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Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 169 - 169
1 Mar 2006
Pourreyron D Nich C Bizot P Sedel L
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Effectiveness of total hip arthroplasty (THA) for acute fracture of the femoral neck is still debated. The purpose of this retrospective controlled study was to compare the results of THA done for fracture of the femoral neck with a similar group of matched THAs done for osteoarthritis (OA).

From 1993 to 2000, 25 patients (25 hips) had THA for displaced femoral neck fracture. There were 18 women and 7 men, with a mean age of 73+/− 8.5 years (range, 55 to 93 years). The control group was composed of 25 patients (27 hips) who had THA for primary OA. Patients were matched for age, sex, medical comorbidity, surgical approach, prosthesis, and surgeon. Cemented implants with a Me-PE couple were used in the great majority. All patients had radiographic assessment. Functional results were rated according to the grading system of Merle d’Aubigné.

One patient (one hip) was lost to follow-up in each group. The mean follow-up was 6 years (range, 3.5 to 10 years). No revision was performed in this series. Complications included one postoperative dislocation in both groups. At the last follow up evaluation, 21 hips and 23 hips were classified excellent or very good in the “fracture” group and in the control group respectively. No progressive radiolucent line and no osteolysis were recorded. Mean annual PE wear was 0.096 +/− 0.094 (range, 0 to 0.26 mm) in the studied group compared with 0.125+/− 0.095 (range, 0 to 0.24 mm) in the control (p=0.30).

THA for acute femoral neck fracture and THA for OA provided comparable mid to long term results in elderly patients.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 6 | Pages 755 - 758
1 Jun 2005
Nizard R Sedel L Hannouche D Hamadouche M Bizot P


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 133 - 133
1 Apr 2005
Nich C Angotti P Bizot P Van Gaver E Witvoet J Sedel L Nizard R
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Purpose: Total hip arthroplasty after failure of femoral osteotomy raises high risk of complications. Outcome has been controversial. The purpose of this retrospective analysis was to evaluate the difficulties and results.

Material and methods: Between March 1974 and January 1995, 68 patients (82 hips), 51 women and 17 men, mean age 59±11.5 years (32–84) underwent surgery. Initial indications were mainly acetabular and/or femoral dysplasia (n=47 hips) or congenital dislocation (n=21 hips). Mean time between osteotomy and arthroplasty was 13.8±8.4 years (10 months-45 years). We used cemented titanium femoral stems (Ceraver Ostal) with an alumina (n=66) or polyethylene (n=16) cup. An alumina-alumina bearing was used in 67 hips (81%). Functional outcome was assessed with the Postel-Merle-d’Aubligné score. Radiological analysis searched for lucent lines and signs of wear. The actuarial survival was determined.

Results: One patient (1 hip) was lost to follow-up. Thirteen patients (14 hips) died of intercurrent causes. Six hips required revision for aseptic loosening (isolated cup loosening in five and bipolar loosening in one) at 8.5 years on average (4.5–12). There were 22 intraoperative complications (27%) including 18 fractures or femoral stem misalignments and four cases of damage to the acetabular fundus. Other complications included one postoperative dislocation, two sciatic nerve palsies with partial recovery, and one non-union of the greater trochanter. There were no infections. At maximum follow-up (11.8±4.7 years, ragne 5.4–20), the mean functional score was 16.5 (15–18) versus 9.9 (6–14) preoperatively (p< 0.05). There were no femoral lucent lines. A complete lucent line around the cup was observed in eleven hips including six with a massive cemented alumina cup. Considering revision for aseptic loosening as failure, cumulative survival at 12 years was 82% (95%IC 67–96%) for the cup and 98% (92–99.7%) for the femoral stem.

Discussion: These results confirm the high risk of intraoperative complications of total hip arthroplasty performed for failure of femoral osteotomy. Architectural changes expose these patients to technical problems. The survival of the implants appears to be relatively unaffected by the prior procedure but the functional results are slightly less satisfactory then for primary arthroplasties.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 133 - 133
1 Apr 2005
Nich C Dekeuwer P Van Gaver E Bizot P Nizard R Sedel L
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Purpose: The aim of this study was to evaluate quality-of-life (QoL) in patients undergoing bilateral hip arthroplasty implanted during the same operation.

