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Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_5 | Pages 57 - 57
1 Apr 2018
Dong N Yang S Zhu Z Wang A Gao J Qiu Y Zhang X
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Introduction

One of the objectives of total hip arthroplasty is to restore femoral and acetabular combined anteversion. It is desirable to reproduce both femoral and acetabular antevesions to maximize the acetabular cup fixation coverage and hip joint stability. Studies investigated the resultant of implanted femoral stem anteversion in western populations showed that the implanted femoral stems had only a small portion can meet the desirable femoral anteversion angle1, and anteversion angle increases after the implantation of an anatomical femoral stem with anteverted stem neck comparing to anatomical femoral neck2. The purpose of this study was to anatomically measure the anteversion angular difference between metaphyseal long axis and femoral neck in normal Chinese population. The metaphyseal long axis represents the coronal fixation plane of modern cementless medial-lateral cortical fitting taper stem. This angular difference or torsion Δ angle provides the estimation of how much the neck antevertion angle of femoral stem would be needed to match for desirable anatomical femoral neck version.

Methods

140 (77 male and 63 female) anonymous normal adult Chinese CT data with average age of 54.6 (male 54.6, female 54.5, P=0.95) were segmented and reconstructed to 3D models in Trauson Orthopeadic Modeling and Analytics (TOMA) program. Femoral head center, femoral neck axis and center point of diaphyseal canal 100mm bellow calcar formed the femoral neck plane. The metaphyseal stem implantation plane was determined by the center point of medial calcar, proximal canal central axis formed by femoral neck plane and the center point of diaphyseal canal 100mm bellow calcar. [Fig. 1] The angle between two planes was the torsion Δ angle between femoral placement plane and anatomical femoral neck. [Fig. 2] The torsion Δ angles were measured for all 140 cases. The traditional anteversion angle for anatomical femoral neck was also measured by Murphy's method. Student T test was perform to compare the angles for male and female. The 98% confidence level was assumed.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_4 | Pages 47 - 47
1 Feb 2017
Kang J Yang S
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Purpose

The purpose of this study was to assess the efficacy of newly designed topical administration of tranexamic acid (TXA) in reducing postoperative bleeding in total hip arthroplasty (THA) and bipolar hip hemiarthroplasty (BHA).

Method

Consecutive series of 160 hip arthroplasty were enrolled for this study. Topical administration of TXA was done in group 1(40 hips of THA and 40 hips of BHA). We compared the amount of blood loss and rates of postoperative transfusion with group 2 (40 cases of THA and 40 cases of BHA) in which TXA solution was not applied


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_9 | Pages 51 - 51
1 May 2016
Moon K Yang J Yang S
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Purpose

The results of ceramic-on-ceramic (CoC) bearing surfaces in primary total hip arthroplasty (THA) were well known. However, it was not known in revision THA. The purpose of this study is to report the results of revision THA with ceramic articulation.

Materials and Methods

112 revision THAs with ceramic articulation were evaluated. The mean age at the time of surgery was 58.3 years (28 to 97). The mean duration of the follow-up periods was 6.4 years (2 to 11.8 years).


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_3 | Pages 73 - 73
1 Jan 2016
Naganuma Y Takakubo Y Hirayama T Tamaki Y Oki H Yang S Sasaki K Kawaji H Ishii M Takagi M
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Introduction

Macrophages phagocytes implant wear debris and produce various cytokines to evoke inflammation and periprosthetic osteolysis of aseptic loosening. It had been reported that expression of Toll-like receptor (TLR) 2 and other TLRs increased in periprosthetic tissues of aseptic loosening. Pathogen-associated molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs) have been known as ligands of TLRs and considered to be involved in the osteolytic reactions via TLRs. Another type of immune sensors, nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR) with a pyrin domain 3 (NLRP3) can also recognize PAMPs and DAMPs as their lignds, which has been presumed to participate in the local host response of macrophage cascade via phagocytosis of implant wear particles. However, the contribution of NLRP3 in periprosthetic tissues of aseptic loosening and the correlation between TLR2 and NLRP3 are still unclear.

Materials and methods

TLR1, TLR2, TLR6, NLRP3, TNF-α and IL-1β of macrophages in aseptic loose periprosthetic tissues were immnohistorically evaluated and compared to osteoarthritic synovium. RAW264.7 cells, macrophagic cell line, were stimulated by titanium particles (Ti) and lipoteichoic acid (LTA)-coated Ti. The celluar reaction associated with TLR2 and NLRP3 and the correlation of them were analyzed at mRNA expression levels with small-interfering RNA of Irak2, one of adaptor molecules in TLR2 cascades.