To assess implant performance, to evaluate fusion and to assess clinical and radiologic outcome of circumferential fusion using porous tantalum cages for ALIF in a 360-degree fusion. A retrospective cohort study was performed over a 4-year period that included the implantation of 280 tantalum cages in 98 patients by the technique of anterior lumbar interbody fusion (ALIF) and posterolateral spondylodesis. Radiographic follow-up was performed to document any implant related problems. Preoperative and postoperative clinical outcome measures were assessed. No neurological, vascular or visceral injuries were reported. There were no rod breakages and no symptomatic non-unions. One revision procedure was performed for fracture. Mean VAS back pain score in our patient cohort improved from 7.5 preoperatively to 1.9 at latest follow-up, mean VAS leg pain score improved from 6.2 to 1.1 and mean ODI score improved from 51.1 to 18.3. Porous tantalum cages have high strength and flexibility, in addition to having similar biomaterial properties to cancellous bone. Their use in 360-degree spondylodesis to treat degenerative lumbar spine deformity has been demonstrated to be very safe and effective, with excellent clinical and functional outcomes

To identify the most cited British author, unit and country within Great Britain among the scoliosis and spinal deformity literature.

Using methods as described by Skovrlj (2014), a search of the Thomson Reuters Web of Science was performed using the terms ‘scoliosis’ and ‘spine deformity’ from 1900 to 2013 published from authors in the following countries: UK, England, Scotland, Ireland, Wales. Additional citations searches were performed using PubMed and Google scholar. Results were sorted according to number of citations; papers applicable to scoliosis or spinal deformity were chosen.

The Top 25 citations from British authors were established. 80% of papers were published before 2000. Citation counts and therefore rankings varied for each of the three citation searches, producing differences in rank of as great as 28 for the same paper. Ruth Wynne-Davies from Edinburgh ranked number one in all three searches, followed by SG Boyd, R Dickson, and M McMaster. Half of the top ten papers were published by authors from Edinburgh.

The most cited author in Great Britain from all citation searches is Ruth Wynne Davies. However, the citation count of all papers varied depending on the search platform used, producing varying ranks for all other papers.

80% of myeloma patients have lytic bone lesions and osteoporosis secondary to corticosteroid therapy with high rate of vertebral compression fractures (VCFs). The consequences include pain and spinal deformity. The treatment ideally should address both the fracture-related pain and associated spinal deformity. Kyphoplasty provides a new tool that may impact bone care entailing the insertion and expansion of an inflatable bone tamps (IBT) in a fractured vertebral body. Bone cement is then deposited into the cavity to correct the deformity and improvement in structural integrity of collapsed vertebra.

Eighteen VCFs were treated during 11 balloon kyphoplasty procedures in 7 multiple myeloma patients. The clinical outcomes were assessed according to visual analogue scale with 0 representing no pain and 10 severe pain. Patients rated their pain before surgery, 1 week after surgery and at 1 year-postoperative period.

Mean improvement in local sagittal alignment was 12.3°. All of the patients who had reached the 1-year postoperative period had reported a high reduction in pain.

Treatment with chemotherapy and/or radiation therapy is very important in the control of bone disease. Patients treated with kyphoplasty in combination with pharmacologic therapy return to higher activity levels, leading to increased independence and quality of life.

