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Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 395 - 395
1 Jul 2010
Periasamy K Spencer S Patil S Mohammed A Murray H Watson W Meek R
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Introduction: The ideal acetabular component has low wear, permanent fixation and physiological bone loading. Recently trabecular metal has been promoted as reproducing the modulus of trabecular bone with a cementless fixation. The aim of this trial was to see if a monobloc trabecular backed polyethylene acetabular component loaded the pelvis physiologically as a cemented polyethylene component.

Method: Between 2004 and 2006 54 patients were ran-domised to a cemented polyethylene acetabular component versus a monobloc trabecular backed polyethylene acetabular component. The primary outcome measurement was bone density in peri-prosthetic acetabular regions of interest measured preoperatively and post operatively at 6 weeks and 1 year. Secondary outcomes measured were radiographic and functional outcomes (HHS and Oxford score).

Results: Radiographically 8 patients in the trabecular group had a significant gap in zone II which resolved in 6 by 1 year. The cemented group had 3 patients with a radiolucent line (zone 1) at 1 year. HHS and OXFORD scores improved with no significant difference between the groups. Both groups had significant loss of bone density in the ilium and ischium. The trabecular group produced a significant increase in bone density in the superolateral region. The cemented group produced increased bone density in the superomedial region.

Discussions and Conclusions: There is a significant reduction in BMD for both groups in the upper pelvis and ischium in keeping with finite element modelling predictions. The press-fit group relative to the cemented group resulted in decreased BMD in the superomedial peri-prosthetic region. The trabecular monobloc cup therefore behaves more like a rigid cementless shell despite the properties of trabecular metal.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 387 - 388
1 Jul 2010
Augustine A Macdonald D Murray HM Mohammed A Meek R Patil S
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Introduction: Infection following hip arthroplasty although uncommon can have devastating outcomes. Obesity, defined as a BMI of ≥ 30, is a known risk factor for infection in this population. Coagulase negative Staph Aureus (CNS) is the commonest causative organism isolated from infected arthroplasties. This study was performed to determine if there has been a change in the causative organisms isolated from infected hip arthroplasties and to see if there is a difference in obese patients.

Methods: Data on all deep infection following primary and revision hips was obtained from the surgical site infection register from April 1998 to November 2007. All case notes were reviewed retrospectively.

Results: There were 49 patients with 51 infected arthroplasties; 25 infected Primary THAs and 26 infected Revision THAs. We found a female preponderance in the infected primary and revision THAs (n=30). 65.3% of all patients had a BMI of ≥ 30. Over the period studied, Coagulase negative Staph was the most common organism isolated (56.8%) followed by mixed organisms (37.2%) and Staph Aureus (25.4%). Multiple organisms were found exclusively in obese patients. In more than half of cases the causative organisms were resistant to ≥ 2 antibiotics.

Discussion: This study shows that over the last 10 years, CNS continues to be the most frequently isolated organism in infected hip arthroplasties. Multiple organisms with multiple antibiotic resistances are common in obese patients. On this basis we recommend that combination antibiotic therapy should be considered in obese patients.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 307 - 307
1 May 2010
Panousis K Meek R Roberts P Grigoris P
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Hip resurfacing preserves proximal femoral bone stock, optimises stress transfer to the proximal femur and offers inherent stability and optimal range of movement. The early results of metal–on-polyethylene resurfacing designs were poor and the resurfacing concept was largely abandoned. Modern metal-on-metal articulations enabled the introduction of a new generation of hip resurfacings with encouraging early results. In 1997 two of the authors developed a hip resurfacing system utilizing a metal-on-metal bearing. Our study reports on the clinical and radiological outcomes of the first 200 hips that were treated with the Durom hip resurfacing at an average follow up of 4.6 years (range 3.5–6).

Between May 2001 and December 2003, 200 consecutive hip resurfacings were performed on 189 patients, using the Durom hybrid metal-on-metal system. The average age of the patients was 50 years (range 22.5 – 72.3) and 119 were male. Patients were seen at 6 weeks and at 3, 6 and 12 months and annually thereafter for clinical and radiological evaluation. Clinical results were evaluated using the Harris Hip Score. A subjective assessment of patient satisfaction was obtained and patient activity was assessed using the UCLA activity score.

