Abstract. Cemented total hip arthroplasty (THA) in the younger patient has historically been associated with higher wear and revision rates. We carried out a retrospective study of a prospectively collected database of patients at Wrightington hospital undergoing cemented THA under 55 years of age to determine acetabular wear and revision rates. Between August 2005 and December 2021 a cohort of 110 patients, 56 males and 54 females, underwent Cemented Total Hip Replacement through a posterior approach. Mean age at operation was 50yrs (35–55). The mean follow up was 6 years 9 months (0–16 years). 3 patients were lost to follow-up. Of the remaining 107 patients, Conventional and cross lined polyethylene were used in 54 and 53 patients respectively. Ceramic heads were used in 102 patients. 22.225mm and 28mm heads were used in 60 and 47 patients respectively. Clinical outcomes were assessed by Merle d'Aubigne and Postel scores which showed significant functional improvement. Linear wear was measured on plain radiographs using TRAUMA CAD and cup loosening was assessed by classification of Hodgkinson et al. No cases were revised during the observed follow up period. The mean wear rate in conventional and crosslinked polyethylene cups were 2.31mm (0.1–4.6) and 1.02mm (0.1–2.6) respectively. Cemented THA with both conventional and crosslinked polyethylene provides excellent survival rates in adults under the age of 55 years and crosslinked polyethylene may further improve these results due to improved wear rates

Studies have shown that 10–30% patients do not achieve optimal function outcomes after total hip replacement (THR). High quality randomised controlled trials (RCTs) evaluating the clinical and cost-effectiveness of techniques to improve functional outcomes after THR are lacking. We performed this study to evaluate the feasibility of a RCT comparing patient-reported functional outcomes after hybrid or fully cemented THR (ISRCTN11097021).

Patients were recruited from two centres and randomised to receive either a fully cemented or hybrid THR. Data collection included Patient Reported Outcome Measures (PROMs), non-serious adverse events of special interest (AESI), serious adverse device effects (SADE) and NHS resource use. Qualitative interviews were undertaken to understand a) patient experiences of study processes and their reasons for taking part or not, and b) to understand surgeons’ perceptions of the study, factors affecting willingness to participate, and barriers to implementation of the future RCT findings.

The target of 40 patients were successfully recruited for the feasibility RCT; the ratio of successful recruitment to eligible patients was 0.61 across both sites. Treatment crossovers occurred in four patients, all related to bone quality. Four patients were withdrawn due to not undergoing surgery within the study window because of the pandemic. Follow-up was 100% and PROMs were completed by all patients at all time points. The feasibility of conducting a within-trial cost-utility analysis was demonstrated. Interviews were conducted with 27 patients and 16 surgeons. Patients and surgeons generally found the study procedures acceptable and workable. Some declined participation because they did not want treatment allocated at random, or because blinding was off-putting. Surgeons’ perceptions of equipoise varied, and implementation of findings from the future RCT would need to recognise the ‘craft’ nature of surgery and the issue of training.

We conclude that a full RCT with economic analysis will be both feasible and practicable, although mechanisms to safely implement potential changes to practice because of RCT findings may need consideration by the wider arthroplasty community.

In this RCT the primary aim was to assess whether a short (125mm) Exeter V40 stem offered an equivalent hip specific function compared to the standard (150mm) stem when used for cemented total hip arthroplasty (THA). Secondary aims were to evaluate health-related quality of life (HRQoL), patient satisfaction, stem height and alignment, radiographic loosening, and complications between the two stems.

A prospective multicentre double-blind randomised control trial was conducted. During a 15-month period, 220 patients undergoing THA were randomised to either a standard (n=110) or short (n=110) stem Exeter. There were no significant (p≥0.065) differences in preoperative variables between the groups. Functional outcomes and radiographic assessment were undertaken at 1- and 2-years.

There were no differences (p=0.428) in hip specific function according to the Oxford hip score at 1-year (primary endpoint) or at 2-years (p=0.767) between the groups. The short stem group had greater varus angulation (0.9 degrees, p=0.003) when compared to the standard group and were more likely (odds ratio 2.42, p=0.002) to have varus stem alignment beyond one standard deviation from the mean. There were no significant (p≥0.083) differences in the Forgotten joint scores, EuroQol-5-Dimension, EuroQol-VAS, Short form 12, patient satisfaction, complications, stem height or radiolucent zones at 1 or 2-years between the groups.