Adult Spine Deformity (ASD) is a degenerative condition of the adult spine leading to altered spine curvatures and mechanical balance. Computational approaches, like Finite Element (FE) Models have been proposed to explore the etiology or the treatment of ASD, through biomechanical simulations. However, while the personalization of the models is a cornerstone, personalized FE models are cumbersome to generate. To cover this need, we share a virtual cohort of 16807 thoracolumbar spine FE models with different spine morphologies, presented in an online user-interface platform (SpineView). To generate these models, EOS images are used, and 3D surface spine models are reconstructed. Then, a Statistical Shape Model (SSM), is built, to further adapt a FE structured mesh template for both the bone and the soft tissues of the spine, through mesh morphing. Eventually, the SSM deformation fields allow the personalization of the mean structured FE model, leading to generate FE meshes of thoracolumbar spines with different morphologies. Models can be selectively viewed and downloaded through SpineView, according to personalized user requests of specific morphologies characterized by the geometrical parameters: Pelvic Incidence; Pelvic Tilt; Sacral Slope; Lumbar Lordosis; Global Tilt; Cobb Angle; and GAP score. Data quality is assessed using visual aids, correlation analyses, heatmaps, network graphs, Anova and t-tests, and kernel density plots to compare spinopelvic parameter distributions and identify similarities and differences. Mesh quality and ranges of motion have been assessed to evaluate the quality of the FE models. This functional repository is unique to generate virtual patient cohorts in ASD. Acknowledgements: European Commission (MSCA-TN-ETN-2020-Disc4All-955735, ERC-2021-CoG-O-Health-101044828)

Mechanical failure of spine posterior fixation in the lumbar region Is suspected to occur more frequently when the sagittal balance is not properly restored. While failures at the proximal extremity have been studied in the literature, the lumbar distal junctional pathology has received less attention. The aim of this work was to investigate if the spinopelvic parameters, which characterize the sagittal balance, could predict the mechanical failure of the posterior fixation in the distal lumbar region. All the spine surgeries performed in 2017-2019 at Rizzoli Institute were retrospectively analysed to extract all cases of lumbar distal junctional pathology. All the revision surgeries performed due to the pedicle screws pull-out, or the breakage of rods or screws, or the vertebral fracture, or the degenerative disc disease, in the distal extremity, were included in the junctional (JUNCT) group. A total of 83 cases were identified as JUNCT group. All the 241 fixation surgeries which to date have not failed were included in the control (CONTROL) group. Clinical data were extracted from both groups, and the main spinopelvic parameters were assessed from sagittal standing preoperative (pre-op) and postoperative (post-op) radiographs with the software Surgimap (Nemaris). In particular, pelvic incidence (PI), sagittal vertical axis (SVA), pelvic tilt (PT), T1 pelvic angle (TPA), sacral slope (SS) and lumbar lordosis (LL) have been measured. In JUNCT, the main failure cause was the screws pull-out (45%). Spine fixation with 7 or more levels were the most common in JUNCT (52%) in contrast to CONTROL (14%). In CONTROL, PT, TPA, SS and PI-LL were inside the recommended ranges of good sagittal balance. For these parameters, statistically significant differences were observed between pre-op and post-op (p<0.0001, p=0.01, p<0.0001, p=0.004, respectively, Wilcoxon test). In JUNCT, the spinopelvic parameters were out of the ranges of the good sagittal balance and the worsening of the balance was confirmed by the increase in PT, TPA, SVA, PI-LL and by the decrease of LL (p=0.002, p=0.003, p<0.0001, p=0.001, p=0.001, respectively, paired t-test) before the revision surgery. TPA (p=0.003, Kolmogorov-Smirnov test) and SS (p=0.03, unpaired t-test) differed significantly in pre-op between JUNCT and CONTROL. In post-op, PI-LL was significantly different between JUNCT and CONTROL (p=0.04, unpaired t-test). The regression model of PT vs PI was significantly different between JUNCT and CONTROL in pre-op (p=0.01, Z-test). These results showed that failure is most common in long fused segments, likely due to long lever arms leading to implant failure. If the sagittal balance is not properly restored, after the surgery the balance is expected to worsen, eventually leading to failure: this effect was confirmed by the worsening of all the spinopelvic parameters before the revision surgery in JUNCT. Conversely, a good sagittal balance seems to avoid a revision surgery, as it is visible is CONTROL. The mismatch PI-LL after the fixation seems to confirm a good sagittal balance and predict a good correction. The linear regression of PT vs PI suggests that the spine deformity and pelvic conformation could be a predictor for the failure after a fixation

