Introduction

Charcot neuroarthropathy is a limb threatening condition and the optimal surgical strategy for limb salvage in gross foot deformity remains unclear. We present our experience of using fine wire frames to correct severe midfoot deformity, followed by internal beaming to maintain the correction.

Introduction

Management of deformity involving limb length discrepancy (LLD) using intramedullary devices offers significant benefits to both patients and clinicians over traditional external fixation. Following the withdrawal of the PRECICE nail, the Fitbone became the primary implant available for intramedullary lengthening and deformity correction within our service. This consecutive series illustrates the advantages and complications associated with the use of this device, and describes a novel technique modification for antegrade intramedullary lengthening nails.

Introduction

External fixation (EF) devices are commonly used in the management of complex skeletal trauma, as well as in elective limb reconstruction surgery for the management of congenital and acquired pathology. The subsequent removal of an EF is commonly performed under a general anaesthetic in an operating theatre. This practice is resource intensive and limits the amount of operating theatre time available for other surgical cases. We aimed to assess the use of regional anaesthesia as an alternative method of analgesia to facilitate EF removal in an outpatient setting.

Introduction

IM (Intra Medullary) nail fixation is the standard treatment for diaphyseal femur fractures and also for certain types of proximal and distal femur fractures. Despite the advances in the tribology for the same, cases of failed IM nail fixation continue to be encountered routinely in clinical practice. Common causes are poor alignment or reduction, insufficient fixation and eventual implant fatigue and failure. This study was devised to study such patients presenting to our practice and develop a predictive model for eventual failure.

Introduction

Methoxyflurane can cause hepatotoxicity and nephrotoxicity at anaesthetic doses but has excellent analgesic properties and no nephrotoxic effects in patients without preexisting disease. Approved for use in the UK and Ireland in 2015, it is currently being used in emergency departments for analgesia during fracture reduction. During the Covid emergency, with theatre access severely restricted and many patients unwilling to use inhaled Nitrous oxide, Penthrox had the potential to provide adequate pain relief to aid frame removals and minor procedures in the clinic.

Background

The optimal treatment of segmental tibial fractures (STF) is controversial. Intramedullary nailing (IMN) and external fixation (EF) have unique benefits and complications.

Care of complex and open fractures may provide better results if undertaken in larger units, typically Major Trauma Centres (MTCs) or Orthoplastic units. Some ‘complex injuries’ may still be admitted to units lacking specialist services potentially delaying definitive treatment. The aim of this study was to analyse the referral pattern for acute inpatient transfer in an adult limb reconstruction unit for one calendar year.

Prospectively collected data from an electronic database for 2016 was reviewed. All records were evaluated for, diagnosis, time from injury to referral, nature of initial treatment, time to transfer, details of definitive surgery, and time to repatriation.

There were 91 formal electronic referrals, 84 of which considered appropriate for inpatient transfer. 74 were for fresh complex fractures, including 22 pilon fractures and 23 bicondylar tibial fractures. Median delay to request transfers for acute trauma was 3 days (0d-19d), delay from referral to transfer was 8.5 days (1d-31d) and delay from date of injury to definitive surgery was 13 days (1d-52d). 9 patients with Grade 3 open fractures and had primary debridement at the referring institution with a median delay to definitive orthoplastic surgery of 9 days (5d-20d). Only 17 of 61 per-articular fractures had spanning external fixation at the referring institution. Delay to repatriation was 8 days (0d–72d).

This study demonstrates organisational failures in acute orthopaedic care: open fractures not being primarily treated in orthoplastic centres or MTCs, delays in transfers due to bed-blocks, and significant delays in repatriation. It also demonstrates scope for improvement in clinical practice, and in particular, the need to reinforce the advantages of spanning external fixation of periarticular fractures.

Our data serves to highlight continuing problems in delivery of acute fracture care, despite widely publicised recent national guidelines.

Calcium sulphate (CaSO₄) is a recognised form of delivery of antibiotic for the treatment of bone infection. Complications inherent in the rapid reabsorption are well recognised (predominantly that of wound breakdown and leakage). There is little data on the frequency of these complications. The purpose of this study was to quantify the incidence of wound leakage from CaSO₄ and the service impact in orthopaedic surgery.

