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Bone & Joint Open
Vol. 1, Issue 6 | Pages 309 - 315
23 Jun 2020
Mueller M Boettner F Karczewski D Janz V Felix S Kramer A Wassilew GI

Aims

The worldwide COVID-19 pandemic is directly impacting the field of orthopaedic surgery and traumatology with postponed operations, changed status of planned elective surgeries and acute emergencies in patients with unknown infection status. To this point, Germany's COVID-19 infection numbers and death rate have been lower than those of many other nations.

Methods

This article summarizes the current regimen used in the field of orthopaedics in Germany during the COVID-19 pandemic. Internal university clinic guidelines, latest research results, expert consensus, and clinical experiences were combined in this article guideline.


Introduction

We report the outcomes of minimally invasive technique for posterior lumbar interbody fusion (PLIF) procedure using Hollow Modular Anchorage (HMA) screws supplemented by routine pedicle screw fixation (Dynesis).

Patients and Methods

Seventy-nine patients, who had undergone PLIF procedure using HMA screws supplemented by pedicle screw fixation, were included. Patients deemed suitable for surgery following discography under sedation, with Marcaine instillation establishing reducibility of the listhesis and temporary relief of symptoms. Clinical outcome included visual analogue scale scores for leg pain and back pain, Oswestry Disability Index (ODI) and SF-36 questionnaires.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVI | Pages 72 - 72
1 Jun 2012
Mueller M Hoskinson S Shepperd J
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Objective

From our series of 570 Dynesys flexible stabilisation procedures, we studied two prospective series of patients with a minimum one-year follow-up comparing uncoated and hydroxyapatite-coated (HA) screws.

Methods

Patients were entered prospectively and followed up at 6 weeks, 3, 6, and 12 months and annually thereafter. Plain radiographs were obtained annually. 58 patients who underwent Dynesys stabilisation with HA coated screws (312 screws) were evaluated. The data was compared with 71 patients who underwent Dynesys stabilisation with non-coated pedicle screws (366 screws). Outcome measures were screw loosening, breakage, implant removal or revision. Follow up was 96 %.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_X | Pages 70 - 70
1 Apr 2012
Mueller M Hoskinson S Shepperd J
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We have studied two matching cohorts of patients treated by Dynesys flexible stabilisation with and without hydroxyapatite (HA) coating of the pedicle screws.

From our series of 570 Dynesys procedures, we studied patients with HA coated screws with a minimum one year follow-up.

Patients were entered prospectively and followed up at 6 weeks, 3, 6, and 12 months and annually thereafter. Plain radiographs were obtained annually. 58 patients (26 males, 32 females, mean age 55 years at surgery) underwent Dynesys stabilisation with HA coated screws. The data was compared with 69 patients who underwent Dynesys stabilisation with non-coated pedicle screws between 2004 and 2006 (26 male, 53 female, mean age 54 years). Outcome measures were screw loosening, breakage, implant removal or revision.

A total of 320 HA coated pedicle screws were inserted. 12 patients were lost to follow-up. 2 patients underwent subsequent level extension, and 2 had their implants removed. There were four screw breakages in three patients, all affecting S1 screws. There was no evidence of screw loosening in any patient. In the non-HA coated group 354 pedicle screws were inserted. 5 patients required revision or subsequent surgery. 12 patients had screw loosening and required implant removal. There was a significant improvement of anchorage of the HA coated screws.

Change to HA coating was investigated because of high loosening in plain screws. The improvement has been highly significant. Flexible stabilisation is a better model than fusion because the implant remains under constant load.

Disclosure: The authors did not receive any outside funding in support of preparation of this work.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 67 - 67
1 Mar 2012
Pape H Rixen D Morley J Ellingson C Dumont C Garving C Vaske B Mueller M Krettek C Giannoudis P
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Purpose

The timing of definitive fixation for major fractures in polytrauma patients is controversial. To clarify this aspect of trauma management, we randomised patients with blunt multiple injuries to either initial definitive stabilisation of the femur shaft with an intramedullary nail or an external fixator which was converted to an intramedullary nail at a secondary procedure and documented the post-operative clinical condition.

