Purpose: The aim of this study is to analyze objectively pathoanatomical changes of clubfoot treated with Ponseti method. Introduction: In the treatment of clubfoot, regardless of the grade and severity of the disease, first conservative treatment and serial casting should be chosen. The follow up period for surgery performed group ranges usually from 2 to 8 years (not longer than 10–15 years). Thirty years results of Ponseti’s idiopathic clubfoot treatment is with 78% success. In some recent series 95% success rate was reported. Standard conservative treatment (Kite’s) success rates are only 11% to 58% for idiopathic group. Material and Methods: Seventy patients, 115 feet (45 Bilateral, F/M 15/55) were included in the study. 28 of these patients were neurogenic group (20 Spina Bifida and 8 Artrogripotic). Since 1997, we strove Ponseti’s strict casting protocol. Bensahel’s a la carte PMR surgery was performed in 2 cases. Downey’s MRI evaluation criterias were used. In statistical analysis of the idiopathic, neurogenic and normal groups, ANOVA test was used. Results: The Navicular angle assessment was statistically significant (p< 0.05). Assessment of the results of idiopathic group was in normal range. Pathological components of Clubfoot were significantly reduced in the neurogenic group. Conclusions: Ponseti method is the effective treatment way of both the idiopathic clubfoot and the neurogenic foot. It is concluded that sound understanding of the anatomy of the foot, the biological response of young connective tissue and bone to changes in direction of mechanical stimuli, can gradually reduce or almost eliminate these deformities in most clubfeet

Purpose and background. To evaluate the clinical and cost-effectiveness of a physical and psychological group intervention (BOOST programme) compared to physiotherapy assessment and advice (best practice advice [BPA]) for older adults with neurogenic claudication (NC) which is a debilitating spinal condition. Methods and results. A randomised controlled trial of 438 participants. The primary outcome was the Oswestry Disability Index (ODI) at 12 months. Data was also collected at 6 months. Other outcomes included Swiss Spinal Stenosis Questionnaire (symptoms), ODI walking item, 6-minute walk test (6MWT) and falls. The analysis was intention-to-treat. We collected the EQ5D and health and social care use to estimate cost-effectiveness. Participants were, on average, 74.9 years old (SD 6.0). There was no significant difference in ODI scores between groups at 12 months (adjusted mean difference (MD): −1.4 [95% Confidence Intervals (CI) −4.03,1.17]), but, at 6 months, ODI scores favoured the BOOST programme (adjusted MD: −3.7 [95% CI −6.27, −1.06]). Symptoms followed a similar pattern. The BOOST programme resulted in greater improvements in walking capacity (6MWT MD 21.7m [95% CI 5.96, 37.38]) and ODI walking item (MD −0.2 [95% CI −0.45, −0.01]) and reduced falls risk (odds ratio 0.6 [95% CI 0.40, 0.98]) compared to BPA at 12 months. Probability that the BOOST programme is cost-effective ranged from 67%–89% across cost-effectiveness thresholds. Conclusions. The BOOST programme improves mobility and reduces falls in older adults with NC compared to BPA at 12 months follow-up. It is good value for the NHS. Future iterations of the programme will consider ways to reduce symptoms and disability long-term. Conflicts of interest: No conflicts of interest. Sources of funding: National Institute of Health Research – Programme for Applied Research NIHR - PTC-RP-PG-0213-20002: Better Outcomes for Older people with Spinal Trouble (BOOST). Publication and presentations: The clinical effectiveness paper has just been accepted for publication in the Journal of Gerontology Series A. The health economic analysis is not yet published. It was presented at the Physiotherapy UK conference and the International Back and Neck Pain Forum in 2021