Infective limb reconstruction cases managed with gentamicin impregnated CaSO₄ between 2004–2012 were identified. Co-morbidities and factors influencing wound leakage were recorded. Medical and wound care notes were analysed. Episodes of delayed discharge and unscheduled clinic attendance due to wound leakage were recorded.

80 patients (18 female, 62 male), with a mean age of 45 years (18–80 years, median 46 years) underwent 84 procedures utilising CaSO₄. 47 were in the tibia, 14 in the femur, 10 in the humerus. A mean of 36 mL (4–150 mL, median 22 ml, unknown in 18 cases) was used.

31 cases (37%) had post-operative wound leakage, the majority from the tibia(55%) and femur(25%). 21 cases (25%) leaked within the first week. Each 10 ml rise in CaSO₄ volume lead to a 50% rise in leakage incidence. Leak duration ranged from 4 days–10 months. The majority leaked between 1–4 months before ceasing spontaneously and without specific treatment.

14 cases (17%) required a cumulative 32 unscheduled clinic appointments for leakage. Further surgery was required for infection in 7 cases (8.3%). Delayed discharge was not clearly attributable to CaSO₄. The mode of skin closure and cultured organism did not affect leakage.

CaSO₄ has unpredictable leakage, but is present in 1/3 of patients. Volume of CaSO₄ impacts on leakage. Leakage usually self-resolves and does not clearly impact on final outcomes. The cost impact of ongoing wound care and additional clinic appointments may be substantial.

Definitions and perceptions of good and poor outcome vary between patients and surgeons, and perceived inadequate outcome can lead to litigation. We investigated outcomes of litigation claims relating to non-union and deformity following lower limb long bone fractures from 1995 to 2010.

The database of all 10456 claims related to Trauma and Orthopaedic Surgery was obtained from the NHS Litigation Authority. Data was searched for “deformity, non-union and mal-union”, excluding spine, arthroplasty, foot and upper limb surgery. The type of complaint, whether defended or not, and costs was analysed.

241 claims met our criteria, 204 of which were closed, and 37 unsettled. Deformity/mal-union constituted 97, and non-union 143. Coronal/sagittal deformity cost £4.2 million, mean £45,487 (60% received compensation). Rotational mal-unions cost £1.6 million, mean £114,263 (87% received compensation). Non-union cost £5.3 million, mean £75,866 (60% received compensation).

Mean legal fees for coronal/sagittal deformity was £18,772, rotational deformity £37,384, and non-union £24,680. The total cost of litigation was £12.2 million, with a mean of £59,597 per settled claim. The mean pay-out for all confirmed negligence/liability was £56,046 (£1,300–£500,000, median £21,500) per case.

Non-union is an accepted complication following fracture surgery. However, this does not mitigate against non-union being seen as representing a poor standard of care. While it is unclear whether the payouts reflect a defensive culture or were due to avoidable errors, and notwithstanding the limitations of the database, we argue that failure of the index surgery should prompt a referral to a specialist centre.

The cosmetic appearances of rotational malalignment results in higher compensation, reinforcing outward perception of outcome as being more important than harmful effects.

We also note that the database sometimes contained conflicting and incomplete data, and make a case for standardisation of this component of the outcome process to allow for learning and reflection.

Claims for clinical negligence are increasing annually. Limb reconstructive surgery recognises ‘problems, obstacles, and complications’ as part of the treatment process, but this does not prevent a claim for an alleged poor result or a complication.

We analysed claims for clinical negligence in the National Health Service in England and Wales for issues following limb reconstructive surgery.

A database of all 10,456 claims related to Trauma and Orthopaedic Surgery from 1995–2010 was obtained from the NHS Litigation Authority. A Search Function for keywords “Ilizarov, limb reconstruction, external fixation, and pin-site” was used for subset analysis. Data was analysed for type of complaint, whether defended or not, and for costs.