Introduction and Objective. Virtual Surgical Planning (VSP) is becoming an increasingly important means of improving skills acquisition, optimizing clinical outcomes, and promoting patient safety in orthopedics and traumatology. Pediatric Orthopedics (PO) often deals with the surgical treatment of congenital or acquired limbs and spine deformities during infancy. The objective is to restore function, improve aesthetics, and ensure proper residual growth of limbs and spine, using osteotomies, bone grafts, age-specific or custom-made hardware and implants. Materials and Methods. Three-dimensional (3D) digital models were generated from Computed Tomography (CT) scans, using free open-source software, and the surgery was planned and simulated starting from the 3D digital model. 3D printed sterilizable models were fabricated using a low-cost 3D printer, and animations of the operation were generated with the aim to accurately explain the operation to parents. All procedures were successfully planned using our VSP method and the 3D printed models were used during the operation, improving the understanding of the severely abnormal bony anatomy. Results. The surgery was precisely reproduced according to VSP and the deformities were successfully corrected in eight cases (3 genu varum in Blount disease, 2 coxa vara in pseudo achondroplasia, 1 SCFE, 1 missed Monteggia lesion and 1 post-traumatic forearm malunion deformity). In one case, a focal fibrocartilaginous dysplasia, the intraoperative intentional undersizing of the bone osteotomy produced an incomplete correction of a congenital forearm deformity. Conclusions. Our study describes the application of a safe, effective, user-friendly, VSP process in PO surgery. We are convinced that our study will stimulate the widespread adoption of this technological innovation in routine clinical practice for the treatment of rare congenital and post-traumatic limb deformities during childhood

Currently, between 17% of patients undergoing surgery for adult spinal deformity experience severe instrumentation related problems such as screw pullout or proximal junctional failure necessitating revision surgery. Cables may be used to reinforce pedicle screw fixation as an additive measure or may provide less rigid fixation at the construct end levels in order to prevent junctional level problems. The purpose of this study is to provide insight into the maximum expected load during flexion in UHMWPE cable in constructs intended for correction of adult spine deformity (degenerative scoliosis) in the PoSTuRe first-in-man clinical trial. Following the concept of toppinoff, a new construct is proposed with screw/cable fixation of rods at the lower levels and standalone UHMWPE cables at the upper level (T11). A parametric FE model of the instrumented thoracolumbar spine, which has been previously validated, was used to represent the construct. Pedicle screws are modeled by assigning a rigid tie constraint between the rod and the lamina of the corresponding spinal level. Cables are modeled using linear elastic line elements, fixing the rod to the lamina medially at the cranial laminar end and laterally at the caudal laminar end. A Youngs modulus was assigned such that the stiffness of the line element was the same as that of the cable. An 8 Nm flexion moment was applied to the cranial endplate. The maximum value of the force in the wire (80 N) is found at the T11 (upper) level. At the other levels, forces in the cable are very small because most of the force is carried by the screw (T12) or because the wires are force shielded by the contralateral and adjacent level pedicle screws (L2, L3). The model provides first estimates of the forces that can be expected in the UHMWPE cables in constructs for kyphosis correction during movement. It is expected that this approach can help in defining the number of wires for optimal treatment