Purpose: Claudication is a common complaint of elderly patients. Lumbar spinal stenosis (LSS) and peripheral arterial disease (PAD) are the two main etiologies, producing neurogenic and vascular claudication respectively. Physicians initially diagnose claudication based on a “typical” symptom profile. The reliability of this symptom profile to accurately diagnose LSS or PAD as a cause of claudication is unknown, leading to the potentially unnecessary utilization of expensive and overly sensitive imaging modalities. Furthermore, clinicians rely on this symptom profile when directing treatment for patients with concurrent imaging positive for LSS and PAD. This study evaluates the reliability of various symptom attributes, which classically have characterized and differentiated the two. Method: Patients presenting at a tertiary care center’s vascular or spine clinics with a primary complaint of claudication were enrolled in the study. Diagnosis of either LSS or PAD was confirmed with imaging for each patient. They answered 14 questions characterizing their symptoms. Sensitivity, specificity, positive and negative likelihood ratio (PLR and NLR) was determined for each symptom attribute. Results: The most sensitive symptom attribute to rule out LSS is “triggering of pain with standing alone” (0.96). Four symptom attributes demonstrated a high PLR and three had low NLR for diagnosing neurogenic claudication (PLR= 3.08, 2.51, 2.14, 2.9; NLR=0.06, 0.29, 0.15). In vascular patients, calf symptoms and alleviation of pain with simply standing had a high PLR and NLR (PLR= 3.08 and 4.85; NLR= 0.31 and 0.36). Conclusion: Only four of 14 “classic” symptom attributes are highly sensitive for ruling out LSS, and should be considered by primary care physicians before pursing expensive diagnostic imaging. Six symptom attributes should be relied upon to differentiate LSS and NLR. Numbness, pain triggered with standing alone, located in the buttock and thigh, and relieved following sitting, are symptom attributes which reliably characterize neurogenic claudication

Introduction: Patients with cerebral palsy or other neurological diseases have a high incidence of foot deformities, limiting the mobility and quality of life for these patients. We analyzed the results of surgical correction and determined the optimal treatment for the main deformities. Material and Methods: We analysed retrospectively the results of surgical correction of foot deformities. 87 Patients were treated between 1995 and 2003. We have actual data from 51 Patients (59%) with 68 feet treated. Mean follow up time is 4,25 years. We had 23 Patients with neurogenic clubfoot, 16 with flatfoot, 25 with pes equinus, 2 pes cavus and 2 hallux valgus. Of these patients 73% were able to walk before surgery. Results: For the quality of life we evaluated pain, problems while walking and problems with ulcers with a Visual Analogue Scale (0–10). Pain decreased from 4,01 to 1,58 (p< 0.001), Problems with walking improved from 6,87 to 3,31 (p< 0.001), Problems with ulcers improved from 3,79 to 1,35 (p< 0.001). Maximum walking time increased from a mean of 17 minutes to 52 minutes (p< 0.001). The level of mobility was increased in 34%. These results were the basis for the analysis of the best treatment for each deformity. For each group (neurogenic clubfoot, flatfoot and equinus) the best and poorest patients were selected and analysed. What was the diagnosis, indication for surgery, mobility and expectations of the patient before the surgery compared with the outcome. Discussion: Surgical reconstruction of neurogenic foot deformities shows very good results. Essential is a muscular balancing to achieve long lasting results. Regular physiotherapy and night orthoses can improve the outcome

Purpose: Few studies have been devoted to neurogenic paraosteoarthorpathy (PAOn). We characterised the expression of genes specific for osteoblastic and chon-drocytic phenotypes using the osteomy wedge and non-mineralised tissue near the osteotome. Material and methods: Osteotomy fragments and non-mineralised tissue near the osteotomy were obtained during surgery performed in 25 patients. The explants were cultured for 56 days. We searched for the messenger RNA of the principal markers of osteoblastic, chon-drocytic, and adipocytic phenotypes, as well as certain specific proteins. Serial cryotome sections were stained for histology and immunolabelling tests. Results: Cells issuing from the osteotomy fragment and neighbouring tissues formed structures that miner-alised in culture. The following osteoblast markers were observed: alkaline phosphatase (bone isoform), osteo-calcin, Cbfa1, type 1 collagen; for chondrocytes: type II collagen, aggrecane; type X collagen as well as VEGT demonstrating the presence of hypertrophic chondrocytes.The adipocyte-specific transcription factor PPAR 2 was also found in the two cultures. The proportions and chronological expression of these markers were slightly different for the two tissues. Ex vivo study demonstrated the typical sequence of enchondral type bony formation from non-osseous cell populations. Discussion: This work provided the first characterisation of non-mineralised tissue near osteotomy. It also provided clear indications concerning the history of ectopic bone formation. The osteochondrogenic potential of connective tissue lying close to an osteotomy has not been reported previously. The persistence of this potential could explain recurrence after resection. The observation that this potential is suppressed in vivo but expressed in vitro opens a new avenue of research concerning the mechanisms controlling bone formation. Conclusion: The culture model developed in this study provides a means of studying factors determining the outcome of cell populations implicated in the formation of neurogenic paraosteoarthropathies