The Exeter short stem offers equivalent hip specific function, HRQoL, patient satisfaction, and limb length when compared to the standard stem at 2-years post-operation. However, the short stem was associated with a greater rate of varus malalignment which may influence future implant survival.

Controversy persists over whether cemented or uncemented fixation is more effective in reducing revision and mortality risks following primary total hip arthroplasty (THA). Despite a shift towards uncemented THA in Europe, Australia, and the US, no consensus exists on superior outcomes. This ambiguity in evidence from randomized controlled trials (RCTs) and observational studies necessitates advanced research methodologies to derive more definitive conclusions.

This study investigates the causal impact of THA fixation type on 2-year and 5-year revision rates, along with 90-day mortality, utilizing a regression discontinuity (RD) design in scenarios where fixation choice is guided by patient age.

Employing data from the Dutch Arthroplasty Register, we conducted a cohort study on primary THAs for osteoarthritis from 2007 to 2019. A “fuzzy” RD design was executed to compute the Local Average Treatment Effect for subjects around the age-based selection threshold for fixation type. The main outcome of interest was the revision rate at 2 years post-operation.

Analysis for the 2-year revision endpoint, covering any cause, included 2,344 females and 1,671 males across 5 hospitals each, with no significant variation in revision rates observed. For the 5-year mark, 1,058 females in 3 hospitals and 214 males in 1 hospital were examined, similarly showing no significant differences. Mortality within 90 days post-operation was also investigated in 5 female and 7 male cohorts, with 2,180 and 2,145 surgeries respectively, yielding no substantial disparities.

In conclusion, the RD analysis revealed no notable differences in revision rates at 2 and 5 years or in early mortality based on the fixation method used in THA. These outcomes suggest that the age-based preference for THA fixation may not influence the revision or mortality risk, underscoring the value of RD design in deriving causal insights from observational data.

Occlusion of the femoral canal is an important step in cemented hip arthroplasty. The goal of occlusion is to allow cement pressurisation and prevent cement egress into the femoral diaphysis. There are numerous designs of cement plugs made out of different materials but there is no consensus or clinical guideline for the choice of cement restrictors. At our centre two types of plugs are used – autologous bone block from femoral canal and the gelatine C-plug (Depuy International). We conducted this study to evaluate the stability of these two plugs and their effect on quality of cementation.

The purpose of our study was to assess retrospectively both the length of the “cement tail” i.e. the length of the cement column distal to the stem tip and the cement mantle quality in both groups.

A retrospective comparative review was designed after approval from the local R & D department. Power analysis indicated that a minimum of 74 patients per group would be needed. A total of 203 consecutive patients were analysed, 89 received an autologous bone block and 114 had C-plugs. Apart from the plugs both the groups were treated similarly with regards to surgical approach, cementing and operative technique. Surgical technique was to achieve adequate pressurisation and a minimum length of cement tail.

Immediate post-operative radiographs were used for analysis. The primary outcome measure was the length of the cement tail, i.e. the length of the cement column from the tip of the stem. The secondary outcome measure was the quality of cementing which was quantified using Barrack's grading.

The data was tested for normality using the Shapiro-Wilk test. The means of cement tail lengths in between the two groups were compared using the Wilcoxon ranked sum test. The cementation grades were compared using ANOVA. The correlation between the length of cement tail and the quality of cementation was calculated using ordinal regression.

Both the groups were similar in terms of age, sex and primary diagnosis. The mean cement tail length was 6.42 (SE 0.71 mms; range-0–31) in the bone block group and 17.11 (SE-1.34 mms; range 0–65.7 mms) in the C-plug group. This difference was statistically significant (p< 0.0001). The proportion of patients with good quality of cementation (grade A) was significantly higher in the bone block group (80.6%) as compared to the C-plug group (56%) (p < 0.0001). There was a negative correlation between the length of the cement tail and the Barrack grade (rho=0.398), indicating that a short cement tail is associated with better quality cementation.