Since the commencement of the Neuromuscular-Unit in the Children’s-Hospital “Agia Sofia”, from December 2002 until December 2008, 306 patients were examined suffering from different neuromuscular diseases (ND). In the present study we examined. the frequency of spine deformities,. the management in correlation with the poor general health of these patients, analyzing the most frequent presenting disease, that is Duchenne’s-muscular-dystrophy,. cases of surgical management of our Unit are presented. From the analysis of our material we found that 152 patients were suffering from Duchenne’s-Becker muscular-dystrophy, 59 patients from spinal-muscular-atrophy I-III, 13 patients from fascioscapulohumeral muscular-dystrophy, 15 patients from hereditary motorsensory-neuropathies, 5 patients from Friedreich’s Ataxia and 62 patients from different types of dystrophinopathies–myopathies. The ages of the patients varied between 8 months and 37 years. From the total, 89% of the patients above 10 years presented with spine deformities. Most of them were managed with wheelchairseating modifications and 33 patients were fitted with braces in an attempt to slow curve progression. Surgically were managed 24 patients with spine arthrodesis, 5 of them abroad (USA-Eng-land-France). The older patients (> 17 years wheelchair-bound) were frequently, because of impaired general health, not suitable candidates for surgery. Pulmonary function was examined in 84 patients suffering from Duchenne’s muscular dystrophy. The crucial age, were pulmonary function has fallen dramatically (FVC< 40%), was between ages 12–15 years. In conclusion spine deformities are very common in patients suffering from neuromuscular diseases. Because of the rapid deterioration of the general health of these patients spine arthrodesis should be performed early, in the patients severely affected, between ages 12–15 years

Since the first pathography of Idiopathic Scoliosis (IS) and Scheuermann’s disease (SD) clinicians consider these two pathologies as separate nosological entities. The reason for this is different clinical implications of diseases. SD is known to be more common in boys, while IS is a sad privilege of girls. Kyphotic spinal deformity is typical for patients with Scheuermann’s disease while scoliotic one for patients with idiopathic scoliosis. Schmorl’s nodes are found more frequently in SD. Both deformities are attributed to the growth asymmetry, anterior growth plates are affected in SD and lateral ones – in IS. Despite different clinical presentations, these two nosologies have the same pathogenetic mechanism and semiology. To our regret, there are no reports on comparative morphological and biochemical investigations of SD and IS. Long-term studies have given rise to the question of a single nature of scoliotic and kyphotic spine deformities. Material and methods: Clinical and genetic examination with segregational analysis of pedigrees was performed in 350 families with IS and in 95 families with SD. Structural components of the spine obtained from IS and SD patients operated in our Institute were studied with morphological and biochemical techniques. The potency for synthesis and structural organization of chondroblasts isolated from vertebral body growth plates of patients with IS and SD were subjects of morphological, biochemical, and ultrastructural analyses. Qualitative and quantitative composition of growth plates was investigated in culture mediums. Results: Clinical and genetic examination of families with IS and SD have shown that both pathologies are inherited both from maternal and paternal lines. Families presented combinations of these pathologies. Segregational analysis of IS and SD pedigrees has revealed major gene dependence of both pathologies inherited by autosomal-dominant type with incomplete penetrancy genotypes according to gender and age. In experimental animal model of genetically dependent spine deformity there were cubs either with scoliosis or with kyphosis in one litter. The target organ for pathologies discussed is growth plate and secondary disorders of vertebral body and disc structure. Morpho-histochemical study of the spine structural elements has revealed the same changes in patients with IS and patients with SD:. Disturbance of structural and chondral organization of cells and matrix in vertebral body growth plate. Decrease of chondroitin sulfate content and increase of keratan sulfate content. Lower response to oxidation-reduction enzymes in cytoplasm of chondroblasts. Change of the ultrastructural organization of cells: Golgi complex with flat vacuoles and enlarged cisterns of endoplasmic reticulum. Extracellular matrix with fragmented collagen fibrils and small fragments of proteoglycans

