Introduction. Total knee replacement (TKR) is an established and effective surgical procedure in case of advanced osteoarthritis. However, the rate of satisfied patients amounts only to about 75 %. One common cause for unsatisfied patients is the anterior knee pain, which is partially caused by an increase in patellofemoral contact force and abnormal patellar kinematics. Since the malpositioning of the tibial and the femoral component affects the interplay in the patellofemoral joint and therefore contributes to anterior knee pain, we conducted a computational study on a cruciate-retaining (CR) TKR and analysed the effect of isolated femoral and tibial component malalignments on patellofemoral dynamics during a squat motion. Methods. To analyse different implant configurations, a musculoskeletal multibody model was implemented in the software Simpack V9.7 (Simpack AG, Gilching, Germany) from the SimTK data set (Fregly et al.). The musculoskeletal model comprised relevant ligaments with nonlinear force-strain relation according to Wismans and Hill-type muscles spanning the lower extremity. The experimental data were obtained from one male subject, who received an instrumented CR TKR. Muscle forces were calculated using a variant of the computed muscle control algorithm. To enable roll-glide kinematics, both tibio- and patellofemoral joint compartments were modelled with six degrees of freedom by implementing a polygon-contact-model representing the detailed implant surfaces. Tibiofemoral contact forces were predicted and validated using data from experimental squat trials (SimTK). The validated simulation model has been used as reference configuration corresponding to the optimal surgical technique. In the following, implant configurations, i.e. numerous combinations of relative femoral and tibial component alignment were analysed: malposition of the femoral/tibial component in mediolateral (±3 mm) and anterior-posterior (±3 mm) direction. Results. Mediolateral translation/malposition of the tibial component did not show high influence on the maximal patellofemoral contact force. Regarding the mediolateral translation of the femoral component, similar tendencies were observed. However, lateralisation of the femoral component (3 mm) clearly increased the lateral patella shift and medialisation of the tibial component (3 mm) led to a slightly increased lateral patella shift. Compared to the reference model, pronounced posterior translation of the tibial and femoral component resulted in a lower patellofemoral contact force, further increasing with higher anterior translation of the components. The translation of the tibial component showed smaller influence on the patellofemoral contact force than the translation of the femoral component. Discussion. In our present study, the mediolateral malposition of the femoral and tibial component showed no major impact on patellofemoral contact force and contribution to anterior knee pain in patients with CR TKR. However, the influence of implant component positioning in anterior-posterior direction on patellofemoral contact force is evident, especially for the femoral component. Our generated musculoskeletal model can contribute to computer-assisted preclinical testing of TKR and may support clinical decision-making in preoperative planning

The prevalence of anterior knee pain in the general population is relatively high. Patellar height, and more specific patella alta, is one of the several factors that have been associated with anterior knee pain, but the precise mechanism by which patella alta leads to a less favourable situation in terms of patellofemoral contact force, contact area and contact pressure, is poorly understood. The recent availability of validated dynamic knee simulators and advances in the analysis of contact force and area, give us today the possibility to study the influence of patellar position and patellar height on patellofemoral biomechanical characterisitics. Simulating a knee squat in different configurations with variable predetermined patellar height, reveals a clear association of patella alta with the highest maximal patellofemoral contact force and contact pressure, probably as a consequence of the delay in tendofemoral contact. When averaged across all flexion angles, the normal height of the patella seems to be the most optimal position in terms of contact pressures. This may provide a biomechanical explanation for anterior knee pain in young patients with patella alta and in older patients following total knee prosthesis resulting in an altered patellar position in terms of height

