Short stems have been developed for some years for preservation of femoral bone stock and achieve physiological proximal loading. Shortening stem length is a merit for bone stock preservation. However, it might lead to reduction of primary stability. We investigated relationship between stem length and primary stability by patient specific finite element analysis (FEA). Thirty-one hips in 31 patients were performed total hip arthroplasty with standard length tapered wedge-shaped (TW) cementless stem (CTi-II: Corin, Cirencester, UK). There were 6 males and 25 females. The average age at operation was 69 years old. The average body mass index was 23.9 kg/m2. Primary diagnoses were secondary osteoarthritis due to developmental dysplasia of the hip in 29 hips. Femoral canal shapes were normal in 21, stovepipe in 6 and champagne-flute in 4 hips. Bone qualities were type A in 6, B in 19 and C in 6 hips. The patients underwent computed tomography (CT) preoperatively and postoperatively. We constructed preoperative three dimensional (3D) femur surface models from preoperative CT data with individual bone mineral density (BMD) mapping. The postoperative 3D femur and rough stem surface models were obtained from postoperative CT data. The coordinates of the postoperative femur were transformed to fit the preoperative femur model. A precise stem model constructed using computer-assisted design data was matched to the transformed rough stem model using the iterative closest point algorithm. We obtained a patient-specific model with the proximal bone geometry, allocation of BMD and stem alignment. We estimated the average of axial and rotational micromotion (MM) at stem-bone interface and the ratio of area (MM � 40 micrometers) on the porous surface in order to analyze primary stability of TW stem with several lengths (standard (100 %), 75 %, 50 %, 40 % and 30 % length).Introduction
Materials and Methods
Excessive mechanical stress on synovial joints causes osteoarthritis
(OA) and results in the production of prostaglandin E2 (PGE2), a
key molecule in arthritis, by synovial fibroblasts. However, the
relationship between arthritis-related molecules and mechanical
stress is still unclear. The purpose of this study was to examine
the synovial fibroblast response to cyclic mechanical stress using
an Human synovial fibroblasts were cultured on collagen scaffolds
to produce three-dimensional constructs. A cyclic compressive loading
of 40 kPa at 0.5 Hz was applied to the constructs, with or without
the administration of a cyclooxygenase-2 (COX-2) selective inhibitor
or dexamethasone, and then the concentrations of PGE2, interleukin-1β (IL-1β),
tumour necrosis factor-α (TNF-α), IL-6, IL-8 and COX-2 were measured.Objective
Method
Short tapered wedge-shaped cementless (TW) stems have been widely used for several years. The concept of fixation of TW stem is wedge-fit fixation in the proximal metaphysis. Developmental dysplasia of the hip (DDH) has anatomical abnormality, such as excessive femoral anteversion, short femoral neck length, narrow femoral cavity, or proximal-distal mismatching of the femoral canal. Therefore, Mismatching between stem and bone might be occurred in DDH. We evaluated intramedullary matching of short TW stem for DDH by three dimensional (3D) digital template in order to clarify whether mismatching between stem and bone is seen in DDH implanted short TW stem. One hundred hips (92 patients) with DDH were performed preoperative simulation for total hip arthroplasty by 3D digital template system (ZedHip: Lexi, Tokyo, Japan). The average age was 63.5 years old. There were 12 males and 80 females. The average bone mass index was 21.5 kg/m2. Femoral canal shape was normal in 71, champagne-flute in 16 and stovepipe in 13 hips. Bone quality was classified into type A in 23, type B in 74 and type C in 3 hips. Preoperative computed tomography data were used for 3D digital template and reconstructed to 3D femoral model. Short TW stem (Taperloc Complete Microplasty: Biomet, Warsaw, IN) model constructed from computer-assisted design was matched to the reconstructed femoral model. Short TW stem model was in principle implanted according to the femoral neck anteversion with neutral alignment (varus and valgus < 2 degrees, flexion and extension < 2 degrees) at the coronal and sagittal plane of the femur. Stem size was determined in order to obtain the largest intramedullary matching at the coronal plane. Area of stem fitting with the cortical bone was investigated at 10 mm intervals above and below of mid minor trochanter. Intramedullary matching pattern was classified into proximal mediolateral metaphyseal fit, proximal flare fit and diaphyseal fit at multiple reconstructed planes of the 3D femoral model according to stem fitting area.[Introduction]
[Materials and Methods]