Hypothesis: For Neer, humeral head ascension is caused by anterior impingement. The anatomic or ischemic factors favoring anterior impingement are well known, but have not been shown to have a determining effect. Our work on the comparative action of the rotator cuff muscles to lower the humeral head (1992), led to the conclusion that the infraspinatus muscle plays a highly dominant role. The frequent association of anterior impingement and a history of cervical pain might suggest that neurogenic paresia of the infraspinatus might be involved with the impingement effect as can be observed in intermittent paresia of the lower limbs revealing a narrow lumbar canal. Since this hypothesis was put forward, we have made converging observations in a prospective study of 200 cases. Obervations:. When patients with anterior impingement were questioned, 80 were found to have a history of cervical pain which was confirmed radiographically and/or on computed tomography (CT). Physical examination of the cervical spine revealed pain at pressure on the anterolateral aspect of the C4, C5, and C6 vertebrae, always homolateral to the impingement. Search for this sign has thus become part of our routine examination and, according to Maigne, confirms the vertebral origin of peripheral pain. We found it to be absent in anterior impingements caused by trauma in young subjects, and to be inconstant in traumatic anterior impingements observed in patients aged over 55 years. After cervical arthrodesis for cervicobrachial pain, we observed five cases of progressive anterior impingement requiring decompression. In their series of 76 cervical arthrodeses for cervicobrachialgia, Hawkins et al on observed 13 cases of proven anterior impingement. They concluded there must be a relation between these two conditions. Golg et al. provided a decisive contribution to the theory when the discovered that in anterior impingement patients, rotator cuff muscles exhibit specific histological markers of muscle denervation. Conclusion: Most cases of degenerative anterior impingement result from atrophy of the rotator cuff muscles arising because of a cervical canal syndrome

Neurogenic heterotopic ossification (NHO) is a disorder of aberrant bone formation affecting one in five patients sustaining a spinal cord injury or traumatic brain injury. Ectopic bone forms around joints in characteristic patterns, causing pain and limiting movement especially around the hip and elbow. Clinical sequelae of neurogenic heterotopic ossification include urinary tract infection, pressure injuries, pneumonia and poor hygiene, making early diagnosis and treatment clinically compelling. However, diagnosis remains difficult with more investigation needed. Our pathophysiological understanding stems from mechanisms of basic bone formation enhanced by evidence of systemic influences from circulating humor factors and perhaps neurological ones. This increasing understanding guides our implementation of current prophylaxis and treatment including the use of non-steroidal anti-inflammatory drugs, bisphosphonates, radiation therapy and surgery and, importantly, should direct future, more effective ones

The neurogenic clubfoot is composed of several deformities – such as cavus and equinus, hind foot varus, supination and adduction of the forefoot – which develop due to the neurological disease leading to muscle imbalance. Whereas over-activity and spasticity occur after damage of the central nervous system, flaccid paralysis is the result of damage of the spinal motor neuron or the nerve itself. Local overload at the lateral border of the foot, poor stability and small supporting area may interfere with function and hence require treatment of the deformity. The primary aim is a functioning foot. Treatment options are conservative means or surgical procedures. Insoles are applied to correct the foot position: a lateral support forces the foot into valgus and pronation being effective only when loaded and worn in reinforced shoes. They can also be used to distribute pressure in case of local overload and sores. An individually manufactured foot orthosis provides more stability. If the forces are still overly big, the lever arm of an ankle foot orthosis is required. Surgical procedures may be carried out in addition to or instead of conservative means. Skeletal surgery should not be performed early because the neurological disease persists despite the local correction and increases the risk for recurrences. Stiffening of the foot needs to be avoided in order to preserve function. Stiffness due to cavus is reduced by a Steindler release of the plantar fascia. Equinus should not be overstressed. If necessary, it is corrected by heel cord lengthening resulting in a persistent loss of force, or by aponeurotomy maintaining force but being less efficient to gain length. To balance supination, split or complete transfer corrects the pull of hyperactive anterior or posterior tibial muscles. Lacking skeletal deformation is a prerequisite for these soft tissue procedures. Thus their presence requires bony correction alone or in addition to soft tissue surgery. The varus of the os calcis is best corrected by an original or modified Dwyer valgus osteotomy. Cavus, supination and adduction deformity can all be corrected at the midfoot. These procedures preserve mobility and hence function of the foot. Severely contracted feet, however, may need corrective fusions. Nevertheless, stiffness is badly tolerated. An alternative is application of an external fixater of the Ilizarov type to correct the skeletal deformity and followed by an additional corrective osteotomy. Botulinum toxin A paralysing a muscle for three months can be used to switch off overactive anterior or posterior tibial muscles in order to delay surgery or to prevent pull out after transfer. Application of casts to stretch overly short muscles can help to keep the deformity under control, but they need to be followed by splints in order to avoid early recurrence