No patient was lost to follow up. There were no dislocations and no femoral neck fractures. One femoral component was revised due to aseptic loosening 3.9 years postoperatively. There was one late acute haematogenous infection that was successfully treated elsewhere by debridement and retention of the prosthesis. The mean Harris Hip Score improved significantly from 46.7 preoperatively to 94.4 postoperatively. The mean HHS constituents for pain, function and motion all were significantly improved from the preoperative values of 11.9, 25.7 and 4.2 to 41.8, 43.4 and 4.8 respectively following the resurfacing procedure. The mean UCLA activity score was 7.2 indicating a relatively active patient population and 179 hips were rated as excellent by the patients. No cup was considered radiographically loose. Extensive radiologic changes were observed around the femoral stem in 2.5% of the hips, with migration of the femoral component in one case and stem demarcation in 4 cases. All 5 patients maintained excellent function and had no hip pain. Pelvic osteolysis was observed in 2 cases. Neck remodelling changes were observed in 35 hips (17.5%). Kaplan-Mayer survivorship analysis demonstrated the rate of survival of the resurfacing components to be 99.5% (95% confidence interval 98.5 to 100) with revision for any reason as the endpoint.

Early results with the Durom resurfacing system appear encouraging. Although these should be regarded with caution, modern metal-on-metal hip resurfacing potentially offers the ultimate bone preservation and restoration of function in appropriately selected young patients.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 284 - 284
1 May 2010
Fearon P Helmy N Meek R
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Purpose: To evaluate the appropriateness of posterior blade plate ankle arthrodesis as a salvage procedure, in a complex subgroup of ankle trauma patients.

Methods: We retrospectively identified all patients who underwent an ankle arthrodesis from our prospectively collected trauma database at Vancouver General hospital from 1997 to 2005. We then extracted those who had blade plate arthrodesis via the posterior approach for previous failed fracture fixation or failed previous fusion. Demographics, pre arthrodesis diagnosis, previous surgeries, deformity and complications were recorded. Clinical examination was based on outpatient evaluation and physical evaluation. This was supplemented with radiological follow up to confirm union and outcome scoring using the AOFAS and SF36 systems.

Results: Sixteen patients were identified from the trauma database who had undergone posterior blade plate ankle arthrodesis. Of these thirteen were available for follow up. There average age was 47 years (range 23–63 years). The male to female ratio was 3:1. Three cases were for failed previous ankle fusion by other means. Of the remaining ten patients with post traumatic osteoarthritis, seven had previous pilon fractures, two talar fractures and one fracture dislocated ankle. All cases went onto bony union. Patient satisfaction was good although functional outcome scoring was not normal

Conclusion: We have found this procedure to have several excellent benefits. It allows the surgeon to operate through virgin skin, reducing potential wound complications, and achieve good soft tissue coverage. The blade plate allows reconstitution of a normal plantar grade ankle and distal tibial orientation, when secured appropriately to bone. Excellent compression and union can be achieved with the AO compression device, but it’s important to have a second screw in the talus to prevent blade pull out. The procedure has good satisfaction among patients following previous failed surgery, as a salvage procedure.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 255 - 255
1 May 2009
Apostle KL Blachut P Broekhuyse H Guy P Meek R O’Brien P
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To determine if intraoperative positioning in the supine or lateral position affects morbidity and mortality in orthopaedic trauma patients with femur fractures.

Retrospective cohort study of 991 patients representing 1030 femoral shaft fractures admitted to our level one trauma center between the years of 1987 to 2006. Primary outcome measures included mortality and admission to ICU. Secondary outcome measures included length of stay in hospital, length of time admitted to the intensive care unit and discharge disposition. Logistic regression analysis was performed to compare to effect of intraoperative position in addition to other known dependent variables on primary and secondary outcome measures.

Intraoperative position in the supine or lateral position had no effect on morbidity or mortality in orthopaedic trauma patients with femur fractures.

There is no difference in immediate mortality or morbidity between patients with femur fractures treated with IM nails in either the lateral or supine position. We conclude that either position is safe for the surgical stabilization of femur fractures and intraoperative position should be determined by surgeon preference.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 293 - 293
1 May 2009
Ogunwale B Brewer J Schmidt-Ott A Tabrizi N Meek R
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Unlike metal-on-Polyethylene, metal-on-metal (MoM) implants seem to affect the adaptive immune response as evident from the associated perivascular infiltrate containing lymphocytes and plasma cells. This is more pronounced in implant failure secondary to aseptic loosening, and may represent the failure mode. A reduction in CD8+ T lymphocyte counts has also been described with Hip Resurfacing. MoM articulations produce a much smaller order of size of wear particles (nanoparticles) than metal-on- Polyethylene, which may be responsible for the observed adaptive immune system effects. We therefore analyzed the effects of CoCr nanoparticles (CoCrNP) on Dendritic Cells, T cells & B cells.

We produced CoCrNP using repetitive short spark discharges between electrodes of prosthetic CoCr alloy. Electron micrography and Brunauer-Emmet-Teller method both confirmed nanoparticle size. The following experiments were then undertaken.

Dendritic Cells were cultured from mouse bone marrow and incubated with CoCrNP of varying concentrations for 24hrs, or lipopolysaccharide as a positive control. Activation status was then characterized by CD40 expression on fluorescence activated cell sorting (FACS) analysis.

