Aims

This systematic review aimed to summarize the full range of complications reported following ankle arthroscopy and the frequency at which they occur.

Preoperative talar valgus deformity increases the technical difficulty of total ankle replacement (TAR) and is associated with an increased failure rate. Deformity of ≥15° has been reported to be a contraindication to arthroplasty. The goal of the present study was to determine whether the operative procedures and clinical outcomes of TAR for treatment of end-stage ankle arthritis were comparable for patients with preoperative talar valgus deformity of ≥15° as compared to those with <15°. We will describe the evolving surgical technique being utilized to tackle these challenging cases.

Fifty ankles with preoperative coronal-plane tibiotalar valgus deformity of ≥15° “valgus” group) and 50 ankles with valgus deformity of <15° (“control” group) underwent TAR. The cohorts were similar with respect to demographics and components used. All TARs were performed by a single surgeon. The mean duration of clinical follow-up was 5.5 years (minimum two years). Preoperative and postoperative radiographic measurements of coronal-plane deformity, Ankle Osteoarthritis Scale (AOS) scores and Short Form (SF)-36 scores were prospectively recorded. All ancillary (intraoperative) and secondary procedures, complications and measurements were collected.

The AOS pain and disability subscale scores decreased significantly in both groups. The improvement in AOS and SF-36 scores did not differ significantly between the groups at the time of the final follow-up. The valgus group underwent more ancillary procedures during the index surgery (80% vs 26%). Tibio-talar deformity improved significantly toward a normal weight-bearing axis in the valgus group. Secondary postoperative procedures were more common in the valgus group (36%) than the controls (20%). Overall, re-operation was not associated with poorer patient outcome scores. Metal component revision surgery occurred in seven patients (three valgus and four controls). These revisions included two deep infections (2%), one in each group, which were converted to hindfoot fusions. Therefore, 94% of the valgus group retained their original components at final follow-up

Thus far, this is the largest reported study that specifically evaluates TAR with significant preoperative valgus alignment, in addition to having the longest follow-up. Satisfactory midterm results were achieved in patients with valgus mal-alignment of ≥15°. The valgus cohort required more procedures during and after their TAR, as well as receiving more novel techniques to balance their TAR. Whilst longer term studies are needed, valgus coronal-plane alignment of ≥15° should not be considered an absolute contraindication to TAR if the associated deformities are addressed.

Multiligament knee injuries (MLKI) are rare and life-altering injuries that remain difficult to treat clinically due to a paucity of evidence guiding surgical management and timing. The purpose of this study was to compare injury specific functional outcomes following early versus delayed surgical reconstruction in MLKI patients to help inform timing decisions in clinical practice.

A retrospective analysis of prospectively collected data from patients with MLKIs at a single academic level 1-trauma center was conducted. Patients were eligible for inclusion if they had an MLKI, underwent reconstructive surgery either prior to 6wks from injury or between 12weeks and 2 years from injury, and had at least 12months of post-surgical follow-up. Patients with a vascular injury, open injuries or associated fractures were excluded. Study participants were stratified into early (12 weeks - 2 years from injury). The primary outcome was patient reported, injury specific, quality of life in the form of the Multiligament Quality of Life questionnaire (MLQOL) and its four domains (Physical Impairment, Emotional Impairment, Activity Limitations and Societal Involvement). We secondarily analyzed differences in the need for manipulation under anesthesia, and reoperation rates, as well as radiographic Kellgren Lawrence (KL) arthritis grades, knee laxity grading and range of motion at the most recent follow-up.

A total of 131 patients met our inclusion criteria, all having had surgery between 2006 and 2019. There were 75 patients in the early group and 56 in the delayed group. The mean time to surgery was 17.6 ± 8.0 days in the early group versus 279 ± 146.5 days in the delayed. Mean postoperative follow-up was 58 months. There were no significant differences between early and delayed groups with respect to age (34 vs. 32.8 years), sex (77% vs 63% male), BMI (28.3 vs 29.7 kg/m2), or injury mechanism (p>0.05). The early surgery group was found to include more patients with lateral sided injuries (n=49 [65%] vs. n=23 [41%]; p=0.012), a higher severity of Schenck Classification (p=0.024) as well as nerve injuries at initial presentation (n=35 [49%] vs n=8 [18%]; p0.05), when controlling for age, sex, Schenck classification, medial versus lateral injury, and nerve injury status. In terms of our secondary outcomes, we found that the early group underwent significantly more manipulations under anesthesia compare with the delayed group (n=24, [32%] vs n=8 [14%], p=0.024). We did not identify a significant difference in physical examination laxity grades, range of motion, KL grade or reoperation rates between groups (p>0.05).

We found no difference in patient reported outcomes between those who underwent early versus delayed surgery following MLKI reconstruction. In our secondary outcomes, we found significantly more patients in the early surgery group required a manipulation under anesthesia following surgery, which may indicate a propensity for arthrofibrosis after early MLKI reconstruction.

There is limited literature on the effects of socioeconomic factors on outcomes after total ankle arthroplasty (TAA). In the setting of hip or knee arthroplasty, patients of a lower socioeconomic status demonstrate poorer post-operative satisfaction, longer lengths of stay, and larger functional limitations. It is important to ascertain whether this phenomenon is present in ankle arthritis patients. This is the first study to address the weight of potential socioeconomic factors in affecting various socioeconomic classes, in terms of how they benefit from ankle arthroplasty.

This is retrospective cohort study of 447 patients who underwent a TAA. Primary outcomes included pre-operative and final follow-up AAOS pain, AAOS disability, and SF-36 scores. We then used postal codes to determine median household income using Canadian 2015 census data. Incomes were divided into five groups based on equal amounts over the range of incomes. This method has been used to study medical conditions such as COPD and cardiac disease. These income groups were then compared for differences in outcome measures. Statistical analysis was done using unpaired t-test.

A total of 447 patients were divided into quintiles by income. From lowest income to highest income, the groups had 54, 207, 86, 64, and 36 patients, respectively. The average time from surgery to final follow up was 85.6 months. Interestingly, we found that patients within the middle household income groups had significantly lower AAOS disability scores compared to the lowest income groups at final follow-up (26.41 vs 35.70, p=0.035). Furthermore, there was a trend towards middle income households and lower post-operative AAOS pain scores compared to the lowest income group (19.57 vs 26.65, p=0.063). There was also a trend toward poorer AAOS disability scores when comparing middle income groups to high income groups post-operatively (26.41 vs 32.27, p=0.058). Pre-operatively, patients within the middle-income group had more pain, compared to the lowest and the highest income groups. No significant differences in SF-36 scores were observed. There were no significant differences seen in middle income groups compared to the highest income group for AAOS pain post-operatively. There were no significant differences found in pre-operative AAOS disability score between income groups.

Patients from middle income groups who have undergone TAA demonstrate poorer function and possibly more pain, compared to lower and higher income groups. This suggests that TAA is a viable option for lower socioeconomic groups and should not be a source of discouragement for surgeons. In this circumstance there is no real disparity between the rich and the poor. Further investigation is needed to explore reasons for diminished performance in middle class patients.

Multiligament knee injuries (MLKI) are rare and life-altering injuries that remain difficult to treat clinically due to a paucity of evidence guiding surgical management and timing. The purpose of this study was to compare injury specific functional outcomes following early versus delayed surgical reconstruction in MLKI patients to help inform timing decisions in clinical practice.

A retrospective analysis of prospectively collected data from patients with MLKIs at a single academic level 1-trauma center was conducted. Patients were eligible for inclusion if they had an MLKI, underwent reconstructive surgery either prior to 6wks from injury or between 12weeks and 2 years from injury, and had at least 12months of post-surgical follow-up. Patients with a vascular injury, open injuries or associated fractures were excluded. Study participants were stratified into early (<6wks from injury) and delayed surgical intervention (>12 weeks – 2 years from injury). The primary outcome was patient reported, injury specific, quality of life in the form of the Multiligament Quality of Life questionnaire (MLQOL) and its four domains (Physical Impairment, Emotional Impairment, Activity Limitations and Societal Involvement). We secondarily analyzed differences in the need for manipulation under anesthesia, and reoperation rates, as well as radiographic Kellgren Lawrence (KL) arthritis grades, knee laxity grading and range of motion at the most recent follow-up.

