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Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_15 | Pages 81 - 81
1 Dec 2021
Beldman M Löwik C Soriano A Albiach L Zijlstra W Knobben B Jutte P Sousa R Carvalho AD Goswami K Parvizi J Belden K Wouthuyzen-Bakker M
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Aim

Rifampin is considered as the antibiotic corner stone in the treatment of acute staphylococcal periprosthetic joint infections (PJI). However, if, when, and how to use rifampin has been questioned. We evaluated the outcome of patients treated with and without rifampin, and analysed the influence of timing, dose and co-antibiotic.

Method

Acute staphylococcal PJIs treated with surgical debridement between 1999 and 2017, and a minimal follow-up of 1 year were evaluated. Treatment failure was defined as the need for any further surgical procedure related to infection, PJI-related death, or the need for suppressive antimicrobial treatment.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_14 | Pages 10 - 10
1 Dec 2019
Löwik C Parvizi J Jutte P Zijlstra W Knobben B Xu C Goswami K Sousa R Carvalho AD Soriano A Wouthuyzen-Bakker M
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Aim

Treatment success of debridement, antibiotics and implant retention (DAIR) is in early periprosthetic joint infection (PJI) is largely dependent on the presence or absence of a mature biofilm. In what time interval a mature biofilm develops is still unclear, and therefore, the time point at which DAIR should be disrecommended remains to be established. This large multicenter trial evaluated the failure rates of DAIR for different time intervals from index arthroplasty to DAIR in early PJI.

Method

We retrospectively evaluated patients with early PJI treated with DAIR between 1996 and 2016. Early PJI was defined as a PJI that developed within 90 days after index arthroplasty. Patients with hematogenous infections, arthroscopic debridements and a follow-up less than one year were excluded. Treatment failure was defined as 1) any further surgical procedure related to infection 2) PJI-related death, or 3) long-term suppressive antibiotics, all within one year after DAIR.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_17 | Pages 40 - 40
1 Dec 2018
Löwik C Zijlstra W Knobben B Ploegmakers J Dijkstra B de Vries A Kampinga G Jutte P Wouthuyzen-Bakker M
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Aim

Obese patients are not only more likely to receive total joint arthroplasty, but are also more prone to postoperative complications. The most severe complication is a prosthetic joint infection (PJI), occurring two to four times more often in severely obese patients (BMI ≥ 35kg/m2) compared to non-obese patients. This higher risk for PJI may be attributed to higher glucose levels in case of diabetes mellitus, diminished wound healing or inadequate antibiotic prophylaxis. To ultimately improve the prevention measures for this specific patient category, we aimed to describe the clinical and microbiological characteristics of early acute PJI in severely obese patients.

Method

We retrospectively evaluated patients with early acute PJI of the hip and knee treated with DAIR between 2006 and 2016 in three Dutch hospitals. According to protocol, cefazolin was administered as antibiotic prophylaxis during arthroplasty and adjusted to bodyweight. PJI was diagnosed using the criteria described by the Musculoskeletal Infection Society. Early acute PJI was defined as less than 21 days of symptoms and a DAIR performed within 90 days after index surgery. Several clinical and microbiological variables were collected and analyzed. Severe obesity was defined as a BMI ≥ 35kg/m2.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_17 | Pages 3 - 3
1 Dec 2018
Löwik C Tornero PJE Ploegmakers J Knobben B de Vries A Zijlstra W Dijkstra B Soriano A Wouthuyzen-Bakker M
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Aim

Debridement, antibiotics and implant retention (DAIR) is a widely used treatment modality for early acute prosthetic joint infection (PJI). A preoperative risk score was previously designed for predicting DAIR failure, consisting of chronic renal failure (K), liver cirrhosis (L), index surgery (I), cemented prosthesis (C) and C-reactive protein >115mg/L (KLIC). The aim of this study was to validate the KLIC score in an external cohort.

Method

We retrospectively evaluated patients with early acute PJI treated with DAIR between 2006 and 2016 in three Dutch hospitals. Early acute PJI was defined as less than 21 days of symptoms and DAIR performed within 90 days after index surgery. Failure was defined as the need for 1) second DAIR, 2) implant removal, 3) suppressive antimicrobial treatment or 4) infection-related death within 60 days after debridement.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 251 - 251
1 Sep 2005
Knobben B Engelsma Y Neur D van der Mei H Busscher H van Horn J
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Introduction: One of the primary complications in total hip and knee arthroplasty is infection. One of the major risk factors for deep periprosthetic infection is wound infection. This alone is associated with a substantial morbidity-increase which, in turn, increases hospital admittance time and therefore adds significant costs to the healthcare system. The aim of this study is to determine whether contamination of instruments used during primary insertion of a prosthesis, can be considered an early indicator for the occurrence of prolonged wound discharge. Early antibiotic treatment could then prevent this and decrease hospital admittance time and costs to the health care system.

Material and Methods: During 121 procedures, swabs were taken from the first unused broach at the beginning and at the end of the procedure. Removed material from the bone (acetabulum and femur in the hip joint; femur and tibia in case of the knee joint) was tested for contamination as well. During 50 procedures a control swab was taken. The patients on the ward were also monitored to find out whether prolonged wound discharge occurred and to see after how many days the patients were discharged.

Results: In 46 cases (38%) at least one culture showed microbial growth. In the other 75, there was no growth at all. If one of the cultures is positive, there is a 52% risk of prolonged wound discharge. Ifall cultures are negative, this risk is reduced to 13% (Chi-square: PO.001). Patients with a positive peroperative culture have to remain in the hospital for an additional 2.4 days (T-test: P-0.001).

Conclusion: Peroperative culturing during primary insertion of a knee or hip prosthesis, provides a reliable tool to predict postoperative duration of wound discharge and hospital-admittance time.