T Cell Viability; Cells from mouse lymph nodes were incubated with CoCrNP in varying concentrations. At 48hrs, Propidium Iodide (PI) was added and proportion of CD4+ lymphocytes that were PI+ve determined by FACS analysis.

T Cell proliferation; Cells from mouse lymph nodes were cultured in medium without phenol red and incubated with μCD3 (anti CD3), μCD3 + CoCrNP, μCD3 + μCD28 or μCD3 + μCD28 + CoCrNP. At 48hrs, Almar Blue was added & difference in light absorbance at 570nm & 600nm was then used to determine T cell proliferation at 72hrs.

Cells from lymph nodes of an MD4 (Hen Egg Lysozyme (HEL) specific B cell receptor transgenic) mouse were incubated with CoCrNP, HEL (positive control) or CoCrNP + HEL. B cell activation at 48hrs was characterised by CD40 and CD86 expression on FACS analysis.

We found CoCrNP did not significantly increase CD40 expression on DCs, neither did it alter CD40 or CD86 expression on B cells. Using a sublethal concentration of CoCrNP as determined from the viability tests, CoCrNP inhibited CD3 & CD3/CD28 dependent T-cell proliferation. This would indicate CoCrNP reduces T cell proliferation and/or survival, which may explain the observed reduction in CD8+ count with hip resurfacing. Understanding the development of the Peri-vascular infiltrate associated with MoM implants will however, probably require more complex (most likely in vivo) models.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 133 - 133
1 Mar 2009
Ogunwale B Brewer J Meek R
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Background: Increased use of metal on metal (MOM) hip replacements has stimulated interest in immunological effects of chronic CoCr elevation. Unlike metal-on-polyethelylene, MOM implants are associated with a perivascular infiltrate of lymphocytes & plasma cells. This may be the mode of failure of MOM implants. A reduction in CD8+ T lymphocyte counts associated with MOM implants has previously been described. CoCr therefore seems to affect the adaptive immune response even though it is not a proteinous antigen.

We therefore analyzed the effects of CoCr particles on T cells & B cells. We also analyzed it effects on dendritic cells, which are the key antigen presenting cells to T helper cells.

Methods: CoCr nano particles were produced by repetitive short spark discharges between electrodes of prosthetic CoCr alloy. Electron micrography & BET both confirmed nanoparticle size.

Dendritic cells (DCs) were harvested from mouse bone marrow & cultured in medium supplemented with GM-CSF for 6 days, generating DCs typically 80–90% CD11c+. These were incubated with CoCr in concentrations of 25, 10 & 2.5 μg/ml, for 24 hours, or lipopolysaccharide 1 μg/ml as a positive control. Following incubation, activation status of CD11c+ DCs was characterized by MHC Class II, CD40, CD80 & CD86 expression by FACS analysis.

T-Lymphocytes were harvested from mouse lymph nodes & cultured in medium without phenol red. These were incubated at 5 ×105 cells/well with either CoCr, conA (positive control) or CoCr + conA & repeated using 2.5 ×105 cells/well. Other positive controls (CD3 & CD 28) were studied in repeating the experiment. At 48 hours Almar Blue was added & further incubation for 24 hrs. Light absorbance at 570nm & 600nm was then used to determine T cell proliferation

B-Lymphocytes were harvested from the lymph nodes of mice which were only able to mount a B-cell reaction to Hen egg Lysozyme (HEL). These were incubated with medium with CoCr, HEL (positive control) or CoCr+ HEL. The concentration of the CoCr was varied between 25, 10 & 2.5 μg/ml. FACS analysis for markers of B cell regulation was performed after 48 hours incubation..

Results: CoCr did not significantly increase CD 40 expression on DCs, although such expression was increased significantly by lipopolysaccaride CoCr did not significantly up or down regulate B cells as compared to the effects of HEL. CoCr did inhibit proliferation of T-cells & this was more pronounced where the ratio of CoCr/cell density was higher.

Conclusion: Both dendritic & B cells are unaffected by CoCr in vitro. However, CoCr inhibited T cell proliferation. This demonstrates the observed reduction in CD + T cells are probably due to a direct effect of CoCr, & not mediated through another cell type. The perivascular response to MOM implants on the other hand probably requires cell interaction in an in vivo environment.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 547 - 547
1 Aug 2008
Patil S Mohammed A Meek R
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Introduction: Removal of well-fixed, cementless, acetabular components after resurfacing hip arthroplasty remains a challenging problem. Damage to host bone may limit options for reconstruction, compromise the long-term result of the revision operation and fundamentally defeat the aim of bone conserving resurfacing hip surgery.