A total of 131 patients met our inclusion criteria, all having had surgery between 2006 and 2019. There were 75 patients in the early group and 56 in the delayed group. The mean time to surgery was 17.6 ± 8.0 days in the early group versus 279 ± 146.5 days in the delayed. Mean postoperative follow-up was 58 months. There were no significant differences between early and delayed groups with respect to age (34 vs. 32.8 years), sex (77% vs 63% male), BMI (28.3 vs 29.7 kg/m²), or injury mechanism (p>0.05). The early surgery group was found to include more patients with lateral sided injuries (n=49 [65%] vs. n=23 [41%]; p=0.012), a higher severity of Schenck Classification (p=0.024) as well as nerve injuries at initial presentation (n=35 [49%] vs n=8 [18%]; p<0.001). Multivariable linear regression analyses of the four domains of the MLQOL did not demonstrate an independent association with early versus delayed surgery status (p>0.05), when controlling for age, sex, Schenck classification, medial versus lateral injury, and nerve injury status. In terms of our secondary outcomes, we found that the early group underwent significantly more manipulations under anesthesia compare with the delayed group (n=24, [32%] vs n=8 [14%], p=0.024). We did not identify a significant difference in physical examination laxity grades, range of motion, KL grade or reoperation rates between groups (p>0.05).

We found no difference in patient reported outcomes between those who underwent early versus delayed surgery following MLKI reconstruction. In our secondary outcomes, we found significantly more patients in the early surgery group required a manipulation under anesthesia following surgery, which may indicate a propensity for arthrofibrosis after early MLKI reconstruction.

Outcomes following carpal tunnel release are generally favorable. Understanding factors that contribute to inferior outcomes may allow for strategies targeted at improving results in these patients. Our purpose was to determine if patients' underlying personality traits, specifically resiliency and catastrophization, impact their post-operative outcomes following carpal tunnel release.

A prospective case series was performed. Based on our power analysis, 102 patients were recruited. Patients completed written consent, the Boston Carpal Tunnel Questionnaire (BCTQ), the Pain Catastrophizing Scale (PCS) and the Brief Resiliency Scale (BRS). A single surgeon, or his resident under supervision, then performed an open carpal release under local anaesthetic. Our primary outcome measure was a repeat BCTQ at three- and six-months. Univariate and multivariate analysis was performed to assess the correlation between PCS and BRS scores and final BCTQ scores.

Forty-three and sixty-three participants completed the BCTQ at three and six months respectively. All patients showed improvement in their symptoms (p = 0.001). There was no correlation between patients PCS or BRS and the amount of improvement. There was also no correlation between PCS or BRS and the patients' raw scores at baseline or follow-up.

Patients self-assessed resiliency and degree of pain catastrophization has no correlation with the amount of improvement they have three or six months post-operatively. Most patients improved following carpal tunnel release, and patients with low resiliency and high levels of pain catastrophization should expect comparable outcomes to patients without these features.

Fibular head avulsion fractures represent a significant injury to the posterolateral corner of the knee. There is a high rate of concomitant injuries including rupture of the cruciate ligaments. Surgical fixation is indicated to restore stability, protect repaired or reconstructed cruciate ligaments and possibly decrease the likelihood of degenerative change. The current presentation describes a novel technique which provides secure fixation to the fibular head, restoring integrity of the posterolateral ligament complex and facilitating early motion. We also present a case series of our experience by a single surgeon at our tertiary referral center.

Twenty patients underwent open reduction and internal fixation between 2006 and 2016 using a large fragment cannulated screw and soft tissue washer inserted obliquely from the proximal fibula to tibia. Fixation was augmented with suture repair of the lateral collateral ligament and biceps tendon. The orientation of the fracture was assessed based on preoperative imaging. Repair / reconstruction of concomitant injuries was performed during the same procedure. Early range of motion was initiated at 2 weeks postoperatively under physical therapy guidance.

All patients returned for clinical and radiographic assessment (average 3.5 years). All fractures went on to bony union. There were no reoperations for recurrent instability. All patients regained functional range of motion with mean extension of 0.94 degrees and mean flexion of 121.4 degrees. Two patients underwent hardware removal. One patient developed a late local infection, which occurred greater than 5 years after surgery. Eleven patients underwent postoperative varus stress radiographs which demonstrated less than 1 mm difference between the operated and contralateral side. Fracture morphology typically demonstrated an oblique pattern in the coronal plane and a transverse pattern in the sagittal plane.

This study represents a novel surgical technique for the repair of fibular head avulsion fractures with a large fragment cannulated screw placed obliquely from the fibula to tibia. Fixation is augmented with a soft tissue washer and suture repair. Our results suggest that this technique allows for early range of motion with maintenance of reduction, high rates of union, and excellent postoperative stability.

Introduction

The risk of hip dislocation after revision total hip arthroplasty is up to 20% following surgery for periprosthetic fractures. A technique was developed by the senior authors, involving a transtrochanteric osteotomy and superior capsulotomy to attempt to minimise this risk(1).

Introduction & aims

Satisfaction following total knee replacement (TKR) surgery remains suboptimal at around 80%. Prediction of factors influencing satisfaction may help manage expectations and thus improve satisfaction. We investigated preoperative variables that estimate the probability of achieving a successful surgical outcome following TKR in several outcomes important to patients.

End-stage ankle arthritis (ESAA) is a debilitating disease that does not affect all individuals equally. Gender differences have been identified in patients with end-stage hip and knee arthritis and have stimulated research to explain these findings. The present study was undertaken to examine if gender has a significant effect on pre-operative disability and post-operative outcomes in patients with ESAA.

Patients undergoing ankle arthrodesis (AA) or total ankle replacement (TAR) with minimum 2-year follow-up were identified in the Canadian Orthopaedic Foot and Ankle Society prospective ankle reconstruction database. Demographic data, revision data, patient satisfaction questionnaires, and outcome data using the Ankle Osteoarthritis Scale (AOS) and Short-form 36 (SF-36) health survey were collected.

TAR: 384 patients were included, with 198 females and 186 males. Patient BMI, comorbidities, and duration of follow-up were similar between groups. Males were slightly older at the time of surgery (65.1 vs 62.4 years, p=0.01)). The most common etiology was post-traumatic arthritis for both genders, however females had a higher rate of rheumatoid arthritis (17% vs 5%, p=0.001). Implant types included STAR, Hintegra, and Mobility, and were similar between groups. Preoperatively females had higher rates of pain and disability, demonstrated by lower SF-36 physical component scores (PCS) (31.0 vs 34.5, p<0.001), and higher AOS pain (54.7 vs 51.1, p=0.05) and AOS disability scores (66.5 vs 59.6, p<0.001). Postoperatively, both groups had significant improvement in PCS, AOS pain, and AOS disability scores. Females, however, continued to demonstrate lower PCS scores (38.3 vs 41.9, p<0.001) and higher AOS disability (31.0 vs 25.8, p=0.02) than males. Regression analysis found that preoperative PCS, gender, age, and arthritis etiology all had a significant impact on postoperative PCS scores, with preoperative PCS scores having the largest impact. Preoperative AOS pain and disability scores had the largest impact on postoperative AOS pain and disability scores, respectively. Gender had no significant impact on AOS pain and disability scores postoperatively. Patient satisfaction was similar between males and females postoperatively. Secondary surgery was performed in 13.6% of females and 16.1% of males. Five males and five females underwent revision to arthrodesis.

