Aims. This study aims to define a set of family-centred core outcomes for infants undergoing brace treatment to facilitate consistent reporting for future high-quality research. Methods. Family-centred outcomes will be identified through a literature review and a scoping survey involving key stakeholders, including parents, healthcare professionals, and researchers. These outcomes will then be rated for their perceived importance in a two-stage modified Delphi process with the same stakeholders. Finally, a consensus meeting will be held to establish the final core outcome set (COS). Conclusion. The impact of brace treatment on the family is profound, but seldom considered in randomized controlled trials. This COS can independently standardize reporting on the family’s experience, and potentially become part of a broader COS for developmental dysplasia of the hip in infants undergoing brace treatment. Cite this article: Bone Jt Open 2024;6(1):21–25

A Core Outcome Set (COS) for treatment of adolescent idiopathic scoliosis (AIS) is essential to ensure that the most meaningful outcomes are evaluated and used consistently. Measuring the same outcomes ensures evidence from clinical trials and routine clinical practice of different treatments can be more easily compared and combined, therefore increasing the quality of the evidence base. The SPINE-COS-AYA project aims to develop a gold standard COS which can be used internationally in research and routine clinical practice to evaluate the treatment (surgical and bracing) of AIS. In this qualitative study, the views of adolescents and young adults with AIS (10-25 years of age), their family members and healthcare professionals in a UK region were sought, via interviews, on treatment outcomes. Participants were purposively recruited from a variety of sources including NHS outpatient clinics and social media. Semi-structured interviews were analysed using thematic analysis. Key findings will be presented, to include potential core outcome domains identified by the different subgroups. The core outcome domains identified in this research programme will subsequently form part of an international consensus survey to agree a COS. In future, if the COS is used by healthcare staff and researchers, it will be easier for everyone, including patients and their families, to assess which treatment works best

Aims. The aim of this study is to define a core outcome set (COS) to allow consistency in outcome reporting amongst studies investigating the management of orthopaedic treatment in children with spinal dysraphism (SD). Methods. Relevant outcomes will be identified in a four-stage process from both the literature and key stakeholders (patients, their families, and clinical professionals). Previous outcomes used in clinical studies will be identified through a systematic review of the literature, and each outcome will be assigned to one of the five core areas, defined by the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT). Additional possible outcomes will be identified through consultation with patients affected by SD and their families. Results. Outcomes identified in these stages will be included in a two-round Delphi process that will involve key stakeholders in the management of SD. A final list including the identified outcomes will then be summarized in a consensus meeting attended by representatives of the key stakeholders groups. Conclusion. The best approach to provision of orthopaedic care in patients with SD is yet to be decided. The reporting of different outcomes to define success among studies, often based on personal preferences and local culture, has made it difficult to compare the effect of treatments for this condition. The development of a COS for orthopaedic management in SD will enable meaningful reporting and facilitate comparisons in future clinical trials, thereby assisting complex decision-making in the clinical management of these children. Cite this article: Bone Jt Open 2022;3(1):54–60

Aims. To identify the minimum set of outcomes that should be collected in clinical practice and reported in research related to the care of children with idiopathic congenital talipes equinovarus (CTEV). Methods. A list of outcome measurement tools (OMTs) was obtained from the literature through a systematic review. Further outcomes were collected from patients and families through a questionnaire and interview process. The combined list, as well as the appropriate follow-up timepoint, was rated for importance in a two-round Delphi process that included an international group of orthopaedic surgeons, physiotherapists, nurse practitioners, patients, and families. Outcomes that reached no consensus during the Delphi process were further discussed and scored for inclusion/exclusion in a final consensus meeting involving international stakeholder representatives of practitioners, families, and patient charities. Results. In total, 39 OMTs were included from the systematic review. Two additional OMTs were identified from the interviews and questionnaires, and four were added after round one Delphi. Overall, 22 OMTs reached ‘consensus in’ during the Delphi and two reached ‘consensus out’; 21 OMTs reached ‘no consensus’ and were included in the final consensus meeting. In all, 21 participants attended the consensus meeting, including a wide diversity of clubfoot practitioners, parent/patient representative, and an independent chair. A total of 21 outcomes were discussed and voted upon; six were voted ‘in’ and 15 were voted ‘out’. The final COS document includes nine OMTs and two existing outcome scores with a total of 31 outcome parameters to be collected after a minimum follow-up of five years. It incorporates static and dynamic clinical findings, patient-reported outcome measures, and a definition of CTEV relapse. Conclusion. We have defined a minimum set of outcomes to draw comparisons between centres and studies in the treatment of CTEV. With the use of these outcomes, we hope to allow more meaningful research and a better clinical management of CTEV. Cite this article: Bone Jt Open 2022;3(1):98–106

