Aims. Revision rates for ankle arthroplasties are higher than hip or knee arthroplasties. When a total ankle arthroplasty (TAA) fails, it can either undergo revision to another ankle replacement, revision of the TAA to ankle arthrodesis (fusion), or amputation. Currently there is a paucity of literature on the outcomes of these revisions. The aim of this meta-analysis is to assess the outcomes of revision TAA with respect to surgery type, functional outcomes, and reoperations. Methods. A systematic review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Medline, Embase, Cinahl, and Cochrane reviews were searched for relevant papers. Papers analyzing surgical treatment for failed ankle arthroplasties were included. All papers were reviewed by two authors. Overall, 34 papers met the inclusion criteria. A meta-analysis of proportions was performed. Results. Six papers analyzed all-cause reoperations of revision ankle arthroplasties, and 14 papers analyzed failures of conversion of a TAA to fusion. It was found that 26.9% (95% confidence interval (CI) 15.4% to 40.1%) of revision ankle arthroplasties required further surgical intervention and 13.0% (95% CI 4.9% to 23.4%) of conversion to fusions; 14.4% (95% CI 8.4% to 21.4%) of revision ankle arthroplasties failed and 8% (95% CI 4% to 13%) of conversion to fusions failed. Conclusion. Revision of primary TAA can be an effective procedure with improved functional outcomes, but has considerable risks of failure and reoperation, especially in those with periprosthetic joint infection. In those who undergo conversion of TAA to fusion, there are high rates of nonunion. Further comparative studies are required to compare both operative techniques. Cite this article: Bone Jt Open 2022;3(7):596–606

Aims. To determine the likelihood of achieving a successful closed reduction (CR) of a dislocated hip in developmental dysplasia of the hip (DDH) after failed Pavlik harness treatment We report the rate of avascular necrosis (AVN) and the need for further surgical procedures. Methods. Data was obtained from the Northern Ireland DDH database. All children who underwent an attempted closed reduction between 2011 and 2016 were identified. Children with a dislocated hip that failed Pavlik harness treatment were included in the study. Successful closed reduction was defined as a hip that reduced in theatre and remained reduced. Most recent imaging was assessed for the presence of AVN using the Kalamchi and MacEwen classification. Results. There were 644 dislocated hips in 543 patients initially treated in Pavlik harness. In all, 67 hips failed Pavlik harness treatment and proceeded to arthrogram (CR) under general anaesthetic at an average age of 180 days. The number of hips that were deemed reduced in theatre was 46 of the 67 (69%). A total of 11 hips re-dislocated and underwent open reduction, giving a true successful CR rate of 52%. For the total cohort of 67 hips that went to theatre for arthrogram and attempted CR, five (7%) developed clinically significant AVN at an average follow-up of four years and one month, while none of the 35 hips whose reduction was truly successful developed clinically significant AVN. Conclusion. The likelihood of a successful closed reduction of a dislocated hip in the Northern Ireland population, which has failed Pavlik harness treatment, is 52% with a clinically significant AVN rate of 7%. As such, we continue to advocate closed reduction under general anaesthetic for the hip that has failed Pavlik harness. Cite this article: Bone Jt Open 2021;2(8):594–598