Methods: A series of 6 consecutive patients who under-went removal of a secure, acetabular resurfacing component at the time of revision arthroplasty were included for review. During the operative procedure, the size of the component which was removed and the diameter of the final reamer used prior to implantation and final acetabular implant were recorded. The modification of the standard explant technique will be described which allows safe removal of any size of acetabular component.

Results: In all patients the indication for index arthroplasty was osteoarthritis. Three cases were MMT (Smith and Nephew), 2 Cormet 2000 (Corin, UK). and 1 DUROM (Zimmer). The indications for acetabular revision were infection in all cases. The median difference between the size of component removed and the size of final component implanted was 4 mm.

Discussion: Our modification uses a pre-existing system. The ease of removal with this modification and the lack of any further damage to the host bone illustrates that the Explant Acetabular Cup Removal System can be safely expanded to removal of well fixed resurfacing monoblock acetabular components. With experience, any manufacturers resurfacing shell can be removed with virtually no bone loss.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 404 - 404
1 Jul 2008
Meek R Sharma H Jane M Raby N Macduff E Reid R
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Intraosseous schwannoma is a rare benign neoplasm, which most commonly arises in the head and neck region particularly the mandible, due to the long intraosseous path of sensory nerves in the mandible. We present a 27-year-old lady with an unusual presentation of an intraosseous schwannoma of the first metatarsal. There is only one report published previously of an intraossous schwannoma of the lesser metatarsal bone of the foot.

A 27-year-old woman presented with painful left forefoot following a trip while walking. Plain radiographs demonstrated a pathological fracture through a lytic lesion of the first metatarsal of the left foot. MRI scan using axial T1-weighted spin echo and axial and sagittal T2-weighted gradient echo showed an amorphous mass occupying the medulla of the bone but with a breach of the plantar aspect of cortex with apparent localised destruction. Ultrasound-guided biopsy was performed. Haematoxylin and Eosin stained specimen sections showed a proliferation of spindle cells of alternating hypercellularity and hypocellularity. This case was managed by curettage and grafting with autograft and synthetic bone substitute. At two-year follow-up, the radiographs showed complete graft incorporation and a healed cyst. The patient was clinically asymptomatic with return of full functions. There were no clinico-radiological findings to suggest any recurrence.

Due to rarity and non-specific clinico-radiological features, this case illustrates the necessity of a multi-disciplinary approach with an accurate histological diagnosis in combination with radiological and clinical appearances.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 299 - 299
1 Jul 2008
Spencer S Carter R Murray H Meek R Grigoris P
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Introduction: Hip resurfacing is a popular alternative to total hip arthroplasty. It aims to provide more physiological loading of the proximal femur, avoiding stress shielding and associated bone resorption. However, finite element analysis of hip resurfacing systems suggests stress shielding occurs in the femoral neck below the prosthesis and theoretically may lead to femoral neck fracture. Nevertheless, recent DEXA studies indicate femoral bone stock preservation with no evidence of stress shielding. It is not yet known what actually occurs in clinical practice. The aim of this study was to assess whether femoral neck resorption occurs in one particular type of hip resurfacing post operatively and quantify the degree of narrowing.

Methods: Femoral neck resorption of the Cormet 2000 metal-on-metal resurfacing prosthesis (Corin, UK) was assessed by measuring the prosthesis-neck ratio on postoperative radiographs. 39 prostheses (35 patients) were measured on plain AP pelvis radiographs taken immediately and mean 2 years post-operatively. Subsequent follow up radiographs were measured up to maximum 7 years follow up, mean 4.75 years.

Results: There was evidence of neck atrophy in 35/39 hips at an average of 2 years post operation, with the overall average neck narrowing from a ratio of 0.86 to 0.81 at 2 years. Average neck ratios were calculated up to 7 years post resurfacing; 25 hips measured at 3 years average ratio of 0.81, 20 at 4 years ratio 0.8, 25 at 5 years ratio 0.8, 9 at 6 years ratio 0.8, 1 at 7 years ratio 0.81.

Discussion: A degree neck resorption occurs with this resurfacing prosthesis by 2 years, however no further resorption appears to occur beyond this, to a maximum follow up of 7 years. This may indicate that early narrowing is more likely to be due to harmless bone adaption then a progressive absorption jeopardising the femoral neck.


Introduction: Aseptic osteolysis represents a significant challenge to the orthopaedic surgeon as it limits the long terms survivorship of prosthetic implants.

Aim: To investigate whether the bisphosphonate aledronate alters the cytokine profile in the psuedomembrane excised from individuals undergoing revision hip arthroplasty surgery for aseptic failure.

