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Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 23 - 23
1 Jun 2017
Parker S Grammatopoulos G Dhaliwal K Pradhan R Marshall R Andrade A
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Degenerative hip and spine pathologies often co-exist, as Hip-Spine-Syndrome (HSS). Many patients eventually need surgery in both hip (THR) and spine [decompression-spinal-arthrodesis (DSA)]. This case-control study aims to determine whether the presence of a DSA compromised THR outcome and whether outcome of THR is better if performed prior to- (THR-1st) or after- DSA (THR-2nd).

This is a single centre, multi-surgeon, retrospective, case-control study. Of the 748 patients that underwent DSA between 2004–15, 43 patients (54 THRs) have also had a 1° THR(s) at our unit and formed the cases. Thirty-two THRs were performed prior to the DSA (THR-1st) and 22 were done following the DSA (THR-2nd). Most cases had either 1- (n=3) or 2-level (n=20) DSA. The most common DSA level was L4/5 (n=23). The mean THR-DSA interval was 3.6 years. Controls were patients (n=67) without DSA or previous spinal surgery, that had a THR in our unit over the same study period matched for age, gender and type of THR implanted.

Patient Reported Outcome Measures (PROMs) were obtained using the Oxford-Hip- and Harris-Hip-Scores (OHS/HHS), with the difference between post- and pre-operative scores defined as Δ. Outcome was compared between Cases and Controls and between THR-1st and THR-2nd Groups. Outcome measures included complications, revisions, PROMs and cup orientations achieved.

The mean age at THR was 67 years old (SD: 11) and most patients were female (n=82, 68%). The mean cup inclination and anteversion angles were 41° (SD:8) and 21° (SD:8). At a mean follow-up of 6 years, the OHS improved from OHSpre:16 (SD: 7) to OHSfu:41 (SD:10) and the HHS improved from HHSpre:51 (SD:14) to HHSfu:88 (SD:13).

A greater incidence of complications were seen in the Cases (n=10; ARMD-3, infection-4, loosening-2, dislocation-1) compared to the Controls (n=3; dislocation-2, loosening-1) (p=0.01). Consequently, more THRs required revision in the Cases (n=7) compared to the Controls (n=1) (p=0.01). There were no differences in OHSpre/OHSfu/ΔOHS/HHSpre/HHSfu/ΔHHS between cases and controls (p=0.1 – 0.9).

There were no difference in complications (7/29 Vs. 3/25; p=0.3), nor revision rates (5/29 Vs. 2/25; p=0.3) between THA-1st and THA-2nd Groups. Greater differences in PROMs were detected between the groups. The THA-1st Group, compared to the THA-2nd Group had higher OHSpre (19 Vs 12), HHSpre (54 Vs 48), OHSfu (43 Vs 32) and HHSfu (93 Vs 76), (p=0.001–0.005). However, no statistically significant difference in ΔOHS (24 Vs 17) and ΔHHS (39 Vs 26) were seen between the THA-1st and THA-2nd Groups (p=0.1).

Patients with a 1° THR and DSA, had a greater rate complications and revisions compared to a matched control. Overall, no difference in PROMs were seen between Cases and Controls. No significantly increased risk of dislocation was seen in this predominantly 1- and 2-level DSA cohort. The superior PROMs detected in the THA-1st Group provide evidence that the hip pathology should be addressed 1st (in cases with 1- or 2-level planned DSA).


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_12 | Pages 6 - 6
1 Mar 2013
Mills R Andrade A
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In January 2012, the Department of Health reportedly claimed that data demonstrated ‘half of knee surgery does not substantially change the outcome for patients: their mobility is not improved that much, nor their pain’. Furthermore, in recent years knee replacement surgery has been described as a procedure of limited clinical value (PLCV) by commissioning bodies nationwide. This study aimed to establish whether patients in Reading were satisfied with their surgery at five years and whether there was an objective improvement in their pain and function following surgery.

Five-year data was retrospectively reviewed from 130 knee replacements performed between January 2004 and July 2005. Patient details, intra-operative data and patient reported outcome measures (PROMs) were downloaded from our OrthoWave database. The Oxford Knee Score was completed pre-operatively, at six months and then yearly to five years, measuring pain and function specific to the knee operated on. In addition, patients were asked directly whether they felt satisfied with their joint replacement surgery.

The sample population consisted of 52 males and 78 females, with a mean age of 70 and mean body mass index of 30.2. Twenty-three of the patients had undergone uni-compartmental surgery (either Oxford or St George), with the remainder having either PFC or Scorpio total knee replacements. The mean pre-operative Oxford Knee Score was 20.4. The mean improvement in scores at six months was 14.77 (95% confidence interval 13.25–16.28, p<0.0001) and 17.23 at five years (95% confidence interval 15.66–18.79, p<0.0001). On direct questioning, 85.6% of patients were satisfied with their knee replacement, 3.4% were dissatisfied and 10.9% remained unsure. Reasons identified for dissatisfaction included chronic pain syndromes and the need for early revision surgery.

