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Bone & Joint Open
Vol. 3, Issue 4 | Pages 302 - 306
4 Apr 2022
Mayne AIW Cassidy RS Magill P Mockford BJ Acton DA McAlinden MG

Aims

Waiting times for arthroplasty surgery in Northern Ireland are among the longest in the NHS, which have been further lengthened by the onset of the COVID-19 global pandemic in March 2020. The Department of Health in Northern Ireland has announced a new Elective Care Framework (ECF), with the framework proposing that by March 2026 no patient will wait more than 52 weeks for inpatient/day case treatment. We aimed to assess the feasibility of achieving this with reference to total hip arthroplasty (THA) and total knee arthroplasty (TKA).

Methods

Mathematical modelling was undertaken to calculate when the ECF targets will be achieved for THA and TKA, as well as the time when waiting lists for THA and TKA will be cleared. The number of patients currently on the waiting list and percentage operating capacity relative to pre-COVID-19 capacity was used to determine future projections.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_4 | Pages 6 - 6
1 Apr 2022
Mayne A Cassidy R Magill P Mockford B Acton D McAlinden G
Full Access

Waiting times for arthroplasty surgery in Northern Ireland are among the longest in the National Health Service, which have been further lengthened by the onset of the SARS-CoV-19 global pandemic in March 2020. The Department of Health (DoH) in Northern Ireland has announced a new Elective Care Framework (ECF), with the framework proposing that by March 2026 no patient will wait more than 52 weeks for inpatient/day case treatment. We aimed to assess the feasibility of achieving this with reference to Total Hip Arthroplasty (THA).

Waiting list information was obtained via a Freedom of Information request to the DoH (May 2021) and National Joint Registry data was used to determine baseline operative numbers. Mathematical modelling was undertaken to calculate the time taken to meet the ECF target and also to determine the time to clear the waiting lists for THA using the number of patients currently on the waiting list and percentage operating capacity relative to pre-Covid-19 capacity to determine future projections.

As of May 2021, there were 3,757 patients awaiting primary THA in Northern Ireland. Prior to April 2020, there were a mean 2,346 patients/annum added to the waiting list for primary THA and there were a mean 1,624 primary THAs performed per annum.

The ECF targets for THA will only be achieved in 2026 if operating capacity is 200% of pre COVID-19 pandemic capacity and will be achieved in 2030 if capacity is 170%. Surgical capacity must exceed pre-Covid capacity by at least 30% to meet ongoing demand.

THA capacity was significantly reduced following resumption of elective orthopaedics post-COVID-19 (22% of pre-COVID-19 capacity – 355 THAs/annum post-COVID-19 versus 1,624/annum pre-COVID-19).

This modelling demonstrates that, in the absence of major funding and reorganisation of elective orthopaedic care, the targets set out in the ECF will not be achieved with regards to hip arthroplasty. Waiting times for THA surgery in the NHS in Northern Ireland are likely to remain greater than 52 weeks for most of this decade.


The Bone & Joint Journal
Vol. 103-B, Issue 10 | Pages 1595 - 1603
1 Oct 2021
Magill P Hill JC Bryce L Martin U Dorman A Hogg R Campbell C Gardner E McFarland M Bell J Benson G Beverland D

Aims

In total knee arthroplasty (TKA), blood loss continues internally after surgery is complete. Typically, the total loss over 48 postoperative hours can be around 1,300 ml, with most occurring within the first 24 hours. We hypothesize that the full potential of tranexamic acid (TXA) to decrease TKA blood loss has not yet been harnessed because it is rarely used beyond the intraoperative period, and is usually withheld from ‘high-risk’ patients with a history of thromboembolic, cardiovascular, or cerebrovascular disease, a patient group who would benefit greatly from a reduced blood loss.

Methods

TRAC-24 was a prospective, phase IV, single-centre, open label, parallel group, randomized controlled trial on patients undergoing TKA, including those labelled as high-risk. The primary outcome was indirect calculated blood loss (IBL) at 48 hours. Group 1 received 1 g intravenous (IV) TXA at the time of surgery and an additional 24-hour postoperative oral regime of four 1 g doses, while Group 2 only received the intraoperative dose and Group 3 did not receive any TXA.


