Aims. The aim of this investigation was to compare risk of
Aims. Deep surgical site
Aims. Delayed postoperative inoculation of orthopaedic implants with persistent wound drainage or bacterial seeding of a haematoma can result in periprosthetic joint
Aims. To explore the clinical efficacy of using two different types of articulating spacers in two-stage revision for chronic knee periprosthetic joint
Aims. This study aimed to evaluate the BioFire Joint
Aims. Fracture-related
Aims. Periprosthetic joint
Aims. Despite numerous studies focusing on periprosthetic joint
Aims. This study evaluated the definitions developed by the European Bone and Joint
Aims. Musculoskeletal
Aims. Biofilm-related
Aims. The number of revision arthroplasties being performed in the elderly is expected to rise, including revision for
Aims. Periprosthetic hip-joint
Aims. The aim of this study was to perform the first population-based description of the epidemiological and health economic burden of fracture-related
Aims. To investigate the efficacy of ethylenediaminetetraacetic acid-normal saline (EDTA-NS) in dispersing biofilms and reducing bacterial
Aims. Histology is widely used for diagnosis of persistent
Aims. Gram-negative
Aims. The aims of this study were to determine the incidence and factors for developing periprosthetic joint
Aims. A higher failure rate has been reported in haematogenous periprosthetic joint
Aims. Bacteriophages infect, replicate inside bacteria, and are released from the host through lysis. Here, we evaluate the effects of repetitive doses of the Staphylococcus aureus phage 191219 and gentamicin against haematogenous and early-stage biofilm implant-related
Periprosthetic joint
Aims. This study aimed to evaluate the clinical application of the PJI-TNM classification for periprosthetic joint
Aims. This study aims to determine difference in annual rate of early-onset (≤ 90 days) deep surgical site
Aims. The aim of this study was to analyze the prevalence of culture-negative periprosthetic joint
Aims. Arthroplasty surgery of the knee and hip is performed in two to three million patients annually. Periprosthetic joint
Aims. One-stage exchange for periprosthetic joint
Aims. Periprosthetic joint
Aims. Gram-negative periprosthetic joint
Aims. Trained immunity confers non-specific protection against various types of infectious diseases, including bone and joint
Aims. Orthopaedic
Aims. The aim of this study was to determine the prevalence of depressive and anxiety disorders prior to total hip (THA) and total knee arthroplasty (TKA) and to assess their impact on the rates of any
Aims. Achievement of accurate microbiological diagnosis prior to revision is key to reducing the high rates of persistent
Aims. There is conflicting evidence on the safety of intra-articular injections of hyaluronic acid (HA) or corticosteroids (CSs) before total knee arthroplasty (TKA). We performed a meta-analysis of the relationship between intra-articular injections and subsequent
Aims. Periprosthetic joint
Aims. Hand trauma accounts for one in five of emergency department attendances, with a UK incidence of over five million injuries/year and 250,000 operations/year. Surgical site
Aims. Hand trauma, consisting of injuries to both the hand and the wrist, are a common injury seen worldwide. The global age-standardized incidence of hand trauma exceeds 179 per 100,000. Hand trauma may require surgical management and therefore result in significant costs to both healthcare systems and society. Surgical site
Aims. Treatment outcomes for methicillin-resistant Staphylococcus aureus (MRSA) periprosthetic joint
Aims. The aim of this study was to estimate the 90-day periprosthetic joint
Aims. Fracture-related
Aims. Serum inflammatory parameters are widely used to aid in diagnosing a periprosthetic joint
Aims. Fungal periprosthetic joint
Aims. There is a considerable challenge in treating bone infections and orthopaedic device-associated
Aims. The outcome of repeat septic revision after a failed one-stage exchange for periprosthetic joint
Aims. The new COVID-19 variant was reported by the authorities of the UK to the World Health Organization (WHO) on 14 December 2020. We aim to describe the clinical characteristics and nosocomial
Aims. Histology is an established tool in diagnosing periprosthetic joint
Aims. Fungal and mycobacterial periprosthetic joint
Aims. Antibiotic prophylaxis involving timely administration of appropriately dosed antibiotic is considered effective to reduce the risk of surgical site
