Across much of medicine, activity levels predict life expectancy, with low levels of activity being associated with increased mortality, and higher levels of activity being associated with longer healthier lives. Resurfacing is a technically demanding procedure that has suffered significant fallout from the failure of a couple of poorly performing designs. However strong evidence associates resurfacing with improved life expectancy in both the short and longer term following surgery. We wondered if there was any relationship between the function of hips following surgery and the extent of that surgery. Could a longer stem inside the femur be the reason for a slightly reduced step length? We proposed the nul hypothesis that there was no clinically relevant difference between stem length and gait. After informed consent each subject was allowed a 5 minute acclimatisation period at 4km/hr on the instrumented treadmill (Kistler Gaitway, Amherst, NY). Their gait performance on an increasing incline at 5, 10 and 15%. At all 0.5km incremental intervals of speed, the vertical component of the ground reaction forces, center of pressure and temporal measurements were collected for both limbs with a sampling frequency of 100Hz over 10sec. They were also asked to log onto our JointPRO website and report their function using Oxford, EQ5D, and Imperial scores. Owing to current restrictions in indications, the patient groups selected were not comparable. However, from our database of over 800 patients who have been through the gait lab. 82 subjects were tested from 2 diagnostic groups (29 conventional THR, 27 hip resurfacing) and compared with a slightly younger group of 26 healthy controls. Patients were excluded if less than 12 months postop, or with any other documented joint disease or medical comorbidities which might affect gait performance. Body weight scaling was also applied to the outputted mechanical data to correct for mass differences. All variables for each subject group were compared to each other using an analysis of variance (ANOVA) with Tukey post hoc test with significance set at α=0.05.Intro
Method
Constitutional knee varus increases the risk of medial OA disease due to increase in the knee adduction moment and shifting of the mechanical axis medially. Hueter-Volkmann's law states that the amount of load experienced by the growth plate during development influences the bone morphology. For this reason, heightened sports activity during growth is associated with constitutional varus due to added knee adduction moment. In early OA, X-rays often show a flattened medial femoral condyle extension facet (EF). However, it is unknown whether this is a result of osteoarthritic wear, creep deformation over decades of use, or an outcome of Hueter-Volkmann's law during development. A larger and flattened medial EF can bear more weight, due to increased load distribution. However, a flattened EF may also extrude the meniscus, leading meniscus degeneration and joint failure. Therefore, this study aimed to investigate whether varus knees have flattened medial EFs of both femur and tibia in a cohort of patients with no signs yet of bony attrition. Segmentation and morphology analysis was conducted using Materialise software (version 8.0, Materialise Inc., Belgium). This study excluded knees with bony attrition of the EFs based on Ahlbäck criteria, intraoperative findings, and operation notes history. Standard reference frames were used for both the femur and tibia to ensure reliable and repeatable measurements. The hip-knee-angle (HKA) angle defined varus or valgus knee alignment. Femur: The femoral EFs and flexion facets (FFs) had best-fit spheres fitted with 6 repetitions. (Fig1) Tibia: The slopes of the antero-medial medial tibial plateau were approximated using lines. (fig2)Background
Methods
Financial and human cost effectiveness is an increasing evident outcome measure of surgical innovation. Considering the human element, the aim is to restore the individual to their “normal” state by sparing anatomy without compromising implant performance. Gait lab studies have shown differences between different implants at top walking speed, but none to our knowledge have analysed differing total hip replacement patients through the entire range of gait speed and incline to show differences. The purpose of this gait study was to 1) determine if a new short stem femoral implant would return patients back to normal 2) compare its performance to established hip resurfacing and long stem total hip replacement (THR) implants. 110 subjects were tested on an instrumented treadmill (Kistler Gaitway), 4 groups (short-stem THR, long-stem THR, hip resurfacing and healthy controls) of 28, 29, 27, and 26 respectively. The new short femoral stem patients (Furlong Evolution, JRI) were taken from the ongoing Evolution Hip trial that have been tested on the treadmill minimum 12months postop. The long stem total hip replacements and hip resurfacing groups were identified from our 800+ patient treadmill database, and only included with tests minimum 12 months postop and had no other joint disease or medical comorbidities which would affect gait performance. All subjects were tested through their entire range of gait speeds and incline after having a 5 minute habituation period. Speed were increased 0.5kmh until maximum walking speed achieved and inclines at 4kmh for 5,10,15%. At all incremental intervals of speed 10seconds ere collected, including vertical ground reaction forces (normalized to body mass), center of pressure and temporal measurements were for both limbs (fs=100Hz). Symmetry Index(SI) were calculated on a range of features comparing leg with implanted hip to the contralateral normal hip. Group means for each feature for each subject group were compared using an analysis of variance (ANOVA) with Tukey post-hoc test with significance set at α=0.05.Introduction