In patients with ESAA, females tend to have higher pre-operative levels of pain and disability compared to males, which persists post-operatively. This is consistent with the hip and knee arthroplasty literature. This finding may be due to females undergoing surgery at more advanced disease states, arthritis etiology, referral bias, or treatment bias. Both males and females have significant and similar degrees of improvement in pain and disability scores after TAR, and reoperation rates and patient satisfaction rates are similar despite the apparent disparity in outcomes.

We identified 26 tibial tubercle osteotomies (TTOs) performed in 23 revision knee arthroplasties between 2009 and 2013. Average age at last operation was 66 (33–92). Mean follow-up period was 14 months (3–33).

Eleven TTOs were performed in 10 knees for single stage revisions and 15 TTOs were performed in 13 knees for 2 stage revisions in the setting of deep infection. In this infected subset 11 patients had a TTO performed at the first stage. This osteotomy was left unfixed to avoid leaving metalwork in a potentially contaminated wound, reopened, and then definitively secured with screws at the second stage. Our technique involves fashioning a long 7×1cm tibial tuberosity osteotomy without a proximal step-cut.

All osteotomies united with no fractures. Minor proximal migration was noted in one case associated with screw loosening. There was no proximal migration noted in the 2 stage cases where the osteotomy had been left initially unfixed. There were no extensor lags.

We conclude that TTO is a safe and reproducible procedure when adequate exposure cannot be obtained in revision knee arthroplasty. In 2 stage revisions sequential osteotomies does not decrease union rates and leaving the osteotomy unfixed after the first stage does not cause any issues.

Eligible patients were randomly allocated to PMI or standard intramedullary jigs. Smith and Nephew's patient specific cutting blocks (Visionaire) were used for PMI. Postoperative component positioning was investigated using the ‘Perth CT protocol’. Deviation of more than 3° from the recommended position was regarded as an outlier. Exact Mann-Whitney U test was used to compare component positioning and difference in proportion of outliers was calculated using Chi Squared analysis.

Fifty-five knees were enrolled in the standard instrumentation group and fifty-two knees in the PMI group.

Coronal femoral alignment was 0.7 ± 1.9° (standard) vs 0.5 ± 1.6° (PMI) (P=0.33). Outliers 9.4% vs 7.4% (P=0.71). Coronal tibial alignment was 0.4 ± 1.5° (standard) vs 0.6 ± 1.4° (PMI) (P=0.56). Outliers 1.9% vs 1.9% (P=0.99). Sagittal femoral alignment was 0.6 ± 1.5° (standard) vs 1.3 ± 1.9° (PMI) (P=0.07). Outliers 3.8% vs 13.2% (P=0.09). Tibial slope was 1.7 ± 1.9 ° (standard) vs 1.8 ± 2.7° (PMI) (P=0.88). Outliers 13.2% vs 24.1% (P=0.15). External rotation of femoral component was 0.6 ± 1.4° (standard) vs 0.2 ± 1.8° (PMI) (P=0.14). Outliers: 3.8% vs 5.6% (P=0.66).

Compared to standard intramedullary jigs, patient matched instrumentation does not improve component positioning or reduce alignment outliers.

Background

The long-term impact of dividing Piriformis when performing a standard posterior approach to the hip has not been assessed. A less invasive approach in which the tendon is preserved has been described (the Piriformis-sparing minimally invasive [PSMI] approach). With advances in MRI technology it is now possible to image structures in close proximity to metal without artifact. The aim of the study was to compare the MRI features (muscle grade and bulk) of the divided and repaired Piriformis tendon group (by the standard posterior approach) with the preserved tendon group (by the PSMI approach).

Roentgen stereophotogrammetric analysis (RSA) is the most accurate radiographic technique for the assessment of three-dimensional micromotion in joints. RSA has been used previously to study the kinematics of the anterior cruciate ligament (ACL)-deficient knee and to measure knee laxity after bone-tendon-bone (BTB) reconstructions. There is no published evidence on its use in assessing hamstring grafts in vivo, in comparing hamstring versus BTB reconstruction, or in-depth analyses of graft performance.

The aim of this project was to use RSA to measure laxity in both BTB and hamstring reconstructions, and to attempt a detailed analysis of graft behaviour in both reconstructions, with particular attention to graft stretching and slippage of the bony attachments.

A prospective study was undertaken on 14 patients who underwent ACL reconstruction. Seven had BTB reconstruction, and seven had four-stranded semitendinosus/gracilis (STG). Tantalum markers were inserted at the time of surgery, into distal femur and proximal tibia, and also directly into the graft itself. Stress radiographs (90N anterior and 90N posterior force) were taken early post-operatively, and then at 6 weeks, and 3, 6 and 12 months.

In addition to measuring total anteroposterior knee laxity, a detailed analysis of the graft itself was possible. The BTB grafts had stretched by an average of 1.54%, and the bone plugs had migrated by 0.50 mm at the femoral end and by 0.61mm at the tibial end. The hamstring grafts had stretched on average 3.94%, and the intraosseous ends had migrated by 3.96mm at the femoral end and by 7.10mm at the tibial end. This is believed to be the most detailed application of RSA in analysing the performance of the two commonly used grafts in ACL reconstruction. Details such as graft stretching and fixation slippage have not been available previously; the data obtained in this study may have implications for clinical practice.

Aim

The aim of this study was to compare a single-incision minimally invasive (MI) posterior approach with a standard posterior approach in a double-blind prospective randomised controlled trial.

Introduction: In 1990 an estimated 1.3 million hip fractures occurred worldwide, a figure which is expected to double by 2025 and increase to 4.5 million by 2050.

Clostridium difficile associated diarrhoea (CDAD) has emerged as a healthcare associated infection of great clinical and economic significance especially in the frail and vulnerable group of fracture neck of femur patients. A major risk factor for the development of CDAD in patients who undergo operation for fracture neck of femur is the perioperative antibiotic exposure, with cephalosporins being particularly implicated. The type ‘027’ strains of C. Difficile are multi-resistant and cause severe morbidity and mortality. A retrospective audit was performed to study the effect of C. Difficile infection in operated fracture neck of femur patients.

Material and Methods: All the patients who were diagnosed with C. Difficile after an operated fracture neck of femur at the District general hospital during the three year study period from April 2004 till March 2007 were included in the present study. All patients received the routine peri-operative antibiotic prophylaxis of three doses of intravenous cefuroxime. Data collected included age, sex, duration between operation and the onset of diarrhoea, length of stay and associated mortality.

Results: A total of 1023 patients underwent surgery for fracture neck of femur during the three years of study period. The average age of the patients was 81 years. 80% of the patients were females. A total of 62 patients suffered from C. Difficile diarrhoea (6%) after the arthroplasty procedure, and within this cohort, 29 patients died during the same admission to the hospital (47%). The average length of stay for a patient with fracture neck of femur was increased from 23.4 days to 60 days in those affected with C. Difficile diarrhoea.

Discussion: The patients with fracture neck of femur are generally elderly, frail and with poor body reserves. C.difficile infection in such patients not only adds to the morbidity, but also causes significant increase in the mortality rate. The broad spectrum peri-operative antibiotics used to prevent infection generally render the patient vulnerable to this highly lethal hospital bug. Introduction of simple infection control measures such as hand-washing and isolation, and change of peri-operative antibiotic protocol led to a statistically significant reduction in the incidence of C. Difficile infections after surgery for fracture neck of femur.

Objectives: To compare the results of various surgical approaches to the knee in primary total knee arthroplasty (TKA) surgery.

Design: Systematic review with meta-analysis.

Data Sources: Cochrane Bone, Joint, and Muscle Trauma group trials register (2007), Cochrane central register of controlled trials (Cochrane Library issue 2, 2007), Medline (1950–2007), Embase (1974–2007), CINAHL (1982–2007), Pubmed, SCOPUS and ZETOC.