Aims. This study aims to define a set of core outcomes (COS) to allow consistent reporting in order to compare results and assist in treatment decisions for idiopathic clubfoot. Methods. A list of outcomes will be obtained in a three-stage process from the literature and from key stakeholders (patients, parents, surgeons, and healthcare professionals). Important outcomes for patients and parents will be collected from a group of children with idiopathic clubfoot and their parents through questionnaires and interviews. The outcomes identified during this process will be combined with the list of outcomes previously obtained from a systematic review, with each outcome assigned to one of the five core areas defined by the Outcome Measures Recommended for use in Randomized Clinical Trials (OMERACT). This stage will be followed by a two round Delphi survey aimed at key stakeholders in the management of idiopathic clubfoot. The final outcomes list obtained will then be discussed in a consensus meeting of representative key stakeholders. Conclusion. The inconsistency in outcomes reporting in studies investigating idiopathic clubfoot has made it difficult to define the success rate of treatments and to compare findings between studies. The development of a COS seeks to define a minimum standard set of outcomes to collect in all future clinical trials for this condition, to facilitate comparisons between studies and to aid decisions in treatment. Cite this article: Bone Jt Open 2021;2(4):255–260

INTRODUCTION:. Acetabular retroversion has been implicated as a risk factor for the development of early hip osteoarthritis. In clinical practice standard osseous signs such as the cross-over sign (COS) and the posterior wall sign (PWS) are widely used to establish the diagnosis of acetabular retroversion on plain radiographs. Despite standardized radiological evaluation protocols, an increased pelvic tilt can lead to a misdiagnosis of acetabular retroversion in AP radiographs and 2D MR or CT scans. Previous studies have shown that the elimination of observer bias using a standardized methodology based on 3D-CT models and the anterior pelvic plane (APP) for the assessment of COS and PWS results in greater diagnostic accuracy. Using this method a prevalence of 28% for COS and 24% for PWS has been found in a cohort of patients with symptoms indicative of FAI, however the prevalence of both signs in asymptomatic adults remains unknown. This study therefore sought to establish the prevalence of the COS and PWS in relation to the APP in an asymptomatic population using a reliable and accurate 3 D-CT based assessment. METHODS:. A large pool of consecutive CT scans of the pelvis undertaken in our department for conditions unrelated to disorders of the hip was available for analysis. Scans in subjects with a Harris hip score of less than 90 points were excluded leaving a sample of 100 asymptomatic subjects (200 hips) for this study. A previously established 3D analysis method designed to eliminate errors resulting from variations in the position and orientation of the pelvis during CT imaging was applied to determine in order to assess the prevalence of the COS and PWS in relation to the APP. Here, the acetabuli were defined as retroverted if either the COS, PWS or both were positive. RESULTS:. From the total of 200 hips a positive COS was identified in 24% (48/200) and a positive PWS was detected in 6.5% (13/200) relative to the APP using the CT data. A. In male adults a COS was observed in 25.4% (29/114) and a PWS in 10.5% (12/114). In female adults a COS were observed in 22.1% (19/86) and a PWS in 1.2% (1/86). DISCUSSION:. The high incidence of acetabular retroversion observed using an accurate 3D-CT based methodology shows that this anatomic configuration might not differ in frequency between asymptomatic individuals and patients with symptomatic FAI. Patients presenting with hip pain and evidence of FAI should therefore be subjected to strict diagnostic scrutiny, as the presence of a COS and/or PWS shows a poor correlation with the presence of symptomatic disease. In our collective of asymptomatic adults the COS showed a higher incidence than the PWS. Additionally a deficiency of the posterior acetabular wall was rare in asymptomatic adults compared to FAI patients. Therefore, the question whether an abnormal acetabular version does indeed lead to the development of osteoarthritis in all patients warrants further study. Although an association between osteoarthritis and femuro-acetabular impingement is believed to exist, long-term epidemiological studies are needed to establish the natural history of these anatomical configurations