Material and methods: Sixty-one patients (28 women and 33 men) underwent surgery between November 1989 and February 2002. Average age was 42±14 years (13–76). Indications were primary osteoarthritis (n=24), secondary osteoarthritis (n=31), aseptic osteonecrosis (n=25) and rheumatoid disease (n=6). The implants (Ceraver Osteal) were cemented (50 stems, 11 cups) or coated with hydroxyapatite (72 stems, 11 cups). An alumina-alumina bearing was used in all cases. The Postel-Merle-d’Aubigné score was noted to assess function. QoL was measured prospectively in 27 patients using the SF-36 and the WOMAC, preoperatively and every three months.

Results: None of the patients were lost to follow-up. Complications included two intraoperative femoral fractures treated by cerclage, one early dislocation, three thromboemoblic events (including one case of pulmonary embolism). Unipolar revision was required for one hip due to aseptic acetabular loosening at 6.5 years. Surgical cleansing was performed in one other hip for infection. Intraoperative blood loss was 1529±451 ml (540–2550). Mean hospital stay was 13±2.5 days (8–22). At mean follow-up of 49±33 months (12–162), the mean function score was 17.8±0.5 (16–18) versus 10±2.7 (3–14) preoperatively (p< 0.05). Clinical outcome was good or excellent in 98% of the hips. There were no radiological signs of wear. A complete lucent line developed around one cup. The quality of life scores improved significantly (p< 0.01) as soon as three months postoperatively for the items ‘social activity’, ‘physical activity’ and ‘pain’, particularly in men p< 0.05).

Discussion: Bilateral hip arthroplasty during the same operative time is not advocated by all authors. It is a difficult surgical situation requiring rigor and skill. The drawbacks include longer operative time, greater blood loss, and in some patients, higher morbidity. This approach however enables treating bilateral disease in one operation, particularly in younger subjects. Use of an alumina-alumina bearing and non-cemented implants is particularly indicated. The results of this series validate the efficacy of this technique which allows rapid improvement in the patients’ quality-of-life.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 132 - 132
1 Apr 2005
Nizard R Porcher R Ravaud P Vangaver E Sedel L
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Purpose: Surgical techniques must be evaluated before proceeding with widespread use. The evaluation system is usually copied after that used for drugs, relying on randomised trials. This system fails however to assess one dimension, i.e. quality control. The purpose of the present study was to demonstrate the usefulness of an evaluation technique taking into account the capacity to control the quality of a surgical procedure and determine the reliability, reproducibility, and controllability of the technique. This method of evaluation was applied to computer-assisted surgery for total knee arthroplasty.

Material and methods: Computer-assisted surgery based on 3D bone reconstruction was used for 78 knees. The main outcome assessment criterion was the mechanical axis from the centre of the femoral head to the centre of the ankle. The desired alignment was between 3° varus and 3° valgus. Alignments were measured continuously by an independent operator. A Cusum curve was drawn over time and tested after each operation to determine whether the procedure under evaluation could be continued. The same method was applied to the position of the individual femoral and tibial implants setting the limits at two degrees around the perpendicular mechanical axis (AP view).

Results: The mechanical axis was between 3° varus and 3° valgus in 91% of the knees. The continuous evaluation curve showed that the procedure was under control throughout the trial. There was a learning curve that plateaued at 27 knees. Evaluation of the position of the individual implants showed a trend towards femur valgus over time which was compensated by a trend towards tibial varus.

Discussion: Industrial quality control procedures are well established and widely used. The goal of this work was to apply the same quality control methodology to a surgical procedure. Before undertaking a randomised trial this type of evaluation can affirm that the procedure is well controlled and that using an innovating technique under these conditions does not expose patients to undue risks.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 142 - 142
1 Apr 2005
van Gaver E Nizard R Nich C Sedel L
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Purpose: Classical instrument sets for implantation of total knee arthroplasty (TKA) can be perfected. Computer-assisted implantation appears to offer improved technical quality. The purpose of this study was to compare a matched series of TKA implanted with the conventional method and with a computer-assisted navigation system.