52 claims fitted our filters - 48 were closed, and 4 ongoing. The claims included damage to local structures (n=3), missed compartment syndrome (n=2), premature frame removal (n=5), infection (n=13), wrong-site-surgery (n=1), poor outcome (n=16) and technical error (n=10). Seven patients underwent amputation. The total cost of litigation was £4,444,344, with a mean of £90,700 per settled claim. 40% were successfully defended, with defence cost of £15,322. The mean pay-out for confirmed negligence/liability was £90,056 (£1,500-£419,999, median £45,000) per case.

We believe this is the first study looking at complications following limb reconstruction from this perspective.

Analysis reveals a spectrum of claims for negligence. Perceived technical errors and poor outcome predominate. Whilst the limitations of the database preclude against identification of whether the procedures were carried out in specialist units, claims for technical errors are a cause for concern. These will be discussed in detail. Outcomes following limb reconstruction are difficult to quantify, and the settling of claims for a perceived poor outcome makes the case for pre-operative counselling and the need for robust outcome measures in our specialty.

The purpose of this study was to investigate the usefulness of PET-CT in the diagnosis and treatment of long bone infections following trauma.

All patients referred to the limb reconstruction service for management of non-unions were treated by the same protocol. PET-CT with FDG was performed in all patients to assess if the non-union site was infected and if so, the extent of the infection. Those requiring operative management were treated in a 2-stage manner. Initially with debridement based on PET-CT; sampling for microbiology and histology; and then Teicoplanin and Ciprofloxacin. If samples were positive then the patients were treated for a total of 6 weeks with antibiotics based on microbiology advice before undergoing definitive fixation. The sensitivity, specificity, PPV, and NPV were then calculated for PET-CTs ability to predict presence of infection using extended cultures and histology as the gold standard.

38 consecutive patients underwent surgery, 24 male and 14 female. 24 were deemed infected on extended culture or histology. PET-CT was anecdotally found to be extremely useful at determining the extent of infection to plan debridement.

PPV 0.83

NPV 0.89

Sensitivity 0.96

Specificity 0.61

As well as providing unique ability to demarcate areas of bony infection in the presence of metalwork, the ability to detect or exclude infection was exceptional.

This is a test, however, which is operator dependent and requires a skilled Nuclear Radiology Consultant to accurately interpret images. In our relatively small pilot study the accuracy improved noticeably over one year.

PET-CT has potential to be a powerful tool in the diagnosis and treatment of long bone infection following trauma and certainly warrants further investigation.

Statement of purpose

To determine the outcome of the use of Bone Morphogenetic Protein 7 (BMP7) as a replacement for bone graft in a limb reconstruction unit

Statement of purpose

To describe the results and technique of ankle fusion following failed Total Ankle Replacement (TAR) in a limb reconstruction unit.

Introduction

The treatment of chronic osteomyelitis involves a debridement of affected non-viable tissue and the use of antibiotics. Where surgery leaves a cavity, dead space management is practised with antibiotic impregnated cement. These depots of local antibiotics are variable in elution properties and need removal. We review the use of bioabsorbable synthetic calcium sulphate as a carrier of gentamicin and as an adjunct in treating intramedullary osteomyelitis.

The treatment of chronic osteomyelitis involves a debridement of affected non-viable tissue and the use of antibiotics. Where surgery leaves a cavity, dead space management is practised with antibiotic impregnated cement. These depots of local antibiotics are variable in elution properties and need removal. We review the use of bioabsorbable synthetic calcium sulphate as a carrier of gentamicin and as an adjunct in treating intramedullary osteomyelitis.

A retrospective review of cases treated consecutively from 2006 to 2010 in the Royal Liverpool University Hospital was undertaken. Variables recorded included aetiology, previous interventions, diagnostic criteria, radiological features, serology and microbiology. The Cierney-Mader system was used to classify. Treatment involved removal of implants (if any), intramedullary debridement and local resection (if needed), lavage and instillation of the gentamicin carrier, supplemented with systemic antibiotics. Follow-up involved a survival analysis to time to recurrence, clinical and functional assessment (AOFAS-Ankle/IOWA knee/Oxford Hip) and general health outcome (SF36).