Aims. Bone regeneration during treatment of staphylococcal bone infection is challenging due to the ability of Staphylococcus aureus to invade and persist within osteoblasts. Here, we sought to determine whether the metabolic and extracellular organic matrix formation and mineralization ability of S. aureus-infected human osteoblasts can be restored after rifampicin (RMP) therapy. Methods. The human osteoblast-like Saos-2 cells infected with S. aureus EDCC 5055 strain and treated with 8 µg/ml RMP underwent osteogenic stimulation for up to 21 days. Test groups were Saos-2 cells + S. aureus and Saos-2 cells + S. aureus + 8 µg/ml RMP, and control groups were uninfected untreated Saos-2 cells and uninfected Saos-2 cells + 8 µg/ml RMP. Results. The S. aureus-infected osteoblasts showed a significant number of intracellular bacteria colonies and an unusual higher metabolic activity (p < 0.005) compared to uninfected osteoblasts. Treatment with 8 µg/ml RMP significantly eradicated intracellular bacteria and the metabolic activity was comparable to uninfected groups. The RMP-treated infected osteoblasts revealed a significantly reduced amount of mineralized extracellular matrix (ECM) at seven days osteogenesis relative to uninfected untreated osteoblasts (p = 0.007). Prolonged osteogenesis and RMP treatment at 21 days significantly improved the ECM mineralization level. Ultrastructural images of the mineralized RMP-treated infected osteoblasts revealed viable osteoblasts and densely distributed calcium crystal deposits within the extracellular organic matrix. The expression levels of prominent bone formation genes were comparable to the RMP-treated uninfected osteoblasts. Conclusion. Intracellular S. aureus
Aims. With the ageing population, fragility fractures have become one of the most common conditions. The objective of this study was to investigate whether microbiological outcomes and fracture-healing in osteoporotic bone is worse than normal bone with fracture-related
Aim. The time to onset of symptoms after fracture fixation is still commonly used to classify fracture-related
Aims. Fracture-Related
Aims. The principle strategies of fracture-related
Aim. The aim of this investigation was to compare risk of
Aim. The current antibiotic treatment of periprosthetic joint
Aim. Accurate diagnosis is key in correctly managing prosthetic joint infection (PJI). Our aim is to compare the preoperative performance of three PJI definitions comparing it to definitive postoperative classification. Method. This is a multicenter retrospective study of patients who have undergone total hip or knee revision surgery in four different European institutions. For this specific study, cases with no preoperative synovial fluid differential leukocyte count and less than four intraoperative microbiology samples were excluded. Cases were classified using the 2021 EBJIS, the 2018 International Consensus Meeting (ICM) and the 2013 Musculoskeletal
Aim. There have been many attempts to define the criteria by which prosthetic joint infection (PJI) is diagnosed. Our aim is to validate the 2021 European Bone and Joint
Aims. We aimed to report the mid- to long-term rates of septic and aseptic failure after two-stage revision surgery for periprosthetic joint
Aim. Synovial fluid investigation is the best alternative to diagnose prosthetic joint infection (PJI) before adequate microbiological/histology sampling during revision surgery. Although accurate preoperative diagnosis is certainly recommended, puncturing every patient before revision arthroplasty raises concerns about safety and feasibility issues especially in difficult to access joint (e.g., hip), that often require OR time and fluoroscopy/ultrasound guidance. Currently there is no clear guidelines regarding optimal indications to perform preoperative joint aspiration to diagnose PJI before revision surgery. The main goal of this study is to determine the accuracy of our institutional criteria using the new European Bone and Joint
Aims. There is a paucity of long-term studies analyzing risk factors for failure after single-stage revision for periprosthetic joint
Purpose. Fracture-related
Acute bone and joint
Aim. One of the most severe complications of primary total knee arthroplasty (TKA) is periprosthetic joint
Aims. Despite numerous studies on periprosthetic joint
Aim. In recent years, many studies on revision for
To determine risk factors of
Aim. Diagnosing periprosthetic joint
Aim. Treatment algorithms for fracture-related nonunion depend on the presence or absence of bacterial
Background. Increasing evidence suggests a link between the bearing surface used in total hip arthroplasty (THA) and the occurrence of
Introduction. Accurate diagnosis of peri-prosthetic joint
Aims. Wrist arthroscopy is a standard procedure in hand surgery for diagnosis and treatment of wrist injuries. Even though not generally recommended for similar procedures, general administration of perioperative antibiotic prophylaxis (PAP) is still widely used in wrist arthroscopy. Methods. A clinical ambispective dual-centre study was performed to determine whether PAP reduces postoperative