Purpose: Lumbar spinal stenosis is the most common indication for spine surgery in the elderly. XStop IPD is an attractive alternative to traditional laminectomy or laminectomy with fusion as it avoids a longer procedure and anaesthesia with significantly less blood loss. The purpose of this study is to prospectively evaluate clinical outcomes, complications and functional evaluation of symptom severity, physical function and patient satisfaction following XStop IPD procedure. Method: Preoperative and postoperative clinical data as well as SF 36, visual analog scale and Roland Morris questionnaire data collected on 16 consecutive patients over 60 years undergoing XStop IPD at L3-4 and L4-5 levels or both levels. All patients had symptomatic lumbar spine stenosis with intermittent neurogenic claudication. Evaluations were made pre-operatively and post-operatively at 3, 6, 12 and 24 months. All patients had clinical radiographic data as well as data on visual analog scale SF 36 and the Roland Morris back questionnaire. Results: Patients ages ranged from 58 to 86 years with an average age of 74.25 years. In 75 percent of patients there were two or more significant co-morbidities with 18.75 percent requiring 2 level surgery. Four of the 16 patients had lumbar degenerative scoliosis with cobb angle less than 25 degrees. 50.25% the patients had grade I spondylolisthesis. No patient had previous spine surgery. In 31.25 percent of patients there was a history of diabetes. BMI ranged from 20 to 40. Seventy five percent of patients were discharged home within 24 hours. Ninety percent of patients reported relief of their leg pain at their first follow up visit within two weeks of the surgery. There were no significant complications. One-year follow up in six patients demonstrated improvements in VAS, Roland Morris criteria and SF 36 while the remaining patients have up to nine months of follow-up clinical data. Conclusion: We present our early results of this prospective study. There were significant improvements in functional outcomes. We therefore recommend the use of XStop IPD for elderly patients with multiple co-morbidities suffering from symptomatic lumbar spine stenosis with neurogenic claudication

Purpose of the study: The rate of intra and postoperative complications is generally high after surgery for neurogenic paraosteoarthropathy, also termed hetero-topic ossification. Material and methods: We present a series of 60 cases of osteoma involving the hip joint, analyzing complications in comparison with data in the literature. Results and discussion: Vascular complications (n=7): one required suture of the common femoral artery, three ligature of the deep femoral artery, two ligature of the deep femoral vein and one ligature of the collateral branches of the deep femoral vessels. Mean intraoperative blood loss was 1300 cc. None of the vascular complications gave rise to death or amputation. Early septic complications (n=4): three occurred after simple resection of the ossification and cured after surgical revision and antibiotics with no major impact on joint motion; one occurred after a procedure for resection of the ossification plus total hip arthroplasty and led to ankylosis of the hip joint but cured after surgical revision and prolonged antibiotic therapy. Sepsis was favored by a long hemorrhagic surgical procedure in patients at risk. Neurological complications (n=0): such complications are greatly feared but rare. Posterior ossifications expose the sciatic nerve to injury but generally displacement the nerve rather than enclosing it in the osteoma. Fracture complications (n=1): the outcome was favorable, both in terms of bone healing and joint motion. A classical complication mentioned in the literature and synonym to recurrent ossification or invalidating residual stiffness. Most are favored by ankylosis, osteoporosis, immobilization and a particularly dynamic surgeon. Recurrences (n=6): all were posttraumatic with a delay from accident to surgery ≥ 18 months. Conclusion: Complications are related to the localization of the osteoma (relations with nerves and vessels), associated osteopathy, and the complete or partial joint stiffness. Preoperative imaging (x-rays and computed tomography with contrast injection) should localize the osteoma, keeping in mind that certain localizations create preferential conditions for certain risks. An analysis of the topography of the paraosteoarthropathy should enable the surgeon to choose the most appropriate approach. Intraoperatively, risk assessment can usefully anticipate complications which always compromise functional outcome

