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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 572 - 572
1 Sep 2012
Khan A Ebreo D El Meligy M Armstrong C Peter V
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Introduction

The advantages of metal on metal (MOM) hip replacement are decreased wear rate, preservation of bone stock, anatomical restoration and enhanced stability. Large amounts of metal wear particles and metal ions are released which may induce adverse reactions including local soft tissue toxicity, hypersensitivity reactions, bone loss and risk of carcinogenesis. Aseptic loosening can be the result of a peri prosthetic osteolysis generated as a result of a biological response to particulate wear debris.

Our aim in this study was to determine whether a steeply inclined acetabular component would give rise to a higher concentration of metal ions.

Patients and methods

Between April 2003 and June 2006, 22 patients had MOM hip replacement for osteoarthritis by a single Surgeon. There were 12 male and 10 female patients. The average age at the time of surgery was 56 years (Range: 44–69 years). We divided the 22 patients into 2 groups, one group (A) of 11 patients with the acetabular inclination angle more than 50 degrees and the other group (B) of 11 patients with the angle less than 50 degrees. The inclination of the acetabular cup was measured using a standard AP radiograph of the pelvis.

The patients had metal ion levels (blood chromium and serum cobalt) measured at an average follow up of 3.2 years (Range 2.4 to 5 years).


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 224 - 224
1 Sep 2012
Ebreo D Khan A El-Meligy M Armstrong C Peter V
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INTRODUCTION

The advantages of large diameter metal on metal total hip arthroplasty (MoM THA) and hip resurfacing arthroplasty are decreased wear rate, preservation of bone stock, anatomical restoration and enhanced stability. Large amounts of metal wear particles and metal ions are released which may induce adverse reactions including local soft tissue toxicity, hypersensitivity reactions, bone loss and risk of carcinogenesis. Aseptic loosening can be the result of a peri-prosthetic osteolysis generated as a result of a biological response to particulate wear debris.

No reports in the literature exist as to whether circulating levels of Chromium (Cr) and Cobalt (Co) decrease upon removal of a symptomatic large diameter MoM implant or whether levels remain high due to the effect of metal ions debris left behind in the soft tissues after revision surgery.

PATIENTS AND METHODS

Between June 2006 and June 2009 we undertook 44 revision surgeries of both large head MoM THAs (femoral head diameter 38mm) and metal-on-metal hip resurfacings for suspected metallosis. Mean time from original implant to revision was 4 years, 8 months (1yr 4mo–7yr 9mo).

The mean follow up evaluation was 2 years and 2 months (1yr 2mo–4 years). Blood samples were taken for whole blood Cr and serum Co according to a recognised protocol and compared with reference levels indicated by the Medicines and Healthcare Regulatory Agency recommendation of less than 7ppb for Cr (130nM/L) and Co (119nM/L).


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 39 - 39
1 Jan 2011
El-Meligy M Armstrong C Miller D
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On hundred and ninety unselected patients, mean age 62(SD12.8) were operated upon by one surgeon, using same approach.

HSS improved from 33 to 75 post-operatively, the low figures reflecting a high percentage of Charnley C patients (71%). There was a 5% mortality rate from unrelated causes. Early complications included a 2.97% femoral fracture rate within 4–8 weeks of surgery (analysis showed no relation between implant position, BMI, age or Charnley classification, but there was correlation between high level of satisfaction and early weight bearing). There was one infection and one dislocation. Late complications included 3 periprosthetic fractures, 3 dislocations and 2 aseptic cup failures. However, 30% of patients developed groin pain, increasing stiffness and clunking at 1–2 years following surgery. These patients were investigated with an ultrasound scan. 28 patients (14%) had an effusion and were aspirated. Chrome and cobalt levels in synovial fluid, blood and urine were very high. 13 patients have been revised. 1 showed infection, 10 showed metal allergy and 2 a mixed picture of allergy and foreign body reaction.

In our MOM database (762 hips including the current study) a total of 35 patients were revised for similar problems. Two distinct histological finding were observed. Metal allergy occurred independently of cup angle. The implants were well fixed; there was tissue necrosis and histological evidence of ALVAL. There was no infection or metalosis.

FB reaction occurred more frequently when the cup was open. The Implants were loose; there was naked eye evidence of metalosis and metallic particles seen on light microscopy. We concluded that Birmingham/Freeman Hybrid had high complication rate without significant functional superiority, and other MoM devises shared similar complication. Both Metal allergy and FB reaction can occur in MOM THR. Ultra sound is a good screening tool in symptomatic patients.