Aims. To analyze outcomes reported in studies of Ponseti correction of idiopathic clubfoot. Methods. A systematic review of the literature was performed to identify a list of outcomes and outcome tools reported in the literature. A total of 865 studies were screened following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and 124 trials were included in the analysis. Data extraction was completed by two researchers for each trial. Each outcome tool was assigned to one of the five core areas defined by the Outcome Measures Recommended for use in Randomized Clinical Trials (OMERACT). Bias assessment was not deemed necessary for the purpose of this paper. Results. In total, 20 isolated outcomes and 16 outcome tools were identified representing five OMERACT domains. Most outcome tools were appropriately designed for children of walking age but have not been embraced in the literature. The most commonly reported isolated outcomes are subjective and qualitative. The quantitative outcomes most commonly used are ankle range of motion (ROM), foot position in standing, and muscle function. Conclusions. There is a diverse range of outcomes reported in studies of Ponseti correction of clubfoot. Until outcomes can be reported unequivocally and consistently, research in this area will be limited. Completing the process of establishing and validating COS is the much-needed next step. Cite this article: Bone Joint Open 2020;1-8:457–464

Purpose. Diagnosis of acetabular retroversion is essential in femoroacetabular impingement (FAI), but its assessment from radiographs is complicated by pelvic tilt and the two-dimensional nature of plain films. We performed a study to validate the diagnostic accuracy of the crossover sign (COS) and the posterior wall sign (PWS) in identifying acetabular retroversion. Method. COS and PWS were evaluated from radiographs and computed tomography (CT) scans as the standard of reference in 50 hips of subjects with symptoms of FAI. A CT-based method using 3-D models was developed to measure the COS, PWS, true acetabular version and pelvic tilt relative to the anterior pelvic plane. The new CT-based method aimed to eliminate errors resulting from variations in the position and orientation of the pelvis during imaging. Results. A low level of agreement for COS and PWS was found between radiographs and CT scans. A positive COS strongly correlated with pelvic tilt. Conclusion. These results suggest that COS and PWS determined from anteroposterior (AP) radiographs are considerably limited by pelvic tilt and inherent limitations of radiographs. Their use as the sole basis for deciding whether or not surgical intervention is indicated seems questionable. NO DISCLOSURES

Acetabular retroversion (ARV) is a cause of femoroacetabular impingement leading to hip pain and reduced range of motion. We aimed to describe the radiological criteria used for diagnosing ARV in the literature and report on the outcomes of periacetabular osteotomy (PAO) and hip arthroscopy (HA) in its management. A systematic review using PRISMA guidelines was conducted on the MEDLINE, CINAHL, EMBASE, COCHRANE database in December 2022. English-language studies reporting outcomes of PAO, or open or arthroscopic interventions for ARV were included. From an initial 4203 studies, 21 non-randomised studies met the inclusion criteria. Eleven studies evaluated HA for ARV, with average follow-up ranging from 1 to 5 years, for a cumulative number of 996 patients. Only 3/11 studies identified ARV using AP standardized pelvic radiographs. The most frequent signs describing ARV identified were: Ischial Spine Sign (98% of patients), Posterior Wall Sign (PWS, 94%) and Crossover Sign (COS, 64%); with mean Acetabular Retroversion Index (ARI) ranging from 33% to 35%. 39% of HA patients had all three radiographic signs. Clinically significant outcomes were reached by 33–78% of patients. Eight studies evaluated PAO for ARV, with a follow-up ranging from 2 to 10 years, for a cumulative number of 379 patients. Five of the eight studies identified ARV using standardized radiographs. ISS, COS and PWS were positive in 54%, 97% and 81% of patients, respectively with 52% of PAO patients having all three radiographic signs. Mean ARI ranged from 36–41%. Clinically significant results were reported in 71%–78% of patients. The diagnostic criteria for ARV is poorly defined in the literature, and the quality of evidence is low. Studies on HA are more likely to have used lenient diagnostic criteria. It remains difficult to recommend which cases maybe more suitable for treatment by HA rather than PAO

