Abstract
Purpose
The objective of this meta-analysis was to compare the effects of early and delayed surgery on the risk of mortality, common post-operative complications, and length of hospital stay among elderly hip fracture patients.
Methods
We searched MEDLINE and EMBASE for relevant prospective studies evaluating surgical delay in patients undergoing surgery for hip fractures published in all languages between 1966 and 2008. Two reviewers independently assessed methodological quality and extracted relevant data.
Results
Of 1939 citations identified, 16 observational studies that included a total of 13,478 patients with complete mortality data (1764 total deaths) met our inclusion criteria. Irrespective of the cut-off for delay (24, 48, or 72 hours), earlier surgery (< 24, < 48, or < 72 hours) was significantly associated with a reduction in the risk of unadjusted one-year mortality (relative risk 0.55; 95% confidence interval, 0.40 to 0.75, p=0.0002) and adjusted mortality rates (relative risk 0.81; 95% confidence interval, 0.68 to 0.96, p=0.01). Based on unadjusted data, earlier surgery also reduced in-hospital pneumonia (relative risk 0.59; 95% confidence interval, 0.37 to 0.93, p=0.02), pressure sores (relative risk 0.48; 95% confidence interval, 0.34 to 0.69, p< 0.0001) and hospital stay (weighted mean difference 9.95 days; 95% confidence interval, 1.52 to 18.39, p=0.02).
Conclusion
Earlier surgery was associated with a reduced risk of mortality, post-operative pneumonia, pressure sores, and length of hospital stay among elderly hip fracture patients. This suggests that it may be warranted to reduce surgical delays whenever possible. However, unadjusted analyses are certainly confounded, and residual confounding may be responsible for apparent effects in adjusted analyses. A definitive answer to this issue will require the conduct of a large randomised controlled trial to evaluate the effect of earlier surgery among patients admitted with a hip fracture.