Review Methods: Randomised and quasi-randomised controlled trials comparing surgical approaches in patients undergoing primary TKA. Relative risks and 95% CIs were calculated for dichotomous outcomes, and weighted mean differences and 95% CIs calculated for continuous outcomes. Individually randomised trials were pooled whenever possible with the use of the fixed-effects model of Mantel-Haenszel.

Results: 53 articles were identified using our search strategy; of these, 32 were excluded from the systematic review. 21 trials involving 1082 patients (1170 TKAs) were included.

Midvastus (MV) vs Medial Parapatellar (MPP) approach:

Quadriceps function in the early post operative period was better preserved in the MV group. Post operative pain, blood loss and the need for LRR tended to be lower in the MV group.

Conclusions: Approaches preserving the quadriceps tendon improve the early extensor mechanism function and tend to decrease the need for LRR. Combined with a decrease in blood loss and postoperative pain, these approaches improve early rehabilitation and allow for a more rapid recovery of knee function. However, these early improvements fail to provide any long term benefit, do not improve knee scores, or decrease the length of hospital stay.

MIS tends to result in an improved early quadriceps function and decreased blood loss. However, these approaches are technically more demanding, result in longer operative times and provide no long-term benefit. There is concern that they result in a greater number of major complications and risk implant mal-alignment. Eversion of the patella seems to correlate with poor quadriceps function.

The aim of this study was to compare a single-incision minimally invasive posterior approach with a standard posterior approach in a double-blind prospective randomised controlled trial.

A pilot study was carried out to assess the efficacy of the minimally invasive (MI) approach. The protocol described in the CONSORT statement was used as a template for the study design. 100 Primary total hip replacements meeting the inclusion criteria were randomised in theatre to either the MI approach (using a small incision with preservation of piriformis and distal aspect of quadratus femoris) or the standard posterior approach. Hips meeting the inclusion criteria were randomised in theatre using sealed identical opaque envelopes. Patients were blinded to allocation and all patients remained in the group they were allocated to. Pre and post-operative care programmes were identical. Patients were scored by a blinded research physiotherapist pre-operatively, at Day 2, 2 weeks, 6 weeks and 3 months post operation. The primary outcome measure was function, assessed using the Oxford hip score, SF-12 questionnaire, Iowa score, 6-minute walk test and the number of walking aids required after 2 and 6 weeks post operatively. Secondary outcomes were complication rates, patient satisfaction, difficulty of the procedure as perceived by the surgeon, soft tissue trauma (CRP and blood loss) and radiographic analysis.

50 patients were recruited to each group. There was no difference in demographics Mean incision length was 12.8cm and 19.1cm respectively. There was no statistically significant difference in operation time, post-op functional recovery (ILOA score) or length of stay. Pain (VAS) was similar post-operatively, and at 6 and 12 weeks. There was no significant difference in 10 metre walking speed or 6 minute walking distance at 2, 6 or 12 weeks; nor was there a difference in Oxford hip score, patient satisfaction with surgery (VAS), or SF-12 score at 6 or 12 weeks. Blood loss, fall in haematocrit, transfusion rate and CRP rise were similar. There was no significant difference in cementation of the stem (Barrack) or cup position (Dorr). There was one death from PE in the MIS group and one deep infection in the standard group. There was one dislocation in the standard group. The only statistical difference between the groups was less dependence on walking aids at 2 and 6 weeks in the MIS group; there was no difference at 12 weeks.

MIS surgery is safe, and may allow earlier independent mobility after THR. However, the claims of significantly reduced pain, less morbidity, better function and improved patient satisfaction appear to be unfounded.

Despite initial enthusiasm for minimally invasive total hip replacements (THR), there has been a marked paucity of level 1 evidence studies assessing it.

100 patients fulfilling the inclusion criteria were randomised in theatre to a standard posterior or muscle-sparing short incision (MIS) approach. A hybrid hip replacement was used routinely. Post-operative management was the same. Follow-up occurred at 2, 6 and 12 weeks. Patients, as well as functional and radiographic assessors were blinded.

50 patients were recruited to each group. There was no difference in demographics Mean incision length was 12.8cm and 19.1cm respectively. There was no statistically significant difference in operation time, post-op functional recovery (ILOA score) or length of stay. Pain (VAS) was similar post-operatively, and at 6 and 12 weeks. There was no significant difference in 10 metre walking speed or 6 minute walking distance at 2, 6 or 12 weeks; nor was there a difference in Oxford hip score, patient satisfaction with surgery (VAS), or SF-12 score at 6 or 12 weeks. Blood loss, fall in haematocrit, transfusion rate and CRP rise were similar. There was no significant difference in cementation of the stem (Barrack) or cup position (Dorr). There was one death from PE in the MIS group and one deep infection in the standard group. There was one dislocation in the standard group. The only statistical difference between the groups was less dependence on walking aids at 2 and 6 weeks in the MIS group; there was no difference at 12 weeks.

MIS surgery is safe, and may allow earlier independent mobility after THR. However, the claims of significantly reduced pain, less morbidity, better function and improved patient satisfaction appear to be unfounded.

A recurrence of objectively measured knee laxity after anterior cruciate ligament (ACL) reconstruction has previously been reported in various papers; the purpose of this study was to accurately measure in vivo knee laxity after both bone-tendon-bone (BTB) and hamstring reconstruction using radiostereometric analysis (RSA), and to differentiate between graft fixation slippage and graft stretching and their relative contributions to any increase in laxity.

Twenty patients were studied prospectively after ACL reconstruction. Ten had been operated on using BTB grafts, and ten using hamstring (four-stranded semitendinosus/gracilis) grafts. Tantalum markers were inserted in the distal femur, proximal tibia and into the graft itself. (RSA) was used to measure sagittal laxity, graft stretching and fixation slippage early post-operatively, and then at intervals up to 1 year.

A steady increase in total anteroposterior laxity was found in both groups over the year. For the BTB group, total mean slippage of the bone plugs increased to 1.28 mm at 1 year. For the hamstring group, the tunnel attachments had slipped by a total of 6.82 mm. More stretching was found for the hamstrings grafts than for the BTB grafts and the amount of stretching increased significantly with time post-surgery. The hamstring grafts stretched by a mean of 4.18%, the BTB grafts by 1.18%.

This is believed to be the most detailed application of RSA in analysing the performance of the two commonly used grafts in ACL reconstruction. Details such as graft stretching and fixation slippage have not been available previously; the data obtained in this study may have implications for clinical practice.

Introduction: There is an increased risk of revision for aseptic loosening with a transgluteal approach as described in the Swedish Hip Register. Femoral component malpositioning is itself associated with a poor outcome. A cuff of posteriorly situated glutei during the direct lateral approach may result in levering the proximal stem anteriorly and the tip of the stem posteriorly and does not allow the entry point of the stem to be placed posteriorly at the level of neck resection resulting in possible malpositioning.

The purpose of this study was to determine whether there is a significant difference in femoral component alignment when the posterior and direct lateral approaches are compared.

Materials and methods: Forty patients underwent a direct lateral approach and forty a posterior approach (n = 80). Inclusion criteria included primary hip arthroplasty using a cemented Exeter femoral component. At 6 weeks a standard AP and a modified lateral radiograph were taken. Measurements were taken from digitized radiographs as follows:

AP radiograph

Tip of stem to outer medial cortex.

Component alignment was defined as A – B and C – D.

Results: A–B was 0.71 for the modified direct lateral approach and 2.56 for the posterior approach. C–D was 1.47 for the direct lateral approach and 1.21 for the posterior approach. This difference was not statistically different using paired t tests as p > 0.05(P=0.69) for lateral views measurements.

Discussion: This study demonstrates that there is no significant difference between direct lateral and posterior approaches as far as femoral component alignment is concerned. The increased revision rate noted by the Swedish Hip Register when a transgluteal approach is likely to be multifactorial, but not likely to be due to femoral component malalignment.