Material and methods: Seventy-eight prostheses implanted with a computer-assisted system based on 3D CT-scan reconstruction of the lower limb were matched with 78 prostheses implanted by a highly-trained operator. The knees were matched for gender, aetiology, surgical approach, and axial deviation. There were no significant differences between the groups for these variables. An intramedullary aiming device was used for knees undergoing the conventional procedure. Navitrack(r) was used for the computer-assisted implantations. The same prosthetic system (Wallaby) was used for both series. An independent operator assessed the double-foot stance gonometries. The femorotibial axis was measured as was the individual position of the tibial and femoral pieces.

Results: Axis was within 3° varus and 3° valgus for 92% of the knees operated on with the navigation system. This same range was found for 59% of the conventional procedures. The difference was significant (p< 0.0001). Analysis of the individual femoral and tibial components did not demonstrate any significant difference.

Discussion: Results of TKA are dependent in part on operative technique. The objective is generally achieved with the computer-assisted technique but is not with the conventional technique. Navigation could be useful to achieve successfully short-term objectives. Its contribution to mid-term outcome remains to be demonstrated.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_IV | Pages 412 - 412
1 Apr 2004
Komistek R Dennis D Sedel L Northcut E Anderson D
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Introduction: Previous in vivo kinematic analyses of the hip joint have determined that femoral head separation from the medial aspect of the acetabular component occurs in metal-on-polyethylene THA. The present study analyzes subjects having either an alumina-on-alumina (AOA),alumina-on-polyethylene (AOP),metal-on-metal (MOM) or metal-on-polyethylene (MOP) THA during gait to determine if the incidence of hip joint separation varies based on articular surface material.

Methods: Forty subjects were analyzed in vivo using video fluoroscopy. Ten subjects had a AOA THA, ten an AOP THA, ten a MOM THA, and ten having a MOP THA. All THA subjects were implanted by two surgeons and were judged clinically successful (Harris hip scores > 90.0). Each subject performed normal gait on a treadmill and an abduction/adduction leg lift maneuver while under fluoroscopic surveillance. The two-dimensional (2D) fluoroscopic videos were converted into 3D using a computer automated model-fitting technique. Each implant was analyzed at varying flexion angles to assess the incidence of hip joint separation.

Results: During gait and the abduction/adduction leg lift, no separation was observed in subjects having an AOA THA or in subjects having a MOM THA. Similar to our previous studies pertaining to subjects having a THA with a polyethylene acetabular insert, all ten subjects having a MOP THA and 6/10 subjects having an AOP THA experienced hip joint separation. The maximum amount of separation was 7.4 mm for a subject having an AOP THA and 3.1 mm for a subject having a MOP THA.

Discussion: This study shows femoral head separation from the medial aspect of the acetabular component can occur in the presence of a polyethylene liner. The femoral head often remains in contact with the liner, hinging superolaterally. Potential detrimental effects resulting from hip joint separation include premature polyethylene wear, component loosening (secondary to impulse loading conditions) and hip instability. Wear may be enhanced due to creation of multidirectional wear vectors or excessive loads due to eccentric femoral head pivoting. The absence of separation observed in AOA and MOM THA designs may be related to increased wettability of these materials and tighter radial tolerances resulting in a cohesive lubrication film. This data may be of value in hip simulation studies to better duplicate wear patterns observed in retrieval analyses and assist in the understanding of the lubrication regime and wear rates in AOA and MOM designs, allowing for the synthesis of prosthetic components that minimize wear and optimize kinematics.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 205 - 205
1 Mar 2004
Biette G Nizard R Bizot P Sedel L
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From 1979 to 2002, 131 total hip replacement were performed consecutively in patients less than 30 years of age (13 to 30,7 mean 24;2) in 75 patients (44 in males and 31 in females. Seventy six in 57 patients could have more than 2 years follow-up and will presented hereby. Regarding the type of prosthesis, 59 stem were cemented and 16 cementless. Five different socket were implanted: 6 screw-in metal back: 8 bulky cemented, 23 bulky cementless, 13 metalback press fit with titanium mesh and 26 HA covered.

