Increased intensity of therapy for osteosarcoma in the last 30 years has improved prognosis. 70–80% of patients with non metastatic osteosarcoma can now be cured, but late side effects occur. Fertility of survivors is becoming of greater importance. We retrospectively studied all consecutive female long term survivors of localized osteogenic sarcoma of childhood and adolescence treated at the Schneider Children‘s Medical Center of Israel. Patients were treated with 3 different protocols including the use of Methotrexate, Adriamycin, Cisplatin, Bleomycin, Cytoxan, Vincristine, Actinomycin D, Melphalan and Ifosfamide. Sixteen female survivors of non metastatic osteogenic sarcoma were treated from 1/1977 to 12/2001, with a minimum follow up of 6.3 years (max. 29 years) from the end of therapy. Median age at diagnosis was 11.7 (range 9.0–16.8) years. Twelve out of 16 (75%) are married and have between them 31 children, mean 2.7 (range 1–7) children. Of these 11 have children and one is currently pregnant with her first child. None of the females reported difficulties in conceiving their first child. The maximum interval from marriage to first delivery was 2.5 years. Two females had 3 spontaneous abortions between the 2nd–4th pregnancies. Four out of 9 female survivors who received > 360mg/m2 of adriamycin were treated with cardiomimetic drugs and/or ACE inhibitors during pregnancy. All four had 2–4 children/ female survivor. The children of survivors are healthy with no birth defects. Mean length of pregnancy was 38.6 weeks and mean birth weight was 2865 grams. No survivors had undergone invasive fertility preservation procedure and only one unmarried patient was using GnRH analogs. Despite reports of transient disturbances in menstruation, all married females were fertile. Our results question the need for fertility preservation using GnRH analogs or invasive procedures such as ovary or egg preservation for non metastatic osteogenic sarcoma female patients

Aims. The number of females within the speciality of trauma and orthopaedics (T&O) is increasing. The aim of this study was to identify: 1) current attitudes and behaviours of UK female T&O surgeons towards pregnancy; 2) any barriers faced towards pregnancy with a career in T&O surgery; and 3) areas for improvement. Methods. This is a cross-sectional study using an anonymous 13-section web-based survey distributed to female-identifying T&O trainees, speciality and associate specialist surgeons (SASs) and locally employed doctors (LEDs), fellows, and consultants in the UK. Demographic data was collected as well as closed and open questions with adaptive answering relating to attitudes towards childbearing and experiences of fertility and complications associated with pregnancy. A descriptive data analysis was carried out. Results. A total of 226 UK female T&O surgeons completed the survey. All regions of the UK were represented. Overall, 99/226 (44%) of respondents had at least one child, while 21/226 (9.3%) did not want children. Median age at first child was 33 years (interquartile range 32 to 36). Two-thirds (149/226; 66%) of respondents delayed childbearing due to a career in T&O and 140/226 (69%) of respondents had experienced bias from colleagues directed at female T&O surgeons having children during training. Nearly 24/121 (20%) of respondents required fertility assistance, 35/121 (28.9%) had experienced a miscarriage, and 53/121 (43.8%) had experienced obstetric complications. Conclusion. A large proportion of female T&O surgeons have and want children. T&O surgeons in the UK delay childbearing, have experienced bias and have high rates of infertility and obstetric complications. The information from this study will support female T&O surgeons with decision making and assist employers with workforce planning. Further steps are necessary in order to support female T&O surgeons having families. Cite this article: Bone Jt Open 2023;4(12):970–979

