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Bone & Joint Open
Vol. 2, Issue 11 | Pages 974 - 980
25 Nov 2021
Allom RJ Wood JA Chen DB MacDessi SJ

Aims

It is unknown whether gap laxities measured in robotic arm-assisted total knee arthroplasty (TKA) correlate to load sensor measurements. The aim of this study was to determine whether symmetry of the maximum medial and lateral gaps in extension and flexion was predictive of knee balance in extension and flexion respectively using different maximum thresholds of intercompartmental load difference (ICLD) to define balance.

Methods

A prospective cohort study of 165 patients undergoing functionally-aligned TKA was performed (176 TKAs). With trial components in situ, medial and lateral extension and flexion gaps were measured using robotic navigation while applying valgus and varus forces. The ICLD between medial and lateral compartments was measured in extension and flexion with the load sensor. The null hypothesis was that stressed gap symmetry would not correlate directly with sensor-defined soft tissue balance.


The Bone & Joint Journal
Vol. 102-B, Issue 6 | Pages 727 - 735
1 Jun 2020
Burger JA Dooley MS Kleeblad LJ Zuiderbaan HA Pearle AD

Aims

It remains controversial whether patellofemoral joint pathology is a contraindication to lateral unicompartmental knee arthroplasty (UKA). This study aimed to evaluate the effect of preoperative radiological degenerative changes and alignment on patient-reported outcome scores (PROMs) after lateral UKA. Secondarily, the influence of lateral UKA on the alignment of the patellofemoral joint was studied.

Methods

A consecutive series of patients who underwent robotic arm-assisted fixed-bearing lateral UKA with at least two-year follow-up were retrospectively reviewed. Radiological evaluation was conducted to obtain a Kellgren Lawrence (KL) grade, an Altman score, and alignment measurements for each knee. Postoperative PROMs were assessed using the Kujala (Anterior Knee Pain Scale) score, Knee Injury and Osteoarthritis Outcome Score Joint Replacement (KOOS JR), and satisfaction levels.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_2 | Pages 69 - 69
1 Feb 2020
Kebbach M Geier A Darowski M Krueger S Schilling C Grupp T Bader R
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Introduction. Persistent patellofemoral (PF) pain is a common postoperative complication after total knee arthroplasty (TKA). In the USA, patella resurfacing is conducted in more than 80% of primary TKAs [1], and is, therefore, an important factor during surgery. Studies have revealed that the position of the patellar component is still controversially discussed [2–4]. However, only a limited number of studies address the biomechanical impact of patellar component malalignment on PF dynamics [2]. Hence, the purpose of our present study was to analyze the effect of patellar component positioning on PF dynamics by means of musculoskeletal multibody simulation in which a detailed knee joint model resembled the loading of an unconstrained cruciate-retaining (CR) total knee replacement (TKR) with dome patella button. Material and Methods. Our musculoskeletal multibody model simulation of a dynamic squat motion bases on the SimTK data set (male, 88 years, 66.7 kg) [5] and was implemented in the multibody dynamics software SIMPACK (V9.7, Dassault Systèmes Deutschland GmbH, Gilching, Germany). The model served as a reference for our parameter analyses on the impact on the patellar surfacing, as it resembles an unconstrained CR-TKR (P.F.C. Sigma, DePuy Synthes, Warsaw, IN) while offering the opportunity for experimental validation on the basis of instrumented implant components [5]. Relevant ligaments and muscle structures were considered within the model. Muscle forces were calculated using a variant of the computed muscle control algorithm. PF and tibiofemoral (TF) joints were modeled with six degrees of freedom by implementing a polygon-contact model, enabling roll-glide kinematics. Relative to the reference model, we analyzed six patellar component alignments: superior-inferior position, mediolateral position, patella spin, patella tilt, flexion-extension and thickness. The effect of each configuration was evaluated by taking the root-mean-square error (RMSE) of the PF contact force, patellar shift and patellar tilt with respect to the reference model along knee flexion angle. Results. The analysis showed that the PF contact force was mostly affected by patellar component thickness (RMSE=440 N) as well as superior-inferior (RMSE=199 N), and mediolateral (RMSE=98 N) positioning.. PF kinematics was mostly affected by mediolateral positioning, patellar component thickness, and superior-inferior positioning. Medialization of the patellar component reduced the peak PF contact force and caused a lateral patellar shift. Discussion. Based on our findings, we conclude that malalignment in mediolateral and superior-inferior direction, tilt and thickness of patellar resurfacing are the most important intraoperative parameters to affect PF dynamics. It could be shown that the translational positioning is more critical than rotational positioning regarding PF contact force. Reported findings are in good agreement with previous experimental and clinical studies [2–4]. Our data reveal that patellar component positioning has to be aligned precisely during total knee arthroplasty to prevent postoperative complications. For any figures or tables, please contact authors directly