Aims. This study aims to assess the relationship between history of pseudotumour formation secondary to metal-on-metal (MoM) implants and periprosthetic joint
The incidence of PJI in knee replacements is 2.8% and slightly lower with hip replacement surgery. PJI make up 15% (or even more) of knee revisions. To combat PJI, antibiotic laden bone cement has been used for many decades, but antibiotic stewardship dictates more prudent management of antimicrobials. Projected increase in
Aim. Previous publications have suggested that the incidence of revisions due to
Aims. Excision of chronic osteomyelitic bone creates a dead space which must be managed to avoid early recurrence of
Aims. Hip fracture commonly affects the frailest patients, of whom many are care-dependent, with a disproportionate risk of contracting COVID-19. We examined the impact of COVID-19
Aim. Debridement, Antibiotics, Irrigation, and implant Retention (DAIR) is a surgical treatment protocol suitable for some patients with fracture related
Introduction. The management of fracture-related
There is no consensus on how to evaluate and grade pin site
Open tibial fractures can be difficult to manage, with a range of factors that could affect treatment and outcome. We present a large cohort of patients, and analyse which factors have significant associations with
Aims. A revision for periprosthetic joint
While pre-soaking grafts in vancomycin has demonstrated to be effective in observational studies for anterior cruciate ligament reconstruction (ACLR)
Abstract. Aim. To identify the difference in
Aims. This study was designed to characterize the recurrence incidence and risk factors of antibiotic-loaded cement spacer (ALCS) for definitive bone defect treatment in limb osteomyelitis. Methods. We included adult patients with limb osteomyelitis who received debridement and ALCS insertion into the bone defect as definitive management between 2013 and 2020 in our clinical centre. The follow-up time was at least two years. Data on patients’ demographics, clinical characteristics, and
Aims. Total femoral arthroplasty (TFA) is a rare procedure used in cases of significant femoral bone loss, commonly from cancer,
Aims. The diagnosis of periprosthetic joint
Aims. The purpose of this study was to compare the clinical outcomes, mortalities, implant survival rates, and complications of total knee arthroplasty (TKA) in patients with or without hepatitis B virus (HBV)
Aim. The number of operatively treated clavicle fractures has increased over the past decades. Consequently, this has led to an increase in secondary procedures required to treat complications such as fracture-related
Aim. Serum parameters continue to be a focus of research in diagnosing periprosthetic joint
The documentation of deep
Aims. The aim of this study was to determine the consensus best practice approach for the investigation and management of children (aged 0 to 15 years) in the UK with musculoskeletal
Aim. Failed consolidation (nonunion) after foot and ankle arthrodesis is a major complication, which can lead to additional revision arthrodesis with increased risk of morbidity. Multiple factors can contribute to developing a nonunion, including a low-grade
Aim. Acute post-surgical
Aims. Periprosthetic joint
Aims. Current diagnostic tools are not always able to effectively identify periprosthetic joint
Aims. The aim of this study was to examine whether socioeconomic status (SES) is associated with a higher risk of
Aims. This study aimed to evaluate the effectiveness of the induced membrane technique for treating infected bone defects, and to explore the factors that might affect patient outcomes. Methods. A comprehensive search was performed in PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases between 1 January 2000 and 31 October 2021. Studies with a minimum sample size of five patients with infected bone defects treated with the induced membrane technique were included. Factors associated with nonunion,
Aims. This study aimed to investigate the clinical characteristics and outcomes associated with culture-negative limb osteomyelitis patients. Methods. A total of 1,047 limb osteomyelitis patients aged 18 years or older who underwent debridement and intraoperative culture at our clinic centre from 1 January 2011 to 31 December 2020 were included. Patient characteristics,
Aims. Implant-related postoperative spondylodiscitis (IPOS) is a severe complication in spine surgery and is associated with high morbidity and mortality. With growing knowledge in the field of periprosthetic joint