Introduction: Lumbar spinal stenosis (LSS) is a condition involving the narrowing of either the spinal canal or neural foramina and may lead to intermittent neurogenic claudication (INC). Traditionally LSS is been treated by conservative therapy followed by decompression and, if required, stabilizing of the lumbar spine for non-responders. Current results indicate that decompression may lead to increase of biomechanical stresses at levels adjacent to the operated level causing degenerative disorders. In the last years dynamic devices represent an alternative for the more invasive decompression surgery. Currently a registry is maintained to collect data on patients implanted with the X STOP. Methods: Patients who were diagnosed with LSS and planned for an implantation of the X STOP were included in the study. Diagnosis was confirmed by CT or MRI scans. Outcome was measured by the Zurich Claudication Questionnaire measuring symptom severity (SS), physical function (PF), and patient satisfaction (PS). An analysis was performed for the patient who completed the pre-operative and either the 1-year follow-up or 2-year follow-up assessment. Results: 283 patients participated in the study by completing either the questionnaires by the patient or data forms by the specialist. From these 89 patients completed the pre-operative and 1-year assessment and 20 completed the pre-operative and 2-year assessment. The results showed a clinical significant change for the domains SS and PF for both 1-year follow-up and 2-year follow-up. For the domain PS the mean score is 1.81 (very satisfied = 1, somewhat satisfied = 2). The clinically significant success rate based on clinically improvement in 2 of the 3 domains is 71.9% and 65.0 % after respectively 1-year and 2-year follow-up. Discussion: Our results suggest that intermediate term clinical outcomes of X STOP IPD surgery are stable over time although it may indicate that over time a decrease in clinical significant improvement may be observed. As INC caused by LSS is an ongoing degenerative disease, this may be explained by the ongoing degenerative process

Purpose. To observe the safety and efficacy of a minimally destructive decompressive technique without fusion in patients with lumbar stenosis secondary to degenerative spondylolisthesis. Methods. 30 patients with degenerative spondylolisthesis (DS) were consecutively managed by a single consultant spinal surgeon. All patients presented with neurogenic claudication secondary to DS. All patients were managed operatively with lumbar decompression utilising an approach technique of “spinous process osteotomy” (1). Briefly, this approach requires only unilateral muscle stripping with preservation of the interspinous ligament. A standard centrolateral decompression is then performed. Data consisting of VAS back and leg pain and ODI were collected pre and post-operatively. Results. The majority of patients were women (23) with a median age of 66 years. 29 patients had grade 1 slip and 1 patient grade 2. The index level was predominantly L4/5 (25 pts; 83%) and L3/4 in the remainder (5 pts; 17%). 5 patients were noted to have a coronal plane deformity as well as DS. 3 patients underwent 2 levels of decompression. Median length of stay was 2 days (range: 1 to 13 days). 2 patients suffered a dural tear during surgery (both with scoliosis). Of these, one required a second operation to repair a pseudomeningocele. All patients improved post op (Range: 3 months to 23 months; mean 8 months). ODI significantly improved post operatively (p < 0.05). One patient, however, developed a severe recurrence of symptoms at 3 months. Repeat imaging confirmed an increased slip and recurrent stenosis. This patient underwent re-decompression supplemented with instrumented fusion. Conclusion. The technique described above facilitates a safe method of decompression alone without fusion in patients with DS, even in patients with scoliosis. The procedure is safe, successful and easy to learn. Post-operative recovery is rapid with a short hospital stay. In spite of preserving the interspinous ligament, 1/30 patients (3 %) progressed to a greater sagittal slip requiring fusion

Introduction. The objective of the work is construction of a multi-bioactive scaffold based on that allows a space/time control over the regeneration of damaged bones by Medication-Related Osteonecrosis of the Jaw using a minimal invasive approach based on the injection of the fast-degrading pro neuro and angiogenic ELR (Elastin-Like Recombinamers) based hydrogels. Method. Chemical crosslinking facilitated the creation of multi-bioactive scaffolds using ELRs with reactive groups. Cell-loaded multi-bioactive scaffolds, prepared and incubated, underwent evaluation for adhesion, proliferation, angiogenic, and neurogenic potential. In vitro assessments utilized immunofluorescence staining and ELISA assays, while live-recorded monitoring and live-dead analysis ensured cytocompatibility. In rat and rabbit models, preformed scaffolds were subcutaneously implanted, and the regenerative process was evaluated over time. Rabbit models with MRONJ underwent traditional or percutaneous implantation, with histological evaluation following established bone histological techniques. Result. A 3D scaffold using ELR that combines various peptides with different degradation rates to guide both angiogenesis and neurogenesis has been developed. Notably, scaffolds with different degradation rates promoted distinct patterns of vascularization and innervation, facilitating integration with host tissue. This work demonstrates the potential for tailored tissue engineering, where the scaffold's bioactivities and degradation rates can control angiogenesis and neurogenesis. In an animal model of medication-related osteonecrosis of the jaw (MRONJ), the scaffold showed promising results in promoting bone regeneration in a necrotic environment, as confirmed by histological and imaging analyses. This study opens avenues for novel tissue-engineering strategies where precise control over vascularization and nerve growth is crucial. Conclusion. A groundbreaking dual approach, simultaneously targeting angiogenesis and innervation, addresses the necrotic bone in MRONJ syndrome. Vascularization and nerve formation play pivotal roles in driving reparative elements for bone regeneration. The scaffold achieves effective time/space control over necrotic bone regeneration. The authors are grateful for funding from the Spanish Government (PID2020-118669RA-I00)