Introduction: Spine and trunk deformity are different; trunk deformity is probably more important to the patient, and trunk deformity has received much less attention. This study was designed to determine the extent and stability of trunk deformity correction and is part of an ongoing effort to study trunk deformity. Material and methods: This is a prospective case series the inclusion criteria being pre-, post- and follow-up surface topography evaluation of idiopathic scoliosis patients undergoing posterior instrumentation and arthrodesis. Twenty-eight patients (25 female, 3 male) met these inclusion criteria. The average age at surgery was 15 years 3 months (11 years 3 months – 38 years 2 months). Spine deformity measurement and classification were done from standing 36” PA and lateral scoliosis radiographs. Trunk asymmetry was determined from standing posterior rastersterography. Coronal plane asymmetry was calculated utilising the Posterior Trunk Symmetry Index (POTSI), threshold for change being ±8. Transverse plane asymmetry was determined by the Suzuki Hump Sum (SHS), threshold for change being ±3.5. Curve classification and number in each category were King Moe I – three; IIA – two; IIB – three; III – ten; IV – four;V – five and Triple – one. Initial follow-up averaged 2.3 months (±7) and latest follow-up 15.8 months (±8.1). Results: Pre-operative; post-operative; and 1atest follow-up spine deformity measurements with percent correction (for spine and trunk deformity) were as follows: Major scoliosis-63°, 19° (69%) and 21° (66%); POTSI 52, 26 (50%), and 24 (54%); and SHS 18, 11 (38%), and 12 (37%). Thus, spine deformity (Cobb) and trunk deformity (POTSI and SHS) correction appeared to be stable over the follow-up period. Spine deformity correction was better than coronal trunk plane asymmetry correction which was better than transverse plane asymmetry correction. At latest follow-up, spine deformity correction for single curves was similar to multiple curve, 69% versus 64% as was transverse plane trunk asymmetry correction 34% versus 37%. However, coronal plane trunk asymmetry correction was better for single curves than double curves 63% versus 42%. At follow-up POTSI was better in all patients with single curves whereas in double curves it was better in nine, same in three, and worse in two. Transverse plane trunk asymmetry for single curves was better in ten, same in three, and worse in one, whereas for double curves it was better in eight, same in four and worse in two. Discussion and conclusion: The obvious weaknesses in this study are the small numbers and relative short follow-up. However, the trend seems clear. Trunk deformity correction is not as good as spine deformity correction. This is especially true for the transverse plane for all curves and the coronal plane for double curves in comparison to single curves

Background: Congenital anomalies of the chest wall and Sprengel’s shoulder are often associated with congenital deformities of the spine. It has been suggested that extensive rib fusions on the concavity of a congenital scoliosis may adversely affect progression of the spine deformity, thoracic function and growth of the lungs, which can lead to a thoracic insufficiency syndrome. Methods: This is a retrospective study of the medical records and spine radiographs of 620 consecutive patients with congenital spine deformities. The rib anomalies were classified into simple and complex and the presence of a Sprengel’s shoulder was recorded. Subjects: There were 497 patients (80%) with scoliosis, 88 patients (14%) with kyphoscoliosis, and 35 patients with kyphosis (6%). The mean rate of scoliosis deterioration without treatment, age and curve size at surgery was compared for the different types of vertebral abnormalities in patients with and without rib anomalies. Results: Rib anomalies occurred in 124 patients. The rib anomalies were simple in 97 patients (78%) and complex in 27 (22%). The most common simple rib anomaly (70 patients; 72%) was a fusion of two or three ribs. The most common complex rib anomaly (20 patients; 74%) was a fusion of multiple ribs associated with a large chest wall defect. Rib anomalies were most commonly associated with a congenital scoliosis (116 patients; 93.6%), and much less frequently with a congenital kyphoscoliosis or kyphosis (8 patients). In those patients with a scoliosis, the rib anomalies were simple in 91 patients (78.5%) and complex in 25 patients (21.5%). Eighty-eight of the 124 patients (76%) with rib abnormalities had a scoliosis due to a unilateral unsegmented bar with or without contra-lateral hemivertebrae at the same level, and 8 patients had mixed unclassifiable vertebral anomalies. In contrast, only 17 patients with a scoliosis and rib anomalies had hemivertebrae alone. The rib anomalies were most frequently associated with a thoracic or thoracolumbar scoliosis (107 patients; 92.2%) and occurred on the concavity in 81 patients (70%), convexity in 27 patients (23%), and were bilateral in 8 patients. Sprengel’s deformity occurred in 45 patients; 43 patients with congenital scoliosis (8.6%), and 2 with kyphoscoliosis or kyphosis. A Sprengel’s shoulder occurred most frequently in association with a thoracic scoliosis due to a unilateral failure of vertebral segmentation (28 patients). The elevated shoulder was on the concavity of scoliosis in 26 patients and on the convexity in 16 patients. We compared the mean rate of curve progression without treatment, the age and curve size at spine surgery for the different types of spine deformities in patients with and without rib anomalies either simple or complex and found no significant difference (p> 0.05); the only statistical difference was that the mean age at surgery was higher for patients with a unilateral unsegmented bar without rib anomalies (p=0.005). Conclusion: Congenital rib anomalies and Sprengel’s shoulder occur most commonly on the concavity of a thoracic or thoracolumbar congenital scoliosis due to a unilateral failure of vertebral segmentation. However, these anomalies do not have an adverse effect on curve size or rate of progression