This was a double-blind randomised controlled study. The objective of this study was to determine the cause of post-injection pain after peri-articular steroid injection. Approval for this study was granted by the hospital’s Ethics Committee. Selection criteria included all patients undergoing a peri-articular injection under the care of the senior author. Patients who elected to be in this study gave their consent following a detailed explanation of the study and provision of a patient information leaflet. The enrolled patients were randomised into one of two groups. Group A received a standard triamcinolone acetonide injection mixed with bupivicaine. Group B patients received triamcinolone acetonide without the preservative part of the drug and bupivicaine. Both the patient and the surgeon were unaware which group the patient was selected to be in. Patients’ scores were recorded using visual analogue scales and pain severity scores prior to injection and 4 days following injection. Inflammatory signs were also recorded at 4 days post-procedure. A total of 52 patients were enrolled. Pain scores reduced by 46% in group A and 43% in group B. Inflammatory signs occurred in 26% less cases when group B was compared with group A, however this was not statistically significant.

Introduction Primary and revision total hip surgery in the face of poor neuromuscular function, cognitive impairment or recurrent dislocation are fraught with complications. A useful option for such cases is the constrained acetabular component, or “captive cup”. We present the largest series reported to date, and use radiostereometric analysis (RSA) to assess cup migration.

Method Between February 1999 and September 2003 133 patients (141 hips) were identified as high risk of dislocation and were treated with a constrained acetabular component. One hundred and twenty cases were revision arthroplasties and 21 were primary replacements. Patients were assessed pre-operatively (WOMAC, Harris Hip Scores and SF-36). Defects were reconstructed with allograft (massive, morsellised or strut) where required. Most components were inserted into uncemented metal cups. Radiostereometric beads were inserted. Post-operatively patients were followed up regularly and clinical scores repeated. Radiostereometric analysis (RSA) was performed at 6 months, and then annually to assess prosthesis migration.

Results Mean follow-up was 3.1 years (range 1 – 5.6 years). At last review 26 patients had died, and 7 were lost to follow-up. There were 8 revisions for cup loosening. There were 5 dislocations and 2 dissociations in 6 patients. There was a statistically significant improvement in WOMAC and Harris Hip scores. RSA confirmed cup migration was greater than for non-captive cups, but was nevertheless minimal. Interestingly there was no statistically significant difference at 6, 12 and 24 months suggesting most migration occurs early on.

Conclusion Our results suggest the “captive cup” is an effective and safe option for the treatment of primary and revision arthroplasty in those at high risk of dislocation.

Introduction: Primary and revision total hip surgery in the face of poor neuromuscular function, cognitive impairment or recurrent dislocation are fraught with complications. A useful option for such cases is the constrained acetabular component, or “captive cup”. We present the largest series reported to date, and use radiostereometric analysis (RSA) to assess cup migration.

Method: Between February 1999 and September 2003 126 patients were identified as high risk of dislocation and were treated with a constrained acetabular component. One hundred and sixteen cases were revision arthroplasties and 10 were primary replacements. Patients were assessed pre-operatively (WOMAC, Harris Hip Scores and SF-36). Defects were reconstructed with allograft (massive, morsellised or strut) where required. All components were inserted into uncemented metal cups. Radiostereometric beads were inserted. Post-operatively patients were followed up regularly and clinical scores repeated. Radiostereometric analysis (RSA) was performed at 6 months, and then annually to assess prosthesis migration.

Results: Mean follow-up was 3.1 years (range 1 – 5.6 years). At last review 8 patients had died, and 2 were lost to follow-up. There were 7 revisions: 3 for infection, 2 for periprosthetic fractures, and 2 for aseptic loosening. There was one case of cup disassociation successfully treated with open reduction. There have been no further dislocations. There was a statistically significant improvement in WOMAC and Harris Hip scores. RSA confirmed cup migration was greater than for non-captive cups, but was nevertheless acceptable: 0.16mm medially, 0.47mm proximally, 0.16mm posteriorly. Interestingly there was no statistically significant difference at 6, 12 and 24 months suggesting most migration occurs early on.

Conclusion: Our results suggest the “captive cup” is an effective and safe option for the treatment of primary and revision arthroplasty in those at high risk of dislocation. RSA analysis confirms minimal prosthesis migration.

Introduction and aim: Early symptomatic osteoarthritis (OA) of the knee poses a difficult challenge to orthopaedic surgeons, particularly in the presence of malalignment. Most surgical options are palliative. Our aim was to assess combined high tibial osteotomy (HTO) and matrix-induced autologous chondrocyte implantation (MACI) as a curative option.

Methods Patients with localised medial compartment OA and varus malalignment were identified. Suitability for the above procedure was confirmed at arthroscopy and specimen taken for culture. HTO and MACI procedures were performed in one sitting by a single surgeon. Patients received three months rehabilitation and function was assessed preoperatively and at three-monthly intervals.

Results Twelve patients were identified: nine male; average age 46 years (27–58). Mean varus deformity was 6 degrees. Two patients also had evidence of osteochondritis dissecans, and two early patello-femoral OA. Eight patients had had previous surgery to the knee.

Eleven patients had a lateral closing wedge osteotomy; the medial opening wedge was performed in a case of leg shortening. Mean operation duration was 72 minutes (60–90). The graft was fixed with fibrin glue in all cases, and augmented with stitches or vicryl pins in five cases. Mean defect size was 6.2cm2 (2–12). There were three complications: one DVT, a haemarthrosis and a graft detachment.

Average follow-up was 16 months. MRI scans at three months show oedematous tissue at the defect sites, contrasting with the fluid filled defects seen preoperatively. Scans at one-year show hyaline-like cartilage infill with similar signal characteristics to native hyaline cartilage. Six minute walk test and knee injury and osteoarthritis outcome score indicate significantly improved functional capacity at six months and one year.

Conclusions Preliminary results suggest combined HTO and MACI is successful for young patients with early OA associated with malalignment.

Introduction: Iontophoresis is a method to introduce antibiotic molecules into allograft bone using an electrical potential; the antibiotics may then be released at therapeutic levels for extended periods of time. This is the first report of iontophoresed allograft implantation into patients.

Method: A method of loading tubular sections of cortical bone was used in theatre prior to implantation. Postoperative serum, drain and allograft antibiotic assays were performed. Patients were followed-up clinically and radiologically. All patients who received a bulk segmental allograft from June 1997 were entered into the trial.

Results: Since June 1997, 35 patients have received 37 allografts. Indications for allograft insertion were limb salvage for tumour (18), and poor bone stock associated with infection (11), periprosthetic fracture (6), aseptic loosening (1) and recurrent dislocation of total hip replacement (1). Mean follow-up is 3.3 years, and no patients have been lost to follow-up. One patient received two allografts in different sites and one had an allograft exchange. There has been one superficial wound infection and one deep infection. The latter patient was revised to another iontophoresed allograft and has had no recurrence at 34 months. One allograft has been revised to a vascularised fibular graft and allograft exchange following fracture of metal fixation. There was one case of persistent non-union in a knee arthrodesis which was treated after 21 months by removal of the intramedullary fixation and use of an Illizarov frame. The allograft was not revised. All other allografts are in situ with no complications related to the allograft. Eleven patients had pre-existing proven infections. None of these patients have been re-infected to date. Therapeutic gentamicin and flucloxacillin levels were detected in drain fluid samples post-operatively.

Conclusions: Iontophoresis is a safe and inexpensive technique that delivers high local dose of antibiotic, which may reduce infection in avascular allograft bone.

Introduction: Acute compartment syndrome is most commonly seen in the lower limb. Only four cases have been reported in the paraspinal muscles. The common features of this condition have not been described.

Methods: Following the successful surgical treatment of a case of bilateral paraspinal muscle compartment syndrome, a thorough search was made of all similar cases in Medline, and by hand-searching of references lists.