The aim of this study was to examine causes of the failed knee arthroplasty. Since 1980 the Bristol Knee Replacement Registry has prospectively recorded data on 3024 patients. Complete original and 5 year follow up data was available on 999 knees. The surgery was judged a failure if there was no improvement in the American Knee Society score at 5 years or if there had been a revision within that time. The prosthesis used was Kinematic in 471 knees, the Medial Unicompartmental Sled in 258 knees, the Kinemax Plus in 134 knees and a variety of other designs. At 5 years, 79 (7. 9%) either showed no improvement in the American Knee Society score or had been revised. The failure rate was 7% for the Kinematic, 7% for the medial Sled and 5% for the Kinemax Plus. 20% of the less frequently used designs failed. Five (0. 5%) knee replacements failed because of infection. 22 knees (2. 2%) had significant comorbidity that precluded a satisfactory functional outcome. For 7 knees (0. 7%), the patient exhibited patterns of abnormal illness behaviour that were thought to explain the poor outcome. A further 27 knees (2. 7%) failed because of technical errors either at the time of surgery (13 cases, 1. 3%), or in selecting a prosthesis which failed prematurely (14 cases 1. 4%). No cause for failure could be identified in 12 cases (1. 2%). The high failure rate amongst infrequently used prosthesis emphasises the need to use established designs. No cause for failure could be identified in 12 cases and 5 were due to infection; such cases are hard to avoid. This study shows the importance of assessing both the overall physical and psychological state of the patient if disappointing results are to be avoided. The most frequent cause of an unsatisfactory outcome was a technical one, which should be avoidable

Aims

Metal particles detached from metal-on-metal hip prostheses (MoM-THA) have been shown to cause inflammation and destruction of tissues. To further explore this, we investigated the histopathology (aseptic lymphocyte-dominated vasculitis-associated lesions (ALVAL) score) and metal concentrations of the periprosthetic tissues obtained from patients who underwent revision knee arthroplasty. We also aimed to investigate whether accumulated metal debris was associated with ALVAL-type reactions in the synovium.

Introduction:. We report the outcomes of salvage procedures in total ankle replacement (TAR) in a single surgeon series. Methods:. This study was a retrospective review of patients who had undergone salvage procedures with tibio-talo-calcaneal (TTC) fusion for failed TAR over a period from 1999–2013 in a single centre. In this period, 317 TAR were performed of which 11 have failed necessitating conversion to TTC fusion. Clinical documentation and radiographs were reviewed for cause of failure, type of graft for fusion, time to radiological/clinical union and complications including further surgeries. Results:. The causes of failure of the TAR were pain from instability/impingement in 8, fracture in one, subsidence of the talar component in one and infection in one. From the group of 11 patients, 8 patients went onto union at a mean of 10 months (7–14). All 8 patients had femoral head structural allografts to maintain limb length for the procedure and 3 required a secondary procedure to dynamise the nail. 2 patients with femoral head structural allografts developed infections necessitating removal of the graft and conversion to an external fixator of which one united and the other developed a painless fibrous union. 1 patient developed non-union with progressive deformity of the ankle resulting in a Symes amputation. Conclusions:. From our series of patients we have demonstrated that failure of TAR requiring salvage procedures is a relatively rare event (3.5%). The use of TTC fusion is successful in the majority of patients and the use of femoral head structural allografts allows preservation of leg length with good rates of union

Objectives. T-cells are considered to play an important role in the inflammatory response causing arthroplasty failure. The study objectives were to investigate the composition and distribution of CD4+ T-cell phenotypes in the peripheral blood (PB) and synovial fluid (SF) of patients undergoing revision surgery for failed metal-on-metal (MoM) and metal-on-polyethylene (MoP) hip arthroplasties, and in patients awaiting total hip arthroplasty. Methods. In this prospective case-control study, PB and SF were obtained from 22 patients (23 hips) undergoing revision of MoM (n = 14) and MoP (n = 9) hip arthroplasties, with eight controls provided from primary hip osteoarthritis cases awaiting arthroplasty. Lymphocyte subtypes in samples were analysed using flow cytometry. Results. The percentages of CD4+ T-cell subtypes in PB were not different between groups. The CD4+ T-cells in the SF of MoM hips showed a completely different distribution of phenotypes compared with that found in the PB in the same patients, including significantly decreased CD4+ T-central memory cells (p < 0.05) and increased T-effector memory cells (p < 0.0001) in the SF. Inducible co-stimulator (ICOS) was the only co-stimulatory molecule with different expression on CD4+ CD28+ cells between groups. In PB, ICOS expression was increased in MoM (p < 0.001) and MoP (p < 0.05) cases compared with the controls. In SF, ICOS expression was increased in MoM hips compared with MoP hips (p < 0.05). Conclusions. Increased expression of ICOS on CD4+ T-cells in PB and SF of patients with failed arthroplasties suggests that these cells are activated and involved in generating immune responses. Variations in ICOS expression between MoM and MoP hips may indicate different modes of arthroplasty failure. Cite this article: Professor P. A. Revell. Increased expression of inducible co-stimulator on CD4+ T-cells in the peripheral blood and synovial fluid of patients with failed hip arthroplasties. Bone Joint Res 2016;5:52–60. doi: 10.1302/2046-3758.52.2000574