Patient reported outcome measures are increasingly being used to justify outcomes of surgery and the Oxford Knee Score is particularly helpful as it relates function and pain to the knee operated on, whilst attempting to minimise the effect of confounding co-pathology. This five-year data suggests that the majority of patients are satisfied with their knee surgery. A significant improvement in pain and function is evident at six months post-operatively and continues to be demonstrable at five years, supporting the British Orthopaedic Association's strong rebuttal of the recent negative press regarding knee surgery.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 528 - 528
1 Oct 2010
Rajkumar S Andrade A Tavares S
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We undertook a retrospective audit to assess the effectiveness of use of Quixil in reducing the amount of blood transfusion requirements following revision THR. As Quixil was used from mid 2007 for revision THRs, we looked at blood transfusion requirements for 1 year before introduction of Quixil and compared it with requirements after introduction of Quixil for a similar period.

Method and Materials: 44 patients underwent revision THR by the senior author during the period from June 2007 – June 2008 (Quixil group) while 45 patients did not have Quixil during revision THR for the period May 2006 – May 2007 (Non-quixil group). In the quixil group, M: F = 18:26 and average age 75.3 (range: 63 – 88 yrs). In the non-quixil group, M: F = 17:28 and average age 71.3 (range: 47 – 85 yrs). The duration of surgery was similar in both groups. Blood loss during the operation was evaluated by measuring the volume in the suction apparatus and by estimating the amount of lost blood in the swabs at the end of the operation. Drains were not used in these procedures. All blood transfusions were recorded.

Results: The average blood loss was 1010 mls (range: 300 – 2200 mls) in the quixil group vs. 1021 mls (range: 500 – 2000 mls) in the non-quixil group. The use of cell saver and intra-operative blood transfusion were similar in both groups. The mean pre-op Hb in quixil vs. non-quixil group was 13.0 g/dl (range: 9.7– 16.2) vs. 12.4 g/dl (range: 8.8 – 16.2). The mean post-op Hb in quixil group vs. non-quixil group was 10.2 g/dl (range: 6.4 – 13.2) vs. 9.1 g/dl (range: 5.3 – 12.9)(a difference of 1.1 g/dl). There was a difference in the blood transfused post-operatively between the two groups – 21 vs. 29 patients. Total units of blood transfused in quixil vs. non-quixil group were 60 vs. 86 (a difference of 26 units stastically significant) and total units of intra-op blood transfused in quixil vs. non-quixil group were 16 vs. 23 (a difference of 7 units).

Limitations of the study: Retrospective study, Small numbers of patients

Conclusion: The use of fibrin tissue adhesive in revision total hip arthroplasty seems to be an effective and safe means with which to reduce blood loss and blood-transfusion requirements as well as prevent in the postoperative decrease in the level of hemoglobin.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 235 - 235
1 Mar 2004
Andrade A Lemos C Sá J Canela P Neves J
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Diabetic foot is a disease with social, familiarly and economic charge.

Usually the patients with neuropathic diabetic foot have a compromise in large vessels of the calf that invalids most of the techniques of Plastic Surgery for reconstruction for skin losses of the foot.

The authors describe the utilization of little fragments of skin (proximally 4 mm diameter) draw under local anaesthesia in the tight. The receptor area due not have infection and clean of necrotic tissue. Tendons have also due excised or recovered of granulation tissue With this technique they have treated 4 patients; 3 have total recuperation of the lesion and in one, with a scar in the hallux, all the skin has lost. The largest area of the lesion treated has 8 x 6 cm, and time o healing has 12 weeks.

The reconstitution of the donor area is complete at 4 weeks with no scars.

The authors conclude that this technique is valid for dorsal loss of skin due to neuropathic diabetic foot.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 163 - 163
1 Feb 2003
Andrade A Costi J Stanley R Spriggins A
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We sought to identify the tensile properties of the medial patellofemoral ligament (MPFL), and determine whether its repair was sufficient as a means of restoring stability after acute lateral patella dislocation. We also sought to establish whether there was a correlation between the tensile properties of the anterior cruciate ligament (ACL) and the MPFL.

16 hind limbs of Merino Wethers were obtained and stored fresh frozen. The specimens were thawed overnight, dissected out and then placed in a water bath at 37 degrees centigrade for 30 minutes prior to testing. All testing was carried out in the water bath to approximate a more physiological environment. For each specimen the ACL was first tested to failure on an Instron 8511. The MPFL was then tested to failure, then repaired and retested to failure. Finally a reconstruction was carried out, using a flexor tendon, which was again tested to failure.