Methods: A prospective, double-blinded, randomised controlled trial was conducted with relevant ethical approval. 10 patients were randomly assigned to receive a placebo or alendronate 70mg for a 6 week period prior to revision surgery. All individuals had aseptic failure of primary cemented femoral stems and acetabular cups with UHDPE inserts. Infection was excluded in all individuals prior to surgery. Multiple tissue samples were subsequently excised at surgery and sent for histology and culture. If either was subsequently positive for infection the individual was excluded from the study. Tissue samples were preserved using liquid nitrogen and formalin. Frozen tissue was stored at −70oC pending Polymerase Chain Reaction analysis. Formalin preserved samples were paraffin sectioned for immunohistochemical analysis. PCR was carried out to assess expression of mRNA for Interleukins 1,6,17,18; TNF alpha, RANK-L, OPG and RANK. IHC was performed to confirm protein expression in the pseudomembrane excised from the femur and acetabulum. Multiple samples were used in each patient.

Results: In the 5 individuals who received the placebo there was expression of mRNA and protein for Interleukins 1,6,17,18; TNF alpha; RANK-L; OPG and RANK in all cases. There was no statistically significant difference in the expression of any of the aforementioned cytokines/receptors in the group receiving alendronate.

Discussion: A six seek course of oral alendronate 70mg had no effect upon osteoclastogenic cytokine expression when compared to the placebo group. This would suggest that alendronate may offer little benefit in reversing established particle induced osteolysis.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 301 - 301
1 Jul 2008
Clarke J Campbell C Murray H Meek R
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Introduction: Despite clinical history, examination and plain radiography it is occasionally difficult to locate the origin of hip pain. This is particularly relevant where the management will be a total hip arthroplasty. Local anaesthetic arthrogram of the hip may provide a simple, safe and reliable test to determine if the hip is the source of the patient’s symptoms. The aim of this study was to establish the use of this investigation in the management of hip pain.

Methods: All local anaesthetic hip arthrograms were reviewed from 1999 to 2005. All patients had completed a pain questionnaire following the arthrogram. Patients were classified into 3 groups; 1) Mild osteoarthritic changes on plain radiographs with possible referred pathology; 2) Minimal radiological changes but no obvious other pathology to refer pain; 3) Previous hip arthroplasty with unexplained pain. Those who subsequently had a primary or revision hip arthroplasty were assessed post-operatively by means of the Oxford hip score.

Results: Fifty-seven patients in total underwent a local anaesthetic hip arthrogram. From all the groups 34 patients obtained pain relief and 24 proceeded to primary or revision hip arthroplasty. Twenty three (96%) had a satisfactory post-operative outcome at an average follow-up of 2 years (average Oxford score 28). The remaining 10 patients with positive arthrograms are still waiting for surgery. All negative arthrogram patients were successfully discharged.

Discussion: A positive response to local anaesthetic hip arthrogram predicts a successful response to surgery. This permits accurate information of the results of hip surgery to be given to patients and aids in a management plan for a group of patients that can be otherwise challenging.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 25 - 25
1 Mar 2008
Deo S Loucks C Blachut P O’Brien P Broekhuyse H Meek R
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The long-term results of patients with multiple knee ligament injuries, i.e. at least 3 ligament ruptures, including both cruciates, in patients entered prospectively onto the trauma database between 1985 and 1999, were reviewed. Forty patients with this injury had modified Lysholm scores at long term follow-up a mean of 8 years post-injury. The mode of operative treatment fell into 3 groups: direct suture or screw fixation of avulsions (Group 1), mid-substance ruptures treated with cruciate reconstruction with hamstring tendons (Group 2), or suture repairs of mid-substance ruptures (Group 3). All operative procedures were undertaken within 2 weeks of injury. Non-operative treatment involved a cast or spanning external fixator (2–4 weeks) followed by bracing. Statistical analysis was performed on the Lysholm scores.

The 40 patients in the study group were predominantly young males, 40% had polytrauma, 33% had isolated injuries. Thirteen patients (33%) had non-operative management, the remainder had early operative treatment of their ligament injuries, tailored to the type of ligament injuries identified.

Long-term patient outcome data shows statistically significant differences (p< 0.05) between the best results, in patients with direct fixation of bony avulsions (mean = 89), followed by those who had early hamstring reconstruction (mean = 79), followed by those who underwent simple ligament repairs (mean = 65). There was a statistically significant difference (p< 0.05) between the overall scores for the operative group (mean = 80) compared with the non-operative group (mean = 50).

Operative treatment of multiple ligament injuries, particularly fixation of avulsions and primary reconstruction of the posterior cruciate ligament appears to yield better results than non-operative or simple repair in the long term follow-up in this group with significant knee injuries.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 34 - 34
1 Mar 2008
Meek R Greidanus N Garbuz D Masri B
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This study evaluated the effect of prosthetic patellar resurfacing on outcome of revision total knee arthroplasty. One hundred and twenty-six patients who underwent consecutive revision of total knee arthroplasty were identified. The status of the patella was ascertained post revision as to the presence or absence of patellar prosthesis. WOMAC, Oxford-12, SF-12 and patient satisfaction data were obtained at a minimum of two years follow-up. Follow-up was obtained in one hundred and ten patients. There was no significant difference between the two cohorts with regards to outcomes. A patellar prosthesis does not appear to significantly affect pain, function, or satisfaction outcomes following revision total knee arthroplasty.