Method
Because of the low cost and easy access, surgical video has become a popular method of acquiring surgical skills outside operating rooms without disrupting normal surgical flow. However, currently existing video systems all use a single point of view (POV). Some complex orthopedic procedures, such as joint replacement, require a level of accuracy in several dimensions. So single and fixed POV video may not be enough to provide all the necessary information for educational and training purposes. The aim of our project was to develop a novel multiple POV video system and evaluate its efficacy as an aid for learning joint replacement procedure compared with traditional method. Based on the videos of a hip resurfacing procedure performed by an expert orthopedic surgeon captured by 8 cameras fixed all around the operating table, we developed a novel multiple POV video system which enables users to autonomously switch between optimal viewpoints (Figure 1). 30 student doctors (undergraduate years 3–5 and naive to hip resurfacing procedure) were recruited and randomly allocated to 2 groups: experiment group and control group, and were assigned to learn the procedure using multiple or single POV video systems respectively. Before learning they were first asked to complete a multiple choicetest designed using a modified Delphi technique with the advice and feedback sought from 4 experienced orthopedic surgeons to test the participants' baseline knowledge of hip resurfacing procedure. After video learning, they were asked to answer the test again to verify their gained information and comprehension of the procedure, followed by a 5-point Likert-scale questionnaire to demonstrate their self-perception of confidence and satisfaction with the learning experience. The scores in the 2 tests and in the Likert-scale questionnaire were compared between 2 groups using Independent-Samples t-test (for normally distributed data) or Mann-Whitney U test (for non-normally distributed data). Statistical significance was set as p<0.05.Introduction
Materials and Methods
Bisphosphonates (BP) are the first-line therapy for preventing osteoporotic fragility fractures. However, concern regarding their efficacy is growing because bisphosphonate use is associated with over-suppression of remodeling. Animal studies have reported that BP therapy is associated with accumulation of micro-cracks (Fig. 1) and a reduction in bone mechanical properties, but the effect on humans has not been investigated. Therefore, our aim was to quantify the mechanical strength of bone treated with BP, and correlate this with the microarchitecture and density of micro-damage in comparison with untreated osteoporotic hip-fractured and non-fractured elderly controls. Trabecular bone cores from patients treated with BP were compared with patients who had not received any treatment for bone osteoporotic disease. Non-fractured cadaveric femora from individuals with no history of bone metabolic disease were also used as controls. Cores were imaged in high resolution (∼1.3µm) using Synchrotron X-ray tomography (Diamond Light Source Ltd.) The scans were used for structural and material analysis, then the cores were mechanically tested in compression. A novel classification system was devised to characterise features of micro-damage in the Synchrotron images: micro-cracks, diffuse damage and perforations. Synchrotron micro-CT stacks were visualised and analysed using ImageJ, Avizo and VGStudio MAX.Introduction
Methods
Osteoarthritis and the pain associated with it result in gait pattern alteration, in particularly gait asymmetry when the disease is unilateral [1–2]. The quantification of such asymmetry could assist with the diagnosis and follow up. Various asymmetry indices have been proposed to compare the spatiotemporal, kinematic and kinetic parameters of lower limbs during the gait cycle. One, the Continuous Relative Phase [3] compares the joints angle and its derivatives to assess the gait asymmetry during the gait cycle. However, the indices rely on marker based gait measurement systems that are costly and generally require manual examination, calibration procedures and the precise placement of sensors/markers on the body of the patient. Create an automatic method to assess gait asymmetry with low cost depth camera system like Kinect.Background
Aim
