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Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 348 - 348
1 Mar 2004
Mohan AR Gross M
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Aim: The long- term results of selective patients undergoing resection of primary malignant tumours followed by allograft arthrodesis of the hip supplemented by vascularised þbula were prospectively studied. Patients and methods: 8 patients underwent resection of the primary malignant tumor of the proximal femur followed by reconstruction with allograft arthrodesis and vascularised þbular graft. The patients were clinically assessed by MSTS functional scoring system and radiologically assessed at regular intervals. All the patients were male with a mean age of 29 years (range18–39). The diagnoses included, Ewingñs sarcoma in three patients, Osteosarcoma and MFH in two patients each and Chondrosarcoma in one patient. Results: 2 patients died of extensive systemic disease without any local recurrence. At a mean follow-up was 112 months (range 28–153), the remaining six patients scored good or excellent in the MSTS scoring system and are engaged in physically active occupations. Radiologically, in three cases there was evidence of fracture of the allograft with loosening of the screws holding the plates but without the failure of the construct. The þbular graft hypertrophied with time in all the cases. Conclusions: Our experience clearly indicates that resection arthrodesis of the hip with allograft supplemented by vascularised þbula is a useful limb salvage procedure with the þbula hypertrophying slowly with time. This is especially so in carefully selected physically active patients who have poor long-term survival with resection followed by custom-made prosthesis


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 212 - 212
1 Nov 2002
Gross M Mohan R
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Introduction: Osteochondral reconstruction following tumour resections has a high complication rate. We hypothesized that the vascularised fibular graft as a supplement to the allograft reconstruction following tumour resections would provide a biological solution. Purpose of the study: A prospective study of the results of patients receiving large fragment allografts and vascularised fibular grafts following tumour resections around the hip and the knee. Patients and methods: 18 patients underwent resection of primary malignant bone tumors followed by reconstruction with large fragment allograft and vascularised fibular graft. 8 patients underwent resection arthrodesis of the hip, six underwent resection arthrodesis of the knee and five underwent intercalary resections around the knee followed by a large fragment allograft and vascularised fibular graft reconstruction to span the gap left by resection. The patients were assessed clinically (MSTS scoring system) and radiologically at regular intervals. Results: There were 14 males and 4 females, with a mean age of 26 years (12–70). Mean follow-up was 65 months (8–144). Five patients died of metastatic disease but without local recurrence. In six of the patients with resection arthrodesis of the hip, there was evidence of fracture of the allograft but without the failure of the construct. One fibula fractured but eventually healed uneventfully. There were no cases of non-union in cases of intercalary resections. All the patients scored good or excellent in the MSTS scoring system. Discussion: Our experience clearly indicates that tumour resection followed by reconstruction with large fragment allograft and vascularised fibular graft is a useful limb salvage procedure providing a biological long-term solution with superior results when compared to prosthetic reconstruction


The modified Dunn procedure has the potential to restore the anatomy in hips with slipped capital femoral epiphyses (SCFE) while protecting the blood supply to the femoral head. However, there is controversy about the risks associated with the procedure especially in the most severe capital slips. Therefore, we report on (1) clinical outcome, (2) the cumulative survivorship with endpoints AVN and/or OA progression and (3) radiographic anatomy of the proximal femur at followup in patients treated with a modified Dunn procedure for severe SCFE. We performed a retrospective analysis involving 46 hips of 46 patients treated with a modified Dunn procedure for severe SCFE (slip angle >60°) between 1999 and 2016. Followup averaged 8 years, (range 1–17) with 2 patients lost to followup after one year. The mean age was 13 years (range 9–19 years). Mean preoperative slip angle was 64° (range 60–90) and 14 out of 46 hips (30%) presented with unstable slips. Clinical scores and PROMs were evaluated and the hips were followed standard x-rays. Cumulative survivorship (Kaplan-Meier) with three defined endpoints: (1) AVN; (2) progression by at least one OA grade according to Tönnis; (3) non-preserved hip joint. (1)Mean Harris Hip score (HHS) was 93 points (66–100) and mean Hip Disability and Osteoarthritis Outcome Score (HOOS) was 90 points (67–100) at last followup. (2)Cumulative survivorship was 93% at 10-year followup. Three hips reached an endpoint. Two hips (4%) had AVN, one of them underwent hip arthrodesis. One hip had OA progression. (3)Postoperative slip angle was 7° (1–16). Alpha angle on axial radiograph was 39° (26–71) at followup. 41/44 hips (93%) had no OA (Tönnis 0). The modified Dunn procedure largely corrected slip deformities with low apparent risk of progression to avascular necrosis or osteoarthritis at mean 8-years followup. The AVN rate in severe and unstable (30%) capital slip was 4% (2 hips) with this procedure