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_4 | Pages 127 - 127
1 Apr 2019
Yamada K Hoshino K Tawada K Inoue J
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Introduction. We have been re-evaluating patellofemoral alignment after total knee arthroplasty (TKA) by using a weight- bearing axial radiographic view after detecting patellar maltracking (lateral tilt > 5° or lateral subluxation > 5 mm) on standard non-weight-bearing axial radiographs. However, it is unclear whether the patellar component shape affects this evaluation method. Therefore, we compared 2 differently shaped components on weight-bearing axial radiographs. Methods. From 2004 to 2013, 408 TKAs were performed with the same type of posterior-stabilized total knee implant at our hospital. All patellae were resurfaced with an all-polyethylene, three-pegged component to restore original thickness. Regarding patellar component type, an 8-mm domed component was used when the patella was so thin that a 10-mm bone cut could not be performed. Otherwise, a 10-mm medialized patellar component was selected. Twenty-five knees of 25 patients, in whom patellar maltracking was noted on standard axial radiographs at the latest follow-up, were included in this study. Knees were divided into 2 groups: 15 knees received a medialized patella (group M) while 10 received a domed patella (group D). Weight-bearing axial radiographs with patients in the semi-squatting position were recorded with the method of Baldini et al. Patellar alignment (tilt and subluxation) was measured according to the method described by Gomes et al. using both standard and weight-bearing axial views. Results. Patients’ demographic data, such as age at surgery, sex, and disease were similar for both groups. The average follow-up period was significantly longer in group D than group M (5.4 years vs. 2.5 years, respectively; p = 0.0045, Mann- Whitney U-test). The lateral tilt angle decreased significantly (p < 0.0001, paired t-test) from 6.5° ± 2.8° to 1.0° ± 1.2° with weight bearing in group M. However, this parameter in group D changed from 6.7° ± 2.7° to 4.7° ± 3.0° with weight bearing; the difference was not significant. Lateral subluxation also decreased significantly (p < 0.0001, paired t-test) from 5.1 mm ± 2.4 mm to 2.5 mm ± 1.4 mm with weight bearing in group M. However, that in group D changed from 2.8 mm ± 2.7 mm to 2.4 mm ± 2.8 mm with weight bearing, and the difference was not significant. On weight-bearing views, patellar maltracking was noted in 4 knees in group D but no knees in group M. The difference was significant (p = 0.017, Fisher's exact test). One of the 21 patients with adequate patellar tracking (4.8%) and 1 of 4 patients with maltracking (25%) complained of mild anterior knee pain. Discussion. Patellar tracking on axial radiographic views improved better in group M than in group D with weight bearing. The patellofemoral contact area was maintained with a domed patella despite tilting, but not with a medialized patella. Our results indicate that the shape difference affected the degree of radiographic improvement. Thus, the weight-bearing axial radiographic view devised by Baldini et al. is useful for evaluating patellofemoral alignment after TKA, but the shape of the patellar component should be considered for result interpretation


The Bone & Joint Journal
Vol. 101-B, Issue 3 | Pages 325 - 330
1 Mar 2019
Balcarek P Zimmermann F

Aims

The aim of this study was to evaluate cartilaginous patellotrochlear congruence and patellofemoral alignment parameters after deepening trochleoplasty in severe trochlear dysplasia.