Underlying diseases were Avascular necrosis in 46, 8 inflammatory disease, 6 after infected articulation, epiphysiolysis in 4 and acetabular fracture in 3.

48 were done primarily, 28 were a revision procedure and 10 had some past history of infection.

Mean follow up was 7,84 years (range 1,13-22,9). One patient (two hips deceased at 1,1 year. One hips was lost to follow-up. 73 had complete clinical and radiological evaluation.

Nine hips were revised from 2,97-18,64 years after the index procedure (mean 8,53). In 7 only the socket was revised, in two both components. Two of these were infected (secondary infection in one). Of the remaining: 45 had no pain, 18 slight uncommon pain, 10 were classified 5 and 8 had some limp.

Radiological evaluation: 56 had no lucent lines nor subsidence, 4 had some radiolucent line none progressive and 1 had a complete lucent line: and is considered as impending failure. In no case osteosysis was documented.

With the exception of socket loosening due to non optimal design of the initial system (bulky alumina cemented or cementless) the overall results are in favor of theis material in young and active patients.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 332 - 332
1 Mar 2004
Bizot P Nizard R Witvoet J Sedel L
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Aim: The aim of the study was to analyze the results of hybrid alumina prothesis using a pressþt metal backed socket and a cemented stem in young and active patients. Methods: From 1990 to 1992, 71 hybrid alumina-onalumina hip replacements were performed in 62 consecutive patients under age 55, with a mean age of 46 years at surgery. There were 56 primary procedures and 15 revision procedures. The prostheses included a cemented Ti alloy stem, a 32-mm alumina head, and a press-þt metal backed socket with an alumina insert. Results: 3 patients (4 hips) died from unrelated causes. 4 hips had revision surgery for deep infection, unexplained persistant pain, fracture of alumina head, and socket aseptic loosening. The 9-year survival rate was 93.7% if revision for any cause was the end point, and 98.4% if revision for aseptic loosening was the end point. Results in surviving patients with a minimal 5-year followup and an average followup of 8 years (57 hips) were excellent in 47 hips (82.5%), very good in 8 hips (14%), good in 1 hip and fair in one hip. 38% of the sockets had a thin and partial lucent line and 1 socket had a complete lucency less than 1mm thick. One stem had isolated femoral osteolysis. There was no detectable component migration nor acetabular osteolysis. Conclusion: Hybrid alumina prosthesis gave satisfactory results at mid term in active patients. Press-þt metal backed socket appeared as a reliable method of acetabular þxation in alumina-alumina hip replacement. Excellent results of cemented stem þxation may be related to low wear debris production.


The Journal of Bone & Joint Surgery British Volume
Vol. 86-B, Issue 2 | Pages 190 - 194
1 Mar 2004
Bizot P Hannouche D Nizard R Witvoet J Sedel L

Between 1990 and 1992, we implanted 71 hybrid alumina-on-alumina hip arthroplasties in 62 consecutive patients under the age of 55 years, with a mean age of 46 years at surgery. There were 56 primary and 15 secondary procedures. The prostheses involved a cemented titanium alloy stem, a 32 mm alumina head, and a press-fit metal-backed socket with an alumina insert. Three patients (four hips) died from unrelated causes. Four hips had revision surgery for either deep infection, unexplained persistent pain, fracture of the alumina head, or aseptic loosening of the socket. The nine-year survival rate was 93.7% with revision for any cause as the end-point and 98.4% with revision for aseptic loosening as the end-point.

The outcome in the surviving patients (50 patients, 57 hips) with a minimum five-year follow-up (mean eight years) was excellent in 47 hips (82.5%), very good in eight (14%), good in one and fair in one. A thin, partial, lucent line, mainly in zone III was present in 38% of the sockets and one socket had a complete lucency less than 1 mm thick. One stem had isolated femoral osteolysis. There was no detectable component migration nor acetabular osteolysis.

This hybrid arthroplasty gave satisfactory medium-term results in active patients. The press-fit metal-backed socket appeared to have reliable fixation in alumina-on-alumina hip arthroplasty. The excellent results using cemented fixation of the stem may be related to the low production of wear debris.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 50 - 50
1 Jan 2004
Nich C Bizot P Dekeuwer P Sedel L
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Purpose: Filling bone loss during revision total hip arthroplasty raises many problems related both to the surgical technique and to the type of bone substitute used. The purpose of this study was to report the clinical and radiographic results obtained in a series of femur reconstructions using impacted calcium phosphate ceramics.

