Advertisement for orthosearch.org.uk
Results 1 - 2 of 2
Results per page:
Bone & Joint Research
Vol. 3, Issue 6 | Pages 187 - 192
1 Jun 2014
A versatile model of open-fracture infection
Penn-Barwell JG Rand BCC Brown KV Wenke JC
Full Access
View article Download PDF

Objectives

The purpose of this study was to refine an accepted contaminated rat femur defect model to result in an infection rate of approximately 50%. This threshold will allow examination of treatments aimed at reducing infection in open fractures with less risk of type II error.

Methods

Defects were created in the stablised femurs of anaethetised rats, contaminated with Staphylococcus aureus and then debrided and irrigated six hours later. After 14 days, the bone and implants were harvested for separate microbiological analysis. This basic model was developed in several studies by varying the quantity of bacterial inoculation, introducing various doses of systemic antibiotics with and without local antibiotics.

Bone & Joint Research
Vol. 1, Issue 11 | Pages 289 - 296
1 Nov 2012
The development of a novel model of direct fracture healing in the rat
Savaridas T Wallace RJ Muir AY Salter DM Simpson AHRW
Full Access
View article Download PDF

Objectives

Small animal models of fracture repair primarily investigate indirect fracture healing via external callus formation. We present the first described rat model of direct fracture healing.

Methods

A rat tibial osteotomy was created and fixed with compression plating similar to that used in patients. The procedure was evaluated in 15 cadaver rats and then in vivo in ten Sprague-Dawley rats. Controls had osteotomies stabilised with a uniaxial external fixator that used the same surgical approach and relied on the same number and diameter of screw holes in bone.

Image linking to Orthomedia