The purpose of this study is to evaluate the effect of prosthetic patellar resurfacing on outcome of revision total knee arthroplasty in a matched cohort study.

The presence or absence of a patellar prosthesis does not appear to significantly affect pain, function, or satisfaction outcomes following revision total knee arthroplasty.

Attempting to resurface the patella in revision cases may not be worthwhile.

Follow-up was obtained in one hundred and ten patients (fifty-two with patellar component, fifty-eight bony shell), matched for age, sex and co-morbidity scores and followed for a minimum of two years. There was no significant difference between the two cohorts with regards to outcomes of WOMAC pain (mean seventy-two and sixty-five, p=0.17), WOMAC function (mean sixty-four and fifty-nine, p=0.26) scores, Oxford −12 (mean sixty-three and sixty-seven, p=0.2), SF-12 (mean forty and thirty-six, p=0.27) and satisfaction outcomes (mean eight and nine, p=0.07), (power of 0.8, beta=0.2).

From January 1997 to December 1999 one hundred and twenty-six patients who underwent consecutive revision total knee arthroplasty were identified. The status of the patella was ascertained post revision as to the presence or absence of patellar prosthesis. At a minimum of two years follow-up, pain and function were assessed by questionnaire for WOMAC, Oxford-12, SF-12 and patient satisfaction data. Co-morbidity, surgical exposure, HSS knee scores and ROM were also collected. Univariate and multivariate analyses were performed.

It is questionable whether patient’s pain, function and satisfaction are affected in revision total knee arthroplasty by patellar prosthetic resurfacing.

Funding: One or more of the authors has received funding from a commercial party. This was DePuy, Inc, Warsaw, IN.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 59 - 59
1 Mar 2008
Meek R Garbuz D Masri B Greidanus N Duncan C
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A concern with diaphyseal-fitting cementless stems in revision total hip arthroplasty is intra-operative fractures. Two hundred and eleven patients consecutively underwent revision hip arthroplasty using Solution stems (DePuy, Warsaw, IN). Intra-operative fractures or perforations occurred in sixty-four patients (30% prevalence), with diaphyseal splits in thirty-nine patients (18% prevalence). Risk factors were pre-operative osteolysis, cortex to canal ratio, under-reaming the cortex and large diameter stems. The majority of diaphyseal linear cracks occurred at the distal end of extended trochanteric osteotomies during stem insertion. Intra-operative fracture is associated with an average two days longer length of stay (p< 0.05).

The purpose of this study was to determine the identification of the risk factors and outcomes of intra-operative fractures using a diaphyseal fitting revision stem.

There is an association of intra-operative fracture associated using a diaphyseal-fitting stem in revision total hip arthroplasty with a longer length of stay in hospital.

Identifying preoperative risk factors will allow avoidance of such fractures and prolonged hospital stay.

Intra-operative fractures or perforations occurred in sixty-four patients (30% prevalence) and thirty-nine patients (18% prevalence) sustained diaphyseal splits. Risk factors associated with intra-operative fracture were pre-operative osteolysis, a low cortex to canal ratio, under-reaming the cortex and the use of a large diameter stem. Surgical approach was not directly related to fracture occurrence but the majority of diaphyseal undisplaced linear cracks occurred at the distal end of extended trochanteric osteotomies during stem insertion. Cortical perforation occurred most often with cement removal. Duration of stay was on average two days longer (p< 0.05) for patients with an intraoperative fracture.

Two hundred and eleven patients who had undergone revision hip arthroplasty using the Solution stem (DePuy, Warsaw, IN) between December 1998 and March 2002 were identified. Patients who sustained an intra-operative fracture were compared to controls patients who underwent hip revision at the same time frame but with no fracture. Multiple factors were analyzed to see which were risk factors for intra-operative fractures.

There is a surprisingly high incidence of intra-operative fracture associated with using a diaphyseal-fitting stem in revision total hip arthroplasty. This was associated with a longer length of stay


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 33 - 34
1 Mar 2008
Greidanus N Meek R Garbuz D Masri B Duncan C
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Patient satisfaction is not uniform or consistent following revision total knee arthroplasty. This study evaluates ninety-nine patients with a self-administered patient satisfaction questionnaire at a minimum of two years following the revision procedure (1997–99) to determine differences between satisfied (sixty-six patients) and dissatisfied patients (thirty-three patients). Univariate analysis revealed that patients satisfied with their results were significantly different (p< .05) than dissatisfied patients with regards to post op scores including those of the WOMAC pain and function, oxford, and SF-12. Patients were not different with regards to (p> .05) age, comorbidity score, surgical approach, or sepsis as a reason for the revision procedure. Regression analysis demonstrated that gender, post-op WOMAC score, and pre-op arc of motion were significant determinants of satisfaction.

