Introduction

We present the British Military's experience of treating devastating lower limb injuries in personnel returning from Iraq and Afghanistan. We evaluate current surgical practice of attempting to maximise stump length through sequential debridement, rather that early amputation outside the zone of injury. Following an observation that the frequency of sequential amputation had appeared to increase during spring 2009, it was speculated that there may be factors which would predict which patients would require a more aggressive early amputation.

Methods

The Joint Theatre Trauma Registry was interrogated for all cases of amputation between April 2006 and September 2009. The following data were collected: demographics, mechanism of injury, requirement for massive transfusion, use of combat applied tourniquet, number of stump debridements and echelon of care performed, all microbiology and final level of amputation. A regression analysis was performed to establish correlation between each data-set and final level of amputation.

Introduction

This is the first study to illustrate spinal fracture distribution and the impact of different injury mechanisms on the spinal column during contemporary warfare.

Methods

A retrospective analysis of Computed Tomography (CT) spinal images entered onto the Centre for Defence Imaging (CDI) database, 2005-2009. Isolated spinous and transverse process fractures were excluded to allow focus on cases with implications for immediate management and prospective disability burden. Fractures were classified by anatomical level and stability with validated systems. Clinical data regarding mechanism of injury and associated non-spinal injuries for each patient were recorded. Statistical analysis was performed using Fisher's Exact test.

Introduction and aims

We present a series of patients who have had secondary reconstruction of war injuries to the upper and lower limbs, sustained during the Iraq and Afghanistan conflicts.

Material and Methods

All patients were seen at the combined Peripheral Nerve Injuries Clinic at the Defence Medical Centre for Rehabilitation, Headley Court. All surgery was performed at Odstock Hospital. Procedures include scar excision and neurolysis (all patients), release of scar contractures, tenolysis, tendon transfers, revision nerve grafts, excision of neuroma, and soft tissue reconstruction using pedicled or free flaps.

Introduction

A common injury pattern in current military experience is traumatic lower limb amputation from improvised explosive devices. This injury can co-exist with pelvic girdle fractures.

Methods

We reviewed 67 consecutive patients with traumatic lower limb amputations treated in Camp Bastion Hospital, Afghanistan.

Introduction

Haemorrhage is the main cause of preventable death on the modern battlefield. As Improvised Explosive Devices (IED) in Afghanistan become increasingly powerful, more proximal limb injuries are occurring. Significant concerns now exist about the ability of the windlass Combat Application Tourniquet to control distal haemorrhage following mid-thigh application.

Aim

To evaluate the efficacy of the CAT windlass tourniquet in comparison to the newer pneumatic Emergency Military Tourniquet (EMT).

Introduction

The resurgence of TB worldwide has several underlying causes, but HIV infection has undoubtedly been a key factor in the current TB epidemic. Since TB is endemic in the developing world the influence of HIV is of concern, particularly with the emergence of multi-drug-resistant strains. The remarkable susceptibility of patients with AIDS to develop TB has shown the critical role of CD4 lymphocytes in protective immunity. In the absence of immunological surveillance by CD4 cells, 5-10% of persons with latent foci of TB reactivate each year.

Aim

This paper highlights the presentation and outcome following treatment in HIV patients with spinal TB.

Background

The purpose of this study was to evaluate the independent contributions of surgeon procedure volume, hospital procedure volume, and standardisation of care on short-term post-operative outcomes and resource utilisation in lower-extremity total joint arthroplasty.

Methods

An analysis of 182,146 consecutive patients who underwent primary total joint arthroplasty was performed with use of data entered into the Perspective database by 3421 physicians from 312 hospitals over a two-year period. Adherence to evidence-based processes of care was defined by administration of appropriate perioperative antibiotic prophylaxis, beta blockade, and venous thromboembolism prophylaxis. Patient outcomes included mortality, length of hospital stay, discharge disposition, surgical complications, readmissions, and reoperations within the first 30 days after discharge. Hierarchical models were used to estimate effects of hospital and surgeon procedure volume and standardisation on individual and combined surgical outcomes and length of stay.

Introduction

Intimate partner violence (IPV) is a pattern of coercive behaviours that include repeated physical, sexual and emotional abuse. Musculoskeletal injuries are common symptoms of IPV. We aimed to determine the proportion of female patients, attending orthopaedic fracture clinics, that have experienced IPV defined as physical, sexual, or emotional abuse within the past 12 months.