Results: Only four other cases of non-traumatic paraspinal compartment syndrome were identified in the literature. Closer analysis revealed many features in common with our case. The condition tends to occur in skiers in their 20s with a previous history of exercise-induced back pain. Patients present with paraspinal muscle spasm and loss of sensation of the loin, after a few days of heavy exertion. There is abdominal tenderness and bowel sounds are reduced. Consistent findings on blood chemistry are marked elevation of creatinine kinase, myoglobin and LDH. There is an associated myoglobinuria. MRI is helpful in identifying extent of muscle involvement and guiding surgical intervention. The most useful investigation is the direct measurement of compartment pressures. Treatment can be operative or non-operative, although surgery is associated with more rapid recovery and elimination of pain.

Discussion and Conclusion: The common features of acute paraspinal compartment syndrome of non-traumatic origin have not previously been recognised. We have helped define the characteristics of this condition to aid earlier recognition and treatment.

Introduction We believe minimally invasive surgery should be defined by the extent of soft tissue dissection rather than incision length. We describe a new technique that is truly soft-tissue sparing and report our early results.

The surgical approach The landmarks for the incision are identified and a 6–8cm oblique incision is made over the posterior aspect of the greater trochanter. Longer incisions are required in more difficult cases. Piriformis and the proximal insertion of gluteus maximus are preserved. After implant insertion, meticulous capsular repair is performed through drill holes into bone to reconstruct the posterior envelope. There are no restrictions to mobility. No specialised instruments are required.

Method The standard posterior approach (group 1) was compared with the PSMI approach (group 2) in a prospective cohort study of 200 consecutive patients over 60 years of age. In the standard approach the external rrotators were dettached. The capsule was repaired to bone, and the piriformis tendon reattached to the Gluteus Medius tendon. Routine restrictions to mobility were imposed. Patients were scored pre-operatively and followed up prospectively, by a blinded observer.

Results Demographics and functional scores were similar. Mean operation time was about 1 hour in both groups. Mean incision length was 21.5 cm (range 15 – 25) in group 1 and 8.4 cm (range 6 – 16) in group 2. Mean blood loss in group 1 was significantly higher than group 2 (P< 0.0001, 95%CI 191–547). Mean inpatient stay was 8.0 days in group 1, and 4.8 days in group 2 (P< 0.0001, 95%CI 3.4–6.0).

Minimum follow-up was 3 years in group 1 and 1.5 years in group 2. There were 3 dislocations in group 1, and none in group 2. There were 2 re-operations in both groups. The relative improvement in WOMAC scores was significantly greater in group 2 at 3 months and 1 year (P< 0.05).

Conclusion The PSMI approach to the hip is truly soft-tissue sparing. It is safe and relatively easy to perform. The stability and minimal morbidity allow early mobilisation. This is the first study to suggest the benefits of minimally invasive surgery may be prolonged. Cosmesis is a by-product rather than primary objective.

Introduction and Aims: A number of ‘minimally invasive’ approaches have been described which are essentially a standard approach through a smaller incision: the term ‘mini-incision’ is more appropriate. We describe a new technique that is truly soft-tissue sparing and report our early results.

Method: Following Malchau’s principles we performed cadaver studies to familiarise ourselves with the approach before conducting a pilot study. The approach involves a 6–8cm oblique incision over the posterior aspect of the greater trochanter. Care is taken to preserve piriformis and gluteus maximus. Meticulous capsular repair is performed through drill holes into bone at the end of the procedure to reconstruct the posterior envelope. There are no restrictions to mobility post-op.

Patients were scored pre-operatively and followed up prospectively. The only special instruments required are two large curved Hohmann retractors and an angled cup introducer.

Results: One hundred and one consecutive routine primary total hip replacements were performed via the ‘piriformis-sparing minimally invasive approach’ by a single surgeon. Marked on-table stability was noted in all hips prior to capsular repair.

Forty-two percent of patients were male. Mean age was 68.9 years (42–90) and BMI 26 (14–39). Average operation time was 64.1 minutes and anaesthetic time 92.5 minutes. Mean fall in haemoglobin in the first 24 hours was 2.3g/dl. Mean incision length was 7.4cm.

Follow-up was a minimum of one year (range 12–29 months). There was a highly statistically significant improvement in WOMAC and SF-36 scores at three and 12 months post-operatively (p< 0.0001). Early medical complications occurred in 12 patients, including two superficial infections, all of which resolved. There were no peri-prosthetic fractures and importantly, no dislocations. There were two re-operations: one revision for cup displacement and one washout for deep infection.

Conclusion: We believe that the marked stability that we achieve on-table is only possible by sparing piriformis and careful capsular repair. As with all new procedures however, there is a learning curve for both surgeon and assistant. Preliminary results from our pilot study may be interpreted with guarded optimism.

Introduction and Aims: Iontophoresis is a method to introduce antibiotic molecules into allograft bone using an electrical potential. In-vitro testing has shown that these antibiotics should be released in their bioactive form at therapeutic levels for extended periods of time. This is the first report of iontophoresed allograft implantation into patients.

Method: A method of loading tubular sections of cortical bone was used in theatre prior to implantation. The bone was held vertically in an antibiotic bath with a cylindrical outer electrode and a wire electrode down the centre of the bone. An electrical potential of approximately 90V was applied to drive the antibiotics into the bone. Post-operative serum, drain and allograft antibiotic assays were performed. All patients were followed-up clinically and radiologically. Patients who required a bulk segmental allograft from June 1997 to present were entered into the trial and received iontophoresed bone.

Results: Since June 1997, 35 patients have received 37 iontophoresed allografts. Indications for allograft insertion were limb salvage for tumor (16), poor bone stock associated with infection (12), periprosthetic fracture (seven), aseptic loosening (one) and recurrent dislocation of total hip replacement (one). One patient had acute complications requiring amputation. No patients were lost to follow-up with a mean follow-up of 3.3 years. Two patients required an allograft exchange for fracture and infection. There were two late allograft infections at 10 and 18 months. One patient was revised to another iontophoresed allograft and has had no recurrence at two years. The other infection required above knee amputation. One allograft was revised with allograft exchange and vascularised fibular graft following fracture of metal fixation. There was one case of persistent non-union in a knee fusion, which was treated after 21 months by removal of the intermedullary fixation and allograft and use of an Ilizarov frame. All other allografts are in-situ with no complications related to the allograft. Twelve patients had pre-existing proven infections. None of these patients have been re-infected to date. Therapeutic gentamicin and flucloxacillin levels were detected in drain fluid samples post-operatively, averaging from 39.9 mg/L at two hours to 5.97mg/L at 48 hours for gentamicin and 16.83mg/L at two hours and 2.23 mg/L at 48 hours for flucloxacillin. This was significantly greater than the minimum inhibitory concentration (MIC) against Staphylococcus aureus for gentamicin (0.25mg/L) and flucloxacillin (0.30mg/L). At the same time, blood levels remained in a safe range.

Conclusion: Iontophoresis is a safe and inexpensive method that can be executed in the operating theatre. Iontophoresed bone delivers a high local dose of antibiotic, which may prevent early biofilm formation initiated during allograft handling and exposure to theatre air. With no early infections and no re-infections, further assessment of this technique continues with guarded optimism.

58 patients underwent treatment for Slipped Upper Femoral Epiphysis (SUFE) at our unit from 1984 to 2001. 4 (7%) patients had bilateral SUFE at the time of primary admission, 17 (29%) patients were diagnosed with a slip of the contralateral hip at review during adolescence. The remaining 37 patients whose contralateral hips were not operated upon at completion of growth were reviewed at an average follow-up of 8 years (range 2–17) after the primary admission. 13 patients were not available for review, so 24 patients were examined and their hips radiographed.

