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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_3 | Pages 18 - 18
23 Feb 2023
Grant M Zeng N Lin M Farrington W Walker M Bayan A Elliot R Van Rooyen R Sharp R Young S
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Joint registries suggest a downward trend in the use of uncemented Total Knee Replacements (TKR) since 2003, largely related to reports of early failures of uncemented tibial and patella components. Advancements in uncemented design such as trabecular metal may improve outcomes, but there is a scarcity of high-quality data from randomised trials.

319 patients <75 years of age were randomised to either cemented or uncemented TKR implanted using computer navigation. Patellae were resurfaced in all patients. Patient outcome scores, re-operations and radiographic analysis of radiolucent lines were compared.

Two year follow up was available for 287 patients (144 cemented vs 143 uncemented). There was no difference in operative time between groups, 73.7 v 71.1 mins (p= 0.08). There were no statistical differences in outcome scores at 2 years, Oxford knee score 42.5 vs 41.8 (p=0.35), International Knee Society 84.6 vs 84.0 (p=0.76), Forgotten Joint Score 66.7 vs 66.4 (p=0.91). There were two revisions, both for infection one in each group (0.33%). 13 cemented and 8 uncemented knees underwent re-operation, the majority of these being manipulation under anaesthetic (85.7%), with no difference (8.3% vs 5.3%, 95% CI -2.81% to 8.89%, p = 0.31). No difference was found in radiographic analysis at 2 years, 1 lucent line was seen in the cemented group and 3 in the uncemented group (0.67% v 2.09%, 95%CI -4.1% to 1.24%, p = 0.29).

We found no difference in clinical or radiographic outcomes between cemented and uncemented TKR including routine patella resurfacing at two years.

Early results suggest there is no difference between cemented and uncemented TKR at 2 years with reference to survivorship, patient outcomes and radiological parameters.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 479 - 480
1 Nov 2011
Pearce C Elliot R Seifert C Calder J
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Introduction: Adequately managing post-operative pain following ankle and hindfoot surgery can be difficult. Conventional analgesics have significant side effects including nausea and gastric irritation. The results of a pilot study of continuous infusion v’s single bolus popliteal block encouraged us to perform the full PRCT.

Method: The trial was approved by the local Research and Ethics Committee and registered with the European Clinical Trials Database. Approval was obtained from the Medicines and Healthcare products Regulatory Authority (MHRA) for the use of normal saline infusion as a placebo. The recommendations of Good Clinical Practice in the conduct of clinical trials on medicinal products for human use were respected.

Inclusion criteria were all patients who were undergoing significant hind foot or ankle procedures. Exclusion criteria included coexisting peripheral neuropathy and any inability to fill in the questionnaire.

The pilot study provided a standard deviation of pain scores which allowed us to calculate the sample size required; 25 patients in each group would have 90% power to detect a difference in means VAS scores of 3 which we considered to be clinically significant. A total number of 56 (to allow for 10% loss to follow-up) were recruited. The patients and the assessors were blinded to the treatment allocated. Sealed envelopes contained random allocations and were opened by the anaesthetist. A bolus of 20ml 0.25% bupivacaine was injected and then the catheter was inserted and connected to a pump. Patients were randomly assigned to receive either an infusion of normal saline or bupivacaine over the next 72 hours.

The patients were asked to complete a visual analogue pain chart, three times daily, for 72 hours postoperatively. Data was also recorded regarding supplementary opiate analgesic requirements and any problems or complications.

Statistical analysis was performed using MedCalc for Windows, version 9.6.4 (MedCalc software, Mariakerke, Belgium). A Mann-Whitney U test was used for the non-parametric data sets.

Results: Both groups had very low median VAS pain scores on the day of operation and there was no difference between the two; study 1.167, control 1.000 (p=0.893). On the 3 post operative days studied there were significantly lower pain scores in the study group; day 1: 1.67 v’s 3.67 (p=0.003), day 2: 1.33 v’s 2.83 (p=< 0.001), day 3: 1.11 v’s 2.56 (p=< 0.001).

There was no difference in median milligrams of morphine usage on the day of operation; study = 10, placebo = 10 (p = 0.942). The morphine usage was lower in the study group on all post operative days and this was significant on days 2& 3; day 1: 10 v’s 15 (p=0.054), day 2: 10 v’s 20 (p=< 0.001), day 3: 7.5 v’s 10 (p=0.02). Median total morphine requirements over the 3 post operative days were 30mg for the study group compared to 52.5mg for the control group and this was significant (p=0.012).

The study group on average spent less nights as an inpatient with a median value of 1 compared to 2 for the control but this was not significant (p=0.430).

There were no major complications with the administration of the blocks or with the catheters.

Conclusion: The bolus of bupivacaine given to all patients prior to surgery meant that low pain scores were seen in both groups in the immediate post operative period with no significant difference between them. The continuous infusion of bupivacaine via a pain pump provided significantly better analgesia than normal saline with significantly less requirement for supplementary oral analgesic agents over the 72 hours after major ankle or hind foot surgery. This is a safe and effective method of managing post operative pain in these patients.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 382 - 383
1 Jul 2011
Elliot R Flint M French G
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Objective: Appendicular soft tissue tumours are rare. They represent less than 1% of all malignancy. Failure to appropriately investigate a malignant mass can result in unnecessary loss of limb or life. New Zealand is a sparsely populated country and has four orthopaedic tumour surgeons which is in keeping with the recommended ratio of 1/1,000,000. Consequently some patients find themselves long distances from Tertiary tumour centres. We looked at the investigation and referrals of patients to the Bone and Soft tissue tumour service at our institution.