SUMMARY. We report a prospective study of clinical data collected pre, intra and post operation to remove both cup and head components of 118 failed, current generation metal on metal (MOM) hips. Whilst component position was important, the majority were unexplained failures and of these the majority (63%) had cup inclination angles of less than 55 degrees. Poor biocompatibility of the wear debris may explain many of the failures. BACKGROUND. Morlock et al reported a retrospective analysis of 267 MOM hips but only 34 head and cup couples (ie most were femoral neck fractures) and without data necessary to define cause of failure. The commonest cause of failure in the National Joint Registry (NJR) is unexplained. METHODS. We categorised the cause of failure, as defined by the NJR, of all MOM hips received over an 18 month period that had a full set of pre, intra and post op data. A group of 40 patients with unilateral well functioning MOM hips was used for comparison. RESULTS. In the retrieval group, the median age was 61 years (25 to 87) and there were 80 females and 38 males. The median time between primary and revision operation was 35 months (4 to 121). Femoral head size was <50mm in 89 and >=50mm in 29. The causes of failure were: unexplained in 75; aseptic loosening (acetabular) in 12; aseptic loosening (femoral) in 7; dislocation/subluxation in 1; infection in 11; periprosthetic femoral fracture in 2; malalignment in 6; size mismatch in 3; other in 1. 47 (63%) of unexplained failures had cup inclination angles of less than 55 degrees. The unexplained failures had increased blood metal ions (p <0.0001) and cup inclination angle (p <0.005) but a decreased femoral head size (p <0.0001) when compared to well functioning MOM hip patients. CONCLUSION. The commonest cause of failed MOM hips was unexplained. Comparison to well functioning hips revealed that the mechanism may involve high blood metal ions but high cup inclination angle was not found in the majority of cases. Further biological and mechanical investigation into the underlying mechanism of failure is required

Previous studies examined failure mechanisms for revision TKA performed between 1986 and 2000. These studies demonstrated that a majority of failures occurred in the first few years, with a disproportionate amount for infection and implant-associated failure mechanisms. Since these studies were published, efforts have been made to improve implant performance and instruct surgeons towards best practice total knee arthroplasty techniques. Recently our center participated in a multi-center evaluation of revision TKA cases during 2010 and 2011. The purpose was to report a detailed analysis of the failure mechanism and the time to failure to determine whether the failure mechanism of primary TKA has changed over the past 10–15 years. Further, we evaluated the effect of failure mechanism on extent of revision and whether revision surgery was performed at the same location as the index procedure. We identified 844 revisions of failed primary TKA. Aseptic loosening was the predominant mechanism of failure (31.2%), followed by instability (18.7%), infection (16.2%), polyethylene wear (10.0%), arthrofibrosis (6.9%), and malalignment (6.6%). Mean time to failure was 5.9 years (range 10 days to 31 years). 35.3% of all revisions occurred less than 2 years after the index arthroplasty, with 60.2% in the first 5 years. In contrast to previous reports, polyethylene wear is not a leading failure mechanism and rarely presents before 15 years. Implant performance is not a predominant factor of knee failure. Early failure mechanisms are primarily surgeon-dependent

