Objectives. The aim of this study was to investigate the biomechanical effect of the anterolateral ligament (ALL), anterior cruciate ligament (ACL), or both ALL and ACL on kinematics under dynamic loading conditions using dynamic simulation subject-specific knee models. Methods. Five subject-specific musculoskeletal models were validated with computationally predicted muscle activation, electromyography data, and previous experimental data to analyze effects of the ALL and ACL on knee kinematics under gait and squat loading conditions. Results. Anterior translation (AT) significantly increased with deficiency of the ACL, ALL, or both structures under gait cycle loading. Internal rotation (IR) significantly increased with deficiency of both the ACL and ALL under gait and squat loading conditions. However, the deficiency of ALL was not significant in the increase of AT, but it was significant in the increase of IR under the squat loading condition. Conclusion. The results of this study confirm that the ALL is an important lateral knee structure for knee joint stability. The ALL is a secondary stabilizer relative to the ACL under simulated gait and squat loading conditions. Cite this article: Bone Joint Res 2019;8:509–517

Background. The anatomy of the human body has been studied for centuries. Despite this, recent articles have announced the presence of a new knee ligament- the anterolateral ligament. It has been the subject of much discussion and media commentary. Previous anatomical studies indicate its presence, and describe its location, origin, course and insertion. Magnetic resonance imaging (MRI) is the best and most commonly used investigation to assess the ligamentous structure of the knee. To date, most MRI knee reports make no mention of the anterolateral ligament. The aim of this study was to assess for the presence of the anterolateral ligament using MRI, and to describe the structure if visualised. Methods. All right knee MRIs performed on a Siemens Magnetom Espree 1.5 Tesla scanner in Merlin Park Hospital over a 4 year period were retrospectively analysed. Patients born before 1970, or with reported abnormalities were excluded. The normal MRIs were then analysed by a consultant radiologist specialising in musculoskeletal imaging. Measurements on origin, insertion, course and length were noted. Results. 942 right knee MRIs were performed in the time period. 62 were classed as normal, and within the specified age range. 10 were randomly sampled. Of these the ligament was visible on all 10 MRIs, best viewed in the coronal plane. The average length (visible in 8/10) was 28.88mm +/− 5.14mm. The origin (visible in all 10) was 2.25mm +/− 0.39mm. The insertion (visible in 9/10) was 1.93mm +/− 0.424. The mid thickness was 1.87mm +/− 0.2mm. Conclusions. This study indicates that the ALL is a discrete, visible structure on MRI. This furthers the evidence of the presence of the ALL and also provides information that may be beneficial in future studies, and assessment of knee injuries. Level of evidence. 4

Background. Return to sports after anterior cruciate ligament reconstruction (ACLR) is multifactorial and rotational stability is one of the main concerns. Anterolateral ligament reconstruction (ALLR) has been recommended to enhance rotational stability. Purpose. To assess the effect of ALLR on return to sports. Study Design. Retrospective comparative cohort study;. Level of evidence: III. Methods. A total of 68 patients who underwent ACLR after acute ACL injury between 2015 and 2018 with a follow-up of at least 24 months were enrolled in the study. Patients with isolated ACLR (group ALL(-), n=41) were compared to patients with ACLR+ALLR (group ALL(+), n=27) in regard to subjective knee assessment via Tegner activity scale, Anterior Cruciate Ligament-Return to Sport after Injury (ACL-RSI) scale, Knee Documentation Committee (IKDC) form and Lysholm score. All tests were performed before the surgery, at 6 months and 24 months postoperatively. Results. Mean follow-up was 29.7±2.9 months for group ALL(-) and 31.6±3.0 for ALL(+) (p=0.587). Tegner, ACL-RSI and IKDC scores at last follow-up were significantly better in ALL(+) compared to ALL(-). There were no significant differences in isokinetic extensor strength and single-leg hop test results between the groups. 40 (97.6%) patients in ALL(-) and 27 (100%) in ALL(+) had a grade 2 or 3 pivot shift (p=0.812) preoperatively. Postoperatively, 28 (68.3%) patients in ALL(-) and 25 (92.6%) patients in ALL(+) had a negative pivot shift (p<0.001). 2 (5.9%) patients in ALL(-) and 1 (3.7%) patient in ALL(+) needed ACLR revision due to traumatic re-injury (p=0.165). There was no significant difference in the rate of return to any sports activity (87.8% in ALL(-) vs 88.9% in ALL(+); p=0.532), but ALL(+) showed a higher rate of return to the same level of sports activity (55.6%) than group ALL(-) (31.7%) (p=0.012). Conclusion. ACLR combined with ALLR provided a significantly higher rate of return to the same level sports activity than ACLR alone, probably due to enhanced rotational stability