The purpose of this study is to evaluate determinants of patient satisfaction following revision total knee arthroplasty.

Patient satisfaction with revision knee surgery is most strongly associated with both pre and post-operative descriptors of knee function as well as gender.

Understanding the variables associated with satisfaction/dissatisfaction following revision knee arthroplasty may further assist ongoing research efforts to improve the outcomes of this procedure.

Univariate analysis revealed that patients satisfied with their results were significantly different (p< .05) than dissatisfied patients with regards to WOMAC pain and function score, oxford knee score, and SF-12. Patients were not different with regards to (p> .05) age, comorbidity score, surgical approach, or presence of sepsis as a reason for the revision procedure. Regression analysis demonstrated that gender, post-op WOMAC score, and pre-op arc of motion were significant determinants of satisfaction (p< .05).

A self-administered patient satisfaction survey was completed by ninety-nine patients at a minimum of two years following revision total knee arthroplasty. Fifty-nine patients were females and forty were males. Sixty-six patients were satisfied and thirty-three patients were dissatisfied with the outcome of their surgery at two years post-op. Univariate analysis and multivariate regression suggest that pre and post-operative joint function and gender are the most significant determinants of patient satisfaction


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 22 - 23
1 Mar 2008
Meek R Greidanus N Garbuz D Masri B
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The purpose of this study is to evaluate the effect of prosthetic patellar resurfacing on outcome of revision total knee arthroplasty in a matched cohort study.

From January 1997 to December 1999 126 patients who underwent revision of total knee arthroplasty were identified. The status of the patella was ascertained post revision as to the presence or absence of patellar prosthesis. At a minimum of two years follow-up, pain and function were assessed by questionnaire for WOMAC, Oxford-12, SF-12 and patient satisfaction data. Co-morbidity, surgical exposure, HSS knee scores and ROM were also collected. Univariate and multivariate analysis were performed. Follow-up was obtained in 110 patients (52 with patellar component, 58 bony shell), matched for age (mean 70 and 67 years), sex and co-morbidity scores and followed for a minimum of two years. There was no significant difference between the two cohorts with regards to outcomes of WOMAC pain scores (mean 66 and 74, p=0.14), WOMAC function scores (mean 59 and 65, p=0.22), Oxford- 12 scores (mean 57 and 64, p=0.17), and satisfaction score outcomes (57 and 68, p=0.14). It remains controversial whether the patient’s pain, function and satisfaction are affected in revision total knee arthroplasty by patellar prosthetic resurfacing. Insufficient patellar bone stock may preclude prosthetic resurfacing in which case patel-loplasty is performed. From this series, the presence or absence of a patellar prosthesis does not appear to sig-nificantly affect pain, function, or satisfaction outcomes following revision total knee arthroplasty.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 57 - 57
1 Mar 2008
Cooke C O’Brien P Meek R Blachut P Broekhuyse H
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There are a variety of surgical approaches available for open reduction and internal fixation of acetabular fractures. Some centres have avoided the use of the triradiate approach in the belief that it may result in a significantly higher rate of heterotopic ossification. This has not been our experience. In contrast to many centres, acetabular fractures are treated in an emergent manner, with surgery usually undertaken within the first few days post injury. It is the investigators’ belief that this may in part result in a lower rate of heterotopic ossification.

The triradiate approach has fallen out of favour in the treatment of acetabular fractures due to concerns with both wound healing and heterotopic ossification. This approach however has been utilised frequently at the Vancouver General Hospital (VGH) in the treatment of acetabular fractures. The purpose of this study was to review the results and complications of this approach experienced in the large series at VGH.

We concluded that the results of this approach are acceptable with the exposure allowing anatomical fracture reduction in the vast majority of cases. The complication rate was low, as was the rate of heterotopic ossification.

The significance of this study is to highlight that this approach remains extremely useful in the treatment of acetabular fractures, due to its ability to give excellent exposure while still having an acceptably low complication rate. We believe that the ability of our unit to operate on these injuries in an emergent manner may impart the low rate of heterotopic ossification that we have observed.

There were a total of one hundred and sixty-one acetabular fractures that were treated operatively with the triradiate approach over the period 1989 to 2001. Of these, the majority were two column injuries (79 or 49%), T type fractures (34 or 21%) and transverse fractures (17 or 11%). The average age of the patients was thirty-seven years and the average time to surgery was three days. Our early complications included five cases of failure of fixation or loss of reduction of the fracture, two cases of neurovascular injury, two cases of superficial wound infection, one case of deep wound infection and one case of wound breakdown.