Iowa hip score was used to assess the function of the hips, Antero-posterior and lateral radiographic views were taken to look for evidence of epiphyseal slip and degenerative joint disease. The Calcar Femorale was used as a radiographic landmark to check for a slip. Ahlback’s score was used to grade osteoarthritis.

4 out of 24 patients at the follow-up examination showed displacement of the contralateral femoral head that was greater than 3 standard deviation and was consistent with previously unrecognised physiolysis. 4 contralateral hips showed evidence of butteressing at the site of physeal reminence but the displacement was less than 3 standard deviations and so they were not considered to have slipped. 3 of these hips with buttressing had evidence of Grade I osteoarthritis. Overall incidence of bilateral SUFE in our study, excluding the 13 patients who were not available for follow-up was 25 out of 45 (55%).

This real existence of unrecognised contralateral slip, the increased risk of OA in these hips and significant rate of bilaterality, stresses the need to readdress the current mode of management of the contralateral hips in patients treated for unilateral SUFE.

Introduction and Aims: The Lateral Femoral Cutaneous Nerve is placed at risk of iatrogenic injury in the dual incision minimally invasive approach THA. A number of trials have indicated rates of injury up to 30%. This clinical and cadaver study examined the morphology of the nerve in 101 cadaver specimens and in 78 dual incision THA patients.

Method: One hundred and one lateral femoral cutaneous nerves of the thigh were dissected in fresh and formalin embalmed specimens. Dissection was limited to the anterior thigh and the branch pattern of the LFCN recorded. Dual incision patients were followed prospectively and examined with regard to LFCN paraesthesia.

Results: Despite the variability of the nerve, three basic morphologic patterns emerged. Approximately 55% had a major medial trunk and smaller lateral branch, 30% involved two distinct large branches and 15% had a trifurcation or other pattern.

In our clinical series, over 30% of patients experienced paraesthesia and some experienced a burning dysaesthesia in the distribution of the LFCN.

Conclusion: Iatrogenic injury to the LFCN is relatively common in the dual incision minimally invasive THA and patients must be informed of such a risk. Based on this study we have slightly modified our incision and approach.

Introduction and Aims: The use of ‘superglue’ (2-Octylcyanoacrylate) in wound closure is well established in other surgical specialties, but not described in orthopaedics. The aim was to compare superglue with staples and subcuticular suture in a prospective randomised trial.

Method: One hundred and fifty patients admitted for a primary total knee or hip replacement were randomised to receive either clips, continuous subcuticular suture (3.0 Monocryl) or ‘superglue’ for wound closure. All knee replacements were mobilised on the day of surgery with CPM and hip replacements on the first post-operative day. Patients’ wounds were assessed on day one and at six weeks by a blinded observer.

Results: There were 80 hips and 70 total knee replacements performed; 51 wounds were closed with clips, 50 with suture and 49 with superglue. Mean duration of skin closure was significantly shorter with staples, and superglue was significantly faster than suture. There was no significant difference in the complication rates between the groups, including infection, dehiscence or allergic reaction. There was significantly more ooze by day one from the wounds closed with clips than the other two groups. Significantly more of the wounds closed with glue had no strike-through on to the dressing, and were therefore deemed to be ‘sealed’. Patient satisfaction at six weeks was significantly higher with superglue and suture than staples. The suture and super-glue groups had higher median scores on the Hollander wound evaluation scale than staples, however the difference was not statistically significant. Surgeon satisfaction with technique was highest with superglue and staples (no significant difference between the groups), and significantly higher than with subcuticular suture.

Conclusion: Superglue is safe to use for skin closure in primary knee and hip arthroplasty. Although closure with staples is faster, superglue is associated with less wound ooze and better patient satisfaction. The cosmetic result with superglue is comparable to that of subcuticular sutures but has a better surgeon satisfaction score.

Introduction Roentgen stereophotogrammetric analysis (RSA) is the most accurate radiographic technique for measuring three-dimensional micromotion in joints, and is now being developed for the study of anterior cruciate ligament (ACL) injury and outcome after surgical reconstruction. Using RSA a prospective study of ACL reconstruction is being undertaken. The aim is to obtain accurate information on the performance of both bone-patellar tendon-bone (BPTB) and hamstring grafts post-operatively.

Materials and methods 14 patients with a unilateral ACL tear who underwent ACL reconstruction have been studied prospectively. Seven had BPTB grafts, and seven had four-stranded semitendinosus/gracilis. Tantalum markers were inserted at the time of surgery, 4 each into the femur and tibia, and 8 into the graft, at regular intervals along the length. Stress stereo radiographs (90N anterior and posterior draw forces) were taken at 1, 6, 12 and 24 weeks post-operatively. They were analysed using Medis RSA software.

Results Initial results suggest that in addition to measuring total anteroposterior knee laxity, detailed analysis of the graft itself is possible. Beads placed in the bone blocks of the BPTB grafts, and in the intraosseous ends of the hamstrings, enable calculation of slippage of the fixation. The BPTB bone plugs moved 0.6 to 1.2mm by 12 weeks, the Hamstrings fixation was more variable. Beads placed in the intraarticular graft may enable measurement of any post-operative stretching, but are also somewhat erratic. Identification of the site of stretching – around the tunnel entrances, or intraarticularly, should be possible.

Conclusions We believe that this detailed application of RSA in analysing the performance of the two commonly used grafts in ACL reconstruction has not been previously described. We hope to gain valuable insight into the behaviour of both graft types and reasons for graft failure. This presentation will demonstrate the methods developed and include the technical difficulties encountered in this on-going study.

Introduction: Despite its common occurrence there is still controversy regarding the choice of treatment for the displaced intracapsular hip fracture in the elderly patient. Aim: To compare internal þxation and hemiar-throplasty in a prospective randomised controlled trial. Method: 455 patients aged over 70 years with a displaced intracapsular hip fracture were randomised to either hemiarthroplasty or internal þxation. Results: Internal þxation has shorter length of anaesthesia (p< 0.0001), lower operative blood loss (p< 0.0001) and lower transfusion requirements (p< 0.0001). Additional surgical procedures were required in 90 patients (39.8%) treated by internal þxation and 12 patients (5.2%) in the arthroplasty group. There was no statistical difference in mortality at one year (p=0.91), however there was a trend to improved survival for the older less mobile patients treated by internal þxation. There was no statistical difference in pain and mobility. Limb shortening was more common after internal þxation (p=0.004). Conclusion: We recommend that displaced intracapsular fractures in the elderly should generally be treated by hemiarthro-plasty, but internal þxation may be appropriate for the frail less mobile patient.

Aim: To clarify the issue of whether or not to cement the hemiarthroplasty in the treatment of displaced intra-capsular femoral neck fractures in the elderly. Method: All patients with displaced intracapsular femoral neck fractures treated with hemiarthroplasty between January 1997 and May 1998, in 2 hospitals within the same Deanery, were reviewed. The same prosthesis was used; in hospital A they were uncemented, and in B cemented. There were 121 patients in hospital A and 123 in hospital B; all patients alive at follow-up (50 and 56 respectively) were interviewed for pre-fracture and current assessments of pain and functional ability using validated scoring systems. Follow-up was 32–36 months. Results: Patient demographics were similar. Cemented procedures took 15 minutes longer. In-patient stay was the same. Signiþcantly fewer of the cemented group had been revised or were awaiting revision (p=0.036). There was no difference in mortality rates at any point. Prospective assessment of surviving patients revealed highly statistically signiþcant greater deterioration in pain (p=0.003), walking ability (p=0.002), use of walking aids (p=0.003) and activities of daily living (p=0.009) in the uncemented group. The trend for more dependent accommodation in the uncemented group failed to reach statistical signiþcance (p=0.14). Conclusions: Our þndings support the use of cemented hemiarthroplasty for displaced intracapsular femoral neck fractures in the elderly.