Material and methods: The technique used here was derived from the method developed for impacted fragmentary grafts by Ling and Gie. Grains of macroporous biphasic calcium phosphate ceramic (MBCP) were impacted into the femoral shaft to obtain a stable sheath into which the stem could be cemented (Ceraver Osteal). This technique was used from March 1996 to october 2000 in 18 patients (20 hips) undergoing revision for femoral loosening in 11 (including septic loosening in eight), femoral osteolysis (one hip), pain (one hip), and instability (one hip). Mean age ate revision was 66 years (range 30–79). Most of the femoral bone defects were classed grade IV. The grains of MBCP were used alone in 13 cases, in a mixture with allografts in five cases, and in a mixture with autologous bone in two cases.

Results: Mean follow-up was 31 months (range 8–70). None of the patients were lost to follow-up. There were two intraoperative femur shaft fractures which healed without sequela. Two patients required a second revision for loosening (including one septic) 20 and 16 months after the first revision. At last follow-up, the mean PMA score had improved to 16 (12–18) (p< 0.05) and 67% of the patients achieved a good or excellent clinical result. Radiologically, there were 14 cases of good osteointegration of the MBCP grains without implant migration. Mean shortening was 3 mm (3–5) was observed in three cases and a stable incomplete lucent line was observed in one patient with no clinical impact.

Discussion: Calcium phosphate ceramic material can be useful to overcome the problem of major bone loss in RTHA. It provides an attractive alternative to the disadvantages of bone grafting and helps, in theory, improve primary implant stability. The original technique presented here has allowed us to achieve promising short-term results in young patients with an adequate femur.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 47 - 47
1 Jan 2004
Hannouche D Petite H Meunier A Sedel L Vacanti J
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Purpose: Tissue engineering offers new therapeutic perspectives with the possibility of producing cartilage tissue for a large number of patients. These structures are composed of an absorbable synthetic support and competent cells. Two types of cells can be proposed: articular chondrocytes harvested from the peripheral part of the joint, or mesenchymatous stem cells (MSC) present in the bone marrow and possessing chondrogenic potential. The purpose of this study was to determine the optimal cell source and the best supporting material for in vitro production of cartilage.

Material and methods: Isolated rabbit MSC were harvested and amplified with cell culture for 21 days. After this period, 20–40 million cells/ml were combined with polyglycolic acid sponges (3 types of sponges 1x1x0.2 cm2) and cultured in TGFß-enriched medium under specific dynamic conditions allowing gas exchange. The tissue obtained was compared with structures of identical size obtained with differentiated chondrocytes harvested from the same animals. The study included a histological analysis and immunohistochemistry for type I, II, and X collagen and biochemistry for DNA content, glycosaminoglycanes (GAG) and type II collagen.

Results: After 3 weeks in culture, the composites obtained with MSC preserved their size and had the white pearly aspect of hyalin cartilage. The histological analysis and immunohistochemistry tests for type II collagen confirmed the presence of a cartilaginous matrix throughout the thickness of the fragments. The GAG and type II collagen contents were significantly higher with MSC compared with chondrocytes, irrespective of the supporting material.

Discussion: This study demonstrated that cartilaginous tissue fragments can be obtained with MSC cultured on PGA supporting material under very specific conditions. Use of these cells offers the advantage of easy harvesting followed by in vitro amplification, and thus less harvesting morbidity. Complementary studies are needed to evaluate the behaviour of these living materials after implantation in the articulation.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 50 - 50
1 Jan 2004
Hannouche D Nizard R Meunier A Bizot P Sedel L
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Purpose: During revision of alumina-on-alumina prostheses, reimplantation of a ceramic head on the former stem raises the risk of head fracture. Furthermore, serious deformation of the metal head has been reported after failure of ceramic-on-ceramic prostheses. The purpose of this retrospective study was to evaluate the incidence of these complications and analyse clinical and radiological results of revision for alumina-on-alumina total hip arthroplasties.