The Bone & Joint Journal
Vol. 103-B, Issue 7 | Pages 1197 - 1205
1 Jul 2021
Magill P Hill JC Bryce L Martin U Dorman A Hogg R Campbell C Gardner E McFarland M Bell J Benson G Beverland D

Aims

A typical pattern of blood loss associated with total hip arthroplasty (THA) is 200 ml intraoperatively and 1.3 l in the first 48 postoperative hours. Tranexamic acid (TXA) is most commonly given as a single preoperative dose only and is often withheld from patients with a history of thromboembolic disease as they are perceived to be “high-risk” with respect to postoperative venous thromboembolism (VTE). The TRanexamic ACid for 24 hours trial (TRAC-24) aimed to identify if an additional 24-hour postoperative TXA regime could further reduce blood loss beyond a once-only dose at the time of surgery, without excluding these high-risk patients.

Methods

TRAC-24 was a prospective, phase IV, single centre, open label, parallel group, randomized controlled trial (RCT) involving patients undergoing primary unilateral elective THA. The primary outcome measure was the indirect calculated blood loss (IBL) at 48 hours. The patients were randomized into three groups. Group 1 received 1 g intravenous (IV) TXA at the time of surgery and an additional oral regime for 24 hours postoperatively, group 2 only received the intraoperative dose, and group 3 did not receive any TXA.


The Bone & Joint Journal
Vol. 102-B, Issue 9 | Pages 1146 - 1150
4 Sep 2020
Mayne AIW Cassidy RS Magill P Diamond OJ Beverland DE

Aims

Previous research has demonstrated increased early complication rates following total hip arthroplasty (THA) in obese patients, as defined by body mass index (BMI). Subcutaneous fat depth (FD) has been shown to be an independent risk factor for wound infection in cervical and lumbar spine surgery, as well as after abdominal laparotomy. The aim of this study was to investigate whether increased peritrochanteric FD was associated with an increased risk of complications in the first year following THA.

Methods

We analyzed prospectively collected data on a consecutive series of 1,220 primary THAs from June 2013 until May 2018. The vertical soft tissue depth from the most prominent part of the greater trochanter to the skin was measured intraoperatively using a sterile ruler and recorded to the nearest millimetre. BMI was calculated at the patient’s preoperative assessment. All surgical complications occuring within the initial 12 months of follow-up were identified.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 22 - 22
1 Jul 2020
Mayne A Cassidy R Magill P Diamond O Beverland D
Full Access

Introduction

Previous research has demonstrated increased early complication rates following total hip arthroplasty in obese patients, as defined by body mass index (BMI). Subcutaneous fat depth has been shown to be an independent risk factor for wound infection in cervical and lumbar spine surgery as well as after abdominal laparotomy. The aim of this study was to investigate whether increased peri-trochanteric fat depth was associated with increased risk of early complication following total hip arthroplasty.

Methods

We analysed prospectively collected data on a consecutive series of 1220 patients undergoing primary total hip arthroplasty from June 2013 until May 2018. The vertical soft tissue depth from the most prominent part of the greater trochanter to the skin was measured using a sterile ruler and recorded to the nearest millimetre. BMI was calculated at the patient's pre-operative assessment review. All complications (infection, dislocation and peri-prosthetic fracture) occuring within the initial 12 month follow-up were identified.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 11 - 11
1 Jul 2020
Magill P Hill J Bryce L Dorman A Hogg R Campbell C Benson G Beverland D
Full Access

Background

91% of blood loss in Total Hip Replacement (THR) occurs in the period after skin closure and the first 24 post-operative hours. TRAC-24 was established to identify if an additional 24-hour post-operative oral regime of Tranexamic acid (TXA) is superior to a once-only intravenous dose at surgery.

Methods

This was a prospective, phase IV, single centered, open label, parallel group controlled trial on patients undergoing primary elective THR. A history of thromboembolic or cardiovascular disease were not exclusion criteria. The primary outcome was indirect calculated blood loss at 48 hours (IBL). 534 patients were randomized on a 2:2:1 ratio over three different groups. Group 1 received an intravenous dose of TXA at the time of surgery and an additional 24-hour post-operative oral regime, Group 2 only received the intra-operative dose and Group 3 did not receive any TXA.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_9 | Pages 19 - 19
1 May 2018
McMahon S Magill P Bopf D Beverland D
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Introduction

Radiological inclination (RI) is determined in part by operative inclination (OI), which is defined as the angle between the cup axis or handle and the sagittal plane. In lateral decubitus the theatre floor becomes a surrogate for the pelvic sagittal plane.