Background and purpose:. Inconsistent outcome reporting is a problematic issue in systematic reviews of clinical trials in non-specific LBP (NSLBP). To facilitate statistical pooling and improve reliability of reviews, the development of a core outcome set (COS) is recommended. In 1998, Deyo et al. proposed a standardized set of domains and measurement instruments for LBP clinical research. An international steering committee (ISC) was formed to update 1998 recommendations, and to determine, at first, which outcome domains should be included in a COS for clinical trials in NSLBP. Methods:. The ISC used the OMERACT framework 2.0 to draw a list of potential core domains. This list was presented in a 3-round Delphi survey, in which researchers, clinicians and patients were invited to participate. Criteria for consensus were established a-priori and quantitative responses were analysed together with arguments provided by Delphi participants. The ISC discussed the results and made final decisions. Results:. 280 ‘experts’ were selected and invited to participate in the Delphi survey. Response rates in the three rounds were: 52%, 50%, and 45%. A list of 41 potential core domains was presented but 28 of them did not reach sufficient consensus to be presented in the third round, where overall consensus was reached on three domains: ‘physical functioning’, ‘pain intensity’ and ‘health-related quality of life’. Conclusion:. ‘Physical functioning’, ‘pain intensity’ and ‘health-related quality of life’ were included in this COS, together with the reporting on ‘number of deaths’. The next step in the development of this COS will be to determine which measurement instruments are most fit-for-purpose to measure these outcome domains

It has been suggested that metal ion levels are indicative of in vivo bearing performance of metal-on-metal hip replacements. A cobalt or Chromium level of 7μg/L or higher is proposed to be indicative of a bearing malfunction and the need for clinical intervention. Component design, size, acetabular orientation, patient gender and activity level have been suggested as factors leading to accelerated wear and elevated metal ions. The contact patch to rim (CPR) distance is a calculation that describes the distance from the point where a theoretical joint reaction force intersects the cup to the acetabular rim for a patient in standing position, dependent on the coverage, size, and orientation of the acetabular component. It has been suggested that CPR distance determines the hip joint susceptibility to edge loading, and the risk for increased wear and high ion levels (Langton et al JBJS Br 91: 2009). This study examined the effects of patient activity, gender, and CPR distance on serum metal ion concentrations in a series of patients treated with one type of metal on metal hip resurfacing arthroplasty (MMHRA) performed by one surgeon. 182 patients (73 females and 109 males)with a unilateral Conserve Plus (WMT, TN USA) MMHRA and had who had provided blood for metal ion analysis data from December 2000 to June 2011 were retrospectively studied. Only measurements made more than 12 months after surgery were included in order to exclude hips that had yet to reach steady-state wear. For patients with multiple draws, the most recent qualifying draw was used. Activity level was assessed by the UCLA activity score. The mean age was 51.5 years (20.0 to 77.5 years). The mean follow-up time for the last blood draw was 70 months (range, 12 to 165). Serum cobalt (CoS) and chromium (CrS) levels were analyzed using inductively coupled plasma mass spectrometry in a specialized trace element lab. Using acetabular abduction and anteversion measured by EBRA, component size, and reported coverage angle of the acetabular component, the CPR distance was calculated as previously described. Multiple logistic regression was performed to identify significant relationships between high metal ion levels (7 μg/L or greater) and gender, activity and CPR distance. The median CoS level for the entire cohort was 1.13 μg/L (range, 0.15 to 175.30), and the median CrS level was 1.49 μg/L (range, 0.06 to 88.70). The average CPR distance was 13.8 mm (range, 3.2 to 22.1). There was a significant association between low CPR values and CoS and CrS. There was a 37-fold increase in the risk of CoS >7μg/L (p=0.005) and 11-fold increase in the risk of CrS > 7μg/L (p=0.003) when CPR distance was 10 mm or less. No associations were shown for gender and UCLA activity scores. CPR distance was found to be a reliable predictor of ion levels > 7μg/L and appears to be a useful indicator to evaluate the multi-factorial process of edge-loading and wear. Patients with a low CPR distance should be monitored for increased metal ion levels

Aims

The aim of this study was to develop a core outcome set of what to measure in all future clinical research on hand fractures and joint injuries in adults.