Material and methods: This consectutive series included 107 patients (74 women and 33 men, mean age 65 years, age range 32–91 years) who underwent 118 revision arthroplasties from 1976 to 1997. The cause in the majority of the cases was isolated non-infected cup loosening (80%) or ceramic implant fracture (4%). There were 72 cemented alumina cups, 38 screwed cups, six press-fit metal-backed cups, and two massive alumina impacted cups. Cavitary acetabular osteolysis was present in 67% of the cases. The cup was replaced alone in 94 cases (80%). The implanted cup was a polyethylene cup in 93 cases and an alumina cup in 25. When the femoral stem was left in place, a new ceramic head was implanted in 49 cases (39 alumina, 10 zircone). The alumina head was replaced by a metal head in 18 cases.

Results: Four early dislocations and two infections were noted. Mean follow-up after revision surgery was 67 months. Fourteen patients were lost to follow-up. Sixteen patients required revision surgery, ten of them for repeated cup loosening. At last follow-up (mean 61 months), there were no failures among the 49 ceramic heads implanted on a stem left in place. No revisions were required for polyethylene cup wear or metal head wear. In all, 72 hips were evaluated at a minimum two years follow-up. The functional score at last follow-up was 15.2±3.5. Seven-year actuarial survival was 95.5% taking revision of non-infected revision as the endpoint.

Discussion and conclusion: Analysis of the results shows that acetabular loosening is the main cause of revision of alumina-on-alumina total hip arthroplasties. The femoral stem was loosened in only nine cases and could be preserved in 80% of the cases. Replacement of an alumina-on-alumina couple with a metal-on-polyethylene couple does not appear to be a contraindication in this series.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 37 - 37
1 Jan 2004
Veil-Picard A Sedel L Bizot P
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Purpose: The purpose of this work was to analyse different techniques and outcome of total hip arthroplasty for acetabular degeneration after orthopaedically or surgically treated fracture of the acetabulum.

Material and methods: This retrospective analysis of a consecutive series was conducted by an independent observer. Sixty-four arthroplasties in 63 patients performed between 1979 and 2000 were included. Twenty-eight acetabular fractures had been treated surgically and 36 orthopaedically. Five types of cups were implanted (25 cerafit, 3 cerapress, 17 cemented alumina, 11 screwed, 7 polyethylene). All patients were assessed preoperatively and at last follow-up with the Merle d’Aubigné clinical scale. The postoperative and last follow-up radiograms were assessed according to Charnley and De Lee. Operative difficulties were assessed in terms of operative time, blood loss, and analysis of the operation reports. Actuarial survival was calculated.

Results: Mean follow-up was five years two months. Six patients were lost to follow-up early. Clinical outcome was satisfactory with significant improvement in the Merle d’Aubigné score. The 10-year survival rate was 81% taking aseptic loosening as the endpoint and 74% taking surgical revision as the endpoint. Operative time and blood loss were significantly related to loss of ace-tabular bone stock and to operator experience (p < 0.05). Survival was significantly related to acetabular bone defect (p < 0.05). There was no difference between the treatment modes used for the initial acetabular fracture for peroperative difficulty or survival.

Discussion: Total hip arthroplasty for acetabular degeneration secondary to acetabular fracture has given good functional results. Long-term survival is below that for primary arthroplasty, the only unfavourable factor identified being loss of acetabular bone stock. The surgical procedure is more difficult and requires a certain experience. We did not find any difference related to the type of treatment (orthopaedic or surgical) used for the initial acetabular fracture. It was difficult to interpret the influence of cup type due to the wide range of cups used in this series.


The Journal of Bone & Joint Surgery British Volume
Vol. 85-B, Issue 1 | Pages 17 - 20
1 Jan 2003
Langlais F Kerboull M Sedel L Ling RSM


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 61 - 61
1 Jan 2003
Langlais F Howell JR Lee AJC Ling RSM Sedel L Kerboull M
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Controversy exists with regard to the thickness of cement mantles that are necessary around the femoral components of cemented total hip arthroplasties. Conventional teaching, based on bench-top or computor models and theoretical analyses, as well as post-mortem & follow-up studies, suggests that the cement mantle should be complete and not less than 2–3mm in thickness. Mantles that are less than this are held to be at risk from mechanical failure in the long term; if they are incomplete, focal lysis may occur and progress to aseptic loosening.