Critically at the time of cup insertion if the pelvic sagittal plane is not parallel to the floor either because the upper hemi pelvis is internally rotated or adducted, RI can be much greater than expected. We have developed a simple Pelvic Orientation Device (POD) to help achieve a horizontal pelvic sagittal plane.

The POD is a 3-sided square with flat footplates that are placed against the patient's posterior superior iliac spines following initial positioning (figure 1). A digital inclinometer is then placed parallel and perpendicular to the patient to give readings of internal rotation and adduction, which can then be corrected.

Methods

A model representing the posterior aspect of the pelvis was created. This permitted known movement in two planes to simulate internal rotation and adduction of the upper hemi pelvis, with 15 known pre-set positions. 20 participants tested the POD in 5 random, blinded position combinations, providing 200 readings.

The accuracy was measured by subtracting each reading from the known value.


The Bone & Joint Journal
Vol. 98-B, Issue 12 | Pages 1589 - 1596
1 Dec 2016
Magill P Blaney J Hill JC Bonnin MP Beverland DE

Aims

Our aim was to report survivorship data and lessons learned with the Corail/Pinnacle cementless total hip arthroplasty (THA) system.

Patients and Methods

Between August 2005 and March 2015, a total of 4802 primary cementless Corail/Pinnacle THAs were performed in 4309 patients. In March 2016, we reviewed these hips from a prospectively maintained database.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_11 | Pages 34 - 34
1 Jun 2016
Magill P Blaney J Hill J Beverland D
Full Access

Introduction

The results of cementless total hip arthroplasty (THA) vary with data from the UK national Joint Registry being less favourable than that from the Australian registry. The senior author started using a fully cementless THA in 2005 and we aimed to gauge the performance of the implants based on their revision data.

Patients and methods

Between August 2005 and March 2015, 4,802 primary THA (4,309 patients) were performed with a cementless Corail® stem and a cementless Pinnacle® cup. There were 2,086 (43.4%) males and 2,716 (56.6%) females with a median age of 70 years (IQR 13, Range 16–95). There were a number of changes to the surgical technique with respect to the Corail® stem during the ten-year period, which we have categorised as phase 1 and phase 2. We compared the data in the two phases. Data were extracted from a prospectively maintained patient information database.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XVIII | Pages 57 - 57
1 May 2012
Magill P McGarry J Queally J Morris S McElwain J
Full Access

Introduction

Acetabular fractures are a challenging problem. It has been published that outcome is dependent upon the type of fracture, the reduction of the fracture and concomitant injuries. The end-points of poor outcome include avascular necrosis of the femoral head, osteoarthritis. However, we lack definitive statistics and so counselling patients on prognosis could be improved. In order to achieve this, more outcome studies from tertiary referral centres are required. We present the first long term follow up from a large tertiary referral centre in Ireland.

Methods

We identified all patients who were ten years following open reduction and internal fixation of an acetbular fracture in our centre. We invited all of these patients to attend the hospital for clinical and radiographic follow-up. As part of this, three scoring systems were completed for each patient; the Short-form 36 health survey (SF36), the Merle d'Aubigné score and the Short Musculoskeletal Functional Assessment (SMFA).


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XVII | Pages 23 - 23
1 May 2012
Magill P McGarry J Queally J Morris S McElwain J
Full Access

Introduction

Acetabular fractures are a challenging problem. It has been published that outcome is dependent upon the type of fracture, the reduction of the fracture and concomitant injuries. The end-points of poor outcome include avascular necrosis of the femoral head, osteoarthritis. However, we lack definitive statistics and so counselling patients on prognosis could be improved. In order to achieve this, more outcome studies from tertiary referral centres are required. We present the first long term follow up from a large tertiary referral Centre in Ireland.

Methods

We identified all patients who were ten years following open reduction and internal fixation of an acetbular fracture in our centre. We invited all of these patients to attend the hospital for clinical and radiographic follow-up. As part of this, three scoring systems were completed for each patient; the Short-form 36 health survey (SF36), the Merle d'Aubigné score and the Short Musculoskeletal Functional Assessment (SMFA).