Abstract

There are a number of periprosthetic femoral fracture (PFF) fixation failures. In several cases the effect of fracture configuration on the performance of the chosen fixation method has been underestimated. As a result, fracture movement within the window that seems to promote callus formation has not been achieved and fixations ultimately failed. This study tested the hypothesis that: PFF configuration and the choice of plate fixation method can be detrimental to healing. A series of computational models were developed, corroborated against measurements from a series of instrumented laboratory models and in vivo case studies. The models were used to investigate the fixation of different fracture configurations and plate fixation parameters. Surface strain and fracture movement were compared between the constructs. A strong correlation between the computational and experimental models was found. Computational models showed that unstable fracture configurations increase the stress on the plate fixation. It was found that bridging length plays a pivotal role in the fracture movement. Rigid fixations, where there is clinical evidence of failure, showed low fracture movement in the models (<0.05mm); this could be increased with different screw and plate configurations to promote healing. In summary our results highlighted the role of fracture configuration in PFF fixations and showed that rigid fixations that suppress fracture movement could be detrimental to healing

Locking plates have led to important changes in bone fracture management, allowing flexible biological fracture fixation based on the principle of an internal fixator. The technique of locking plate fixation differs fundamentally from conventional plating and has its indications and limitations. Most of the typical locking plate failure patterns are related to basic technical errors, such as under-sizing of the implant, too short working length, and imperfect application of locking screws. After analysis of the fracture morphology and intrinsic stability following fracture reduction, a meticulous preoperative planning is mandatory under consideration of the principles of the internal fixator technique to avoid technical errors and inaccuracies leading to early implant failure.

Background. Revision total ankle arthroplasty (TAA) can be extremely challenging due to bone loss and deformity. We present the results examining the preliminary indications and short term outcomes for the use of the Salto XT revision prosthesis. Material and methods. We conducted an IRB approved prospective review revision TAA performed in two institutions using the Salto XT. There were 40 patients (24 females and 16 males with an average age of 65 years (45–83), who had undergone previous TAA (Agility 27, Salto 4, STAR 4, Buechal Pappas 1), and 4 patients who underwent staged procedures for infection. The primary indications for the revision were loosening and subsidence (34), malalignment (17), cyst formation (8), infection (4). Results. Severe bone loss of the talus (30) and distal tibia (5) caused by erosion or cysts (8) were treated with cancellous bone graft (33), cement (7), or a combination (12). A press fit of the tibial component was obtained in 25 cases, and of the talus in 17. The talar component was seated directly onto the calcaneus in 4 cases supplemented anteriorly by cancellous bone graft. Patients were followed up for an average of 24.2 months (range 12–36 months). The overall complication rate was 25%. An 85% survivorship of the revision TAA was achieved (4 cases of postoperative infection and 2 cases of implant loosening). At the last follow-up visit, the remaining 34 implants were stable and none had loosened nor failed. Conclusion. Revision ankle replacement with bone loss is a technically challenging procedure with acceptable outcomes for the patient but an 85% survivorship even in the short term. We noted the complexity yet feasibility of performing revision TAA, and determined that the stability of the prosthesis was important. The short term survivorship indicates a likely higher rate of failure in the longer term

Purpose: There is a growing demand on revision surgery in the last decade. 60 – 80% of these revisions are performed for early failure within the first three years. We are a referral center for painful and failed TKAs and have performed more then 400 revision surgeries between 2000 and 2005. In this paper we have analysed the cause(s) of failure(s) in patients with painful or failed TKAs. Material and Methods: 100 consecutive revision surgeries were analysed using a standardized diagnostic algorithm. This included extended history, clinical evaluation with special tests and laboratory examinations. Radiographic analysis included standard x-rays, full leg standing weight bearing x-rays and special fluoroscopic views. Patients with suspicion of implant malrotation received a special computer tomography and stress x-rays. In patients with suspicion of infection aspiration of the joint and if negative a dynamic technetium and leucocyte bone scan was performed. The suspected cause(s) of failure(s) was analysed during revision surgery in all cases. Results: In 48% malalignment (> 4°) caused overloading, pain and/or PE-wear. In 26% malrotation (> 3°) of the tibia and/or femoral component caused either patella malttracking, stiffness or flexion gap instability. In 23% pain was caused by instability either in extension, midflexion and/or full flexion. In 19% the cause of pain was infection. In 24 % several other rare causes could be identified. Only in 9% there was aseptic loosing over the time without any implantation failure. 78% of all revisions were performed within 3 years after the primary surgery. Conclusions: Aseptic loosing, PE-wear and instability had been described as the main failure mechanisms in TKA. In this study it could be shown, that these are only secondary phenomena’s for the three main implantation failures of malalignment, malrotation and mismatch of the flexion/extension gaps. In most of the early failures within 3 years after primary implantation these revision surgeries might be prevented by a more precise primary implantation