There were 31 patients (22 male, 9 female). The mean age was 47 years (20-67). Twenty-five cases were post-surgery (6 open fractures) and 6 were haematogenous in origin. The median duration of osteomyelitis was 1.6yrs. The bones affected were 42% femur, 45% tibia, 3% radius and 10% humerus. 11 cases had diffuse as well as intramedullary involvement. 9 cases underwent segment resection and bone transport. We identified Staphylococcus Aureus in 16 and Coagulase Negative Staphylococcus in 6 cases. The median follow-up was 1.7 years (0.5-5.6). The median scores attained were: AOFAS-78, DASH-32, IOWA-71, Oxford-32. There were two recurrences.

Dead space management of intramedullary infections is difficult. We describe a method for delivery of local antibiotics and provide early evidence to its efficacy. The treatment success to date is 93%.

Bioabsorbable carriers of antibiotics are efficacious adjuncts to surgical treatment of intramedullary osteomyelitis.

Introduction: The treatment of femoral nonunions remains challenging despite modern surgical techniques and adjuncts to fracture healing. We present a series of 14 patients in whom a bifocal treatment technique has been used in order to achieve bony union and correct limb length.

Methods: Patients were identified from theatre records and their hospital notes and x-rays were retrospectively reviewed. All patients underwent bifocal treatment for femoral nonunions – debridement and internal fixation (single or double plating) of the nonunion and lengthening at the opposite end of the bone to correct limb length discrepancy. Initially the procedures were staged, with treatment of the non-union then subsequent lengthening. However, our technique has evolved to perform all procedures in a single stage. All lengthening procedures were done with a monolateral (Orthofix LRS) fixator.

Results: 11 patients had distal and 3 proximal femoral nonunions. 13 patients were male and 1 female. The non-union united with the index procedure in 13 patients, 1 is still undergoing treatment. Limb length discrepancy range 2–5 cm was fully corrected in all patients with no axial deviation of the regenerate. There were no pin site problems.

Discussion: Femoral nonunions are challenging due to multiple previous procedures, insecure grip on the smaller fragment and bone loss. Successful union can be achieved by ORIF with bone grafting, but this does not restore length. Treatment by the Ilizarov method alone is associated with significant morbidity, particularly knee stiffness. A bifocal strategy provides stable internal fixation of the non-union to allow bone healing, and any consequent loss of length is safely restored. We believe this to be a safe and effective technique to treat femoral nonunions.

Introduction: The subtrochanteric area of the femur is subject to large tensile and compressive forces. The rate of nonunion following operative fixation of such fractures is about 7–20%. Revision surgery to obtain union is difficult because of the small size of the proximal fragment, muscle forces acting in 2 planes, and bone loss.

We present the results of a series of 9 consecutive patients with subtrochanteric non-unions treated by double plates.

Methods: Retrospective analysis of 9 consecutive subtrochanteric nonunions treated with double plates and additional osteoinduction (bone graft, or BG+BMP-7).

Results: There were 5 male and 4 female patients, with ages from 50–82 years (mean 65). All were treated in a single-stage procedure by implant removal, a lateral plate and a separate anterior plate. One patient had had a previous unsuccessful revision procedure with an intra-medullary device.

One patient with liver cirrhosis died 5 days postoperatively. Two patients are currently 8 weeks post surgery. All the others healed in a mean of 5.1 months (range 4–6 months).

Two patients underwent distal femoral lengthening to compensate for bone loss.

Discussion: The high muscle forces around the proximal femur require a sound mechanical environment for bone healing to occur. This is particularly marked in nonunions. The small size of the proximal fragment can result in suboptimal fixation. The addition of the anterior plate provides better fixation and also neutralizes the sagittal forces.

We believe that double plating neutralizes all the forces around the proximal femur, providing the best mechanical environment. Given the limits of the small numbers and the retrospective nature of the study, we believe that this method of treatment offers a sound surgical strategy, reflected by our success rate.