Numerous dynamic studies have evaluated the tibiofemoral contact pressures that follow total knee arthroplasty (TKA), and several static studies utilizing finite elements and pressure sensitive film have evaluated malalignment. The objective of this study was to compute the in vivo dynamic tibiofemoral contact forces for normal alignment and evaluate the change in contact pressure with increasing malalignment of the femoral component. A three-dimensional computational model of the lower limb during deep flexion was created using Kane’s method of dynamics. A hybrid approach was used to determine the boundary conditions of the model. The motions of a total knee arthroplasty patient were measured using fluoroscopy. The motions of the patient were varied from the normal motions to simulate malalignment of the femoral component. The change in forces with malalignments of up to 10° valgus, 10° varus, 10° internal rotation, and 10° internal rotation were determined. An increase in the axial tibiofemoral contact force from 2.44 times body weight (BW) to 2.62 BW and a decrease in the quadriceps force from 6.8 to 5.65 BW were observed with varus malalignment. The medial-lateral patellofemoral contact force decreased from 0.95 BW to 0.1 BW with 10° varus positioning of the femur and increased to 2.2 BW with 10° valgus positioning of the femur and a decrease in the patellar ligament forces from 1.70 to 1.63 BW was observed. Changes in the tibiofemoral and patellofemoral forces of 1–2 BW were observed as the femur was malaligned with respect to the tibia. The most significant of these changes was the medial-lateral patellofemoral contact force. The implications of these findings are that malalignment could result in increased patellar subluxation or increased wear of the polyethylene component. Concerns were raised that this initial subject evaluated may not have had optimum alignment, thus leading to more optimal bearing surface stress conditions with varus malalignment. Future studies will be evaluated for subjects having the joint line restored to conditions for non-implanted knees

Introduction. Total knee arthroplasty (TKA) is a well proven surgical procedure. Squat and gait motions are common activities in daily life. However, squat motion is known as most dissatisfying motion in activities in daily life after total knee arthroplasty (TKA). Dissatisfaction after TKA might refer to muscle co-contraction between quadriceps and hamstrings. The purposed of this study was to develop squat and gait simulation model and analyses the contact mechanics and quadriceps and hamstring muscle stability. We hypothesized that squat model shows larger contact forces and lower hamstring to quadriceps force ratio than gait model. Materials and Methods. Squat motion and gait model were simulated in musculoskeletal simulation software (AnyBody Modeling System, AnyBody Technology, Denmark). Subject-specific bone models used in the simulation were reconstructed from CT images by Mimics (Materialize, Belgium). The lower extremity model was constructed with pelvis, femur, tibia, foot segments and total knee replacement components: femoral component, tibial insert, tibial tray, and patella component [Fig.1]. The muscle model was consisted of 160 muscle elements. The TKR components used in this study are PS-type LOSPA Primary Knee System (Corentec Co., Ltd, Republic of Korea). Force-dependent kinematics method was used in the simulation. The model was simulated to squat from 15° to 100° knee flexion, in 100 frames. Gait simulation model was based on motion capture and force-plate system. Motion capture and force-plate data were from grand challenge competition dataset. Results / Discussion. Patellofemoral contact forces ranged from 0.18 to 3.78 percent body weight (%BW) and from 0.00 to 1.36 %BW during squat motion and gait cycle, respectively. Patellofemoral contact forces calculated at 30°, 60°, and 90° flexion during squat motion were 0.53, 1.93, and 3.22 %BW, respectively. Wallace et al. also reported patellofemoral contact forces at 30°, 60°, and 90° flexion, which were 0.31, 1.33, 2.45 %BW during squat motion. Our results showed similar results from other studies, however the squat model overestimated the patellofemoral contact forces. Contact stiffness in the simulation model might affected the overestimated contact forces. Hamstring to quadriceps force ratio ranged from 0.32 to 1.88 for squat model, and from 0.00 to 2.54 for gait model. As our hypothesis, squat motion showed larger patellofemoral contact forces. Also, mean hamstring to quadriceps force ratio of squat model were about half than the mean hamstring to quadriceps force ratio of gait model. From the results, possibility exists that unbalanced force of quadriceps and hamstring can affect dissatisfaction after TKA while squat motion is the most dissatisfying motion after TKA. However, muscle stability is not the only factor that can affect dissatisfaction after TKA. In future study, more biomechanical parameters should be evaluated to find meaningful dissatisfying factor after TKA. Conclusion. In conclusion, TKA musculoskeletal models of squat and gait motion were constructed and patellofemoral contact force / hamstring to quadriceps force ratio were evaluated. Patellofemoral mechanics were validated by comparison of previous study. Additional studies are needed to find dissatisfying factor after TKA