Aims

A core outcome set for adult, open lower limb fracture has been established consisting of ‘Walking, gait and mobility’, ‘Being able to return to life roles’, ‘Pain or discomfort’, and ‘Quality of life’. This study aims to identify which outcome measurement instruments (OMIs) should be recommended to measure each core outcome.

Aims

Traditionally, total hip arthroplasty (THA) templating has been performed on anteroposterior (AP) pelvis radiographs. Recently, additional AP hip radiographs have been recommended for accurate measurement of the femoral offset (FO). To verify this claim, this study aimed to establish quantitative data of the measurement error of the FO in relation to leg position and X-ray source position using a newly developed geometric model and clinical data.

Aims

The aim of this study is to determine the predictors of overall survival (OS) and predictive factors of poor prognosis of conventional high-grade osteosarcoma of the limbs in a single-centre in South Africa.

Aims

Open lower limb fracture is a life-changing injury affecting 11.5 per 100,000 adults each year, and causes significant morbidity and resource demand on trauma infrastructures. This study aims to identify what, and how, outcomes have been reported for people following open lower limb fracture over ten years.

Aims

Open lower limb fracture is life-changing, resulting in substantial morbidity and resource demand, while inconsistent outcome-reporting hampers systematic review and meta-analysis. A core outcome set establishes consensus among key stakeholders for the recommendation of a minimum set of outcomes. This study aims to define a core outcome set for adult open lower limb fracture.

Aims

Slipped upper femoral epiphysis (SUFE) has well documented biochemical and mechanical risk factors. Femoral and acetabular morphologies seem to be equally important. Acetabular retroversion has a low prevalence in asymptomatic adults. Hips with dysplasia, osteoarthritis, and Perthes’ disease, however, have higher rates, ranging from 18% to 48%. The aim of our study was to assess the prevalence of acetabular retroversion in patients presenting with SUFE using both validated radiological signs and tomographical measurements.