Rationale: Osteosarcoma predominantly affects adolescents and young adults. Reduced fertility in men is well documented following treatment for osteosarcoma and related to chemotoxicity. We have however not found data about the health of children of patients formerly treated for osteosarcoma. Among our few patients we have had one offspring with an infantile fibrosarcoma successfully treated with high dose chemotherapy and surgery. One mother has secondary gastric malignancy after successful pregnancy. With this contribution we want to draw the attention to include data of children in the long-term implications of osteosarcoma and its treatment. Materials and Methods: Patients: Of 75 patients with osteosarcoma 11 patients (5 women, 6 men) have 16 children‚ produced’ after completed oncologic treatment. All women became pregnant as planned. There are no female patients evidently infertile. One man among our patients shows azoospermia and is infertile. One man with oliogespermia has a healthy daughter after successful vitro fertilisation. All patients have had treatment for osteosarcoma after puberty. Offsprings: Pregnancy and delivery were uneventful for all children. The one girl mentioned above at birth showed a tumor of the Plexus brachialis which was a biopsy proven infantile fibrosarcoma. She received high dose chemotherapy. Resection of the tumor retaining the brachial at 9 months of age showed only scarce tumor residuals; she is disease free at 4 years of age. Her two siblings are healthy. Conclusion: We want to stress that in follow up studies events during pregnancy and health of offsprings should be included

Background: One stop shoulder clinic was established in the North Tees University Hospital as part of conjoint effort between the department of trauma and orthopaedics and radiology in the year 2005. A consultant shoulder surgeon, consultant radiologist, extended scope shoulder physiotherapist and shoulder nurse practitioners run the clinic on weekly basis. The aims are:. Immediate and more accurate diagnosis and plan accordingly. Avoid unnecessary or inappropriate treatment while waiting for radiological test. High patient satisfaction. Reduce waiting time for definitive treatment. Reduce number of patients’ visits. Improve and advance clinical and radiological skills. Reduce the cost to the NHS. Promote a multi-disciplinary approach to patient healthcare. Methods and materials: A retrospective study of 150 patients who had been seen in the one stop shoulder clinic and conventional clinic. We studied the number of hospital visits, the waiting time for final intervention and or discharge, the accuracy of initial diagnosis and treatment and the cost-benefit analysis. Results and discussions: One-stop clinics have been successfully established in a few fields of medicine. One stop breast lump clinic has been running for almost 10 years with a very good reputation of rapid, accurate and cost-effective diagnosis of breast lumps. Similar successful examples have been emerged in gynaecology such as fertility clinic and uterine bleeding clinic; and in urology such as haematuria clinic. To our best knowledge, this is the first study that investigated the one-stop clinic in shoulder problems. Our results showed similar trend of success in term of reduction of patients’ hospital visits, waiting time to treatment and accuracy of the diagnosis. We also conducted a cost-benefit analysis of the one stop shoulder clinic in comparison with the conventional shoulder clinic and we concluded that it is cost effectiveness

Aims

The purpose of this survey study was to examine the demographic and lifestyle factors of women currently in orthopaedic surgery.

Aims

Periprosthetic proximal femoral fractures (PFFs) are a major complication after total hip arthroplasty (THA). Health status after PFF is not specifically investigated. The aim of this study is to evaluate the health status pattern over two years after sustaining a PFF.

Prolonged survival have been reached in the last two decades in patients with Ewing’s sarcoma due to combination of chemotherapy and radiotherapy. We report the analysis of 493 patients treated according to 4 different protocols in 23 years (Jan1983- Dec 2006).Aim of this study was to evaluate the occurrence of late toxicities as Second Malignant Neoplasms (SMN), Cardiomyopathies and sterility. Methods: We reviewed our database to find out all those patients aged from 1 to 40 yrs with localized Ewing’s sarcoma who were treated with chemotherapy according to 4 different protocols from 1983 to December 2006. Data were updated at Dec 2008. Results: 493 patients had adequate follow up and meet the eligibility criteria. Median age was 16 yrs (1–40) female/male: 183/310.Median overall survival 69 ms (4–302).220 patients died and 273 are alive. 44 pts received HDCT + PBSCR.Eleven SMN were found : 2 AMLeukemia, 2 parotid adenocarcinoma, 1 melanoma, 1 thyroid cancer and 5 radioinduced osteosarcoma. The interval between Ewing’s sarcoma diagnosis and leukaemia diagnosis was shorter then interval between Ewing’s sarcoma and RT osteosarcoma. Six patients reported a Cardiomyopathy : in 4 cases it was mild and pts are well compensated,2 patients needed heart transplant,. One of these two pts received also a kidney transplant due to chronic renal failure due to previous chemotherapy. Fertility: 17 women became pregnant after chemotherapy, 20 women experienced postTx amenorrea: 7 pts received RT in pelvic area, 9 did HDCT, 3 pts were over 30 yrs old. 9 male became father. 8 male patients did sperm analysis 3 azospermia, 4 oligospermia and 1 normal sperm count. No congenital abnormalities in offsprings were reported. Conclusions: In this casuistic the Cumulative Risk to have a SMN at 5 yrs is 1.8% and 2.9% at 10 yr. The SMN cumulative incidence in Ewing’s sarcoma seems to be lower then in our previous casistic in osteosarcoma patients (ASCO 2006)