Appropriate seating of acetabular and femoral components during total hip arthroplasty (THA) surgery is essential for implant longevity. Additionally, the appropriate assembly of components is essential for proper function, for example to prevent taper corrosion or acetabular component disassembly. However the current understanding of the forces and energies imparted during surgery is sparse. Perhaps more importantly, there exists a risk that much of the preclinical testing performed to develop implants and surgical techniques do not apply the appropriate boundary conditions to surgical impaction and component assembly, leading to the possibility of huge overestimations in impaction force. This in-vitro study examines the influence of mechanical boundary condition parameters that affect the forces imparted to implant and patient during THA surgery; including the attenuation of two common types of acetabular cup introducer and the hard tissue (pelvic) boundary conditions. A drop tower test-rig that allows full customisation of impaction and implantation parameters was built, with pelvis boundary conditions simulated with silicone cylinders using adjustable geometry to vary stiffness and damping. The least stiff setup represented a large, unbolstered patient on the operating table. A medium stiffness setup represented a slim, well bolstered patient. An extremely stiff, metal boundary was selected to replicate the pre-clinical testing conditions usually employed in implant or instrument testing, where impact testing takes place in a vice, or metal test frame. For each of these stiffness scenarios, piezo-load cells and LVDTs were used to measure forces and displacement of the pelvis model. We also investigated the use of two common implant introducers; a straight and a bent introducer. The latter is often used for large patients or for specific approaches (e.g. direct anterior). In total, 180 drop weight tests and 120 strikes by an orthopaedic surgeon were measured. For the drop weight testing the peak force measured varied between 7.6kN and 0.4kN for stiffest and softest support conditions respectively. When the surgeon applied the impact strike manually, the range was between 13.2kN and 0.8kN for the stiffest and softest support conditions respectively (Figure 1). Using the bent introducer attenuated the load by between 13.0% and 115% compared to the straight introducer (Figure 1). Pelvic boundary conditions are overlooked in much of the literature on implant seating or assembly in THA surgery. In laboratory settings with impaction performed on a workbench or frame of a materials testing machine, high forces may be sufficient to seat or assemble implants. However our data show that these high forces will not be replicated in vivo, and this could be a causative factor in poor assembly of acetabular components or femoral head/stem tapers, which can lead to clinical problems like disassembly or crevice corrosion. We found the geometry of the introducer and the stiffness of the pelvis support had significant attenuating influence. We also found that the surgeon does not compensate for these differences, resulting in vast differences in the delivered strike force. It is recommended these factors are carefully considered when designing surgical tools and in particular conducting pre-clinical testing.
Bones are thought to become fragile with advancing age due to a loss of mass and structure. However, there are important aspects of bone fragility and fracture that cannot be explained simply by a loss of bone: 30% of all patients told they have healthy bone based on bone mineral density (BMD) measurements go on to fracture. It has been suggested that increased fracture risk might also be due to ageing at the nanoscale, which might deteriorate the overall mechanical properties of a bone. However, it is not clear how mechanics at the level of the collagen-mineral matrix relate to mechanical properties of the whole bone, or whether nano-mechanics contribute to fracture risk. In order to answer these questions our group is developing state of the art methods for analysing the structure and function of the collagen mineral matrix under loading. To image the collagen mineral matrix we obtained beam time on a synchrotron particle accelerator at the Diamond Light Source (Didcot, UK). Electrons are accelerated to near light speed by powerful electromagnets, then slowed to create high energy monochromatic X-Ray beams. Through a combination of X-Ray computed tomography and X-Ray diffraction we have been able to image the collagen/mineral matrix. Furthermore, using in situ loading experiments it has been possible to visualise collagen fibrillar sliding and mineral crystal structure. Our group is analysing how age related changes in nano-structure affect bone mechanical behaviour. As well as comparing fragility fracture patients with ‘healthy’ age matched controls to investigate whether ageing at the nano-scale could increase fracture risk. We are also assessing the effect of common treatments for bone fragility (e.g. bisphosphonate) on nano-mechanics. Unfortunately the expense and high radiation dose associated with synchrotron imaging prevents the technology from being adapted for patients. Therefore the next step will be to identify and test tools that can be used to indirectly assess bone chemistry and mechanical properties at point of care (e.g. laser spectroscopy and indentation). The data could be used to improve the diagnosis, monitoring and treatment of bone fragility.