Methods

We completed a cross-sectional study of 282 injured women attending two Level I trauma centres in Canada. Female patients presenting to the orthopaedic fracture clinics completed two validated self-reported written questionnaires; the Woman Abuse Screening Tool (WAST) and the Partner Violence Screen (PVS) to determine the prevalence of IPV. The questionnaire also contained questions that pertain to participant demographics, fracture characteristics, and experiences with health care utilisation.

Introduction

Most studies now use Patient Reported Outcome Measures (PROMS) as the preferred and only method for assessing ‘functional outcome’ following surgery. It is thought that these questionnaires accurately reflect the patient's pain and physical function. We hypothesised that comprehensive functional examination would therefore correlate strongly with PROMS following total knee arthroplasty (TKA).

Methods

We prospectively assessed the function of 100 consecutive knee replacement patients, pre-operatively, then at 8, 26 and 52 weeks post-operatively. PROMS employed were the Oxford Knee Score (OKS) and the Short Form-36. Additionally, leg strength (Leg Extensor Power Rig(tm)), a validated battery of timed functional tasks (Aggregated Locomotor Function, ALF) and pain scores (numerical rating scale) were also assessed. Statistical analysis was performed using the Minitab version 15 software. Level of significance was set as p = < 0.05.

Introduction

Bearing surfaces used for total hip arthroplasty must have characteristics including bio-compatibility, low friction and low wear rate. Bearing combinations are generally characterised as Soft on Hard/Hard. In general, all newer bearing combinations have reduced wear but may present with other issues that impact on patient outcomes.

Materials

The Australian Orthopaedic Association – National Joint Replacement Registry classifies bearing surfaces into six categories. These are metal on polyethylene, ceramic on polyethylene, metal on metal, ceramic on ceramic, ceramic on metal and a sixth category relating to a small number of procedures where the bearing surface is yet to be classified. 147,422 conventional total hip arthroplasty procedures have been recorded by the Registry between 1 September 1999 and 31 December 2008 and analysis has been performed of the cumulative percentage revision in relation to bearing surface.

Introduction

The management of degenerative arthritis of the knee in the younger, active patient presents a challenge to the orthopaedic surgeon. Surgical treatment options include: high tibial osteotomy (HTO), unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA). The aim of this study was to examine the long-term survival of closing wedge HTO in a large series of patients up to 19 years after surgery.

Methods

Four hundred and fifty-five consecutive patients underwent lateral closing wedge HTO for medial compartment osteoarthritis (MCOA) between 1990 and 2001. Between 2008-2009, patients were contacted via telephone. Assessment included: incidence of further surgery, current body mass index (BMI), Oxford Knee Score, and British Orthopaedic Association (BOA) Patient Satisfaction Scale. Failure was defined as the need for revision HTO or conversion to UKA or TKA. Survival analysis was completed using the Kaplan-Meier method.

Introduction

Although hip arthroplasty has been very successful in relieving pain and optimising function, problems have arisen with wear and osteolysis. Highly cross linked polyethylene has been developed to address this problem. The aim of this study was to compare the in vivo wear of standard versus highly cross linked polyethylene (HXLP) in primary total hip arthroplasty at 5-year follow up.

Methods

Approval was obtained through the Regional Ethics Committee before commencement of the study. 122 patients were enrolled in a prospective, double blinded, randomised trial and followed annually to assess their progress. Annual radiographs were analysed using previously validated edge detection software to assess for 2 dimensional, 3 dimensional and volumetric wear. To reduce the disproportionate effects of bedding in and creep, the initial x-ray used was that taken at 6 months following surgery.

Background

Periprosthetic fracture fixation can be a difficult and complex procedure. The incidence of such fractures is increasing relative to the high prevalence of elderly patients with joint arthroplasty and osteoporosis. Locking plates were introduced for the management of complex periarticular fractures in osteoporotic bone, but there is little information on the use of these plates for the management of periprosthetic fractures. The purpose of this study was to review the early experience with these plates in managing complex Vancouver B1 and C periprosthetic fractures at our academic centre to determine the effectiveness in achieving union, and to identify any potential complications associated with their use.

Methods

We evaluated the results of Vancouver B1 and type C periprosthetic fractures treated with Synthes LCP. The mean age of the patients at the time of surgery was 76 years. 5 patients were men and 10 were women. There were 8 Vancouver B1 and 7 Vancouver C fractures. 6 fractures had failed previous operative treatment. No patient was lost to follow-up. We assessed time to union, complications, and identified criteria for cortical fixation using these plates.

