Tranexamic Acid Reduces Early Post-Operative Blood Loss After Simultaneous Bilateral Total Hip Arthroplasty

Introduction

Simultaneous bilateral total hip arthroplasty is now widely accepted for their economically and functionally advantages than staged total hip arthroplasty.

But there is concerning higher demands of blood transfusion than unilateral procedure.

Multiple studies suggest that tranexiamic acid (TXA) reduces perioperative blood loss.

However there is no report for simultaneous bilateral total hip arthroplasty in these studies.

Hypothesis

TXA reduces significant blood loss after bilateral total hip arthroplasty.

Patients and methods

We retrospectively reviewed the records of 12 patients who did not use TXA, and 12 patients who had used TXA. There were no significant differences between the groups in terms of demographics and preoperative Hb.

1g of TXA was administered just before first skin incision and 1g was administered 6 hours after surgery. Intra operative blood loss, the amount of drainage for the first operative day and perioperative Hb changes were recorded.

Results

TXA administered groups were significant lower intra operative blood loss (mean 1022 ml vs 623 mL) and drainage amount (mean 1930 mL vs 721 mL) and higher Hb levels postoperative 5 days.

Conclusion

TXA significantly reduced perioperative blood loss for simultaneous bilateral total hip arthroplasty.