Conventional TKA surgery attempts to restore patients to a neutral alignment, and devices are designed with this in mind. Neutral alignment may not be natural for many patients, and may cause dissatisfaction [1]. To solve this, kinematical alignment (KA) attempts to restore the native pre-arthritic joint-line of the knee, with the goal of improving knee kinematics and therefore patient's function and satisfaction [1]. Proper prosthetic trochlea alignment is important to prevent patella complications such as instability or loosening. However, available TKA components have been designed for mechanical implantation, and concerns remain relating the orientation of the prosthetic trochlea when implants are kinematically positioned. The goal of this study is to investigate how a currently available femoral component restores the native trochlear geometry of healthy knees when virtually placed in kinematic alignment. The healthy knee OAI (Osteoarthritis Initiative) MRI dataset was used. 36 MRI scans of healthy knees were segmented to produce models of the bone and cartilage surfaces of the distal femur. A set of commercially available femoral components was laser scanned. Custom 3D planning software aligned these components with the anatomical models: distal and posterior condyle surfaces of implants were coincident with distal and posterior condyle surfaces of the cartilage; the anterior flange of the implant sat on the anterior cortex; the largest implant that fitted with minimal overhang was used, performing ‘virtual surgery’ on healthy subjects. Software developed in-house fitted circles to the deepest points in the trochlear grooves of the implant and the cartilage. The centre of the cartilage trochlear circle was found and planes, rotated from horizontal (0%, approximately cutting through the proximal trochlea) through to vertical (100%, cutting through the distal trochlea) rotated around this, with the axis of rotation parallel to the flexion facet axis. These planes cut through the trochlea allowing comparison of cartilage and implant surfaces at 1 degree increments - (fig.1). Trochlear groove geometry was quantified with (1) groove radial distance from centre of rotation cylinder (2) medial facet radial distance (3) lateral facet radial distance and (4) sulcus angle, along the length of the trochlea. Data were normalised to the mean trochlear radius. The orientation of the groove was measured in the coronal and axial plane relative to the flexion facet axis. Inter- and intra-observer reliability was measured.BACKGROUND
METHODS
Lateral meniscal failure and secondary valgus with lateral compartment arthrosis is quite common in the developed world. The varus knee is the common phenotype of the ‘jock’ of both genders, while the valgus knee is a common consequence of lateral meniscal tear, skiing or ‘catwalk’ life. Occurring more commonly in ‘flamingo’ phenotypes, lateral meniscal failure can be disabling, entirely preventing high heels being worn for instance. Lateral UKA is indicated for most valgus knees, and is substantially safer than TKA. ACL integrity is not essential in older people, as the patello-femoral mechanism is in line with the lateral compartment. Severe valgus with substantial bone loss is not a contraindication, if the deformity is simply angular. As long as there is not marked subluxation, fixed flexion deformity invariably corrects after notch osteophyte removal from femur and tibia. Lateral UKA can be combined safely with PFJA: performed through a lateral approach, this is a safe and conservative procedure. ACL integrity is not essential – reconstruction can be undertaken simultaneously, if necessary. Combining lateral UKA with medial UKA is only rarely needed, and sometimes needs ACL reconstruction too. Adding a medial UKA in under 5 years usually results from overcorrection of the valgus. Mid Term Results, at a median of 7 years postop: Between 2005 to 2009, 64 knees in 58 patients had a lateral UKA using a device designed for the lateral compartment. This included 41 females and 17 males with a mean age of 71 years at the time of surgery (range 44–92). Thirty-nine patients underwent surgery on the right knee and 6 underwent bilateral procedures, of which four were performed under a single anesthetic. Primary lateral compartment osteoarthritis was the primary diagnosis in 63 cases with secondary osteoarthritis to a lateral tibial plateau fracture the indication in one patient. At 119 months follow up, the predicted cumulative survival was 0.97. With re-operation as an endpoint, 11% of patients within the study had undergone re-operation with a predicted cumulative survival of 0.81 at 119 months. This compares well with historic fixed bearing series. Preoperative OKS scores were available for 50 knees, scores were available for 63 knees at 9–48 months and 52 knees at 61–119 months post index operation. There was a significant improvement in the OKS between the preoperative scores (median 26 range 9–36) and early postoperative time points of 9–48 months, (median 42 range 23–48) (p<0.001). At the later postoperative time point of 61–119 months the score had been maintained (42 range 10–48).Indications
Combinations
Patients presenting with arthrosis following high tibial osteotomy (HTO) pose a technical challenge to the surgeon. Slight overcorrection during osteotomy sometimes results in persisting medial unicompartmental arthrosis, but with a valgus knee. A medial UKA is desirable, but will result in further valgus deformity, while a TKA in someone with deformity but intact cruciates may be a disappointment as it is technically challenging. The problem is similar to that of patients with a femoral malunion and arthrosis. The surgeon has to choose where to make the correction. An ‘all inside’ approach is perhaps the simplest. However, this often means extensive release of ligaments to enable ‘balancing’ of the joint, with significant compromise of the soft tissues and reduced range of motion as a consequence. As patients having HTO in the first place are relatively high demand, we have explored a more conservative option, based upon our experience with patient matched guides. We have been performing combined deformity correction and conservative arthroplasty for 5 years, using PSI developed in the MSk Lab. We have now adapted this approach to the failed HTO. By reversing the osteotomy, closing the opening wedge, or opening the closing wedge, we can restore the obliquity of the joint, and preserve the cruciate ligaments. Technique: CT based plans are used, combined with static imaging and on occasion gait data. Planning software is then used to undertake the arthroplasty, and corrective osteotomy. In the planning software, both tibial and femoral sides of the UKA are performed with minimal bone resection. The tibial osteotomy is then reversed to restore joint line obliquity. The placing of osteotomy, and the angling and positioning in relation to the tibial component are crucial. This is more important in the opening of a closing wedge, where the bone but is close to the keel cut. The tibial component is then readjusted to the final ‘Cartier’ angle. Patient guides are then made. These include a tibial cutting guide which locates both the osteotomy and the arthroplasty. At operation, the bone cuts for the arthroplasty are made first, so that these cuts are not performed on stressed bone. The cuts are not in the classical alignment as they are based upon deformed bone so the use of patient specific guides is a real help. The corrective osteotomy is then performed. If a closing wedge is being opened, then a further fibular osteotomy is needed, while the closing of an opening wedge is an easier undertaking. Six cases of corrective osteotomy and partial knee replacement are presented. In all cases, the cruciates have been preserved, together with normal patello-femoral joints. Patient satisfaction is high, because the deformity has been addressed, restoring body image. Gait characteristics are those of UKA, as the ACL has been preserved and joint line obliquity restored.