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XVIII | Pages 27 - 27
1 May 2012
Magill P Walsh P Murphy T Mulhall K
Full Access

Introduction

Ischaemic preconditioning (IPC) is a phenomenon whereby a tissue is more tolerant to an insult if it is first subjected to short bursts of sublethal ischaemia and reperfusion. The potential of this powerful mechanism has been realised in many branches of medicine where there is an abundance of ongoing research. However, there has been a notable lack of development of the concept in Orthopaedic surgery. The routine use of tourniquet-controlled limb surgery and traumatic soft tissue damage are just two examples of where IPC could be utilised to beneficial effect in Orthopaedic surgery.

Methods

We conducted a randomized controlled clinical trial looking at the role of a delayed remote IPC stimulus on a cohort of patients undergoing a total knee arthroplasty (TKA). We measured the effect of IPC by analysing gene expression in skeletal muscle samples from these patients. Specifically we looked at the expression of Heat shock protein-90 (HSP-90), Catalase and Cyclo-oxygenase-2 (COX-2) at the start of surgery and at one hour into surgery. Gene analysis was performed using real time polymerase chain reaction amplification. As a second arm to the project we developed an in-vitro model of IPC using a human skeletal muscle cell line. A model was developed, tested and subsequently used to produce a simulated IPC stimulus prior to a simulated ischaemia-reperfusion (IR) injury. The effect of this on cell viability was investigated using crystal violet staining.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 618 - 618
1 Oct 2010
Murphy T Doran P Magill P Mulhall K Walsh P
Full Access

Introduction: Ischaemic preconditioning (IPC) is a well recognised and powerful phenomenon where a tissue becomes more tolerant to prolonged ischaemia when it is first subjected to short bursts of ischaemia/reperfusion. IPC has been most comprehensively studied in cardiothoracic surgery, to date there has been little use of this powerful phenomenon in orthopaedic surgery. In this study, we report on the first clinical trial of IPC on human skeletal muscle, and show the potential of IPC in orthopaedics using global gene expression analysis.

Methods: After local ethics committee approval and informed consent, patients undergoing primary knee arthroplasty were randomly assigned into an IPC group and a control group. Diabetic patients or patients with an ankle/brachial index of less than 1 were excluded.

The IPC consisted of three five-minute periods of tourniquet insufflation on the operative limb, interrupted by five minute periods of reperfusion. The tourniquet was again insufflated and the operation started. The control group simply had tourniquet insufflation as normal prior to the start of surgery.

Muscle samples were taken from the operative knee of all patients at the immediate onset of surgery (t=0), and again, at one hour into the surgery (t=1). Total RNA was extracted from the muscle samples, and the gene expression profiles were determined using microarray technology.

Results: Comparison of IPC and control samples identified 702 transcripts with differences of ≥1.5-fold in their expression. Of these, 137 were altered at t=0 while 565 were altered at t=1. Amongst these changes was an up-regulation in the expression of a number of heat shock proteins (HSPs) in the IPC group as compared to the control group. Notably, there was up-regulation of the well known cytoprotective/anti-apoptotic gene, HSP72, at one hour post IPC (1.5-fold, p=0.039). There was also up-regulation of important oxidative stress defense genes, such as glutathione-S-transferase (1.6-fold, p = 0.021) and superoxide dismutase 2 (3.6-fold, p= 0.048). Microarray analysis also revealed a down-regulation in the expression of genes involved in metabolism, down-regulation of pro-apoptotic genes and up-regulation of genes necessary for transformation to a hypoxia-tolerant state.

Discussion: We present convincing evidence that IPC is beneficial to human skeletal muscle and for the first time show that IPC of human skeletal muscle works in the clinical setting. In this study, the protective effect of IPC involved a down-regulation in the expression of genes associated with metabolism, and an up-regulation in the expression of genes that provide protection from cell stress, oxidative stress and apoptosis. HSPs, and especially HSP72, have well documented roles in cell stress protection. Their presence has been cited by other studies as an indicator of cell adaptation to stress.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 305 - 305
1 May 2010
Magill P Leonard M Kiely P Khayyat G
Full Access

Introduction: The technology available for replacing/resurfacing the hip is constantly evolving. The surgeon can now choose from a wide array of componenets to perform a cemented, hybrid, uncemented total hip arthroplasty (THA) or resurfacing arthroplasty (RSA). The aim of our study was to evaluate and compare the restoration of hip biomechanics following insertion of three different, commonly used constructs.