Introduction: The best method of management of displaced intracapsular femoral neck fractures in elderly patients remains undecided. Most are treated by hemiarthroplasty.

Aim: To clarify the issue of whether or not to use cement in hemiarthroplasty for displaced, intracapsular, femoral neck fractures in the elderly.

Methods: Consecutive patients with displaced, intracapsular, femoral neck fractures treated by hemiarthroplasty between January 1997 and May 1998, in two hospitals within one region were reviewed. The same monoblock prosthesis was used; in Hospital A they were uncemented (121 patients), and in Hospital B they were cemented (123 patients). All surviving patients (50 and 56 respectively) were interviewed for assessments of pre-fracture and current pain, walking ability, use of walking aids and activities of daily living (ADL), using validated scoring systems. The average follow-up was 36 months.

Results: The patients’ demographical data were similar (the mean age was 82 and 84 years respectively). There was no greater incidence of intra-operative fall in diastolic blood pressure or oxygen saturation in the cemented group. Cemented procedures took, on average, 15 minutes longer. Fewer of the cemented group had been revised or were awaiting revision (p=0.036). There was no difference in complication or mortality rates at any time between surgery and follow-up (p=0.86). Prospective assessment revealed highly significant differences in favour of cement, in terms of pain (p=0.003), walking ability (p=0.002), use of walking aids (p=0.004) and ADL (p=0.009).

Conclusion: Our findings support the use of cemented hemiarthroplasty for the displaced intracapsular femoral neck fracture in the elderly patient.

Aim: To establish the surgical treatment of displaced intracapsular femoral neck fractures in hospitals across the United Kingdom.

Methods: The on-call registrars in all 223 hospitals receiving acute orthopaedic admissions in the UK, were interviewed by telephone. Their usual practices were recorded for two groups of patients, active and frail. The proportions of hospitals using the different surgical options were determined.

Results: Despite stereotyped clinical features, management varied between specialists within some hospitals: two or more different methods of treatment were in routine use for active patients in 22% of hospitals, and for frail patients in 27%. The management also varied between hospitals. Overall, for active patients, bipolar hemiarthroplasty was in use in 41%, internal fixation in 37%, unipolar hemiarthroplasty in 32% and total hip replacement in 16% of hospitals. For frail patients either Austin-Moore or Thompson prostheses or both were in use in 94% of hospitals. Where used, Austin-Moore prostheses were uncemented in 93% of hospitals, and Thompson prostheses cemented in 79%. Bipolar prostheses were in use in 8%, and the alternative of internal fixation undertaken for frail patients in 1% of hospitals.

Conclusions: The findings demonstrated a lack of consensus in several aspects of the treatment of displaced intracapsular fractures of the femoral neck, with implications for consideration of best practice, in the UK, and worldwide.

Open reduction and internal fixation is the treatment of choice for patients with displaced fractures of the lateral and medial malleoli. Ideally, operative treatment restores sufficient stability to allow full mobility at the ankle joint. However, because of the necessity to protect the ankle from weight-bearing and other forces, we routinely immobilise the ankle in a below-knee cast because of our concerns about patient compliance. We carried out a prospective study to assess patient compliance with instructions on non-weight bearing following ORIF of ankle fractures.

All 30 patients at our hospital who were treated for an ankle fracture over a 14 month period were included in our study. 22 of these underwent ORIF. A below knee cast was applied in all cases, and patients were instructed not to put any weight on the injured limb. A pressure sensitive film (Fuji Prescale Film, Sensor Products Inc., NJ, USA) was incorporated into the cast beneath the heel pad. Patients were informed that this was being done to measure the pressure within the cast, for the purposes of a trial. The cast was changed (including the pressure sensitive film) at two-week intervals over a six week period, providing three separate measurements of pressure on the heel. The sole of the cast was also examined, to complement the findings on the pressure film. At each visit, the patients level of pain was assessed using a visual analogue score, and the wound (if present) was examined.

There was a remarkable variation in the amount of weight bearing performed by the patients in this study, but several trends could be observed. In most cases, patient compliance was greatest in the first four weeks following cast application, but patients tended to put significant weight on the limb in the 4–6 week period. Female patients tended to comply better than males. Patients with a history of alcohol or drug abuse complied poorly. Compliance was lower in those individuals with lower pain scores. Of interest, the degree of weight bearing did not significantly affect the radiological or clinical outcome at the 6-week mark in any case. We conclude that patient compliance with non-weight bearing is generally poor, although the effect of this poor compliance on the long-term outcome requires further study.

Background: Non-union of fractures is a common problem faced by orthopaedic surgeons. Although the basic processes of fracture healing have been better elucidated in recent years, in terms of their cellular and molecular biology, the pathogenesis of fracture non-union remains poorly understood.

Aims: To examine the pattern of cytokine expression in established non-unions, in particular the inflammatory cytokines interleukin 1 and tumour necrosis factor alpha.

Materials and Methods: Tissue was taken from 7 non united fractures at the time of a surgical procedure aimed at effecting union. Part of the tissue was snap-frozen in liquid nitrogen, and a portion of the sample was processed for routine histology. Normal bone tissue was taken from the femoral shaft at the time of arthoplasty, to provide normal control tissue. Total RNA was extracted from the frozen tissue by means of a mortar and pestle and a modified phenol-chloroform extraction protocol. Cytokine expression patterns were examined using the Cytokine Gene Expression plate I (PE Biosystems) and analysed using the Sequence Detection Software and Microsoft Excel.

Results: A consistent pattern of cytokine expression was seen in all non-union tissue samples. There was marked suppression of interleukin 1 beta, interleukin 8, interleukin 10 and TNF-alpha when compared to resting bone. This environment is thus one where the stimulus for bone resorption is suppressed, with consequent loss of stimulation of bone formation (theory of “bone coupling”), directly and also possibly through interaction with prostaglandin production. In addition, collagen production is stimulated preferentially. These findings argue against the traditional definitions of fracture non-union, and suggest a possible adjunctive role for the administration of interleukins in the treatment of non-united fractures.

This is a retrospective study of 612 cases of iatropathic injury to peripheral nerves seen in one tertiary referral unit between 1991 and 1998. A total of 291 patients was subsequently operated on to explore the nerve lesion. The most common presenting symptom was pain, which often masked underlying loss of function. The delay in diagnosis was up to 40 months.

The findings at operation were analysed according to the type of nerve damaged, the nature of the injury and the referring specialty. Some of the more common causal operations and procedures are discussed. Preventive measures are listed, and early diagnosis and treatment are recommended.

The passage of technetium-labelled methylene diphosphonate (99mTc-MDP) across rat bone was examined by autoradiography. The autoradiographs showed that shortly after an injection of the bone-seeking agent there was activity outside the bone, within the bone marrow and also adjacent to the highly vascular epiphysial plate; the distribution of the isotope in the incubated bone appeared to be non-uniform, a high concentration being seen adjacent to the epiphysial plate and also on the surfaces of the bone. The evidence suggested that a two-fold mechanism resulted in the uneven distribution of 99mTc-MDP. The first factor probably represented the regional distribution of blood flow with a transcapillary movement of the tracer from the capillary bed to the extravascular space; the subsequent incorporation of the tracer into bone appeared to depend on the nature of the bone matrix.

The residue and extraction of technetium-labelled methylene diphosphonate (99mTc-MDP), a substance used in bone scanning, was examined in the canine tibia and found to be low. Examination of washout curves suggested that there were four compartments in cortical bone, a vascular, a perivascular, a bone fluid and a bone compartment. After an osteotomy in the canine tibia the residue of 99mTc-MDP increased. This was believed to be due to an increase in the blood supply to the bone and to an associated increase in new bone available for exchange. Bone scanning in a fracture is therefore a reflection of the vascular status of the bone being examined and of the uptake by bone. This is dependent on there being an adequate blood supply to the bone and an increased number of mineral-binding sites.