Aims: To quantify the complication rate in Ilizarov surgery at an experienced Limb reconstruction Unit. Study Design: A retrospective study of prospectively collected data on complications. Material: Complications in 304 patients, treated between January 1998 and April 2001 were reviewed. Complications relating to the pin site, bones, joints, neurovascular structures, pain, mental status and mechanical failure of the frame were documented. Results: There were 103 complications (34%) in total. Twenty patients (6.6%) required IV antibiotics or curettage of a ring sequestrum. Forty- three (14%) experienced problems with non or delayed union, mal union, incomplete osteotomy, premature consolidation of regenerate or fracture through a pin site. Twelve (4%) developed neural problems in the form of nerve pain or permanent nerve damage. Twenty-one (6.9%) developed loss of joint motion sufþcient to stop distraction or as a permanent sequelae. One (0.3%) suffered from depression during treatment. Three (1%) required referral to a pain team. Despite re-useable hardware mechanical failure was represented by only 3 episodes (1%) of þne wire breakage. Conclusions: Analysis revealed no signiþcant difference between the calendar years and so represents a true complication rate. There was a signiþcant difference in the complication rate for frames applied for acute trauma, late trauma and elective surgery. The difference did not relate to time spent in the frame and seems to represent a separate variable. There was a disproportionate increase in complications for frames applied for upper limb pathology.

This is a retrospective study describing four patients who developed symptomatic subluxation of the hip after stabilisation to the pelvis for myopathic scoliosis in Duchenne Muscular Dystrophy (DMD).

Fusion to the pelvis is recommended for treatment of scoliosis in DMD. Non-spinal extra-pulmonary complications following this have not been described.

4 patients (average age: 14 years) out of a cohort of patients who have undergone spinal stabilisation for DMD between 1991 and 1998 developed symptomatic subluxation of the hip at an average of three months after fusion from the upper thoracic spine to the pelvis. All four had pain and three noticed clicking in the hip.

X-rays revealed subluxation of the hip in all patients, and conservative treatment by adjustment of seating position in the wheelchair was successful in reducing the symptoms in all patients.

Flexion-abduction contractures of the hip, which are a feature of DMD, are known to cause uncovering of the contralateral hip. We postulate that the spine compensates for this uncovering to a large degree, and that spinopelvic fusion for scoliosis in patients with pre-existent abduction contractures negates the capacity of the spine to provide compensation. This leads to uncovering of the hip with the lesser degree of contracture, and the resultant symptoms.

We recommend screening for, and treatment of, flexion-abduction contractures of the hip in all patients undergoing spinal fusion for DMD, to avoid the possibility of development of symptomatic subluxation of the hip.

Aim: To quantify the complication rate in Ilizarov surgery. This study establishes the complication rate for an experienced Limb Reconstruction Team composed of 3 surgeons, 2 specialist nurses and 2 physiotherapists involved with acute trauma, late trauma reconstruction and elective limb deformity cases.

Study Design: Retrospective analysis of prospectively collected data on complications.

Material: Complications in 304 patients, treated between January 1998 and April 2001 were reviewed. Complications relating to the pin site, bones, joints, neurovascular structures, pain, mental status of the patient and mechanical failure of the frame were documented.

Results: Of the 304 cases treated there were 103 complications (34%) in total. Twenty patients (6.6%) required re-admission for IV antibiotics or curettage of a ring sequestrum secondary to a pin site infection. Forty three patients (14%) experienced problems with non or delayed union, mal union, incomplete osteotomy, premature consolidation of the regenerate or fracture through a pin site. Twelve patients (4%( experienced neural problems in the form of nerve pain during distraction or permanent nerve damage. Twenty-one patients (6.9%) developed loss of joint motion sufficient to stop distraction or as a permanent sequelae of treatment. One patient (0.3%) suffered from depression during the period of treatment. Three patients (1%) required referral to the pain team. Mechanical failure of the frame was represented by three episodes (1%) of fine wire breakage despite re-useable hardware.

Analysis revealed no significant difference in complication rates between the calendar years. However, there was a significant difference between complication rates in frames applied for acute trauma, late presentation of trauma, and elective surgery. This difference did not appear to relate to time spent in the frame, and therefore seems to represent a separate variable. There was a disproportionate increase in complications in Ilizarov frames applied for upper limb problems.

Conclusion: This study provides a baseline for the commonly occurring problems associated with the practice of Ilizarov surgery in the United Kingdom and Ireland.