Patients and Methods

The study group comprised 20 patients (two male, 18 female; mean age 24 years (16 to 39)) who underwent deepening trochleoplasty and medial patellofemoral ligament (MPFL) reconstruction for the treatment of recurrent lateral patellar dislocation due to severe trochlear dysplasia (Dejour type B to D). Pre- and postoperative MRI investigations of the study group were compared with MRI data of 20 age- and gender-matched control patients (two male, 18 female; mean age 27 years (18 to 44)) regarding the patellotrochlear contact ratio, patellotrochlear contact area, posterior patellar edge-trochlear groove ratio, and patellar tilt.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_28 | Pages 94 - 94
1 Aug 2013
Belvedere C Ensini A Leardini A Dedda V Cenni F Feliciangeli A De La Barrera JM Giannini S
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INTRODUCTION. In computer-aided total knee arthroplasty (TKA), surgical navigation systems (SNS) allow accurate tibio-femoral joint (TFJ) prosthesis implantation only. Unfortunately, TKA alters also normal patello-femoral joint (PFJ) functioning. Particularly, without patellar resurfacing, PFJ kinematics is influenced by TFJ implantation; with resurfacing, this is further affected by patellar implantation. Patellar resurfacing is performed only by visual inspections and a simple calliper, i.e. without computer assistance. Patellar resurfacing and motion via patient-specific bone morphology had been assessed successfully in-vitro and in-vivo in pilot studies aimed at including these evaluations in traditional navigated TKA. The aim of this study was to report the current experiences in-vivo in two patient cohorts during TKA with patellar resurfacing. MATERIALS AND METHODS. Twenty patients with knee gonarthrosis were divided in two cohorts of ten subjects each and implanted with as many fixed-bearing posterior-stabilised prostheses (NRG® and Triathlon®, Stryker®-Orthopaedics, Mahwah, NJ-USA) with patellar resurfacing. Fifteen patients were implanted; five patients of the Triathlon cohort are awaiting hospital admission. TKAs were performed using two SNS (Stryker®-Leibinger, Freiburg-Germany). In addition to the traditional knee SNS (KSNS), the novel procedure implies the use of the patellar SNS (PSNS) equipped with a specially-designed patellar tracker. Standard navigated procedures for intact TFJ survey were performed using KSNS. These were performed also with PSNS together intact PFJ survey. Standard navigated procedures for TFJ implantation were performed using KSNS. During patellar resurfacing, the patellar cutting jig was fixed at the desired position with a plane probe into the saw-blade slot; PSNS captured tracker data to calculate bone cut level/orientation. After sawing, resection accuracy was assessed using a plane probe. TFJ/PFJ kinematics were captured with all three trial components in place for possible adjustments, and after final component cementing. A calliper and pre/post-TKA X-rays were used to check for patellar thickness/alignment. RESULTS. This protocol was performed successfully in TKAs, resulting in 30 min longer TKA. Final lower limb misalignment was within 0.5°, resurfaced patella was 0.4±1.2 mm thinner than the native, and patellar cut was 0.4°±4.1° laterally tilted. Final PFJ kinematics was taken within the reference normality in both series. PFJ flexion, tilt and medio-lateral shift range were 66.9°±8.5° (minimum÷maximum, 15.6°÷82.5°), 8.0°±3.1° (−5.3°÷2.8°), and 5.3±2.0 mm (−5.5÷0.2 mm), respectively. Significant (p<0.005) correlations were found between the internal/external rotation of the femoral component and PFJ tilt (R. 2. =0.41), and between the mechanical axis on the sagittal plane and PFJ flexion (R. 2. =0.44) and antero-posterior shift (R. 2. =0.45). Patellar implantation parameters were confirmed by X-ray inspections. Discrepancies in thickness up to 5 mm were observed between SNS- and calliper-based measurements. CONCLUSIONS. These results support relevance/efficacy of patellar tracking in in-vivo navigated TKA and may contribute to a more comprehensive assessment of the original whole knee, i.e. including also PFJ. Patellar preparation would be supported for suitable component positioning in case of resurfacing, but, conceptually, also in not-resurfacing if SNS does not reveal PFJ abnormalities., Using this procedure in the future, TFJ/PFJ abnormalities can be corrected intra-operatively by more cautious bone cut preparation and prosthetic positioning on the femur, tibia and patella