Introduction

MRI signal changes are commonly found with myelopathy. The clinical significance of these signal changes in myelopathic patients remains debated. The purpose of this study was to perform a meta-analysis of the data to determine the effect of MRI signal change on pre-operative and post-operative Japanese Orthopaedic Association (JOA) scores and on recovery rate following surgery.

Methods

A comprehensive review of the literature was performed to identify all published studies that provided data on the presence of MRI signal change as well as JOA scores in patients with cervical spondylotic myelopathy. Data was tabulated and JOA scores were normalised to the 17-point scale. T-tests were performed to determine if there were significant differences between pre-operative and post-operative JOA scores in patients with or without MRI signal change. The recovery rate was calculated for all patients undergoing surgery. T-tests were performed to determine if significant differences occurred in recovery rate in patients with or without MRI signal change.

Purpose

The optimal sequencing of radiotherapy (RT) with surgery in soft-tissue sarcomas (STS) remains undefined. We assessed the impact of RT sequencing on overall survival (OS), cause-specific survival (CSS), local failure, and distant failure.

Methods

A retrospective analysis was conducted using the National Oncology Database, a proprietary database of aggregated tumour registries owned by Impac^(r) Medical Systems (Sunnyvale, CA). Eligible sites were soft tissues of the head/neck, thorax, abdomen, pelvis, extremities, trunk, and peritoneum. Only patients with known stage and grade were included. Prognostic factors were identified with multivariate analysis (MVA) using the Cox proportional hazards model. Survival was calculated using the Kaplan-Meier method, and compared for statistical significance (p< 0.05) using the log-rank test.

Introduction

Recently, femoroacetabular impingement has been postulated as an important cause for the development of primary osteoarthritis of the hip. Various studies have shown that primary osteoarthritis of the hip is rare amongst Asians including Indians. We conducted an anthropometric study to evaluate prevalence of abnormal head-neck offset in Indian population and to correlate it with the low prevalence of primary osteoarthritis in Indian population.

Material and Methods

We retrospectively evaluated three dimensional CT scans of hips conducted as a part of another project done over a period of two years at our institute. An axial image was created parallel to the central axis of the femoral neck and passing through the centre of the femoral head using coronal scout view. This image was then used to calculate Alpha and Beta angles and head-neck offset ratio.

Aims

To discover how the management of traumatic anterior shoulder dislocation in the young patient (17-25) has changed, if at all, over the past six years.

Methods

The same postal questionnaire was sent in 2002 and 2009 to 164 shoulder surgeons. Questions were asked about initial reduction, investigation undertaken, timing of surgery, preferred stabilisation procedure, period of immobilisation and rehabilitation programme instigated in first-time and recurrent traumatic dislocators.

Introduction

The purpose of this study was to examine the effects of baseline mental health on functional outcomes after primary knee arthroplasty by reviewing the data collected in a multi-centre prospective observational cohort study. We hypothesised that those patients with lower baseline mental health status would demonstrate significantly worse outcomes vs their counterparts with higher mental status following primary total knee arthroplasty.

Methods

Data from a multi-centre prospective cohort study of PS (posterior stabilising implant) and CR (cruciate retaining implant) primary knee arthroplasty were compared to determine the relationship between baseline mental health status and functional outcomes post-surgery. Subjects were followed from the time of the index surgery to monitor outcomes and complications. Validated quality of life instruments, including SF-36, WOMAC, Knee Society Score, and an activity scale were used. Changes from baseline to 1 year on the SF-36 and WOMAC were evaluated. Regression analysis was completed to assess changes in WOMAC based on baseline SF-36 scores. All analyses were adjusted for age, BMI, gender, and implant type.

Background and aim

Total hip replacements (THRs) are associated with significant blood loss which often requires high transfusion rates of allogeneic blood. Although safer than ever, allogeneic blood transfusion is still associated with risks to the recipients. This meta-analysis aims to investigate the efficacy and safety of tranexamic acid (TXA) in reducing blood loss and allogeneic blood transfusion after THR.

Patients and Methods

A systematic review and meta-analysis of published randomised controlled trials which used TXA to reduce blood loss and transfusion in hip arthroplasty were conducted. The data were evaluated using the generic evaluation tool designed by the Cochrane Bone, Joint and Muscle Trauma Group.

Introduction

Although good mid-term results have been reported with some metal on metal hip replacements, reported complications due to metal on metal (MOM) related reactions are a cause for concern. We have assessed the early clinical outcome and results of routine metal artefact reduction MRI findings in a consecutive series of patients with a modern large head metal on metal hip replacement.