Medial unicompartmental replacement (UKR) has been shown to have superior functional results to total knee replacement (TKR) in appropriately selected patients, and this has been associated with a resurgence of interest in the procedure. This may relate to evidence showing that the kinematic profile of UKR is similar to the normal knee, in comparison to TKR, which has abnormal kinematics. Concerns remain over the survivorship of UKR and work has suggested the anterior cruciate ligament (ACL) may become dysfunctional over time. Cruciate mechanism dysfunction would produce poor kinematics and instability providing a potential mechanism of failure for the UKR. Aim: To test the hypothesis that the sagittal plane kinematics (and cruciate mechanism) of a fixed bearing medial UKR deteriorate over time (short to long term). A cross sectional study was designed in which 24 patients who had undergone successful UKR were recruited and divided into early (2–5 years) and late (> 9 years) groups according to time since surgery. Patients performed flexion/extension against gravity, and a step up. Video fluoroscopy of these activities was used to obtain the Patellar Tendon Angle (PTA), the angle between the long axis of the tibia and the patella tendon, as a function of knee flexion. This is a previously validated method of assessing sagittal plane kinematics of a knee joint. This work suggests the sagittal plane kinematics of a fixed bearing UKR is maintained in the long term. There is no evidence that the cruciate mechanism has failed at ten years. However, increased tibial bearing conformity from ‘dishing’, and adequate muscle control, cannot be ruled out as possible mechanisms for the satisfactory kinematics observed in the long term for this UKA

Introduction

Degenerative, inflammatory, and posttraumatic arthritis of the ankle are the primary indications for total ankle arthroplasty

Ankle arthrodesis has long been the “gold standard” for the surgical treatment

Total Ankle Arthroplasty. implant survivorship has been reported to range from 70% to 98% at three to six years

The combination of younger age and hindfoot arthrodesis or osteoarthritis may lead to a relative increase in failure rates after TAA

Intraoperative complication include malaligment, fracture and tendon Postoperative complications include syndesmotic nonunion, wound problems, infections and component instability and lysis

After TAA few difficulties mainly due to poor Talar and Tibial bone stock. It is difficult to stabilize the fusion and usually there is shortening after removal of the implant. Also there is a need for massive bone graft-allograft or autograft.

In cases when there is significant bone loss there is a need for stable reconstruction and stabilization of the hindfoot. Bone grafting with structural bone graft may collapse and it has to be stabilized with screws or nail.

In the Registry Era, in the Information Age, and with a competitive and expanding marketplace, the focus has been on the prosthetic joint devices. However, a distinction should be made between mechanical failure of a device, failure of an arthroplasty, and the limitations of technology. The patient and the surgeon play central roles in the majority of revisions (failure of an arthroplasty). Analysis of a large United States database indicates that the most common causes of revision are instability/dislocation (22.5%), mechanical loosening (19.7%), and infection (14.8%). Acetabular component position has been linked to higher wear and instability. Increased odds of component mal-position were found with lower-volume surgeons and patients with a higher body mass index. Medical co-morbidities significantly increase the risk for revision within 12 months of surgery. Patient demographics and pre-operative status have been shown to be more important than implant factors in predicting the presence of thigh pain, dissatisfaction, and a low hip score. The most predictive factors were ethnicity, educational level, poverty level, income, and a low pre-operative WOMAC score or pre-operative SF-12 mental component score.