Introduction. Accurate acetabular position is an important goal during THA. It is also well known that accurate acetabular positioning is very frequently not achieved, even by experienced, high volume surgeons. Problems associated with cup malposition are: dislocation, accelerated poly wear, impingement, ceramic squeaking, metalosis. Murray et al described 3 methods of measurement and assessment of acetabular inclination and anteversion (I&A): anatomic, radiographic and operative. It is the hypothesis of the authors, that the differences and details of these 3 methods are poorly understood by many surgeons and this is contributory to inconsistent cup positioning. Additionally, the radiographic method, which is most commonly used for post op assessment and academic studies, contributes to misunderstanding and error. Modern computer guidance and software assessment of radiographs allows us to easily measure anatomic I&A which should be thought of as “true” I&A. Methods. The mathematical criteria for radiographic measurement of anatomic I&A are defined as well as the mathematical relationships and discrepancies between anatomic and radiographic I&A for any given cup. A. =. A. n. g. l. e.  . o. f.  . a. n. t. e. v. e. r. s. i. o. n.  . o. f.  . c. u. p. I. =. A. n. g. l. e.  . o. f.  . i. n. c. l. i. n. a. t. i. o. n.  . o. f.  . c. u. p. E = Angle of ellipse major diameter to horizontal. E = Radiographic inclination. Sin.  . A. =. H. o. r. i. z. o. n. t. a. l.  . w. i. d. t. h.  . o. f.  . e. l. l. i. p. s. e. L. e. n. g. t. h.  . o. f.  . e. l. l. i. p. s. e.  . m. a. j. o. r.  . d. i. a. m. e. t. e. r. Sin.  . I. =. V. e. r. t. i. c. a. l.  . h. e. i. g. h. t.  . o. f.  . e. l. l. i. p. s. e. L. e. n. g. t. h.  . o. f.  . e. l. l. i. p. s. e.  . m. a. j. o. r.  . d. i. a. m. e. t. e. r. Tan I = Tan E / Cos A. Tan E = (Tan I) x (Cos A). Results. Numerical values for radiographic I&A and anatomic I&A coincide for cups placed at 0 degrees anteversion. However, as cup anteversion increases, there is an exponentially increasing discrepancy between anatomic and radiographic inclination values with I always having a higher value than E. Commonly used radiographic inclination values (E) therefore always underestimate anatomic (true) inclination. Additionally, radiographic anteversion, except for 0 degrees anteversion, always underestimates anatomic (true) anteversion. Wear testing of cups by manufacturers and associated recommendations for cup positioning are based on anatomic measurement of inclination while surgeons now use a different method (radiographic) for measuring position. Axial CT analysis of cup anteversion agrees mathematically with anatomic anteversion and does not mathematically agree with the Murray radiographic criteria. Conclusions. Surgeons can intuitively understand that accurate radiographic measurement of femoral neck-shaft angle can only be done if the proximal femur is correctly rotated in relation to the x-ray beam, specifically the x-ray beam must be perpendicular to the plane determined by the intersection of the center lines of the neck and shaft. Any other femoral rotation will show a false increase in the neck shaft angle. Though less intuitive, true cup I is only represented by the angle seen on x-ray at only one A value, 0 degrees. Anteverting the cup as is desirable for THA stability creates a discrepancy between the apparent cup angle (E) and true inclination. Since the principles of solid geometry are widely adopted and accepted, the above results and conclusions are based on mathematical proof, not experimental findings. Erroneous conclusions such as “the cup position is good but the hip still dislocates” can be associated with a surgeon's lack of understanding of true I&A. Surgeons need to understand the differences between what they believe to be represented by x-rays and anatomic or true I&A as represented by the cup's position in relation to the body's transverse, coronal, and sagittal planes and x, y, and z axes. The authors believe that a surgeon's continued lack of understanding of the mathematics can be compensated for by the technologies of computer guidance and/or software analysis of cup x-rays

Background: The purpose of this prospective study was to asses the reliability of image-free navigated cup positioning and its correlation with biometrical parameters (age, sex, body mass index, soft tissue thickness overlying anterior superior iliac spine and symphysis pubis, and lumbar lordosis) and three different orientations of pelvis (tilt, obliquity, and rotation) in patients of Asian ethnicity. Methods: Intraoperative data was obtained from 50 consecutive total hip arthroplasties in which acetabular cup implantation was done with a cementless cup (Plasma Cup SC. ®. , Aesculap AG, Tuttlingen, Germany) using Orthopilot. ®. image-free navigation system. The data was then compared with mathematically calculated synchronized anteversion and inclination obtained postoperatively through computed tomography and 3-dimensional processing. Results: Mean navigated and synchronized inclination obtained were 40.1°±5.34° and 41.79°± 7.96° respectively (mean difference 1.69°±6.95°, range −20.72° ~ 18.47°), while the mean navigated and synchronized anteversion were 19.98°± 6.44° and 20.00°± 6.33° (mean difference 0.01°±6.35°, range −15.15° ~ 11.10°). A discrepancy of > 10° was observed in 5 hips in inclination and 5 hips in anteversion. No correlation was found between all of biometrical parameters and discrepancy of cup orientation. A statistically significant correlation was found between discrepancy of anteversion and pelvic tilt (1.78 + 0.55 x pelvic tilt°, r=0.493, p=0.0016). Conclusion: In spite of variations in pelvic geometry, image-free navigation assisted acetabular cup positioning showed the significant reliability. The next generation of navigation systems must be combined with data on precision of pelvic orientation intraoperatively for complete validation. *Index; Synchronized Inclination = arctan [tan (Operative AV) ÷ tan (Anatomic AV)] Synchronized AV = arctan[tan (Anatomic AV) x sin (synchronized Inclination)] or arctan[tan (Operative AV) x cos (Synchronized Inclination