Aims

To determine whether side-bending films in scoliosis are assessed for adequacy in clinical practice; and to introduce a novel method for doing so.

Introduction and purpose: The relationship between congenital heart disease and the increased prevalence of scoliosis is well known, although the same cannot be said about the etiology of scoliosis in these patients. Although thoracotomy is often associated to scoliosis, median sternotomy has so far not been identified as an etiological agent. he purpose of the study is to determine if patients with congenital heart disease who are subjected to a median sternotomy show a higher prevalence of spine deformities. Materials and methods: A retrospective review is made of patients operated on for congenital heart disease through median sternotomy before the age of 8, assessing the development of spine deformities. Simple chest radiographs of 128 patients were studied once they reached skeletal maturity and it was observed that they presented no spinal or costal deformities before surgery. Results: The prevalence of scoliosis was 34.3%; 16 of these patients (12.5%) had curves of more than 20° and 33 (25.8%) had thoracic kyphosis of less than 20°. Patients operated on before the age of 18 months had a significantly higher risk to develop scoliosis as compared with those treated later (odds ratio: 3.48; p=0.016). The development of scoliosis was not related with the type of cardiac malformation present. Conclusions: There is a high prevalence of scoliosis in patients subjected to a median sternotomy for a congenital heart pathology. The prevalence of scoliosis increases in patients operated on at younger ages

Aims

The aim of this study was to evaluate the reliability and validity of a patient-specific algorithm which we developed for predicting changes in sagittal pelvic tilt after total hip arthroplasty (THA).

We present a study done to measure the change of angle of the acetabulum or cup, due to leg length discrepancy, deformity of hip and spine on standing. In 1998 a 3-dimensional reconstruction of hip model was prepared on CAD and the change of angle of the cup was measured as Functional Acetabular Inclination Angle (FAIA) with patient standing without squaring the pelvis. The FAIA on standing was compared with angle of the cup with patient in supine position with squared pelvis. The position of the cup changed on weight bearing due to multiple issues. The results showed that one centimetre of leg lengthening changed FAIA by 3°, 10° of abduction deformity resulted in apparent lengthening of 2.87 cm and loss of lordosis anteverted the cup on loading and vice-versa. We conclude that fixed hip deformities, leg length discrepancy and spine deformities can affect the angle of cup in hip replacement surgery and may prone to dislocations, impingement and segmental wear of the cup

There is an increased incidence of dislocation, dysplasia, slipped epiphysis, Perthes’ disease, and avascular necrosis leading to degenerative arthritis which occurs in up to 28% of Down's syndrome patients. As the life expectancy for patients with Down's syndrome has increased, so has the presence of hip disease. Hip replacement has been shown to have good results in this population. Special considerations include a high risk of postoperative dislocation and leg length inequality which often require large head THR or dual mobility type reconstruction to reduce these risks. Numerous spine deformities including scoliosis and C1-2 subluxation need to be taken into account-anesthesia consult