The anterolateral ligament (ALL) has been recently recognized as a distinct stabilizer for internal rotation in the ACL-deficient knee and it has been hypothesized that ALL reconstruction may play an important role in improving anterolateral instability following ACL reconstruction. Both the gracilis tendon (GT) and a portion of the iliotibial band (ITB) have been suggested as graft materials for ALL reconstruction, however, there is an ongoing debate concerning whether GT or ITB are appropriate grafting materials. Furthermore, there is limited knowledge in how the mechanical properties of these potential grafts compare to the native ALL. Consequently, the aim of this study was to characterize the elastic (Young's modulus and failure load) and viscoelastic (dynamic and static creep) mechanical properties of the ALL and compare these results with the characteristics of the grafting materials (GT and ITB), in order to provide guidance to clinicians with respect to graft material choice. Fourteen fresh-frozen cadaveric knees (85.2±12.2 yr) were obtained. The ALL, ITB, and the distal (GTD) and proximal gracilis tendons (GTP) (bisected at mid portion) were harvested from each donor and tested with a dynamic material testing frame. Prior to testing, the cross-sectional area of each tissue was measured using a casting method and the force required to achieve a min-max stress (1.2–12 MPa) for the testing protocol was calculated (preconditioning (20 cycles, 3–6 MPa), sinusoidal cycle (200 cycles, 1.2–12 MPa), dwell at constant load (100 s, 12 MPa), and load to failure (3%/s)). Kruskall-Wallis tests were used to compare all tissue groups (p<0.05). The Young's modulus of both ALL (181.3±63.9 MPa) and ITB (357.6±94.4 MPa) are significantly lower than GTD (835.4±146.5 MPa) and GTP (725.6±227.1 MPa). In contrast, the failure load of ALL (124.5±40.9 N) was comparable with GTD (452.7±119.3 N) and GTP (433±133.7 N), however, significantly lower than ITB (909.6±194.7 N). Dynamic creep of the ALL (0.5±0.3 mm) and ITB (0.7±0.2 mm) were similar (p>0.05) whereas the GTD (0.26±0.06 mm) and GTP (0.28±0.1 mm) were significantly lower. Static creep progression of the ALL (1.09±0.4 %) was highest across all tissues, while GTD (0.24±0.05 %) and GTP (0.25±0.0.04 %) were lowest and comparable with ITB (0.3±0.07 %) creep progression. Since grafts from the ITB, GTD and GTP were comparable to the ALL only for certain mechanical properties, there was no clear preference for using one over another for ALL reconstruction. Therefore, further studies should be performed in order to evaluate which parameters play a vital role to determine the optimum grafting choice

Aims. The surgical target for optimal implant positioning in robotic-assisted total knee arthroplasty remains the subject of ongoing discussion. One of the proposed targets is to recreate the knee’s functional behaviour as per its pre-diseased state. The aim of this study was to optimize implant positioning, starting from mechanical alignment (MA), toward restoring the pre-diseased status, including ligament strain and kinematic patterns, in a patient population. Methods. We used an active appearance model-based approach to segment the preoperative CT of 21 osteoarthritic patients, which identified the osteophyte-free surfaces and estimated cartilage from the segmented bones; these geometries were used to construct patient-specific musculoskeletal models of the pre-diseased knee. Subsequently, implantations were simulated using the MA method, and a previously developed optimization technique was employed to find the optimal implant position that minimized the root mean square deviation between pre-diseased and postoperative ligament strains and kinematics. Results. There were evident biomechanical differences between the simulated patient models, but also trends that appeared reproducible at the population level. Optimizing the implant position significantly reduced the maximum observed strain root mean square deviations within the cohort from 36.5% to below 5.3% for all but the anterolateral ligament; and concomitantly reduced the kinematic deviations from 3.8 mm (SD 1.7) and 4.7° (SD 1.9°) with MA to 2.7 mm (SD 1.4) and 3.7° (SD 1.9°) relative to the pre-diseased state. To achieve this, the femoral component consistently required translational adjustments in the anterior, lateral, and proximal directions, while the tibial component required a more posterior slope and varus rotation in most cases. Conclusion. These findings confirm that MA-induced biomechanical alterations relative to the pre-diseased state can be reduced by optimizing the implant position, and may have implications to further advance pre-planning in robotic-assisted surgery in order to restore pre-diseased knee function. Cite this article: Bone Joint J 2024;106-B(11):1231–1239