We reviewed the charts of all patients (126) with a soft tissue tumour referred to the senior authors in 2006 and 2007. The information was stored in a prospective Tumour Registry Database. Where information was not available in records kept at our institution, the referring institution was contacted.

There were 92 tertiary referrals and 34 GP referrals. The majority of the tertiary referrals came from orthopaedic surgeons (55), and general surgeons (28). The mean duration between referral and review was 16 days (0–215 days). There was a of 13 days wait for tertiary referral review. Tissue samples and histology reports accompanied 33 patients which had resulted from 35 invasive Pre Referral Procedures (PRP). This group suffered 21 complications affecting 18 patients. The remainder (91) were Pre Biopsy Referrals (PBR). Biospy was deemed necessary in 47 cases. The PBR group suffered 4 complications. Only one complication occurred to a patient with benign histology in each group. There was an extremely significant relationship between Pre Referral Procedures and suffering a complication (P< 0.0001). The relative risk of complication was 6.2 (C.I. 2.0–18.4) if an invasive procedure was performed prior to referral. There were 3 amputations (plus one recommended but refused by patient) in the PRP group and 1 amputation in the PBR group. This was not statistically significant. The median interval between referral and senior author review was 8 days for the PRP group and 10 days for the PBR group (P=0.2574). Sixty six percent of tertiary referrals were PBR (74% when including GP referrals).

Biopsy of suspected appendicular Soft Tissue Sarcoma should be done by a tumour specialist or in prior consultation with one. There is virtually no delay to see an orthopaedic tumour specialist in New Zealand and achieving a tissue diagnosis does not expedite this.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 165 - 165
1 Mar 2009
Calder J Elliot R Seifert C
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Introduction: Adequate analgesia following hindfoot surgery can be difficult and conventional analgesics have significant side effects. A single bolus popliteal block of the neurovascular bundles is effective but short-lived. We have been using a retained perineural catheter with continuous local anaesthetic infusion for pain relief post-operatively.

Materials and Methods: This 2 cohort observational study compares pain relief following single bolus dose popliteal block and retained continuous infusion peri-neural catheter. With the patient supine in the anaesthetic room a nerve stimulator identified the tibial and peroneal branches of the sciatic nerve which were blocked with 20mls 0.5% marcaine. In 31 patients a perineural catheter was left in situ and connected to a Stryker “Pain Pump” infusing 0.25% bupivacaine at a rate of 4 ml/hour with 1 ml/hour patient controlled boluses. Following discharge the catheter was removed by the district nurse at 72 hours post-operatively.

Results: Patients were asked to fill in Visual Analogue Scores for 72 hours post operatively. The mean pain score for the single block group was 4.9 (range 0–9). The mean pain score for the popliteal catheter group was 1.03 (range 0–5). One patient had an air-lock in the infusion tubing leading to pain once the initial block wore-off. One patient experienced a patch of numbness in the lower leg which resolved by the 2 week follow-up. There were no other complications, such as infection, from placement of the retained popliteal catheter. All patients were satisfied with their post-operative pain control.

Conclusion: We recommend this novel technique as an effective method of pain relief after ankle and hindfoot surgery. To confirm our findings we are running a randomised, double blinded, placebo controlled trial to study this method of pain relief.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 496 - 496
1 Aug 2008
Elliot R Calder J
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Introduction: Adequate analgesia following hindfoot surgery can be difficult and conventional analgesics have significant side effects. A single bolus popliteal block of the neurovascular bundles is effective but short-lived. We have been using a retained perineural catheter with continuous local anaesthetic infusion for pain relief post-operatively.

Materials and Methods: This 2 cohort observational study compares pain relief following single bolus dose popliteal block and retained continuous infusion perineural catheter. With the patient supine in the anaesthetic room a nerve stimulator identified the tibial and peroneal branches of the sciatic nerve which were blocked with 20mls 0.5% marcaine. In 31 patients a perineural catheter was left in situ and connected to a Stryker “Pain Pump” infusing 0.25% bupivacaine at a rate of 4 ml/hour with 1 ml/hour patient controlled boluses. Following discharge the catheter was removed by the district nurse at 72 hours post-operatively.

Results: Patients were asked to fill in Visual Analogue Scores for 72 hours post operatively. The mean pain score for the single block group was 4.9 (range 0–9). The mean pain score for the popliteal catheter group was 1.03 (range 0–5). One patient had an air-lock in the infusion tubing leading to pain once the initial block wore-off. One patient experienced a patch of numbness in the lower leg which resolved by the 2 week follow-up. There were no other complications, such as infection, from placement of the retained catheter. All patients were satisfied with their post-operative pain control.

Conclusion: We recommend this novel technique as an effective method of pain relief after ankle and hindfoot surgery. To confirm our findings we are running a randomised, double blinded, placebo controlled trial to study this method of pain relief.