Are there any patho-anatomical features that might predispose to primary knee OA? We investigated the 3D geometry of the load bearing zones of both distal femur and proximal tibias, in varus, straight and valgus knees. We then correlated these findings with the location of wear patches measured intra-operatively. Patients presenting with knee pain were recruited following ethics approval and consent. Hips, knees and ankles were CT-ed. Straight and Rosenburg weight bearing X-Rays were obtained. Excluded were: Ahlbäck grade “>1”, previous fractures, bone surgery, deformities, and any known secondary causes of OA. 72 knees were eligible. 3D models were constructed using Mimics (Materialise Inc, Belgium) and femurs oriented to a standard reference frame. Femoral condyle Extension Facets (EF) were outlined with the aid of gaussian curvature analysis, then best-fit spheres attached to the Extension, as well as Flexion Facets(FF). Resected tibial plateaus from surgery were collected and photographed, and Matlab combined the average tibia plateau wear pattern. Of the 72 knees (N=72), the mean age was 58, SD=11. 38 were male and 34 female. The average hip-knee-ankle (HKA) angle was 1° varus (SD=4°). Knees were assigned into three groups: valgus, straight or varus based on HKA angle. Root Mean Square (RMS) errors of the medial and lateral extension spheres were 0.4mm and 0.2mm respectively. EF sphere radii measurements were validated with Bland-Altman Plots showing good intra- and interobserver reliability (+/− 1.96 SD). The radii (mm) of the extension spheres were standardised to the medial FF sphere. Radii for the standardised medial EF sphere were as follows; Valgus (M=44.74mm, SD=7.89, n=11), Straight (M=44.63mm, SD=7.23, n=38), Varus (M=50.46mm, SD=8.14, n=23). Ratios of the Medial: Lateral EF Spheres were calculated for the three groups: Valgus (M=1.35, SD=.25, n=11), Straight (M=1.38, SD=.23, n=38), Varus (M=1.6, SD=.38, n=23). Data was analysed with a MANOVA, ANOVA and Fisher's pairwise LSD in SPSS ver 22, reducing the chance of type 1 error. The varus knees extension facets were significantly flatter with a larger radius than the straight or valgus group (p=0.004 and p=0.033) respectively. In the axial view, the medial extension facet centers appear to overlie the tibial wear patch exactly, commonly in the antero-medial aspect of the medial tibial plateau. For the first time, we have characterised the extension facets of the femoral condyles reliably. Varus knees have a flatter medial EF even before the onset of bony attrition. A flatter EF might lead to menisci extrusion in full extension, and early menisci failure. In addition, the spherical centre of the EF exactly overlies the wear patch on the antero-medial portion of the tibia plateau, suggesting that a flatter medial extension facet may be causally related to the generation of early primary OA in varus knees.