However, long term experience with a number of French cemented femoral components suggests that these conventions may be erroneous. These French femoral components include the Charnley-Kerboull (stainless steel) and the Ceraver Osteal (Ti6Al4V) stems, in both of which the underlying design principle is that the stem should completely fill the femoral canal, the cement then being used purely to fill the gaps. Such a design philosophy implies that the cement mantles will be very thin, and since both of these stems are straight and the femoral medullary canal is not, the mantles may not only be thin, but also in places incomplete.

Conventional teaching would suggest that any stem utilising mantles of this type would fail from a combination of focal lysis and cement fracture. Yet the long term results of both of these stems have been outstandingly good, with extremely low levels of aseptic loosening and endosteal lysis, irrespective of the bearing combinations being used. Both these stems have a surface finish of Ra < 0.1 microns. A third French design, the Fare stem, manufactured from Ti6Al4V and based on the same principles, was associated with bad results when manufactured with a rough (> 1.5 microns) surface, and appreciably better results after the surface roughness was changed to < 0.1 microns.

These findings, that constitute the ‘French Paradox’, have profound implications for the mechanical behaviour of cement in the femur and for the mechanisms that underlie stem failure from loosening.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 309 - 309
1 Nov 2002
Sedel L Bizot P Banallec L Nizard R
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In order to avoid the consequences of polyethylene wear in a high-risk population, 128 alumina-alumina total hip arthroplasty were implanted in 116 consecutive patients of 40 years old or less. Osteonecrosis and sequellae of congenital hip dislocation were the main etiologies representing 71% of the hips. The same titanium alloy cemented stem was implanted in all hips. Four alumina acetabular component fixations were used: cemented plain alumina socket (41 hips), screw-in ring with an alumina insert (22 hips), a press-fit plain alumina socket (32 hips) and a press-fit titanium metal back with an alumina insert (33 hips).

Eight patients (11 hips) died during the follow-up period. Sixteen revisions were documented, 12 for ace-tabular aseptic loosening, 3 for bipolar loosening (2 were septic), and 1 for unexplained pain. Eighty-nine hips were followed radiologically for two to twenty years. No femoral nor acetabular osteolysis were observed with an average follow-up of 8.4 years. Wear was unmeasurable. Four additional sockets showed definite migration. The respective survival rate at 7 years were 91.4% for the cemented cup, 88.8% for the screw-in ring, 95.1% for cementless press-fit plain alumina socket and 94.3% for the metal-back press-fit component.

The ten-year survival rate was 88.0% for the cemented socket and 88.8% for the screw-in ring. The fifteen-year survival rate was 76.7% for the cemented socket. The occurrence of a graft was the only prognostic factor with a 62.6% survival rate at ten years for the grafted hips and a 90.1% for the non-grafted hips (p=0.004).

The alumina-alumina bearing surfaces for young patients appeared as a valuable alternative to standard metal-polyethylene system. There is a need to improve socket fixation if we want to have a survival of the arthroplasty as long as the life expectancy of this increasing and demanding population. The last design with a fully coated HA titanium shell and an alumina liner seems to fulfill the requirements.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 300 - 300
1 Nov 2002
Sedel L Picart A
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Introduction: Complex fracture of the acetabulum are difficult to treat. If an osteosynthesis is performed difficult surgery resulted in blood loss, long operating time, high risk of sepsis and failure. Even if the fracture is well operated and ideally stabilised there is a major risk of secondary osteoarthrosis. This can be related to bone necrosis , cartilage surface damage , bone loss.

There are also intraoperative risks of neural damage: sciatic nerve as well as gluteus medius nerve. On the other hand , modern surgical technique including an alumina against alumina bearing could allow very long term survival without any activity limitation and this even in very young patients.

Secondary procedure after a failed osteosynthesis provides statistically worse functional results than primary total hip. The surgery is more difficult because of hardware retrieval, nerve dissection, bone reconstruction and remaining muscular dysfunction.