Methods: We compared the pre and postoperative radiographs from 40 patients who underwent cemented THA, 45 patients who underwent uncemented THA and 40 who underwent RSA. The femoral offset and limb length differences were measured, with reference to the normal contralateral hip.

Results: Resurfacing resulted in a significant reduction in femoral offset, with accurate restoration of limb length. Both cemented and uncemented THA resulted in a significant increase in femoral offset and leg length. Uncemented THA resulted in the greatest degree of leg lengthening.

Discusssion: Restoration of normal hip anatomy optimises biomechanical function and reduces wear of components. The RSA group had the most accurate restoration compared to the two other groups. The reduced femoral offset associated with the RSA group may reduce the lever arm of the abductor muscles however this is unlikely to be clinically important.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 51 - 51
1 Mar 2010
Leonard M Magill P Khayyat G
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Introduction: The pilon fracture extending from the distal tibial metaphysis into the ankle joint represents one of the most challenging injuries faced by orthopaedic surgeons. Achieving the ideal of anatomic reduction and stable fixation is often impeded by the frequently severe soft tissue injuries associated with these fractures. In June 2004 we began treating intra-articular pilon fractures by minimally invasive techniques.

Materials and Methods: The minimally invasive technique used involved reduction of the fracture by ligamentotaxis and manipulation of the foot to correct rotation, varus/valgus, pro/recurvatum. Any further reduction was performed using an ankle arthroscope and a probe introduced through stab incisions. Following reduction a distal tibial locking plate was applied percutaneously to the medial of the tibia. All significant anterior or posterior distal tibial fragments were fixed separately with an anterior percutaneously inserted interfragmentary compression screw.

We compared all cases of closed intra-articluar fractures (AO types C2 and C3) fixed by the method described above in a one year period (June 2004 – June 2005) – Group 1 (n = 26), with the immediate previous one year period (June 2003 – June 2004) of matched closed fracture pattern fixed by formal open reduction and internal fixation – Group 2 (n = 16).

Mean follow up was 26 months. All bony and soft tissue complications were recorded. A specific assessment of outcome was undertaken using the American Orthopaedic Foot and Ankle Score (AOFAS). Scoring was undertaken on two separate occasions at a mean of 9 and 24 months post operatively.

Results: We observed a far greater incidence of complications in the open reduction group when compared with the minimally invasive group. An excellent AOFAS result was obtained in 83% (20/24) of the patients in the minimally invasive group, the same result was achieved in only 12.5 % of the formal open reduction and fixation group.

Conclusion: The use of the minimally invasive reduction method described here in combination with the insertion of percutaneous fixation, represents a valuable method of treating the most complex of closed pilon fractures.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 543 - 544
1 Aug 2008
Leonard M Magill P Kiely P Khayyat G
Full Access

Introduction: The technology available for replacing/ resurfacing the hip joint is constantly evolving. The practicing surgeon can now choose from a wide array of components to perform a cemented, hybrid, uncemented total hip arthroplasty (THA), or a hip resurfacing. The potential advantages and disadvantages of all have been widely reported in the literature. The choice of implant depends on a number of factors, such as, patient age and level of activity, hip anatomy, and the surgeons’ preference and expertise. The aim of our study was to evaluate and compare the restoration of hip biomechanics following the insertion of three different, commonly used constructs.

Methods: We compared the postoperative anteroposterior radiographs from 40 patients who underwent cemented THA, 45 patients who underwent uncemented THA and 40 who underwent Articular Surface Replacement (ASR). All procedures were carried out by a single consultant orthopaedic surgeon who was experienced in the insertion of all three different implant designs. The acetabular offset and height, and the femoral offset and limb length were measured, with reference to the normal contralateral hip, using accepted methods.

Results – Hip resurfacing resulted in a significant reduction in femoral offset (p < 0.001), with accurate restoration of limb length. Both cemented and uncemented THA resulted in a significant increase in femoral offset, both also resulted in significant leg – lengthening (p< 0.001), this was more marked with uncemented THA’s. Radiological measurements of the acetabular reconstruction were similar in all groups.

Discussion – Restoration of normal hip anatomy optimises biomechanical function and reduces wear of components. The ASR group had the most accurate restoration in comparison to the two other groups. The reduced femoral offset associated with the ASR group may reduce the lever arm of the abductor muscles however this is unlikely to be clinically significant.