Summary. Optimum position of pedicle screws can be determined preoperatively by CT based planning. We conducted a comparative study in order to analyse manually determined pedicle screw plans and those that were obtained automatically by a computer software and found an agreement in plans between both methods, yet an increase in fastening strengths was observed for automatically obtained plans. Hypothesys. Automatic planning of pedicle screw positions and sizing is not inferior to manual planning. Design. Prospective comparative study. Introduction. Preoperative planning in spinal deformity surgery starts by a proper selection of implant anchors throughout the instrumented spine, where pedicle screws provide the optimum choice for bone fixation. In the case of severe spinal deformities, dysplastic pedicles can limit screw usage, and therefore studying the anatomy of vertebrae from preoperative images can aid in achieving the safest screw position through optimal fastening strength. The purpose of this study is to compare manually and automatically obtained preoperative pedicle screw plans. Materials and Methods. CT scans of 17 deformed thoracic spines were studied by two experienced spine deformity surgeons, who placed 316 pedicle screws in 3D using a software positioning tool by aiming for the safest trajectory that permitted the largest possible screw sizes. The resulting manually obtained screw sizes, trajectory angles, entry points and normalised fastening strengths were compared to those obtained automatically by a dedicated computer software that, basing on vertebral anatomy and bone density in 3D, determined optimal screw sizes and trajectories. Results. Statistically significant differences were observed between manually and automatically obtained plans for screw sizes (p < 0.05) and trajectory angles (p < 0.001). However, for automatically obtained plans, screws were not smaller in diameter (p < 0.05) or shorter in length (p < 0.001), while screw normalised fastening strengths were higher (p < 0.001). Conclusions. In comparison to manual planning, automatically obtained plans did not result in smaller screw diameters or shorter screw lengths, which is in agreement with the definition of the pull-out strength, but in different screw trajectory angles, which is reflected by higher normalised fastening strengths. Captions. Fig. 1. Visual comparison among automatically obtained (green colour) and manually defined pedicle screw placement plans by two experienced spine surgeons (red and blue colour) for three different patients with adolescent idiopathic scoliosis, shown from top to bottom in a three-dimensional view, left sagittal, right sagittal and coronal view. Fig. 2. Histograms of differences between observers and (left column), between observer and automated method (middle column), and between observer and automated method (right column), shown from top to bottom for differences in pedicle screw pedicle screw diameter, sagittal inclination, and normalised fastening strength. For figures/tables, please contact authors directly.

Introduction: Adolescent idiopathic scoliosis (IS) is the most common spine deformity arising during childhood, but the aetiology of IS remains unknown. A large proportion (75%) of structural scoliosis is clinically classified as idiopathic. Idiopathic scoliosis often appears in several members of the same family, this strongly suggesting a genetic transmission. Clinical studies indicate that approximately 1:4 of the total scoliosis cases and 1:3 of idiopathic scoliosis cases are familial. Also studies on twins showing that concordance of monozygotic twins is greater than that of dizygotic twins suggest a genetic basis for the idiopathic scoliosis. A series of candidate genes, including FBN1, COL1A1, COL1A2, COL2A1 and elastin genes, have already been examined by linkage studies, with negative results, and, at present, the particular mode of inheritance of the idiopathic scoliosis still remains unclear. There are conflicting data in the existing literature. Some reports show that the disorder has many of the characteristics of a complex trait, indicating the presence of a multifactorial inheritance pattern, while other studies indicate a major autosomal dominant gene effect. Even more, not all the linkage studies, which demonstrate that the inheritance pattern of idiopathic scoliosis is based on a major autosomal dominant gene effect, did identify a unique locus responsible for idiopathic scoliosis. A linkage with idiopathic scoliosis has been found at locus 17p11 in a three generation Italian family and at locus 19p13.3 in a Chinese family. Therefore, it is possible that idiopathic scoliosis is caused by alterations in different genes. Study Design: This study aimed at investigating the loci responsible for susceptibility to idiopathic scoliosis in all the population and not only in single families. For this reason, we chose to perform an association study on parent-offspring trios. A genetic study and statistical linkage analysis of a population of 81 trios, each consisting of a daughter/son affected by idiopathic scoliosis (IS) and both parents. Objectives: The objective of this study was to assess a linkage disequilibrium between the matrilin-1 (MATN1) gene and the idiopathic scoliosis (IS). Summary of Background Data: In a previous study (Giampietro et al., 1999), a number of genes, associated with spine musculoskeletal deformity phenotypes in mouse and in synteny between mouse and man, were identified as candidate genes for IS. Among these genes, MATN1, which carries a polymorphic micro-satellite marker within its sequence, was selected for a linkage analysis. MATN1 is localised at 1p35 and is mainly expressed in cartilage. Methods: In all trios components, the region of MATN1 gene containing the microsatellite marker was amplified by a polymerase chain reaction. The amplicons were analysed by a DNA sequencer-genotyper. The statistical analysis was performed using the extended transmission/disequilibrium test. Results: Three microsatellite polymorphisms, respectively consisting of 103 bp, 101 bp and 99 bp, were identified. ETDT evidenced a significant preferential transmission for the 103 bp allele (2 = 5.058, df=1, P=0.024). Main Conclusions: The results suggest that the familial idiopathic scoliosis is linked to the MATN1 gene