Materials and Methods: To address these issues we reviewed our results of total hip for acetabular fractures. 80 patients received a total hip for acetabular fracture. From 1980 to 1998: 58 acetabular fractures in 57 patients sustained a total hip: 39 males and 18 females. Mean age: 50 years (from 21 to 80). 35 had had a conservative treatment, 22 had had an osteosynthesis. Delay between fracture and total hip: operated: 10 years, non-operated: 6 years. All prosthesis had an alumina against alumina couple. The stem was always made of titanium alloy, it was smooth, collared and cemented. The socket was plain alumina cemented 8, cement less : 3, metal back alumlina insert: 29, screw in cup with alumina liner: 10, plain polyethylene cemented: 8.

Results: Follow-up: from 6 months to 20 years (mean 5,5years). Last Postel Merle d’Aubigne rating: 16,1(8–18) 9 revisions : 1 bipolar aseptic loosening, 8 socket loosening : 2 septic , 6 aseptic. (2 screws in , 6 cemented).

There were 22 neural disorder; 19 sciatic palsies; 13 post trauma; 4 post osteosynthesis; 2 post THR; 3 gluteus medius palsy. 7 sepsis: 4 post osteosynthesis, 3 post THR (including 2 post osteosynthesis).

Discussion: The results presented were inferior to a regular total hip if an osteosynthesis have been performed previously. Reasons for these inferior results were limp due to previous palsy of gluteus medius nerve, sciatic sequellae, complications of previous sepsis and so on. In contrast cases who had at first orthopaedic treatment followed some weeks later by a total hip experienced very good results. It is difficult to conclude from this limited series. But we are actually on the way to modify our perspectives.

Many weak results could have been avoided by doing fine primary surgery. We could expect better functional results with less complications regarding sepsis, nerve damage, muscle preservation if we perform a primary total hip in conjunctions with acetabular reconstruction. Osteosynthesis is still recommended for simple acetabular fracture with large displacement involvement of the posterior wall or one column not comminuted.


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 8 | Pages 1207 - 1207
1 Nov 2002
NIZARD R HAMADOUCHE M SEDEL L WITVOET J


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages - 61
1 Mar 2002
Moussa H Boutin P Daussange J Bolanderr M Sedel L
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Purpose: The purpose of this retrospective study was to assess long-term clinical and radiological outcome in a continuous series of alumine-alumine total hip arthroplasties.

Material and methods: This series included 118 total hip arthroplasties performed in 106 patients (70 men and 36 women), mean age 62.2 ± 11.9 years (32–89). Primary degenerative hip disease was the main aetiology. All the arthroplasties were performed by the same operator. In all cases, the femoral piece was a titanium alloy with a Morse cone for fixation of the femoral head; an “all alumine” cup was used for all. The implants were fixed with cement for 85 hips, without cemented for 29, and with a hybrid technique for four. The Merle d’Aubigné score was used to assess clinical outcome. Classical landmarks on the AP pelvis views were used to assess implant migration. Cup wear was measured using the Livermore method. Actuarial survival curves were plotted.

Results: At mean follow-up of 20 years, 45 patients (51 hips) were still living and had not required revision. Twenty-five patients (25 hips) had undergone revision for replacement of the acetabular component and/or the femoral component. Twenty-seven patients (30 hips) had died and nine patients (12 hips) were lost to follow-up. The mean functional score was 16.2 ± 1.8 at last follow-up. Cumulated survival at 20 years was 85.6% (95%CI 72.2–99.0) for cups without cement compared with 61.2% (95%CI 46.8–75.6) for stems without cement (log rank test p = 0.0162). Cumulated survival at 20 years was 84.9% (95%CI 71.1–98.8) for stems without cement compared with 87.3% (95%CI 77.4–97.1) for cemented stems (log rank, p < 0.05). Wear was unmeasurable. Osteolytic lesions required reconstruction with an allograft in three of the 25 revisions. There were no cases with fracture of the alumine head or cup.

Discussion: The limited number of cases with osteolysis at 20 years is probably related to minimal wear of the prosthetic components. Fixation of alumine cups could still be improved.