost is only that of a butch of PMMA.