Quality of cementation is of paramount importance in cemented hip arthroplasty. Revision surgery can be more difficult and higher risk in the presence of a long cement tail. We have shown that better quality cementation and shorter cement tails can be achieved with the cheapest of all options for canal occlusion, an autologous bone block and recommend its use.

Purpose

It is generally accepted that the cement mantle surrounding the femoral component of a cemented total hip arthroplasty (THA) should be complete without any defects, and of at least 2 mm in thickness. Radiographic evaluation is the basis for assessment of the cement mantle. The adequacy of radiographic interpretation is subject to debate. Poor interobserver and intraobserver reproducibility of radiographic cement mantle assessment has been reported. In this study, 3D template software was used that allow anatomical measurements and analysis of three-dimensional digital femura geometry based on CT scans. The purpose of this study is to analyze the three-dimensional cement mantle thickness of cemented hip stem.

Introduction: Aseptic loosening is the commonest complication of cemented total hip arthroplasy. Gaseous voids within the cement mantle are thought to act as stress concentrators and points of origin and preferential fracture propagation at the cement stem interface. Assuming a bone tempereature of 37°C, Bishop recommended heating the prosthesis to 44°C, thereby effecting a reduction in cement-prosthesis interface porosity.

The aim of this study was to (I) determine the intra-operative temperature of the femoral cancellous bed prior to insertion of prosthesis, (II) to investigate whether the magnitude of the temperature gradient effects interface porosity (III) to develop clinically relevant recommendations.

Materials and Methods: (I) The intra-operative determination of femoral cancellous boney bed temperature. Sterile, single use thermocouples (Mon-a-therm) were used to record interface temperature in six patients, after canal preparation and lavage. (II) A simulated femoral model was designed consisting of a waterbath, set at temperature determined by (I) with an inner water-tight chamber formed by 19mm diameter polyethylene tubing. Cement (Palacos) was non-vacuum mixed (to exaggerate porosity) for 1 minute and injected in a retrograde manner into the inner tube at 3 minutes. Femoral stems (Exeter) were pre-heated in a second waterbath to 18, 32,35,37,40,44°C, were thoroughly dried and lowered into the inner tube by a Lloyd universal testing machine via a custom jig. The cement was left to polymerise.

The cement mantle was sectioned transversely, then longitudinally to expose the cement-prosthesis interface. This was stained with acrylic dye to facilitate image analysis. Three mantles for each temperature were produced.

Results: (I) The mean femoral canal temperature was 32.3°C, (II) the effect of stem temperature on interface porosity is shown in fig1.

Conclusions: Bone temperature is 32°C after canal preparation using contemporary cementing techniques. Heating to 35°C reduces interface porosity, heating to 40°C is optimal.

Introduction Considerable advances have been made in improving cementing techniques in total hip replacement. Recently, the increasing need to minimize healthcare costs has led to the development of methods to reduce surgical time. It has been proposed that the curing time for bone cement can be markedly reduced by preheating the femoral component before insertion. A reduction of the period between insertion of the implant and ultimate curing decreases operative time, bleeding into the bone-cement interface and the likelihood of accidental loss of position. In a previous in-vitro study, preheating the femoral component to a temperature of about 50° resulted in a reduction in the bone cement curing time of approximately 50%. No adverse changes of the mechanical properties of cement were found. E-modulus, fracture toughness and fatigue strength were unaffected by increased temperature. A uniform trend of decreasing porosity of bone cement with increased temperature of the implant was also observed. To-date, there have been no reports on the in-vivo outcome of the preheating cementing technique. The aim of this prospective study was to assess the clinical and radiological five year follow-up results of the preheating cementing technique used for the fixation of the femoral stem (Lubinus, Link, Germany).

Methods One hundred consecutive patients (100 hips) with osteoarthritis and an average age of 72 years (range 65 to 85) have been operated on by one surgeon in a single institution. In a cohort of 50 hips a conventional cementing technique was used. The cement used was Cemex (Tecres, Italy). The anterior-posterior and lateral radiographs have been evaluated with a computer-aided system. The quality of cement mantle was assessed on the radiographs according to the A-B-C1-C2-D classification.