We sought to determine the short to medium-term clinical and radiographic outcomes using a short stem in young adults with a proximal femoral deformity (PFD). We prospectively studied 31 patients (35 hips) with PFDs treated with an uncemented primary THA using a short stem with cervicometaphyseal fixation between 2011–2018. There were 19 male (23 hips) and 12 female (12 hips) patients, with a mean BMI of 26.7±4.1 kg/m. 2. Twelve cases had a previous surgical procedure, and six of them were failed childhood osteotomies. Mean age of the series was 44±12 years, mean follow-up was 81±27 months and no patients were lost to follow-up. PFDs were categorized according to a modified Berry´s classification. Average preoperative leg-length discrepancy (LLD) was −16.3 mm (−50 to 2). At a mean time of 81 months of follow-up, survival rate was 97% taking revision of the stem for any reason and 100% for aseptic loosening as endpoints. No additional femoral osteotomy was required in any case. Average surgical time was 66 minutes (45 to 100). There was a significant improvement in the mHHS score when comparing preoperative and postoperative values (47.3±10.6 vs. 92.3±3.7, p=0.0001). Postoperative LLD was in average 1 mm (−9 to 18) (p=0.0001). According to Engh's criteria, all stems were classified as stable without signs of loosening. Postoperative complications included 1 pulmonary embolism, 1 neurogenic sciatic pain, 1 transient sciatic nerve palsy that recovered completely after six months, and 2 acute periprosthetic joint infections. One patient suffered a Vancouver B2 periprosthetic femoral fracture 45 days after surgery and was revised with a modular distally fixed uncemented fluted stem. A type 2B short stem evidenced promising outcomes at short to medium-term follow up in young adult patients with PFDs, avoiding the need for corrective osteotomies and a revision stem

In spite of preventive treatment, particularly in young paraplegics with transverse lesions above T9, a high rate of neurogenic scoliosis must be expected. Due to the loss of sitting balance in the wheelchair, to increased risks of pressure sores, and to progressive restriction to the patient’s ventilatory function, surgical intervention often becomes necessary. A surgical method for successful application in SCI patients should meet specific demands:. High primary stability: External immobilisation in braces or casts would pose problems, long-lasting bed rest must be avoided and no muscular support is possible. Conversely, the instrumentation must resist against often very strong spinal spasticity. High corrective capacity in all planes: Wheelchair dependent patients have fewer facilities for compensation of a remaining spinal deformity than ambulating patients. In sub-optimal correction, the sacrum has to be included into the fusion more frequently, with serious impact on the patient’s independence in ADL. Avoidance of precedent procedures for anterior release: The ventilatory function in patients with mainly high thoracic or cervical transverse lesions is already impaired, let alone the effect of the scoliosis. Additional impacts by thoracotomy should be avoided if possible. The same aspect should also be considered, looking at the following. Posterior procedure: Because neurogenic scoliosis deformities usually need long instrumentations, exclusively anterior procedures can rarely be used. Compared with the combination of anterior (e.g. thoracic VDS) procedures together with a posterior method, a purely posterior procedure would be beneficial, as long as it can achieve equal correction. Since 1991 the author has worked on a concept using pedicle screws as cantilevers for 3-D correction, de-rotation being the core manoeuvre. The evolutive development of suitable, outrigged instruments for the reduction has now been finalised, allowing the presentation of the method. Although more than 20 cases have demonstrated the method’s superior potential in 3-D correction of the deformity, and although the primary stability provided by the method meets the requirements of this patient group, neurogenic scoliosis in para- and tetraplegics still poses inherent problems:. • Insertion of pedicle screws in scoliosis is difficult, at least in the upper thoracic region. It will take time before sufficiently accurate and available modern navigation systems can resolve this. • Once the lumbosacral junction is included in the fusion, negative impacts on the patient’s ADL, as well as on the fusion rate, must be anticipated. In conclusion, a promising and effective method for surgical correction of neurogenic scoliosis is available. The use of this method will become easier by further developments in computer assisted surgery. Having a tool at hand, which, by it’s corrective abilities, allows the sparing of the lumbosacral junction from fusion, as long as pelvic obliquity is not fixed, the detection of initial fixation by thorough follow up of the patients at risk becomes paramount

