Abstract
Purpose
The purpose of this study was to assess the efficacy of newly designed topical administration of tranexamic acid (TXA) in reducing postoperative bleeding in total hip arthroplasty (THA) and bipolar hip hemiarthroplasty (BHA).
Method
Consecutive series of 160 hip arthroplasty were enrolled for this study. Topical administration of TXA was done in group 1(40 hips of THA and 40 hips of BHA). We compared the amount of blood loss and rates of postoperative transfusion with group 2 (40 cases of THA and 40 cases of BHA) in which TXA solution was not applied
Results
The total amount of blood loss of THA group 1 and THA group 2 was 793±50 mL and 1086±73 mL respectively (p = 0.001). The transfusion rates of THA group 1 and THA group 2 was 27.5% and 50%, respectively (p= 0.039). The transfusion rates of BHA group 1 and BHA 2 group was 45% and 60%, respectively (p= 0.179). The amounts of blood loss through the drainage tube were 186±22 mL and 257±24 mL in THA group 1 and THA group 2, respectively, and 101±11 mL and 147±16 mL in BHA group 1 and BHA group 2, respectively, showing statistical significance. No complications such as infection, deep vein thrombosis, cardiovasular disease were observed during the hospital stay and last follow-up.
Conclusion
Topical administration of TXA is an effective and safe method to reduce postoperative bleeding and transfusion rates in hip arthroplasty.