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 156 - 156
1 Sep 2012
Fitzpatrick CK Baldwin MA Clary CW Wright A Laz PJ Rullkoetter PJ
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Complications of the patellofemoral (PF) joint remain a common cause for revision of total knee replacements. PF complications, such as patellar maltracking, subluxation, dislocation and implant failure, have been linked to femoral and patellar component alignment. Computational analyses represent an efficient method for investigating the effects of patellar and femoral component alignment and loading on output measures related to long term clinical success (i.e. kinematics, contact mechanics) and can be utilized to make direct comparisons between common patellar component design types. Prior PF alignment studies have generally involved perturbing a single alignment parameter independently, without accounting for interaction effects between multiple parameters. The objective of the current study was to determine critical alignment parameters, and combinations of parameters, in three patellar component designs, and assess whether the critical parameters were design specific. A dynamic finite element (FE) model of an implanted PF joint was applied in conjunction with a 100-trial Monte Carlo probabilistic simulation to establish relationships between alignment and loading parameters and PF kinematics, contact mechanics and internal stresses (Figure 1). Seven parameters, including femoral internal-external (I-E) alignment, patellar I-E, flexion-extension (F∗∗∗∗∗E) and adduction-abduction (A-A) rotational alignment, and patellar medial-lateral (M-L) and superior-inferior (S-I) translational alignment, as well as percentage of the quadriceps load on the vastus medialis obliquus (VMO) tendon, were perturbed in the probabilistic analysis. Ten output parameters, including 6-DOF PF kinematics, peak PF contact pressure, contact area, peak von Mises stress and M-L force due to contact, were evaluated at 80 intervals during a simulated deep knee bend. Three types of patellar component designs were assessed; a dome-compatible patellar component (dome), a medialized dome-compatible patellar component (modified dome), and an anatomic component (anatomic). Model-predicted bounds at 5 and 95% confidence levels were determined for each output parameter throughout the range of femoral flexion (Figure 2). Traditional sensitivity analysis, in addition to a previously described coupled probabilistic and principal component analysis (probabilistic-PCA) approach, were applied to determine the relative importance of alignment and loading parameters to knee mechanics in each of the three designs. The dome component demonstrated the least amount of variation in contact mechanics and internal stresses, particularly in the 30–100° flexion range, with respect to alignment and loading variability. The modified dome had substantially reduced M-L contact force when compared with the dome. The anatomic design, while wide bounds of variability were predicted, had consistently greater contact area and lowered contact pressure than the dome and modified dome designs. The anatomic design also reproduced more natural sagittal plane patellar tilt than the other components. All three designs were most sensitivity to femoral I-E alignment. Thereafter, sensitivity to component alignment was design specific; for the anatomic component, the main alignment parameter was F-E, while for the domed components it was a combination of F-E and translation (M-L and S-I) (Figure 3). Understanding the relationships and design-specific dependencies between alignment parameters can add value to surgical pre-operative planning, and may help focus instrumentation design on those alignment parameters of primary concern


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 73 - 73
1 Mar 2009
Gustke K Mahfouz M
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Frequently surgeons performing total knee replacements are faced with the dilemma of whether to notch the anterior cortex or overhang the medial and/or lateral cortices when implanting the femoral component. This is almost always seen in female patients. There is also a higher incidence of patellar alignment problems in female patients post total knee replacement. A unique 3D to 3D matching study of 202 cadaveric femurs has demonstrated a significant difference in the average comparable shapes of male versus female distal femoral anatomy. For the same AP dimension, female distal femurs are more than 5mm narrower. Also the angle formed between the anterior condyles and the posterior condyles are significantly different with the female being more trapezoidal in shape. Most existing total knee femoral component designs follow the ratio similar to that found in the average male distal femur. Options for management of this gender variability have been either utilizing instrumentation that references the anterior cortex to avoid notching or placing additional flexion on the distal femoral cut to allow downsizing. Both techniques are potentially problematic. Total knee implants systems are now utilizing this anthropomorphic data to redesign for separate male and female femoral components taking into consideration the relatively narrower female distal condylar width, lower medial anterior femoral condyle, and greater patellofemoral Q-angle


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 12 | Pages 1645 - 1649
1 Dec 2007
Joo SY Park KB Kim BR Park HW Kim HW

We describe our experience with the ‘four-in-one’ procedure for habitual dislocation of the patella in five children (six knees). All the patients presented with severe generalised ligamentous laxity and aplasia of the trochlear groove. All had a lateral release, proximal ‘tube’ realignment of the patella, semitendinosus tenodesis and transfer of the patellar tendon. The mean age at the time of the operation was 6.1 years (4.9 to 6.9), and the patients were followed up for a mean of 54.5 months (31 to 66). The clinical results were evaluated using the Kujala score.