Results The curing time of the bone cement was markedly reduced (average five minutes, range four to seven minutes) by preheating the femoral component (40° to 50°). The estimated reduction of intra-operative blood loss was 75 ml (range 45 to 130). The mean Harris Hip Score was 94.8 points at follow-up (range 79 to 100). The clinical status of 92% of hips was rated good or excellent, eight percent was rated fair. A satisfactory cementing technique was obtained in 96% of hips. Small voids in the cement mantle (grade C1) were present in four percent of hips. Non-progressive radiolucent lines at the bone-cement interface were observed at Gruen zone one in four hips, at zone eight in three hips and at zone 14 in three hips. No signs of osteolysis were observed at follow-up, all stems were rated radiologically stable.

Conclusion A reduction in curing time of bone cement provides a significant time saving without compromising implant performance. We recommend preheating of femoral components to surgeons experienced in joint replacement and have a skilled surgical team, because of the potential risk of premature polymerization before complete seating of the implant.

In relation to the conduct of this study, one or more of the authors is in receipt of a research grant from a non-commercial source.

Hypothesis

Successful total hip arthroplasty (THA) in the presence of developmental dysplasia of the hip (DDH) depends on restoration of the anatomic centre of hip rotation and may require simultaneous femoral osteotomy. Techniques using uncemented components are widely reported. In osteopenic bone an all-cemented technique may be more appropriate; however, the outcome following this procedure is not known. We present the results of a series of thirty-five cemented THA with simultaneous subtrochanteric osteotomy.

Introduction

We have investigated the long-term (minimum follow-up period; 10 years) clinical results of the total hip arthroplasty (THA) using K-MAX HS-3 tapered stem.

British Orthopaedic Association (BOA) Guidelines recommend clinical and radiological follow-up after Total Hip Arthroplasty (THA) at 1 year, 5 years and every 5 years thereafter to detect asymptomatic failure. To evaluate the importance of routine follow-up appointments (OPAs) in detecting failing implants the presentation of patients undergoing revision THA was reviewed.

176 patients who received 183 first-time revision THAs over a seven-year period (2003-2010) were identified from an arthroplasty database. A preliminary study sampled 46 THAs in 45 patients. Retrospective chart review recorded symptoms and mode of presentation. Follow-up OPA costs were calculated to estimate savings.

All patients had symptoms at the time of revision (pain 96%, decreased mobility 76%, limp 35%, stiffness 26%, night pain 24%). Route of presentation was 80% new referrals (GP 63%, in-patient 9%, A&E 4%, Rheumatology 4%) vs 20% routine orthopaedic follow-up. The minimum cost for a routine follow-up OPA was £35. Assuming discharge after the earliest review when the patient has returned to full normal activities the estimated saving for the 2009 cohort of 377 primary THAs performed in our hospital is £13195 at 1 year and £52780 over the lifespan of the implants (assuming average 15 year survival).

Following uncomplicated primary cemented THA in our hospital asymptomatic implant failure is unlikely. Symptomatic patients tend to present mainly to their GP and other specialities, rather than orthopaedic follow-up OPAs. Early discharge after return to full normal activities would be safe and lead to significant financial savings.

Introduction

The global rapid growth of the aging population has some likelihood to create a serious crisis on health-care and economy at an unprecedented pace. To extend Healthy Life Expectancy (HALE) in a number of countries, it is desired more than ever to investigate characteristic and prognosis of numerous diseases. This enlightenment and recent studies on patient-reported outcome measures (PROMs) will drive the increasing interest in the quality of life among the world.

The demand for primary THAs by 2030 would rise up to 174% in USA. It is expected that the number of the elderly will surge significantly in the future, thus more septuagenarian and octogenarian are undergoing THA. Moreover, HALE of Japanese female near the age of 75 years, followed to Singapore, is still increasing. Therefore, concerns exist about the PROMs of performing THA in this age-group worldwide. Nevertheless almost the well-established procedure, little agreement has been reached to the elderly. We aimed to clarify the mid-term PROMs after THA over 75-year old.

Purpose

The purpose of the present study is to assess 5–10 years' follow-up results after acetabular impaction bone grafting (IBG) in primary cemented total hip arthroplasty (THA) for cases with acetabular bone defect.

Purpose: The purpose of this retrospective study was to evaluate at minimal 5 years follow-up outcome in a consecutive series of total hip arthroplasties implanted for fracture of the acetabulum.