The treatment of patients with osteoarthritis of the knee and associated extra-articular deformity of the leg is challenging. Current teaching recognises two possible approaches: (1) a total knee replacement (TKR) with intra-articular bone resections to correct the malalignment or (2) an extra-articular osteotomy to correct the malalignment together with a TKR (either simultaneously or staged). However, a number of these patients only have unicompartmental knee osteoarthritis and, in the absence of an extra-articular deformity would be ideal candidates for joint preserving surgery such as unicompartmental knee replacement (UKR) given its superior functional outcome and lower cost relative to a TKR [1). We report four cases of medial unicondylar knee replacement, with a simultaneous extra-articular osteotomy to correct deformity, using novel 3D printed patient-specific guides (Embody, UK) (see Figure 1). The procedure was successful in all four patients, and there were no complications. A mean increase in the Oxford knee score of 9.5, and in the EQ5D VAS of 15 was observed. To our knowledge this is the first report of combined osteotomy and unicompartmental knee replacement for the treatment of extra-articular deformity and knee osteoarthritis. This technically challenging procedure is made possible by a novel 3D printed patient-specific guide which controls osteotomy position, degree of deformity correction (multi-plane if required), and orientates the saw-cuts for the unicompartmental prosthesis according to the corrected leg alignment. Using 3D printed surgical guides to perform operations not previously possible represents a paradigm shift in knee surgery. We suggest that this joint preserving approach should be considered the preferred treatment option for suitable patients.
Femoral component design is a key part of hip arthroplasty performance. We have previously reported that a hip resurfacing offered functional improved performance over a long stem. However resurfacing is not popular for many reasons, so there is a growing trend towards shorter femoral stems, which have the added benefit of ease of introduction through less invasive incisions. Concern is also developing about the impact of longer stems on lifetime risk of periprosthetic fracture, which should be reduced by the use of a shorter stem. For these reasons, we wanted to know whether a shorter stem offered any functional improvement over a conventional long stem. We surmised that longer stems in hip implants might stiffen the femoral shaft, altering the mechanical properties. From our database of over 800 patients who have been tested in the lab, we identified 95 patients with a hip replacement performed on only one side, with no other lower limb co-morbidities, and a control group: 19 with long stem implant, age 66 ± 14 (LONG) 40 with short stem implant, age 69 ± 9 (SHORT) 26 with resurfacing, age 60 ± 8 (RESURF) 43 healthy control with no history of arthroplasty, age 59 ± 10 (CONTROL) All groups were matched for BMI and gender. Participants were asked to walk on an instrumented treadmill. Initially a 5 minute warm up at 4 km/h, then tests at increasing speed in 0.5 km/h increments. Maximum walking speed was determined by the patients themselves, or when subjects moved from walking to running. Ground reaction forces (GRF) were measured in 20 second intervals at each speed. Features were calculated based on the mean GRF for each trial, and on symmetry measures such as first peak force (heel strike), second peak force (toe-off), the rate at which the foot was loaded and unloaded, and step length.Introduction
Materials and Methods
Normal human locomotion entails a rather narrow base of support (BoS), of around 12cm at normal walking speeds. This relatively narrow gait requires good balance, and is beneficial, as it minimises the adduction moment at the knee. Normal knees have a slightly oblique joint line, and slight varus, which allow the normal human to walk rapidly with a narrow BoS. Patients with increased varus and secondary osteoarthritis have a broader BoS, which exacerbates the excessive load, making walking painful and ungainly. We wondered if there would be a difference between the base of support of patients whose knee kinematics had been preserved, by retaining the native jointline obliquity and the acl, in comparison with those whose alignment had been altered to a mechanically correct ‘neutral’ alignment. Of 201 patients measured following knee arthroplasty, 31 unicondylar patients and 35 total knee patients, with a single primary arthroplasty, and no co-morbidities, over 1 year post-operatively were identified. Two control groups of controls, a younger cohort of 112 people and 17 in an age matched older cohort. All operations were performed by the same surgeon. The total knees were cruciate retaining devices, inserted in mechanical alignment, and the unicondylar knees were inserted retaining the native alignment and joint-line obliquity. The gait of all subjects was analysed on an instrumented, calibrated treadmill with underlying force plates. Patients start by walking at a comfortable speed for them for 5 minutes, before the speed of the treadmill is increased at 1/2 km/h increments until maximum walking speed obtained, spending 30 seconds at each. After the flat test, it was then repeated on a downhill slope of 6°. Base of Support is interpreted as the distance between the centre point of heel strike and toe off from one foot to that of the other. The top walking speed in the unicondylar group was significantly greater than that of the total knee group, as we reported in 2013. TKA patients have an average BoS of 14cm, while UKA patients and controls have a 12cm BoS. The BoS did not reduce with speed. This 2cm, or 17% increase in BoS is significant. Shapiro-Wilk tests demonstrate a normal distribution to the results, and ANOVA testing reveals a significant difference (p<0.05) within the groups between the speeds of 4.5 to 9. Post-Hoc Bonferroni testing reveal a significant difference between the TKA group and each of the other three groups. On the downhill test (figure 1), the mean BoS in the TKA group increased to 16cm. This increase is highly significant, with a p value of <0.001, while the increase in the UKA group at higher speeds failed to reach significance, and the controls both stayed at 12cm. 6 Bi-uni knees tested acted just like the UKAs. A narrow base of support minimises excessive loads across the joint line. Maintenance of jointline obliquity and an ACL enables this feature to be returned to normal following uni, or bi-uni, while a well aligned TKA seems to prevent it.Materials and Methods