Perioperative pain involves both neurogenic and inflammatory mediators. The neurogenic component is produced by the intense stimulation of the surgical procedure itself. However, inflammatory mediators resulting from tissue damage and the release of certain cytokines provoke the inflammatory response. Both the neurogenic and inflammatory elements create central nervous system (CNS) excitability. While conventional pain management responds to pain as it occurs, rather than anticipating it, a more appropriate protocol may involve pre-emptive administration of analgesic medication. By beginning this administration prior to surgery and continuing it throughout the rehabilitation process, CNS pharmacological agents are utilised to achieve the following goals: 1.) decrease the neurogenic component at the wound site; 2.) depress afferent pathways; and 3.) decrease central sensitisation in the spinal column. Our experience with such pre-emptive analgesic clinical trials have included implementation of three different protocols in three groups of patients, Groups A-C. In Group A, a continuous epidural for 72-hours was utilised. A short-term epidural for 2–3 hours, followed by the use of scheduled opioid drugs and the use of anti-inflammatory medications, was used in Group B. Finally, Group C included spinal analgesia with shortacting morphine and the continued use of patient-controlled analgesia (PCA) pumps. In all groups, patients were monitored for the return of motor function, respiratory depression, ileus, pain relief, efficacy in analgesia maintenance, and cost. The following trends were observed among the variances: 1.) approximately equal length of stay in all three groups; 2.) decreased motor function in the continuous epidural group (Group A); 3.) increased ileus in the spinal group (Group C); 4.) equal pain relief in all three groups; 5.) high maintenance in the continuous epidural group (Group A); and 6.) decreased cost when continuous epidurals (Group B) were utilised. In conclusion, of the three methodologies implemented, the continuous epidural had a high failure rate (26%). While spinal analgesia is technically easier and less expensive to perform, it has a poorly defined dose response curve and is associated with an increased incidence of ileus. The scheduled opioid medications proved effective. Pre-emptive analgesia not only significantly suppresses pain, it also provides protective sensation. Our recommendation for pre-emptive pain management consists of the use of multi-modal analgesics attacking various sites along the pain pathway, including regional blocks, oral and parental opioids, topical anaesthetics, and ice. However, ongoing study is required to further delineate appropriate protocol, thorough assessment of consequences, and complications associated with all methodologies. Future protocols to be evaluated at this practice include the local injection of bupivacaine hydrochloride prior to wound closure, in addition to assessing the postoperative integration of rofecoxib into the pain management regime

Objective: The purpose of this study was to determine the safety and efficacy and evaluate several radiographic parameters after implantation of coflex™ for the primary diagnosis of spinal stenosis (1 or 2 levels) in patients with neurogenic claudication and low back pain between the ages of 40 and 80 years old. Methods: Retrospective data were gathered on 589 patients from 5 sites with 429 patients having contemporaneous clinical and radiographic follow-up. Clinical analysis was performed on 209 patients with spinal stenosis using VAS and objective examination measures to determine safety and efficacy of the coflex in relieving neurogenic claudication, radiculopathy and back pain. The median follow-up was 20 months (range 6 to 121 months) For the 209 patients, radiographic data was collected for evaluation of spinal segment motion (index and adjacent levels), implant position, migration and bony remodeling at the bone-implant interface. All device complications were recorded and independently reviewed by Medical Metrics, Inc. (Houston, TX) and an independent orthopaedic spinal surgeon (KP). Results: Moderate to severe low back pain improved in 75% of patients, while leg pain improved in 88% of patients. Claudication improved in 91% of patients and improvement in walking distance occurred in 79% of the patients. These results were achieved at 1 year and did not deteriorate over the long-term. Patient satisfaction was 88%. Complete radiographs with excellent quality were available for 180 implanted coflex devices. Sagittal rotation and translation measurements were essentially the same for all diagnoses, follow-up time points and levels of implantation. No expulsions and only 1 migration (> 5 mm) was observed. Mild and moderate bone-implant interface remodeling was noted in 15.4 %. No broken or permanently deformed implants were noted. Conclusions: coflex interspinous stabilization after microsurgical decompression for spinal stenosis demonstrates excellent short term and long term results for back pain, neurogenic claudication and patient satisfaction

