The use of stem cells transplanted into the intervertebral disc (IVD) is a promising regenerative approach to treat intervertebral disc degeneration (IDD). The aim of this study was to assess the effect of a hydrogel composed of
Objective. To study the effect of
The purpose of this study was to examine the effects of
Background. Infiltration is considered the first treatment option for symptomatic Morton's neuroma and can be performed with various medications. The aim of this study was to compare the effects of
Aims. Pigment epithelium-derived factor (PEDF) is known to induce several types of tissue regeneration by activating tissue-specific stem cells. Here, we investigated the therapeutic potential of PEDF 29-mer peptide in the damaged articular cartilage (AC) in rat osteoarthritis (OA). Methods. Mesenchymal stem/stromal cells (MSCs) were isolated from rat bone marrow (BM) and used to evaluate the impact of 29-mer on chondrogenic differentiation of BM-MSCs in culture. Knee OA was induced in rats by a single intra-articular injection of monosodium iodoacetate (MIA) in the right knees (set to day 0). The 29-mer dissolved in 5%
Objectives. To evaluate the in vitro effects of
Aims. There is conflicting evidence on the safety of intra-articular injections of
Abstract. Introduction. The effectiveness of single intra-articular injections of polyacrylamide hydrogel (iPAAG) and
The aim of this study was to evaluate the effect of
The use of intra-articular
Aims: Comparison of the effectiveness of the injection of
Introduction and Objective.
Aims: A mounting research effort has recently been devoted to design a biocompatible, sterile and safe material as nucleus polposus substitute. Several chemical modifications of
The rheological properties of synovial fluid (SF) are largely attributed to the presence of high molecular weight
The extracellular matrix (ECM)-based biomaterials provide a platform to mimic the disc microenvironment in facilitating stem cell transplantation for tissue regeneration. However, little is known about in vitro preconditioning human umbilical cord Wharton Jelly-derived mesenchymal stem cells (MSCs) on 3D
The excursion resistance between the tendon and pulley is an important factor contributing to the limitation of function after surgery to the hand. The administration of
Tissue engineering is a promising approach to regenerate damaged skeletal tissues. In particular, the use of injectable hydrogels alleviates common issues of poor cell viability and engraftment. However, uncontrolled cell fate, resulting from unphysiological environments and degradation rates, still remain a hurdle and impedes tissue healing. We thus aim at developing a new platform of injectable
Objectives:
Objective: Exogenous