Methods

Multiply injured patients with femoral shaft fractures were randomised to either initial (<24 hours) intramedullary femoral nailing or to initial external fixation and conversion to an intramedullary nail at a later phase. Inclusion criteria: New Injury Severity Score >16 points, or 3 fractures and Abbreviated Injury Scale score >2 points and another injury (Abbreviated Injury Scale score >2 points), and age 18 to 65 years. Exclusion criteria: unstable or patients in extremis. Patients were graded as stable or borderline (increased risk of systemic complications). OUTCOMES: Incidence of acute lung injuries.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 99 - 99
1 May 2011
Mueller M Belei P Strake M Kabir K Radermacher K Wirtz D
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Introduction: Femoral neck fractures are common and percutaneous insertion of three cannulated screws is an accepted method of surgical treatment. The accuracy of surgical performance is highly correlated with the cut-out percentages of the screws. The conventional technique relies heavily on fiuoroscopy and could lead to inappropriate implant placement. Further, multiple guidewire passes might prolong the operation time and weaken the cancellous bone. A computer-assisted planning and navigation system based on 2D-fiuoroscopy has been developed for guidewire insertion in order to perform insertion of a guidewire to perform screw insertion. The image acquisition process was supported by a radiation-saving procedure called “Zero-dose C-arm navigation”. The purpose of this experimental study was to compare this technique with conventional C-arm fiuoroscopy with respect to the number of fiuoroscopic images, the number of drilling attempts and operation time. We used two operative settings, with sawbones and with cadavers. For the sawbone study, we also compared the femoral neck and head perforation and the neck-width coverage (the relative area of the femoral neck held by screws).

Methods: Three cannulated hip screws were inserted into 12 femoral sawbones simulating femoral neck fractures and into 6 cadaveric femurs guided by the computer-based navigation. We compared them to the conventional fiuoroscopic technique also using 12 femoral sawbones and 6 cadaveric femurs.

Results: The computer-assisted technique significantly reduced the amount of intraoperative fiuoroscopy (sawbone study: P< 0.001; cadaver study: P< 0.001) and the number of guidewire passes (sawbone study: P< 0.05; cadaver study: P< 0.05) in the sawbone and the cadaver setting. Operation time was significantly longer (sawbone study: P< 0.001; cadaver study: P< 0.05) in the navigation assisted group also in both settings. In the sawbone study, there was no significant difference in the femoral neck and head perforation, whereas the relative neck area held by the screws was significantly (P< 0.05) larger than that in the conventional group.

Discussion: The addition of computer-assisted planning and surgical guidance supported by “Zero-dose C-arm navigation” may be useful for the fixation of femoral neck fractures by cannulated screws as it reduces the amount of intraoperative fiuoroscopy, requires fewer drill tracks and achieves a better neck coverage. Further studies with the goal of reducing the operation time by improving the learning curve are indispensable before integrating this navigation system into the clinical workfiow.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 346 - 346
1 May 2010
Tzioupis C Riexen D Dumont C Pardini D Mueller M Gruner A Krettek C Pape H Giannoudis P
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Patients with bilateral femur shaft fractures are known to have a higher rate of complications when compared with those who have unilateral fractures. Many contributing factors have been considered responsible, however due to the heterogeneity of the studied populations solid conclusions cannot be substantiated. Patients included in our study were separated according to the presence of a unilateral (group USF) (n=146) versus bilateral femur shaft fracture (group BSF) (n=19)Endpoints of the study included the incidence of systemic (SIRS, Sepsis, Acute Lung Injuries) complications. The perioperative assessment included documentation of clinical and laboratory data assessing blood loss, coagulopathy, wound infection, and pneumonia. Local (wound infection, compartment syndrome etc.) and systemic complications (ALI, MOF, Sepsis) were documented. Statistical analyses were conducted to examine the relation between the occurrence of unilateral versus bilateral femoral fractures and variables indexing patient demographic characteristics and other indicators of initial injury severity. Independent sample t-tests were used to examine treatment group differences for variables that approximated a Gaussian distribution. For non-normal indicators of injury severity Mann-Whitney tests were performed. Pearson chi-square tests were performed for binary indicators of injury severity, except when expected cell counts did not exceed 5 participants. When this occurred, the Fisher exact test was used Evidence indicated that patients who suffered a bilateral femoral fracture were significantly more likely to have hemothorax and receive a blood transfusion upon admission to the hospital in comparison to patients who suffered a unilateral femoral fracture. Bivariate analyses also indicated that patients with bilateral femoral fractures exhibited a longer clinical recovery time and were more likely to experience clinical complications in comparison to those with unilateral fractures. However, there were no significant differences between the fracture groups in terms of the number of hours spent on a ventilator or the occurrence of pneumonia, acute lung injury, acute respiratory distress, sepsis, and multiple organ failure following surgery. Patients in borderline condition spent significantly more time in the ICU in comparison to those in stable condition. The high incidence of posttraumatic complications in poly-trauma patients with bilateral femur shaft fractures is caused by the accompanying injuries rather than by the additional femur fracture itself. It also documents that a thorough preoperative assessment can help differentiate those who have a high like hood of developing systemic complications from those who do not.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 167 - 167
1 Mar 2009
Ahluwalia R Mueller M Kempraju N Fonseca J
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We present the use of the Orthopaedic POSSUM Score and Surgical Risk Score (SRS) to identify optimal time for fracture neck of femur surgery. The objective of this study was to identify the physiological status of patients at admission and compare the results of operative physiological condition and differences in predictive and actual operative outcomes.