There has been no recurrence of dislocation. All the patients have returned to full activities and the parents and children were satisfied with the clinical results. The mean Kujala score was 95.3 (88 to 98). Two patients had marginal skin necrosis which healed after debridement and secondary closure. These early results in this small group have shown that the ‘four-in-one’ procedure is effective in the treatment of obligatory dislocation of the patella in children with severe ligamentous laxity and trochlear aplasia.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 102 - 102
1 Mar 2006
Bull JR Prescott S Irwin A Khaleel A
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Introduction: Patellar alignment and tracking are very important to a successful surgical outcome in total knee arthroplasty (TKR) and difficult to assess in arthroscopies of the knee. The need for and use of a tourniquet in TKR’s and knee arthroscopies are debatable. One factor against its use is the possible alteration in the extensor mechanism dynamics making intraoperative assessment of patellofemoral (PF) tracking unreliable. Aim: To assess whether an inflated tourniquet affects patellofemoral tracking. Method: 10 Healthy male subjects, between 25 to 30 years of age, with no history of anterior knee pain; lower limb trauma, deformities or previous operations; or systemic disorders were admitted to the study. Dynamic sequence (Fast Field Echo scans) MRI scans over 57secs (flexed and extending against resistance to full extension), were performed without a tourniquet, on both knees, on all subjects as a control. A tourniquet, placed around the thigh, inflated to 300mmHg. Dynamic MRI scans were then obtained of each PF joint. PF tracking was then compared statistically. Results: Of the 20 knees compared, sulcus and congruence angles were within normal limits. There was no significant difference in patellar tilt angle or patellar displacement. A trend of increased femoral external rotation was seen. Conclusion: An inflated tourniquet placed around the upper thigh with the leg in extension does not alter patellofemoral kinematics in normal subjects. We believe the femoral external rotation seen is a mechanical adaptation of the tourniquet in the groin


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 90 - 90
1 Mar 2006
Udvarhelyi I Hangody L Karpati Z Tacsik B
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Purpose: Authors introduce short term results, hazards and solutions of 52 minimally invasive total knee replacement performed in their institute. Aspects of minimally invasive and minimalised exposures are detailed with differences in indication . Methods: Starting in June 2004 52 minimally invasive total knee replacements were performed in authors institute. The technique is quadriceps sparing, the implants are placed in through a medial parapatellar MIS incision. Types of vastus medialis insertion are crucial in indication of MIS or minimalised total knee. Preparation of the surfaces needs careful preparation, precise instrumentation and skill. Following patellar resection alignment, ligament balance should be treated as important and accurate as with other techniques. No muscles and tendons are detached Neurovascular hazards, complications, difficulties with solutions are introduced. Indication is determined by pathoanatomy and weight of the patient. Malalignment shouldn’t exceed 10–15 degrees. Flexion contracture more than 10 degrees is contraindication of the technique. Depending on the type of vastus insertion midvastus approach was used with good results in 8 cases . Results: The operation performed on properly selected patients results in a good implantation with appropriate ligament balance and stability. Average flexion was 74 degrees in the first two post op days. Post operative pain was significantly reduced. Hospital stay was 3,1 days. There was no infection. Conversion to normal exposure was done in 3 cases. In 8 cases midvastus approach was preferred because of anatomy. Conclusions: Minimally invasive total knee replacement is technically more demanding, requiring adequate training and knowledge. Appropriate indication is inevitable. Hospital stay and rehabilitation time is reduced also resulting in economic benefit, though never compromising good result of TKR