Background. Neurogenic claudication is a well recognised symptom of spinal stenosis. Pain in the lower limbs and back limit walking speed and distance. Outcome of treatment should be easily measurable, but in practice is not. Walking tests are difficult to perform reliably. It is possible to measure speed and endurance with a treadmill, but this is expensive, of doubtful reliability, and many elderly patients are reasonably worried about falling off. Commonly used back pain outcome questionnaires are probably invalid for this population, and few questionnaires have been designed specifically for this complaint. The purpose of this study was to evaluate 3 questionnaires (Swiss Spinal Stenosis Score (SSS), Oxford Claudication Score (OCS) and Oswestry Disability Index (ODI)) and a Shuttle Walking Test (SWT). The Shuttle Walking Test, developed originally in respiratory medicine, shows promise as both a clinical measure and outcome measure for patients with neurogenic claudication. In an internal study, we have found that none of our patients selected for surgery can manage more than 200 metres. A fit adult can usually manage about 600 metres on this test. Study Design: Shuttle Walking Test (SWT), Swiss Spinal Stenosis Score (SSS), Oxford Claudication Score (OCS) and Oswestry Disability Index (ODI) were administered to patients with lumbar spinal stenosis (LSS) and neurogenic claudication. Objective: To determine reliability of SWT, SSS (Q1–12), OCS and ODI in LSS assessment. Methods: Thirty two clinic patients with LSS were assessed twice with one week between assessments to determine reliability. Retrospective data from 17 patients assessed before and 18 months after surgery for LSS were used to investigate use of reliability in a clinical setting. Results: Test-retest reliability was 0.92 for SWT, 0.92 for SSS, 0.83 for OCS and 0.89 for ODI (Intraclass correlation coefficient). Mean scores (percent) were SSS 51, OCS 45 and ODI 40. For 95% certainty of change between assessments for a single patient, SSS would need to change by 15, OCS by 20 and ODI by 16. Mean SWT was 150m, with change of 76m required for 95% confidence. Cronbach’s alpha was 0.91 for SSS, 0.90 for OCS and 0.89 for ODI. Change in ODI correlated most strongly with patient satisfaction after surgery (_=0.80, p< 0.001). Conclusions: Fluctuations in patient’s symptoms result in wide individual confidence intervals. Performance of SSS, OCS and ODI questionnaires are broadly similar. The condition specific SSS is most precise but not much better than the non-specific ODI. SWT gives a snapshot of physical function which is acceptable for group analysis. Use of SWT for individual assessment after surgery is feasible but multiple testing would improve sensitivity for change

Heterotopic ossification (HO) is perhaps the single most significant obstacle to independence, functional mobility, and return to duty for combat-injured veterans of Operation Enduring Freedom and Operation Iraqi Freedom. Recent research into the cause(s) of HO has been driven by a markedly higher prevalence seen in these wounded warriors than encountered in previous wars or following civilian trauma. To that end, research in both civilian and military laboratories continues to shed light onto the complex mechanisms behind HO formation, including systemic and wound specific factors, cell lineage, and neurogenic inflammation. Of particular interest, non-invasive in vivo testing using Raman spectroscopy may become a feasible modality for early detection, and a wound-specific model designed to detect the early gene transcript signatures associated with HO is being tested. Through a combined effort, the goals of early detection, risk stratification, and development of novel systemic and local prophylaxis may soon be attainable.

Patients with neurogenic claudication from lumbar canal stenosis non-responsive to non-surgical treatment are usually managed with spinal decompression with or without fusion. Flexion at stenotic segments relieves symptoms by increasing canal cross-sectional area, intervertebral foraminal height. Interspinous spacers work by causing flexion at the treated segement. We used COFLEX¯ [Paradigm Spine] a titanium interspinous spacer along with interlaminar decompression where indicated. To compare the clinical and radiological results of patients undergoing interlaminar decompression with or without use of COFLEX¯. Pre and post-operative assessment and comparison of clinical outcomes of Oswestry disability index(ODI), Visual analog Scale(VAS), Short Form-36(SF-36) and radiological outcomes of disc heights of operated and adjacent levels, intervertebral foraminal heights, sagittal angles of the operated segment. All consecutive patients undergoing spinal decompression at one or more levels from Jan to Dec 2008 were included. Patients with clinically symptomatic back pain for a duration longer than claudication pain were offered interspinous spacer at L4/5 level or above. In first group(n-20), patients were treated with inter-laminar decompression and COFLEX¯ with a standard posterior approach. In second group(n-25) inter-laminar decompression for the involved segment was performed. All patients are on follow-up. Clinical and radiological outcomes were compared at 6 months and 1 year. Statistically significant(p<0.001) improvements in ODI, VAS(back), VAS(leg) and SF-36 in patients in whom COFLEX¯ was used. Radiological parameters also showed significant improvements(p<0.05). Use of COFLEX¯ spacer is justified in patients with symptomatic disc degeneration with neurogenic claudication when treated operatively