1238 consecutive hip fractures from Jan 2005 to July 2006 at 3 hospitals were assessed. Collection of demographic, admission and operative POSSUM, and SRS scores, fracture pathology, physiological status, and postoperative outcome were conducted.

In total, 1031 (83.3%) patients had surgery. The median age was 72.6 (range 55–95, mean 68). Majority had significant systemic multiple co-morbidity (78%), an average ASA score of 3.3. POSSUM predicted 18.7% (n= 194) of death at 30 days, where as the surgical risk score predicted 13.8% (n=142 deaths), the actual mortality was 11.7% (n=120).

The difference between admission and operative physiological POSSUM score increased with operative delay (see table 1). Physiological scores greater than 30 had a 67.8% risk of 30-day mortality. 361 patients had an increase in physiological score from admission to operation, resulting in higher analgesic requirements and reduced mobility scores (P< 0.005). These patients had a 12.6% increase in mortality when compared with patients operated earlier with a similar initial score (P< 0.005). Furthermore delayed surgery (> 48 hours) lead to reduced in return mobility, function, increased wound infections and other medical complications.

Possum and SRS over predict operative mortality, but are useful in prioritising their time of surgery. Declining operative physiological POSSUM scores indicate room for improvement in preoperative care, and for specific protocols if surgery has to be delayed to prevent further physiological deterioration, and induce optimal functional outcomes.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 309 - 309
1 May 2006
Narayanasetty K Mueller M Fonseca J Ahluwalia R
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Introduction: We present the use of Orthopaedic POSSUM Score and Surgical Risk Score (SRS) in femoral neck fracture surgery. The objective of this study was to identify the physiological status at admission and at operation and identify differences in predictive and actual patient operative outcomes.

Material and Methods: All 338 consecutive, hip fractures from December to July 2005 at three hospitals were assessed prospectively. Collection of demographic, admission, and operative POSSUM, and SRS scores, fracture pathology, physiological status, and outcomes were analyzed.

Results: In total, 306 (90.5%) patients had surgery. The median age was 73 years (range 55–95). The majority had co-morbidities (77.5%; n=237), as suggested by average ASA scores of 3.2. POSSUM predicted mortality was 13.6% (n=25) at 30 days, whereas the SRS predicted 11.4% (n=21), but mortality was 7.1% (n=13) if operated before 48 hours. Differences between admission and operative physiological Possum score increased with operative delay. Physiological scores over 30 had a 67.8% risk of 30-day mortality. Eighty-six patients had an increase in physiological score from admission to operation, resulting in higher analgesic requirements and reduced mobility scores (P< 0.005).

Discussion: Possum and SRS had a tendency to predict prior than actual operative mortality. Nevertheless, comparison of admission and operative physiological POSSUM scores indicate room for improvement in pre-operative care if surgery is delayed.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 334 - 334
1 Nov 2002
Rajaratnam SS Selmon GPF Mueller M Shepperd JAN Mulholland RC
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Objective: To present early results of a new technique of dynamic stabilisation of the lumbo-sacral spine.

Design: Prospective study

Subjects: Between September 2000 and December 2001, 43 patients underwent posterior spinal stabilisation using the Dynamic Neutralisation System (DYNESYS) (Sulzer Medica).

Outcome Measures: Oswestry Disability indices, complications, visual analogue pain scores, patient satisfaction.

Results: The perceived indications were isolated degenerative disc disease (26), spondylolisthesis (8), degenerate adult scoliosis (4), failed Graf stabilisation (1), lumbar canal stenosis (3) and traumatic compression fracture (1).

Fixation was at one level in 14, two levels in 23, and three or four levels in 6 patients. Thirty-seven had Dyne-sys fixation alone and six had additional procedures at the same operation.

Complications included facet fracture (1), broken pedicle screw (1), apparent screw loosening (1) and discitis (1). At average follow-up of eight months (range 2–14 months), the average Oswestry disability score had fallen from 52 to 32 and the visual analogue pain score from 7.5 to 1.7. 65% of patients were pleased or better with their result.

Conclusions: The Dynesys system seems to be a safe alternative to conventional operative treatment for degenerative disorders of the lumbar spine without the need for rigid fusion. The anatomic re-stabilisation may allow the spinal segment to recover. The early results are encouraging. It is hoped that longer term follow-up will clarify the groups of patients who will benefit most from this procedure.