Introduction. EOS® is a low dose imaging system which allows the acquisition of coupled AP and lateral high-definition images while the patient is in standing position. HipEos has been developped to perform pre-surgical planning including hip implants selection and virtual positioning in functional weight-bearing 3D. The software takes advantage of the real size 3D patient anatomical informations obtained from the EOS exam. The aim of this preliminary study on 30 consecutive THP patients was to analyze the data obtained from HipEos planning for acetabular and femoral parameters and to compare them with pre and post-operative measurements on standing EOS images. Material and methods. Full body images were used to detect spino-pelvic abnormalities (scoliosis, pelvic rotation) and lower limbs discrepancies. One surgeon performed all THP using the same type of cementless implants (anterior approach, lateral decubitus). The minimum delay for post-op EOS controls was 10 months. A simulation of HipEos planning was performed retrospectively in a blinded way by the same surgeon after the EOS controls. All measurements were realized by an independent observer. Comparisons were done between pre and post-op status and the “ideal planning” taking in account the parameters for the restitution of joint offset and femur and global limb lengths according to the size of the selected implants. Regarding cup anteversion, the data included the anatomical anteversion (with reference to the anterior pelvic plane APP) and functionnal anteversion (according to the horizontal transverse plane in standing position). Results. The difference between pre-op and post-op APP angles is not statistically significant (p = 0.85), likewise for the sacral slope (p = 0.3). Thus, there has been no change in the orientation of the pelvis after THP. Comparing the two hips on post-op EOS data shows that the difference in femoral offset is not statistically significant (p = 0.76). However, the femoral length is statistically different (p <0.05) (mean 4mm, 0–12mm). The difference for femoral offset between HipEOS planning and post-op EOS data is not statistically significant (p = 0.58). However, the mean difference is significant (p <0.05) for femur length (5mm), inclination (5°) and anteversion of the cup. The mean post-op anatomic anteversion measured in the APP is 27°, whereas it is 11° with HipEOS planning. The mean functional anteversion of the cup on standing post-op EOS data is 35° while planning it is 17°. Otherwise, differences in femoral anteversion are not significant. Conclusion. The planning tools currently available include only the local anatomy of the hip for THP adjustment. This software integrates weight-bearing position, which allows to consider the impact of spine deformities and length discrepancies. This preliminary study is only retrospective, but it highlights the potential interest this “global planning” particularly for the optimization of acetabular anteversion and length adjustment according to pelvic tilt. Planning using the standing lateral view is interesting not only for visualization of the sagittal curvature of the femur and the detection of potential difficulties, but also for the visual data provided on the sagittal orientation of the cup

Aims

The aim of this study is to define a core outcome set (COS) to allow consistency in outcome reporting amongst studies investigating the management of orthopaedic treatment in children with spinal dysraphism (SD).