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_II | Pages 153 - 153
1 Jul 2002
Ruiz AL Nixon PJR
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We performed arthrodesis with a cobra head compression plate in 18 young adults with severely degenerative arthritis of the hip. The aetiology was trauma in 4 patients, sepsis in 3, slipped upper femoral epiphysis in 3, Perthes disease in one, acute lymphblastic lymphoma in one, alcohol related avascular necrosis in 2, epiphyseal dysplasia in one, multiple osteochondromatosis in one, (bilateral) idiopathic chondrolysis in one and in the remaining case there was no apparent cause. At a mean follow up of 4 years 14 patients were complaining of back pain compared to 4 patients preoperatively. Preoperatively 4 patients had ipsilateral knee pain compared to 5 patients postoperatively. Four patients complained of pain at rest or night. Eleven of the 18 patients have returned to work. The average score of satisfaction on a scale of zero to ten was 7.2, with only 3 patients giving a mark of 4 and below. The management of osteoarthritis of the hip in the young adult is challenging and arthrodesis of the hip is a reasonable option for the very painful arthritic hip


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 71 - 71
1 Mar 2005
Hamel A Soulie A Guillard S Rogez J Pouliquen (J Glorion C Letenneur L
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Introduction: The management of a hip destroyed by infection during growth is difficult and controversial. Two clinical cases illustrate differing management options and question what might be the best solution for this problem. Case 1: A 12-year-old girl presented with a Staphylococcus aureus septic arthritis of the left hip. She underwent an arthrodesis of the hip one-year later because of a poor position of the hip. She had 20mm of shortening of the left lower limb. After 6 years of “normal” life she received a total hip replacement when aged 19 years. Since then she has no pain and has 12 mm of shortening of her left lower limb and a mobile left hip (100/0, 40/30, 30/30) and works as a cashier. Case 2 A 2-year-old boy presented with a Salmonella septicaemia and septic arthritis of the right hip. The hip deteriorated but the parents refused a hip arthrodesis. He underwent a Colonna procedure in 1994. Five years later he had developed 50mm of shortening in the right lower limb and he had an epiphysiodesis of the left knee. He is now 17 years old, has a painless hip, satisfactory range of movement (90/0, 0/15, 5/5), a slight limp, equal leg length and enjoys normal teenager activities. Radiographs suggest that he would benefit from a hip replacement


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 49 - 49
1 Jan 2003
Ramamohan N Paletz J Gross M
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This is a prospective study assessing the results of patients receiving large fragment allograft and a vascularised fibular graft following primary malignant tumour resections around the hip and the knee. 18 patients underwent tumor resection followed by reconstruction with large fragment allograft and vascularised fibular graft. Eight patients underwent resection arthrodesis of the hip, four underwent resection arthrodesis of the knee and six underwent intercalary resections. Following tumour resection with adequate margins, an appropriate sized allograft fragment was internally fixed with either a plate or an intramedullary nail. A vascularised fibular graft was used to span the gap between the remaining host bones. Osteosarcoma was the commonest diagnosis. The patients were clinically assessed by MSTS functional scoring system and radiologically assessed at regular intervals. The mean age was 26 years (range12–70) and majority of the patients was men. 11 patients received preoperative chemotherapy. Mean follow-up was 85 months (range 8–153). Six patients have died of metastatic disease at a mean of 33 months. Complications included local recurrence in two, deep infection in one and stress fracture of the fibula in two cases. One patient with local recurrence and the other with deep infection underwent an amputation. Majority of the patients had good or excellent MSTS scores at final follow-up and 75% of the patients are engaged in physically active occupations. Graft hypertrophy was evident in majority of the patients. Our experience clearly indicates that reconstruction with large fragment allograft and vascularised fibular graft is a useful limb salvage procedure with the fibula hypertrophying slowly with time. The eventual fracture of the allograft or failure of the allograft-plate composite is to be expected but is not deleterious due to the physiological response of the vascularised fibula to the weight bearing stresses over time. We feel that this biological solution is likely to demonstrate superior long-term results compared to a prosthetic reconstruction