A high proportion of complications following TKR occur at the patellofemoral articulation secondary to delami-nation and adhesive/abrasive wear. Electron beam cross-linking and melting has been shown to substantially reduce delamination and adhesive/abrasive wear in polyethylene tibial inserts. A series of in-vitro patella wear and fatigue tests were developed to explore the benefits of this material at the patellofemoral articulation. Patellae (NKII, Sulzer Orthopedics, Inc., Austin, TX) were tested on an AMTI (Watertown, MA) knee simulator articulating against the trochlear grove of the femoral component. The simulator controlled flexion/ extension and patellofemoral contact force. Each test included patellae manufactured from conventional and electron beam crosslinked and melted polyethylene. Three different simulations were created: i) normal gait (5 million cycles) with optimal component alignment, ii) stair climbing (2 million cycles) with optimal component alignment, iii) stair climbing (2 million cycles) with 4° of femoral component internal rotation to simulate a component malalignment condition. In the last two simulations all patellae were artificially aged for 35 days in 80°C air to simulate one aspect of the long term oxidative state of each material. In normal gait, the unaged conventional and highly cross-linked materials demonstrated similar behaviour. In stair climbing with optimal component alignment, the aged conventional patellae developed cracks by 2 million cycles. In stair climbing with component malalign-ment the aged conventional patellae developed cracks and delamination by 1 million cycles. None of the highly cross-linked components showed cracks or delamination. These results demonstrate the potential advantage of highly cross-linked polyethylene for the patella

Objectives. The aim of the current study was to analyse the effects of posterior cruciate ligament (PCL) deficiency on forces of the posterolateral corner structure and on tibiofemoral (TF) and patellofemoral (PF) contact force under dynamic-loading conditions. Methods. A subject-specific knee model was validated using a passive flexion experiment, electromyography data, muscle activation, and previous experimental studies. The simulation was performed on the musculoskeletal models with and without PCL deficiency using a novel force-dependent kinematics method under gait- and squat-loading conditions, followed by probabilistic analysis for material uncertain to be considered. Results. Comparison of predicted passive flexion, posterior drawer kinematics and muscle activation with experimental measurements showed good agreement. Forces of the posterolateral corner structure, and TF and PF contact forces increased with PCL deficiency under gait- and squat-loading conditions. The rate of increase in PF contact force was the greatest during the squat-loading condition. The TF contact forces increased on both medial and lateral compartments during gait-loading conditions. However, during the squat-loading condition, the medial TF contact force tended to increase, while the lateral TF contact forces decreased. The posterolateral corner structure, which showed the greatest increase in force with deficiency of PCL under both gait- and squat-loading conditions, was the popliteus tendon (PT). Conclusion. PCL deficiency is a factor affecting the variability of force on the PT in dynamic-loading conditions, and it could lead to degeneration of the PF joint. Cite this article: K-T. Kang, Y-G. Koh, M. Jung, J-H. Nam, J. Son, Y.H. Lee, S-J. Kim, S-H. Kim. The effects of posterior cruciate ligament deficiency on posterolateral corner structures under gait- and squat-loading conditions: A computational knee model. Bone Joint Res 2017;6:31–42. DOI: 10.1302/2046-3758.61.BJR-2016-0184.R1

Aims

This study aims to investigate the effects of posterior tibial slope (PTS) on knee kinematics involved in the post-cam mechanism in bi-cruciate stabilized (BCS) total knee arthroplasty (TKA) using computer simulation.