The Pivot-shift test is a clinical test for knee instability for patinets with Anterior cruciate ligament (ACL), however the test has low inter-observer reliability. Dynamic radiostereometry (dRSA) imaging is a highly precise method for objective evaluation of joint kinematics. The purpose of the study was to quantify precise knee kinematics during Pivot-shift test by use of the non-invasive dynamic RSA imaging. Eight human donor legs with hemipelvis were evaluated. Ligament lesion intervention of the ACL was performed during arthroscopy and anterolateral ligament (ALL) section was performed as a capsular incision. Pivot-shift test examination was recorded with dRSA on ligament intact knees, ACL-deficient knees and ACL+ALL-deficient knees. A Pivot-shift pattern was identifyable after ligament lesion as a change in tibial posterior drawer velocity from 7.8 mm/s in ligament intact knees, to 30.4 mm/s after ACL lesion, to 35.1 mm/s after combined ACL-ALL lesion. The anterior-posterior drawer excursion increased from 2.8 mm in ligament intact knees, to 7.2 mm after ACL lesion, to 7.6 mm after combined lesion. Furthermore a change in tibial rotation was found, with increasing external rotation at the end of the pivot-shift motion going from intact to ACL+ALL-deficient knees. This experimental study demonstrates the feasibility of RSA to objectively quantify the kinematic instability patterns of the knee during the Pivot-shift test. The dynamic parameters found through RSA displayed the kinematic changes from ACL to combined ACL-ALL ligament lesion

The June 2015 Research Roundup360 looks at: Tranexamic acid: just give it – it’s not important how!; The anterolateral ligament re-examined; Warfarin a poor post-operative agent; Passive exoskeleton the orthosis of the future?; Musculoskeletal medicine: a dark art to UK medical students?; Alendronic acid and bone density post arthroplasty; Apples with oranges? Knee functional scores revisited

The anterolateral ligament (ALL) is considered as an important stabilizer of the knee joint. This ligament prevents anterolateral subluxation of the proximal tibia on the femur when the knee is flexed and internally rotated. Injury of the ALL was not investigated in patients with knee dislocation. The aim of the current research is to study the prevalence and characteristics of ALL injury in dislocated knees. A retrospective review of charts and radiological images was done for patients who underwent multiligamentous knee reconstruction surgery for knee dislocation in our institution from May 2008 to December 2016. Magnetic resonance imaging (MRI) was used to describe the ALL injury. The association of ALL injury with other variables related to the injury and the patient's background features was examined. Forty-eight patients (49 knees) were included. The mean age of the patients was 32.3 ± 10.6 years. High energy trauma was the mechanism of dislocation in 28 (57.1%) knees. Thirty-one knees (63.3%) were classified as knee dislocation (KD) type IV. Forty-five (91.8%) knees had a complete ALL injury and three (6.1%) knees had incomplete ALL injury. Forty (81.6%) knees had a complete ALL injury at the proximal fibres of the ALL, while 23 (46.9%) knees had complete distal ALL injury. None of the 46 (93.9%) knees with lateral collateral ligament (LCL) injury had normal proximal ALL fibres (p = 0.012). Injury to the distal fibres of the ALL, as well as overall ALL injury, were not associated with any other variables (p >0.05). Moreover, all patients with associated tibial plateau fractures (9, 18.4%) had abnormality of the proximal fibres of the ALL (p = 0.033). High grade ALL injury is highly prevalent among dislocated knees. The outcomes of reconstructing the ALL in multiligamentous knee reconstruction surgery should be investigated in future studies