The study involved examining patient hospital records and radiographs and included fracture types, patient ages, delay to surgery, post-operative complications and degree of fracture reduction and healing. Grading of heterotopic ossification was performed by reviewing the anteroposterior radiographs and using Gruen’s classification system.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 138 - 138
1 Mar 2008
Adlington J Broekhuyse H O’brien P Guy P Blachut P Meek R Lodhia P
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Purpose: To evaluate early and late perioperative complications and long term quality of life outcomes in patients having undergone immediate open reduction and internal fixation of acute high-energy tibial plateau fractures (AO C3).

Methods: Retrospective review of 70 AO C3 tibial plateau fractures managed with immediate open reduction and internal fixation at the Vancouver General Hospital from December 1987 to April 2004. Chart and database review was conducted for early and late perioperative complications, and patients were surveyed using three quality of life instruments: SF36, SMFA, and WOMAC.

Results: 3(4.3%) patients had died at the time of follow-up. Of the remaining 67, 49(73%) could be located and were contacted for follow-up. 28 of the 49 subjects (57%) completed the mail-out surveys (20 male, 8 female). Mean age of respondents at time of follow-up was 45.2±9.0 years. 10(36%) patients were pedestrians or cyclists struck by cars, 9(32%) were injured as a result of a fall, 5(18%) were motor vehicle collisions, 2(7%) were sustained by a direct blow, and 2(7%) were sustained by twisting mechanisms. Mean time from injury to OR was 56.0+84.3 hours. Duration of follow-up was 8.9+5.3 years. 4(14%) patients had open fractures. Fixation methods included immediate ORIF with a single plate in 24(86%) cases, dual plating in 3(11%) cases, and screws alone in one (3%) case. ISS and LOS scores were 11.4+6.8 and 15.7+8.0 respectively. One patient (3%) experienced an early perioperative complication of excessive soft tissue tension post ORIF requiring delayed skin closure. Late perioperative complications included 9(32%) cases of painful hardware, 2(7%) non-unions, 2(7%) superficial infections, 1(3%) osteomyelitis and 1(3%) mal-union. No patients required amputation. SMFA and WOMAC scores were 55.3+9.6 and 29.44+23.22. SF36v scores were 40.6+10.4(PCS) and 45.1+15.8(MCS).

Conclusions: Immediate open reduction and internal fixation with careful attention to soft tissues can be a viable management option for many high energy tibial plateau fractures. Complication rates are comparable to those of delayed definitive management of these injuries.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 310 - 310
1 Sep 2005
Cooke C Broekhuyse H O’Brien P Blachut P Meek R
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Introduction and Aims: The use of the triradiate approach has been associated with high rates of wound dehiscence, wound infection and significant heterotopic ossification. This approach has been the favoured extensile exposure at the Vancouver General Hospital for many years. We will review the outcomes of the use of this approach in the treatment of acetabular fractures.

Method: Patients were identified from the database at Vancouver General Hospital who had their acetabular fractures treated through a triradiate approach from the period January 1989 through to December 2001. Patients with a delay of greater than three weeks from injury were excluded. A retrospective review of the hospital and out-patient records and all available radiographs was performed. Patients were contacted to determine if they required any further surgery and to assess their current functional status with appropriate outcome scores. Patients were also invited to undergo repeat radiographic assessment.

Results: Of a total of 407 acetabular fractures treated surgically, 152 open reductions were performed through the triradiate approach. The average age of these patients was 38 years and 114 (75%) of these were male. Patients referred from other hospitals totalled 128 (84%). Wound outcomes were known in 138 cases. Wound complications included five cases of wound dehiscence, of which four resolved with no undue effects. There were three cases of superficial wound infection and five cases of deep wound infection. Two of the patients with deep wound infection had sustained compound acetabular injuries and a further two had significant risk factors for infection (septicaemia from chest infection and significant soft tissue necrosis). Trochanteric osteotomy was performed in 139 (91%) cases. There were only two cases of trochanteric non-union in this series, however 21 cases required removal of painful trochanteric screws. With respect to heterotopic ossification, there was a 15% Broker III/IV incidence. In this group, the injury severity scores were higher, there was a greater delay to surgery and there was a greater need for mechanical ventilation due to multiple injuries. In the group, 24 hip reconstructions were required over the period.

Conclusion: In our centre, we found a low rate of wound dehiscence and deep wound infection associated with the triradiate approach in the treatment of acetabular fractures. Both open acetabular fractures developed deep infection. Trochanteric irritation was a problem in a number of the patients. The rate of significant hetero-topic ossification was low.