Discussion
Patellofemoral joint (PFJ) arthroplasty is traditionally performed using mechanical jigs to align the components, and it is hard to fine tune implant placement for the individual patient. These replacements have not had the same success rate as other forms of total or partial knee replacement surgery1. Our team have developed a computer assisted planning tool that allows alignment of the implant based on measurements of the patient's anatomy from MRI data with the aim of improving the success of patellofemoral joint arthroplasty. When planning a patellofemoral joint arthroplasty, one must start from the premise that the original joint is either damaged as a result of osteoarthritis, or is dysplastic in some way, deviating from a normal joint. The research aimed to plan PFJ arthroplasty using knowledge of the relationship between a normal PFJ (trochlear groove, trochlea axis and articular surfaces) and other aspects of the knee2, allowing the plan to be estimated from unaffected bone surfaces, within the constraints of the available trochlea. In order to establish a patient specific trochlea model a method was developed to automatically compute an average shape of the distal femur from normal distal femur STL files (Fig.1). For that MRI scans of 50 normal knees from osteoarthritis initiative (OAI) study were used. Mimics and 3-matic software (Materialise) packages were used for segmentation and analysis of 3D models. Spheres were fitted to the medial and lateral flexion facets for both average knee model and patient knee model. The average knee was rescaled and registered in order to match flexion facet axis (FFA) distance and FFA midpoint of the patient (Fig.2). The difference between the patient surface and the average knee surface allow to plan the patella groove alteration. The Patella cut is planned parallel to the plane fitted to the anterior surface of the patella. The patella width/thickness ratio (W/T=2) is used to predict the post reconstruction thickness3. The position of the patella component (and its orientation if a component with a median ridge is used) is also planned. The plan is next fine-tuned to achieve satisfactory PFJ kinematics4 (Fig.3). This will be complemented by intraoperative PFJ tracking which assists with soft tissue releases. PFJ kinematics is evaluated in terms of patella shift, tilt and deviation from the previously described circular path of the centre of the patella. The effect of preoperative planning on PFJ tracking and soft tissue releases is being examined. Additional study is needed to evaluate whether planning and intraoperative kinematic measurements improve the clinical outcome of PFJ arthroplasty.
The trochlea of a typical patellofemoral replacement or anterior flange of a total knee replacement usually extends past the natural trochlea and continues onto the femoral anterior cortex. One reason for this is that it allows a simple patella button to be permanently engaged in the trochlea groove in an attempt to ensure stability. On the natural patella, the apex helps to guide it into the trochlea groove as the knee moves from full extension into flexion. The aim is to study whether a generalised patella can be created that is close in form to a healthy patella. MRI scans were taken of 30 patellae. Characteristics of these patellae (height, width, thickness, apex angle) were measured. The apex angle was found to be similar between patellae (mean=126 degrees, sd = 8.8), as were the ratios between height and width (mean width/height = 1.05, sd = 0.07) and between thickness and width (mean width/thickness = 1.8, sd = 0.19). These patellae were then segmented to create a surface including cartilage, resulting in 30 STL (stereolithography) files in which the surfaces are represented by triangle meshes. To design the average patella the individual patellae were aligned to a standard frame of reference by placing a set of landmarks on the proximal/distal, medial/lateral and anterior/posterior extents of each (fig.1). The vertical axis was defined as passing parallel to the proximal/distal points and the horizontal as passing parallel to the medial/lateral points when looking along the computed vertical axis. The origin centre of the frame of reference was chosen to be mid-way between these points. The mean width was then computed and each patella scaled linearly around the origin to give them all equal width. All the aligned patellae were then averaged together to provide a composite cartilaginous patella. The averaging process was achieved by taking one patella as a seed. The patella chosen for seed was that whose parameters were closest to the average width, height and thickness. An approximately normal vector was passed a point ‘P’ on the seeds, and the points at which these intersected the other models were then determined. The closest intersection point to ‘P’ on each model was chosen and these averaged together. ‘P’ is then replaced in the model with this average point. The averaging process then continues with all the remaining points on the seed model in the same manner to build the average models.Introduction
Method