Results:

There was no correlation between ACL and MPFL strength (p=0.677). Statistical analysis showed that the intact MPFL was significantly stronger than the repaired MPFL (P=0.001) but no different to the reconstructed MPFL (P=0.224), with no difference between repaired and reconstructed (P=0.174). A Power analysis showed that there was not adequate power to detect a significant difference between the last two pairs, and that we would have needed over 35 specimens to show a difference.

This study does not support carrying out a repair of the MPFL following an acute lateral patella dislocation, as it does not restore its tensile properties. It further suggests that a reconstruction may better restore the tensile properties of this ligament.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 258 - 258
1 Nov 2002
Andrade A Stock D Costi J Stanley R Kelly N Hearn T Oakeshott R Spriggins A
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Aim: To determine the intra operative biomechanical properties of a semitendinosus graft used in ACL reconstruction.

Introduction: ACL reconstruction has become a commonly performed operation with 1,139 of these procedures being performed in South Australia in 1997 (SA Health Commission)

The majority of the scientific literature is based on data obtained from elderly cadaveric material. Little is known about the biomechanical properties of the soft tissue grafts currently used prior to implantation. The correct preconditioning and intraoperative tensioning of the soft tissue grafts has also not been investigated.

The initial graft biomechanical properties are important. Inadequate tension will lead to continuing instability whilst excessive tension may cause accelerated joint arthrosis. The tension in the graft may decrease by 30% if it has not been cyclically pretensioned.

Methods: A machine has been designed that will allow the intraoperative biomechanical testing of soft tissue grafts immediately prior to their implantation into the patient during ACL reconstruction. Data will be available on creep, stress relaxation, and tensile testing.

This device will also allow the accurate preconditioning of the graft, providing objective data that can then be compared to the subsequent clinical progress of the patient.

All testing will be accomplished during the time it takes to prepare the tunnels for insertion of the graft, and as such will not prolong unnecessarily the operative time.

Procedure: Once the graft has been prepared prior to fixation, it will be placed between two clamps. One is fixed to a load cell whilst the other is coupled to a linear actuator. The linear actuator will be driven by a computer controlled stepper motor under close-loop control. Custom software will cyclically load the autograft between two definable load points. A linear variable differential transformer (LVDT) will be used to monitor displacement of the autograft and load will be monitored with a load cell of capacity 125Kg.

This set-up will be immersed in a saline water bath maintained at body temperature during testing. The load cell will be hermetically sealed, with clamps and water bath being autoclavable. With the facilities for draping, the test area will remain sterile. The auto graft clamps will be designed to allow fixation of various graft materials (eg semitendinosus, gracilis, bone-patella tendon-bone) and adjustable for graft lengths. The water bath will house a thermocouple, heating mat and controller to maintain the saline temperature to within 1°C.

The testing system will be mounted on a stainless steel trolley for mobility in the operating room with an underlying shelf to house the associated electronics and a retractable side draw for storage of the laptop computer.

The autograft will be preconditioned between two known loads for 20 cycles recording load and displacement simultaneously on a laptop computer. Once preconditioned, the autograft will then be used for the ACL reconstruction in the standard way.

Summary: Objective data on preconditioning of ACL grafts, has never before been available intra-operatively. We outline the experimental set-up which has been designed and is undergoing testing prior to its use in a prospective study.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 264 - 264
1 Nov 2002
Andrade A Spriggins AJ
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Purpose of Study: The role of surgery in the treatment of acute patella dislocation has always been controversial with procedures falling in and out of popularity.

Since the Medial Patellofemoral ligament was first described in 1979, its importance as a prime patella stabiliser has been defined, and procedures for its repair and reconstruction have been described.

We believe that the MPFL has a pivotal role in the stability of the patella, and is disrupted in all patients with acute patella dislocation. Failure to address this will inevitably lead to ongoing patellofemoral symptoms.

Methods: We summarise the current literature detailing the anatomy and biomechanical properties of the native as well repaired MPFL.

We present our own experience of treating acute patella dislocations by repair of the Medial Patellofemoral Ligament, in acute cases.

A lesion can occur anywhere along its length from the superomedial patella to a point superoposterior to the adductor tubercle. The technique of repair has to address the site of primary disruption, as well as any associated intraarticular knee injuries.

Results: In one series we have shown that of 13 patients who presented with acute patella dislocation, 10 had an MRI proven lesion of the MPFL and went on to have an open repair which reconstituted patella stability.

Conclusion: A lesion of the MPFL is the primary pathology in acute patella dislocation, and we believe that this lesion warrants surgical intervention to avoid progressive symptoms.