Purpose: Physeal distraction can be used for the treatment of the consequences of epiphysiodesis bridges, correcting simultaneously angular deformations and length discrepancy. Material and methods: Chondrodiastasis was performed in six children aged 13.1 years (range 10.4–15.7). The cause of the epiphysiodesis was trauma in three children (2 distal tibia, 1 distal radius), osteomyelitis in two (distal femur), and surgical sequela of a clubfoot (distal tibia). Mean follow-up was two years (18 months – 4 years). An Ilizarov device was used in four cases and an Orthofix in two. Results: Limb length discrepancy was corrected in all cases. Angular correction was insufficient in two. Distraction was continued for four months (1–9) and total duration of treatment was 7.5 months (4–13). Minor complications were pin track infection (n=2) and joint stiffness (n=3). Major complications were one fracture of the femur on a pin site and premature closure of the growth cartilage treated by callotasis and one fracture after removal of the external fixator, treated by plaster cast immobilisation. The final outcome was good in both of these children. Discussion: De-epiphysiodesis with surgical resection of the bony bridge can only be performed before a certain age (10–11 years) and the outcome in uncertain. The principle advantages of physeal distraction applied for angular deformation in growing patients is that it avoids the need for osteotomy and allows progressive correction. This noninvasive method allows angular correction in the upright patient, concomitant lengthening is also achieved. Chondrodiastasis makes an exact correction of the deformation without resection of the bony bride which can be ruptured by simple distraction. The fertility of the growth cartilage after distraction must be considered as lost so the amount of correction must be calculated on the basis of a complete and definitive postoperative epiphysiodesis. Conclusion: Chondrodiastasis allows correction of acquired and predictable epiphysiodesis bridges at the apex of the deformation and without direct access. This method can be used for partial epiphysiodesis (less than 50%) in children who have not reached maturity. After distraction, the growth cartilage must be considered as definitively closed

As our understanding of hip function and disease improves, it is evident that the acetabular fossa has received little attention, despite it comprising over half of the acetabulum’s surface area and showing the first signs of degeneration. The fossa’s function is expected to be more than augmenting static stability with the ligamentum teres and being a templating landmark in arthroplasty. Indeed, the fossa, which is almost mature at 16 weeks of intrauterine development, plays a key role in hip development, enabling its nutrition through vascularization and synovial fluid, as well as the influx of chondrogenic stem/progenitor cells that build articular cartilage. The pulvinar, a fibrofatty tissue in the fossa, has the same developmental origin as the synovium and articular cartilage and is a biologically active area. Its unique anatomy allows for homogeneous distribution of the axial loads into the joint. It is composed of intra-articular adipose tissue (IAAT), which has adipocytes, fibroblasts, leucocytes, and abundant mast cells, which participate in the inflammatory cascade after an insult to the joint. Hence, the fossa and pulvinar should be considered in decision-making and surgical outcomes in hip preservation surgery, not only for their size, shape, and extent, but also for their biological capacity as a source of cytokines, immune cells, and chondrogenic stem cells.

Cite this article: Bone Joint Res 2020;9(12):857–869.