1069 primary hip arthroplasty (THA) (416 males) and 1846 revision (798 males) patients were matched for sex, age and date of primary THA. Data were collected via retrospective chart review. Time to revision averaged 9.5 years. Revision THA patients were younger at primary THA (55 vs. 64 years), had a higher body mass index (27 vs. 30) and more frequently had a cemented acetabulum (p< 0.0001). After controlling for institution, earlier time to revision was predicted by younger age at primary THA, secondary OA or dysplasia, increased BMI, posterior surgical approach, cemented acetabulum, and small femoral head size (28 mm) (p< 0.05).

To determine whether patient (age, gender, underlying disease, body mass index), surgical (surgical approach), and prosthetic (cemented vs. uncemented acetabular or femoral component, femoral head size) factors predict time to revision arthroplasty of primary total hip arthroplasty (THA).

Patients who are younger when undergoing primary THA, have secondary osteoarthritis (OA) or dysplasia, are obese, and have a cemented acetabulum with a small femoral head by a posterior approach are at increased risk for revision THA.

This study identified important, potentially modifiable patient, surgical and prosthetic factors that are adverse predictors of outcome.

For the period 1980 to 2000, 1069 primary hip arthroplasty patients (416 males) and 1846 revision arthroplasty (798 males) patients were matched for sex, age and date of primary THA within two years. Revision THAs for infection were excluded. Data were collected via retrospective chart review. Time to revision THA averaged 9.5 years. In univariate analysis, patients who had revision THA were younger at primary THA (55 vs. 64 years, p< 0.0001), had a higher body mass index (BMI) (27 vs. 30, p< 0.0001), and more frequently had a cemented acetabulum (p< 0.0001). After primary THA, fewer patients who went on to revision arthroplasty had orthopaedic complications (6.5 vs. 16.5%). After controlling for institution, earlier time to revision was predicted by younger age at primary THA, underlying joint disease of secondary OA or dysplasia, increased BMI, posterior surgical approach, cemented acetabulum, and small femoral head size (28 mm) (multivariate Cox model, p< 0.05).

Funding: This work was supported in part by a grant from the Canadian Orthopaedic Foundation and The Arthritis Society

Intra-capsular fracture neck of femur in a young patient is a surgical emergency. Results of internal fixation with cannulated screws to date show high rates of non-union and of avascular necrosis. This leading to a high rate of re-operation with cannulated screws. A tendency therefore is to lean toward total arthroplasty of the hip in the instance of displaced fracture of the neck of femur.

We discuss both the biomechanical and biological reasons for failure of internal fixation of displaced fractures of the neck of femur with cannulated screws, and criteria required to provide adequate fixation of these fractures to allow union and avoid osteonecrosis.

We consider other methods of fixation of displaced intracapsular fractures and analyse illustrative cases demonstrating these methods.

In view of the precarious biological milieu of displaced intracapsular fractures of the neck of femur, we feel that the use of cannulated screws is a poor fixation method. Therefore the option of internal fixation should not be abandoned in favour of arthroplasty because of poor results from this one biologically and biomechanically inadequate operation.

Most early failures of THA are related to patient factors and technical “surgeon” factors. Most late failures of THA are related to patient factors and device factors. Occasionally unexpected device-specific failure modes cause specific early failure patterns. The most common reasons for early THA failure are infection and instability. Infection risk is strongly influenced by patient factors. Instability early after THA is usually a technical problem, but at times also is patient related. Important late failure modes of THA include loosening, wear and osteolysis, and periprosthetic fracture. Loosening and wear are at least in part device related. Late periprosthetic fracture is almost mainly patient related.

Taken together these data suggest the following:

Most strongly related to patient factors: Early and late infection, periprosthetic fracture and wear and osteolysis.

Purpose of study

Results clinically & statistically of a 10 year prospective observational longitudinal study of the effects of sonographic screening for ‘risk’ factors in DDH.