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 146 - 146
1 Apr 2005
Molloy DO Mockford BJ Wilson R Beverland DE
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Purpose: We describe our management of the valgus knee including release of tight lateral structures using a medial approach. Method: Controversy surrounds which approach to use when undertaking a total knee replacement (TKR) in a fixed valgus knee. Poor patellar tracking is associated with this deformity and often rectified by a lateral retinacular release. Those favoring the lateral approach feel, although more demanding, it gives direct access to the tight lateral structures and avoids excessive devas-cularization to the patella, which may be associated with a lateral release and a medial arthrotomy. Two hundred and eight consented patients (24.2%) were identified from 860 primary knee arthroplasties carried out over a 33-month period by a single surgeon. An LCS mobile bearing prosthesis was used in all cases. The mean valgus deformity measured 12.1 degrees (range 1–38). Fifty four percent of patients had a deformity of greater than 10 degrees. The patella was not resurfaced in any patient. Results: Forty-four patients (21%) required no soft tissue release. The mean deformity was 6 degrees (range 2–13). Of the remaining 164 patients, 142 (87%) had a posterolateral capsule release, 17 (10%) posterolateral capsule and iliotibial band release, 4 (2.4%) posterolateral and direct posterior capsule release and 1 (0.6%) a lateral collateral ligament slide for fixed valgus deformity. The mean valgus deformity increased with each additional release required. Of note 61 (29.3%) patients required a lateral patellar release for patellar maltracking. No patellar complications were noted. Mean patellar tilt was 1.1 degrees (sd=0.6 degrees) and mean patellar congruency 98% (sd=0.7%). Conclusion: Using a medial approach in the valgus knee is technically less demanding than a lateral approach, can be used in any primary knee irrespective of the type of deformity and can restore patellar alignment without compromising viability at least in cases where the patella is not resurfaced


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 1 | Pages 36 - 40
1 Jan 2005
Mountney J Senavongse W Amis AA Thomas NP

The tensile strength of the medial patellofemoral ligament (MPFL), and of surgical procedures which reconstitute it, are unknown. Ten fresh cadaver knees were prepared by isolating the patella, leaving only the MPFL as its attachment to the medial femoral condyle. The MPFL was either repaired by using a Kessler suture or reconstructed using either bone anchors or one of two tendon grafting techniques. The tensile strength and the displacement to peak force of the MPFL were then measured using an Instron materials-testing machine.

The MPFL was found to have a mean tensile strength of 208 N (SD 90) at 26 mm (SD 7) of displacement. The strengths of the other techniques were: sutures alone, 37 N (SD 27); bone anchors plus sutures, 142 N (SD 39); blind-tunnel tendon graft, 126 N (SD 21); and through-tunnel tendon graft, 195 N (SD 66). The last was not significantly weaker than the MPFL itself.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 227 - 227
1 Mar 2004
Victor J Hoste D
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Aims: The aim of the study was to determine the accuracy of the kinematical determination of the centre of rotation of the hip and to compare the outcome of the Computer assisted surgery (CAS) group versus a control group of patients with conventionally instrumented TKA, in a prospective randomized way. Methods: A prospective, randomized and controlled trial was undertaken with an image based CAS system (ION®), using specific knee software for the GENESIS II®total knee system. Randomization was performed on a consecutive group of 50 primary TKA’s, without exclusion criteria. All computed kinematical centres of rotation of the hip were compared to the anatomic fluoroscopic images. The difference between the kinematical centre of rotation and the anatomic centre of the femoral head was measured in the frontal plane. Coronal alignment was measured on full leg standing films. Validation of the full leg standing films was carried out in comparing the pre-operative measured angle and the computed deformity angle at the beginning of the surgery. Outcome of the CAS group was compared to the conventional group on the following items: tourniquet time, operative time, blood loss, patellar alignment, tibial slope, coronal alignment, range of motion and complications. Results: ACCURACY: The correlation index between pre-op full legs and CAS measured values was excellent: r. 2. =0.997. Difference between kinematical centre of rotation and anatomic centre of the hip: mean deviation between the two points was 1.2 mm (0–4mm), stdv 1.2 mm. This corresponds with a mean angular deviation of 0.17° (0–0.57°). OUTCOME: Tourniquet time: conventional 56 min., CAS 72 min. p=0.002. Operative time: conventional 70 min., CAS 93 min. p< 0.001. Blood loss: conventional 3.3 g/dl, CAS 4 g/dl. Patellar alignment: no tilt > 5°, no subluxation > 3 mm, both groups. Tibial slope: conventional 3.5°, CAS 3°. Post-operative mechanical alignment was between 0 and 2° of deformity for 16 conventional knees, and between 3–4° for 5 conventional knees. In the CAS group, all 21 knees scored between 0° and 2° of mechanical alignment. ROM at 6 weeks: flexion conventional 106°, CAS 105°. Fixed flexion contracture: conventional 2.9, CAS 2.1. Complications: delayed wound healing: conventional 2, CAS 1. Conclusions: Computer assisted kinematical determination of the centre of the hip can be highly accurate. Post-operative coronal alignment in CAS group is excellent, however not significantly better than conventional instrumentation