Patient Specific Instrumentation (PSI) has the potential to allow surgeons to perform procedures more accurately, at lower cost and faster than conventional instrumentation. However, studies using PSI have failed to convincingly demonstrate any of these benefits clinically. The influence of guide design on the accuracy of placement of PSI has received no attention within the literature. Our experience has suggested that surgeons gain greater benefit from PSI when undertaking procedures they are less familiar with. Lateral unicompartmental knee replacement (UKR) is relatively infrequently performed and may be an example of an operation for which PSI would be of benefit. We aimed to investigate the impact on accuracy of PSI with respect to the area of contact, the nature of the contact (smooth or studded guide surfaces) and the effect of increasing the number of contact points in different planes. A standard anatomy tibial Sawbone was selected for use in the study and a computed tomography scan obtained to facilitate the production of PSI. Nylon PSI guides were printed on the basis of a lateral UKR plan devised by an orthopaedic surgeon. A control PSI guide with similar dimensions to the cutting block of the Oxford Phase 3 UKR tibial guide was produced, contoured to the anterior tibial surface with multiple studs on the tibial contact surface. Variants of this guide were designed to assess the impact of design features on accuracy. These were: a studded guide with a 40% reduction in tibial contact area, a non-studded version of the control guide, the control guide with a shim to provide articular contact, a guide with an extension to allow distal referencing at the ankle and a guide with a distal extension and an articular shim. All guides were designed with an appendage that facilitated direct attachment to a navigation machine (figure 1). 36 volunteers were asked to place each guide on the tibia with reference to a 3D model of the operative plan. The order of placement was varied using a counterbalanced latin square design to limit the impact of the learning effect. The navigation machine recorded deviations from the plan in respect of proximal-distal and medial-lateral translations as well as rotation around all three axes. Statistical analysis was performed on the compound translational and rotational errors for each guide using ANOVA with Bonferroni correction with statistical significance at p<0.05.Introduction
Method
We report 10-year clinical outcomes of a prospective randomised controlled study on uni-compartmental knee arthroplasty using an active constraint robot. Measuring the clinical impact of CAOS systems has generally been based around surrogate radiological measures with currently few long-term functional follow-up studies reported. We present 10 year clinical follow up results of robotic vs conventional surgery in UKA. The initial study took place in 2004 and included 28 patients, 13 in the robotic arm and 15 in the conventional arm. All patients underwent medial compartment UKA using the ‘OXFORD’ mobile bearing knee system. Clinical outcome at 10 years was scored using the WOMAC scoring system.Introduction
Material and methods
Any arthroplasty that offers superior function needs to be assessed using metrics that are capable of detecting those functions. The Oxford Hip Score (OHS), the Harris Hip Score (HHS) and WOMAC are patient reported outcome measures (PROMs) with well documented ceiling effects: following hip arthroplasty, many patients are clustered close to full marks following surgery. Two recent well conducted randomised clinical trials made exactly this error, by using OHS and WOMAC to detect a differences in outcome between hip resurfacing and hip arthroplasty despite published data already showing in single arm studies that these two procedures score close to full marks using either of these PROMS. We have already reported that patients with hip resurfacing arthroplasty (HRA) were able to walk faster and with more normal stride length than patients with well performing hip replacements. In an attempt to relate this functional superiority to an outcome measure that does not rely upon the use of expensive machinery, we developed a patient centred outcome measure (PCOM) based upon a method developed by Philip Noble's group, and the University of Arizona's Metabolic Equivalent of Task Index (MET). This PCOM allows patients to select the functions that matter to them personally against which the success of their own operation will be measured, with greater sensitivity to intensity than is achieved by the UCLA. Our null hypothesis was that this PCOM would be no more successful than the PROMs in routine use in discriminating between types of hip arthroplasty, and that there would be no difference in gait between patients following these procedures. From our database of over 800 patients whose gait has been assessed in the lab, we identified 22 patients with a well performing conventional THAs, and matched them for age, sex, BMI, height, preop diagnosis with 22 patients with a well performing conventional THA. Both were compared with healthy controls using the novel PCOM and in a gait lab. PROMs for the two groups were almost identical, while HRA scored higher in the PCOM. The 9% difference was significant (p<0.05). At top walking speed, HRA were 10% faster, with a 9% longer stride length, both of these metrics also reached significance. Function following hip replacement is very good, with high satisfaction rates, but the use of a PCOM, and objective measures of function reveal substantial inferiority of THA over THR in two well matched groups. This 9% difference is well over the 5% difference that is considered ‘clinically relevant’. When coupled with the very strong data regarding life expectancy and infection, this functional data makes a compelling case for the use of resurfacing in active adults.Results
Discussion