Material and methods: The series included 53 arthroplasties implanted between January 1980 and December 1995 in 53 patients, 16 women and 37 men, mean age 53.1 years (24–84). The initial fracture involved the acetabular wall in 18 patients, one column in seven and two columns in six. It was a complex fracture in eleven cases and classification was unknown in the eleven other hips. Orthopaedic treatment was used for 23 patients and surgery for 30. Mean time between fracture and arthroplasty was 16.4±10.8 years. Cemented Charnley-Kerboull implants with a metal-polyethylene bearing were used. The Postel-Merle-d’Aubigné (PMA) score was used to assess functional outcome. The actuarial survival was determined.

Results: At five years minimum follow-up, 33 patients were alive and had not undergone revision at mean follow-up of 12.4±3.8 years (7–21). Six patients had had revision of the acetabular and/or femoral element, five patients had died, and seven were lost to follow-up. Revisions were required for cup wear associated with periacetabular osteolysis. The mean preoperative functional score was 10.6±2.5 versus 16.2±2.8 (8–18) at last follow-up (Wilcoxon rank test, p< 0.0001). Cumulative survival, taking revision as failure, was 90.3±6.5% at 15 years (95%CI 77.6–100%) for hips treated orthopaedically versus 66.5±14.5 (95%CI 38.1–94.9%) for hips treated surgically. The difference for the analyzable hips was not significant (logrank, p=0.69).

Discussion: The results of this series confirm that the long-term risk of mechanical failure of total hip arthroplasty for fracture of the acetabulum is high.

Introduction: We describe a new technique of using acetabular suction to improve cementing conditions in acetabular arthroplasty.

Aim: To analyse the effectiveness of a technique of applying suction to the acetabular cavity during cementing as a method of maximising the quality of the bone-cement interface.

Methods: In this study, a series of 100 cemented primary Exeter hip replacements performed by the senior author, using contemporary cementing techniques together with an acetabular suction technique were evaluated for the degree of cement penetration and the quality of the cement-bone interface so created. Radiographs were digitally scanned with high resolution and a CAD program was used to assess quantitatively the cement penetration in each of the Charnley-DeLee zones. The quality of the cement-bone interface was assessed using the grading system as described by Ranawat.

Results: An analysis showed significant cement penetration in each of the Charnley-Delee zones especially in zones 1b, 2a and 2b. The quality of the cement-bone penetration was excellent with most showing a Type I interface (perfect cement-bone interlock with gradual merging of cement into the cancellous bone with no radiolucency or rounding off of the cement front) in all zones.

Conclusions: These results indicated that application of acetabular suction significantly improved the cement penetration on the acetabular side in cemented total hip arthroplasty. We recommend this as a satisfactory method to ensure the best possible conditions for creation of an enduring cement- bone interface.

Orthopaedics has been earmarked as one of the specialties that could make significant savings in the National Health Service. A large number of young adults are receiving total hip replacements and there has been a trend towards using uncemented implants. We describe the clinical and functional results at minimum 19 year follow up of cemented total hip replacements in patients under the age of fifty-five in our health region between 1990 and 1997.

104 cemented THRs performed in 100 patients under 55 years were included in this study. The follow-up data had been collected prospectively in the University database. 88.46% hips showed good to excellent results at final follow-up with a mean Harris hip score of 87.9±8.64. Revision was performed in 2 hips (1.92%), one for aseptic acetabular loosening and the other for late haematogenous infection. Probable radiological loosening was seen in 14 acetabular components (14.89%) and 4 femoral components (4.25%) at final follow-up. The mean rate of acetabular wear was 0.12mm/year and was not influenced by gender or diagnosis. The mean follow-up was 21.68±2.11 years (range 19 to 26 years) and the survivorship at 19 years was 98.07%.

The GIRFT report looked at the economic aspect of implant selection and found that the cost of uncemented implants was almost double that of the cemented implants. Savings of atleast £10 million a year can be made if cemented implants were used. We recommend that in a publically funded health system like the NHS, cemented implants can be used in patients under 55 with good long term functional outcomes and large savings in the healthcare costs.

Introduction

Malalignment of some designs of stem is associated with an increased risk of aseptic loosening and revision. We investigated whether the alignment of the cemented polished, double-taper design adversely affected outcome, in a multicentre prospective study.