Introduction. There is little information available to surgeons regarding how the lateral soft-tissue structures prevent instability in knees implanted with total knee arthroplasty (TKA). The aim of this study was to quantify the lateral soft-tissue contributions to stability following cruciate retaining (CR) TKA. Methods. Nine cadaveric knees with CR TKA implants (PFC Sigma; DePuy Synthes Joint Reconstruction) were tested in a robotic system (Fig. 1) at full extension, 30°, 60°, and 90° flexion angles. ±90 N anterior-posterior force, ±8 Nm varus-valgus and ±5 Nm internal-external torque were applied at each flexion angle. The anterolateral structures (ALS, including the iliotibial band, anterolateral ligament and anterolateral capsule), the lateral collateral ligament (LCL), the popliteus tendon complex (Pop T) and the posterior cruciate ligament (PCL) were then sequentially transected. After each transection the kinematics obtained from the original loads were replayed, and the decrease in force / moment equated to the relative contributions of each soft-tissue to stabilising the applied loads. Results. In the CR TKA knee, the LCL was found to be the primary restraint to varus laxity (Fig. 2, an average 56% across all flexion angles), and was significant in internal-external rotational stability (28% and 26% respectively) and anterior drawer (16%). The ALS restrained 25% of internal rotation (Fig. 3), whilst the PCL was significant in posterior drawer only at 60° and 90° flexion. The Pop T was not found to be significant in any tests. Conclusion. This study has for the first time delineated the relative contributions of lateral structures to stability in the implanted knee. It was confirmed that the LCL is the major lateral structure in CR TKA stability throughout the arc of flexion. In the event of LCL deficiency, stability of the knee may only be restored by either changing to a more constrained implant or performing a reconstruction of the ligament. Furthermore, care should be taken when releasing the LCL to correct a valgus deformity as it may result in a combined rotational laxity pattern that cannot be overcome by the other passive lateral structures or the PCL. For figures, please contact authors directly

Injury to the anterolateral ligament (ALL) has been reported to contribute to high-grade anterolateral laxity following anterior cruciate ligament (ACL) injury. Failure to address ALL injury has been suggested as a cause of persistent rotational laxity following ACL reconstruction. However, lateral meniscus posterior root (LMPR) tears have also has been shown to cause increased internal rotation and anterior translation of the knee. Due to the anatomic relationship of the ALL and the lateral meniscus, we hypothesise that the ALL and lateral meniscus work synergistically, and that a tear to the LMPR will have the same effect on anterolateral laxity as an ALL tear in the ACL deficient knee. Sixteen fresh frozen cadaveric knee specimens were potted into a hip simulator(femur) and a six degree-of-freedom load cell (tibia). Two rigid optical trackers were inserted into the proximal femur and distal tibia, allowing for the motion of the tibia with respect to the femur to be tracked during biomechanical tests. A series of points on the femur and tibia were digitised to create bone coordinate systems that were used to calculate the kinematic variables. Biomechanical testing involved applying a 5Nm internal rotation moment to the tibia while the knee was in full extension and tested sequentially in the following three conditions: i) ACLintact; ii) Partial ACL injury (ACLam) – anteromedial bundle sectioned; iii) Full ACL injury (ACLfull). The specimens were then randomised to either have the ALL sectioned first (ALLsec) followed by the LMPRsec or vice versa. Internal rotation and anterior translation of the tibia with respect to the femur were calculated. A mixed two-way (serial sectioning by ALL section order) repeated measures ANOVA (alpha = 0.05). Compared to the ACLintact condition, internal rotation was found to be 1.78° (p=0.06), 3.74° (p=0.001), and 3.84° (p=0.001) greater following ACLfull, LMPRsec and ALLsec respectively. LMPRsec and the ALLsec resulted in approximately 20 of additional internal rotation (p=0.004 and p=0.01, respectively) compared with the ACL deficient knee (ACLfull). No difference was observed between the ALL and LMPR sectioned states, or whether the ALL was sectioned before or after the LMPR (p=0.160). A trend of increasing anterior translation was observed when the 5Nm internal rotation moment was applied up until the ACL was fully sectioned; however, these differences were not significant (p=0.070). The ALL and LMPR seem to have a synergistic relationship in aiding the ACL in controlling anterolateral rotational laxity. High-grade anterolateral laxity following ACL injury may be attributed to injuries of the ALL and/or the LMPR. We suggest that the lateral meniscus should be thought of as part of the anterolateral capsulomeniscal complex (i.e., LM, ITB, and ALL) that acts as a stabiliser of anterolateral rotation in conjunction with the ACL