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 11 - 11
1 Mar 2010
Roye DP Gomez J Vitale MG Hyman JE Matsumoto H Feldman D Marangoz S vanBosse HP Sala DA Stein M
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Purpose: To describe the clinical outcomes of adolescent patients, treated with hip distraction arthroplasty for avascular necrosis (AVN) of the femoral head. Outcomes were examined in order to better understand the usefulness and indications of performing hip arthrodia-stasis in this patient population. Method: Retrospective review was performed on thirty-one hips with femoral head AVN treated with hip distraction arthroplasty. Mean age at treatment was 14.2 years. Preoperative and follow-up pain, and physical limitations, as well as follow-up range of motion (ROM) were assessed. Results: Follow up assessment was obtained at 18.3 years of age. Time of follow up was 55.3 months after distraction. The etiologies of AVN were: 11 Slipped Capital Femoral Epyphysis (SCFE); 5 Idiopathic AVN; 3 with hip dysplasia; and 12 others. There was a significant difference in pain preoperatively and postoperatively (p< .001), the majority of patients (79.5%, n=23) had less pain after the treatment. Multivariate regression model demonstrated that patients with SCFE were likely to have less improvement in pain than patients with other etiologies (odds ratio: 24.8; p=.035). All patients had activity limitations before the treatment; at the postoperative assessment more than half of our patients (n=15) reported no limitations in their activities. Nine patients had minor complications with the fixator. At follow up, 5 (16.1 %) patients converted to total hip replacement or arthrodesis. Conclusion: Hip distraction arthroplasty in adolescent patients with symptomatic AVN reduces the amount of pain and limitation in daily activities, at a follow up of 4.6 years. Arthrodiastasis is not the final solution to AVN, with longer follow up patient’s symptomatology increases. Patients with AVN secondary to SCFE do not beneficiate of this procedure as much as other patients do. Hip distraction is a safe and appropriate procedure to perform in these patients. The procedure might be able to delay definitive surgical procedures at an early age, restoring function and improving the patient s quality of life


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 270 - 270
1 Mar 2004
Matejovsky Z Matejovský Z Povýšil C
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Aims: To evaluate the outcome of surgical treatment of benign and aggressive chondroblastoma in the Prague bone tumours register. Methods: Between 1969–2001 57 patients (38 men and 19 women) with chondroblastoma have been registered. The age ranged from 7 to 52 years – in average 19 years. The most frequent localizations were epiphyses of long bones (13 proximal humerus, 10 proximal femur, distal femur and proximal tibia each 11). We also observed atypical localizations (3 patella, 2 pelvis and 1 each in, fibula, talus, 5th metatarsal). All patients had available x-rays for evaluation and some arteriography or CT. All had histological verification. The treatment of choice was intralesional curetting and filling with auto or allografts. The femoral head lesions were treated through an original femoral neck approach to prevent hip luxation. We registered 5 aggressive variants with a different clinical course. They recur after intralesional surgery, are purely osteolytic and richly vascularized. One patient even developed lung metastasis. Results: In the usual type of benign chondroblastoma all patients were healed after intralesional surgery and graft filling with well-preserved function. In the aggressive form we performed a limb saving reconstructive surgery (knee arthrodesis, total knee or hip endoprosthesis). Conclusions: For benign chondroblastoma intra-lesional surgery brings excellent results. The aggressive form should be differentiated and resected at least marginally without delay to prevent larger skeletal defects


Bone & Joint Research
Vol. 5, Issue 3 | Pages 73 - 79
1 Mar 2016
Anwander H Cron GO Rakhra K Beaule PE

Objectives

Hips with metal-on-metal total hip arthroplasty (MoM THA) have a high rate of adverse local tissue reactions (ALTR), often associated with hypersensitivity reactions. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measures tissue perfusion with the parameter Ktrans (volume transfer constant of contrast agent). Our purpose was 1) to evaluate the feasibility of DCE-MRI in patients with THA and 2) to compare DCE-MRI in patients with MoM bearings with metal-on-polyethylene (MoP) bearings, hypothesising that the perfusion index Ktrans in hips with MoM THA is higher than in hips with MoP THA.

Methods

In this pilot study, 16 patients with primary THA were recruited (eight MoM, eight MoP). DCE-MRI of the hip was performed at 1.5 Tesla (T). For each patient, Ktrans was computed voxel-by-voxel in all tissue lateral to the bladder. The mean Ktrans for all voxels was then calculated. These values were compared with respect to implant type and gender, and further correlated with clinical parameters.


Bone & Joint Research
Vol. 2, Issue 8 | Pages 140 - 148
1 Aug 2013
Gauthier L Dinh L Beaulé PE

Objectives

To quantify and compare peri-acetabular bone mineral density (BMD) between a monoblock acetabular component using a metal-on-metal (MoM) bearing and a modular titanium shell with a polyethylene (PE) insert. The secondary outcome was to measure patient-reported clinical function.

Methods

A total of 50 patients (25 per group) were randomised to MoM or metal-on-polyethlene (MoP). There were 27 women (11 MoM) and 23 men (14 MoM) with a mean age of 61.6 years (47.7 to 73.2). Measurements of peri-prosthetic acetabular and contralateral hip (covariate) BMD were performed at baseline and at one and two years’ follow-up. The Western Ontario and McMaster Universities osteoarthritis index (WOMAC), University of California, Los Angeles (UCLA) activity score, Harris hip score, and RAND-36 were also completed at these intervals.