Introduction: There is little evidence describing the influence of Body Mass Index (BMI) on the outcome of Total Hip Replacement (THR). There are concerns that an increasing BMI may increase complication rates such as superficial and deep infection, blood loss, operation time and aseptic loosening. There is evidence that obese patients receive good symptomatic relief from THR and so it is important that the advisability of surgery is made on good evidence.

Methods: 800 patients undergoing primary Charnley total hip replacement were followed prospectively for a minimum of 18 months. The Harris Hip Score (HHS) and SF-36 were recorded pre-operatively and at 6 and 18 months post-operatively. Other significant events were noted, namely death, dislocation, re-operation, superficial and deep infection and blood loss. Stepwise multiple regression analysis was performed to identify whether BMI was an independently significant predictor of the outcome of THR.

Results: The mean age of patients was 68 years, with 61% females. At 18 months 31 patients (39 hips) had died. There were 15 re-operations, 13 dislocations and 7 deep infections.

No relationship was seen between the BMI of an individual and the development of post-operative complications. The HHS was seen to increase dramatically postoperatively in all patients (mean 43 points at 18 months). BMI did predict for a lower HHS at 6 and 18 months and a lower physical functioning score on the SF-36.

Discussion: THR produces a significant improvement in symptoms in patients, irrespective of BMI. An increasing BMI does not result in an increase in the early complication rate following THR. There is a reduction in the HHS and physical function component of SF-36 with increasing BMI, although this effect is small. On the basis of this study we do not think that THR should be withheld solely on the grounds of BMI.

Introduction: Changes of the proximal femur like oste-olysis, stress shielding and osteopenia are frequently observed after total hip arthroplasty (THA). Such find-ings might be considered as risk factors for aseptic loosening and later revision. Cortical thinning is observed of healthy femora too and it is questioned whether the effect of the implant can be discriminated from age-related changes.

Aim of our study was to analyze cortical bone changes in prosthetic hips with time and compare those changes with the contra lateral non operated femur.

Materials and Methods:From 1984–87 165 hips were operated with a cemented Muller straight stem. Regular clinical and radiological follow up was scheduled after 1, 2, 5, 10, 15 years. We included only patients operated for osteoarthritis without revision and complete follow-up of more than 10 years. 37 THA hips in 35 patients remained for inclusion in the study. The mean follow-up was 16±4,6 years. Thickness of cortices was measured medially and laterally in 6 locations according to the 2nd to 6th Gruen zones and mean cortical thinning was calculated. The measurements were taken on standardized anterior-posterior x-rays of the pelvis. All measurements were analyzed with Image Access 4 Software calibrated with the reference to 32 mm femoral head.

10 patients were not operated on the contralateral hip and were measured in standardized manner in the same locations as in THA femurs.

Results: All included patients had pain free hips and did not require revision surgery at the last follow-up. Mean cortical thinning was 0,17±0,15 mm/year and it was mostly expressed in mid part of the stem (Gruen 2 and 6 zones). Most thinning occurred within the first 5 years (0,32±0,34 mm/year), later thinning was slower (0.09±0,37 mm/year). For the group with non operated contralateral hip mean thickness loss in THA hip was 0,2±0,17 mm/year and there was thickness loss of the contralateral femur too (0,03±0,12 mm/year), being much less as compared to the operated side (p< 0.001).

Conclusions: Loss of cortical thickness in THA hip with the Muller straight stem is frequently observed in long term and is not associated to expression of clinical symptoms and subsequent revision surgery. The effect is pronounced in the first postoperative years, mainly being explained by stress shielding. Additionally there is cortical thinning due to ageing, being much less than the influence of the implant. Thinning of the cortical bone must not be interpreted a sign of aseptic loosening.

Introduction

Especially in young patients, total hip implants with proven long-term follow-up data should be used. Despite this, almost all patients under 30 years old will face a revision of their hip prosthesis during their life time because of their life expectancy. Therefore, all the used implants should be revisable with reliable outcome. Although, several studies have evaluated the outcome of different THA implants in patients under 30, only few report the long term follow-up of 10 years or more. None of them present the outcome of the revised total hips.