The history of knee mechanics studies and the evolution of knee arthroplasty design have been well reported through the last decade (e.g. [1],[2]). Through the early 2000's, there was near consensus on the dominant motions occurring in the healthy knee among much of the biomechanics and orthopaedic communities. However, the past decade has seen the application of improved measurement techniques to permit accurate measurement of natural knee motion during activities like walking and running. The results of these studies suggest healthy knee motion is more complex than previously thought, and therefore, design of suitable arthroplasty devices more difficult. The purpose of this paper is to briefly review the knee biomechanics literature before 2008, to present newer studies for walking and running, and to discuss the implications of these findings for the design of knee replacement implants that seek to replicate physiologic knee motions. Many surgeons point to Brantigan and Voshell [3], an anatomic study of over one hundred specimens focusing on the ligamentous and passive stabilizers of the knee, as being an important influence in their thinking about normal knee function. M.A.R. Freeman and colleagues in London claim particular influence from this work, which motivated their extensive series of MR-based knee studies reported in 2000 [4,5,6]. These papers, perhaps more than any others, are responsible for the common impression that knee kinematics are well and simply described as having a ‘medial pivot’ pattern, where the medial condyle remains stationary on the tibial plateau while the lateral condyle translates posteriorly with knee flexion. Indeed, subsequent studies in healthy and arthritic knees during squatting and kneeling [7,8,9] and healthy and ACL-deficient knees during deep knee bends [10,11] show patterns of motion quite similar to those reported by Freeman and coworkers. These studies make a convincing case for how the healthy knee moves during squatting, kneeling and lunging activities. However, these studies are essentially silent on knee motions during ambulatory activities like walking, running and stair-climbing; activities which most agree are critically important to a high-function lifestyle. In 2008 Koo and Andriacchi reported a motion laboratory study of walking in 46 young healthy individuals and found that the stance phase knee center of rotation was LATERAL in 100% of study participants [12]. One year later, Kozanek et al. published a bi-plane fluoroscopy study of healthy knees walking on a treadmill and corroborated the findings of Koo and Andriacchi, i.e. the center of rotation in healthy knees walking was lateral [13]. Isberg et al. published in 2011 a dynamic radiostereometric study of knee motions in healthy, ACL-deficient and ACL-reconstructed knees during a weight-bearing flexion-to-extension activity, and showed consistent anterior-to-posterior medial condylar translations with knee extension, accompanied by relatively little lateral condylar translation [14]. Hoshino and Tashman reported in 2012 another dynamic radiostereometric analysis of healthy knees during downhill running and concluded “While the location of the knee rotational axis may be dependent on the specific loading condition, during … walking and running … it is positioned primarily on the lateral side of the joint. ”[15] Finally, Claes et al. reported in late 2013 the detailed anatomy of the anterolateral ligament (ALL), another structure serving to stabilize the lateral knee compartment near extension, roughly in parallel with the anterior cruciate ligament (ACL) [16]. Studies since 2008 [9,12–16] show knee motions during walking, running and pivoting activities do not fit the “medial pivot” pattern of motion, but rather point to a “lateral pivot” pattern of knee motion consistent with the stabilizing roles of the ACL and ALL. Having a medial center of rotation in flexion and a lateral center of rotation in extension greatly complicates knee arthroplasty design if the goal is to reproduce kinematics approximating those observed in the natural knee. Consistent kinematics having a fixed center of rotation implies joint stabilizing structures or surfaces, not simply articular laxity allowing the knee to move as forces dictate. Thus, a total knee arthroplasty design seeking to reproduce physiologic motions may need to provide distinct means for controlling tibiofemoral motion in both extension and flexion. Recent studies of natural knee motions have made the implant designer's job more difficult!

Aims

The aim of this study was to compare patient-reported outcomes (PROMs) following isolated anterior cruciate ligament reconstruction (ACLR), with those following ACLR and concomitant meniscal resection or repair.

Aims

The anterior cruciate ligament (ACL) is known to have a poor wound healing capacity, whereas other ligaments outside of the knee joint capsule such as the medial collateral ligament (MCL) apparently heal more easily. Plasmin has been identified as a major component in the synovial fluid that varies among patients. The aim of this study was to test whether plasmin, a component of synovial fluid, could be a main factor responsible for the poor wound healing capacity of the ACL.

Aims

Tibial plateau fractures (TPFs) are complex injuries around the knee caused by high- or low-energy trauma. In the present study, we aimed to define the distribution and frequency of TPF lines using a 3D mapping technique and analyze the rationalization of divisions employed by frequently used classifications.

Objectives

Static radiostereometric analysis (RSA) using implanted markers is considered the most accurate system for the evaluation of prosthesis migration. By using CT bone models instead of markers, combined with a dynamic RSA system, a non-invasive measurement of joint movement is enabled. This method is more accurate than current 3D skin marker-based tracking systems. The purpose of this study was to evaluate the accuracy of the CT model method for measuring knee joint kinematics in static and dynamic RSA using the marker method as the benchmark.