Methods

62 ASR XL Corail total hip replacements (THR) and 17 ASR resurfacings were performed at our hospital between 2005 and 2008. All patients were reviewed and assessed with an Oxford hip score (OHS), a plain radiograph and a MRI imaging was obtained on 76 (96%) hips. Implant position was assessed using Wrightington cup orientation software.

Introduction

The articulating surfaces of a new metal-on-metal (MoM) hip prosthesis system were modified with the ceramic Titanium-Niobium-Nitride (TiNbN) by Physical Vapor Deposition (PVD). The purpose of the study was to investigate whether the elevation of the ion levels of chromium and cobalt, normally seen in the blood of patients after MoM hip arthroplasty, can be prevented by ceramic engineering of the articulating metal surfaces.

Materials and methods

the ACCIS components (manufactured by Implantcast GmbH, Buxtehude, Germany from casted hi-carbon Co-Cr-Mo alloy) are heat treated, polished and micro-surface finished. Then TiNbN ceramic is integrated into the metal surfaces by PVD.

200 ACCIS resurfacing hip prostheses were implanted in three centres: Morriston Hospital, Swansea and Neville Hall Hospital, Abergavenny in the UK and Arthro Clinic, Hamburg, Germany. Blood samples of 60 randomly selected patients were analysed before surgery and at intervals of 3, 6, 12 and 24 months after surgery. Independent trace metal measurements were performed at the Universitätsklinikum Carl Gustav Carus Dresden, Germany.

Introduction

Infection is disastrous in arthroplasty surgery and requires multidisciplinary treatment and debilitating revision surgery. Between 80-90% of bacterial wound contaminants originate from colony forming units (CFUs) present in operating room air, originating from bacteria shed by personnel present in the operating environment. Steps to reduce bacterial shedding should reduce wound contamination. These steps include the use of unidirectional laminar airflow systems and the introduction of theatre attire modelled on this principle (e.g. total body exhaust suits). Our unit introduced the use of the Stryker Sterishield Personal Protection System helmet used with laminar flow theatre systems. This study compares an enclosed helmet system used with standard gowns, with standard hood and mask attire.

Method

12 simulated hip arthroplasties were performed, six using disposable sterile impermeable gown, hood and mask and a further 6 using a Sterishield helmet and hood. Each 20 minute operation consisted of arm and head movements simulating movements during surgery. Air was sampled at wound level on a sterile draped operating table using a Casella slit sampler, sampling at 700l/minute. Samples were incubated on Blood agar for 48 hours at 37°c and the CFUs grown were counted.

Background

Labral tears are now recognised as a common pathology especially in young adults. With advancement of arthroscopic techniques, most recent published literature is focused on short- or mid-term results of labral repair or re-fixation. There is limited data regarding long-term results of labral debridement and effect of co-existing pathology on outcomes. We investigated long-term results after arthroscopic labral debridement, the predictors of outcomes and correlation with any co-existing hip pathology.

Materials and Methods

Between 1996 and 2003, 50 patients who underwent hip arthroscopy and labral debridement with mean follow-up of 8.4±1.7 years (range 7-13.6 years) were included in our study. Patients' pre-operative Harris Hip Score and co-existing pathologies such as FAI, dysplasia or arthritis were recorded as variables. Further, patients' post-operative HHS and satisfaction at the time of follow-up were recorded as outcomes. Spearman's rho correlation coefficient and regression analysis were calculated between these variables and outcomes.

Introduction

In cases of unilateral clubfoot, the leg and foot is visually smaller than the opposite, uninvolved side. Parents want to know how much smaller the leg and foot will be. The purpose of this study was to answer this question and compare the results of children treated with a posterior medial release (PMR) with those treated with the Ponseti method (PM).

Methods

This is a prospective, longitudinal study of calf circumference and foot length. We measured the calf circumference with a tape measure at the visually maximum girth of the uninvolved side and at the symmetrical position of the involved side. We measured each foot length from the tip of the hallux to the end of the heel. We recorded the measurements at each follow-up visit in a database and analysed the data using linear regression analysis.

Aim

The treatment of relapsed clubfeet presents a significant challenge. The Ilizarov method of gradual correction has been shown to provide satisfactory outcome. Since 2001 we have employed a newer differential soft tissue distraction using an Ilizarov frame in relapsed feet based on the Ponseti principles. The aim of our study was to analyse the outcome of this treatment.

Material and Methods

All feet treated with soft tissue distraction only were studied. The feet were assessed using international clubfoot study group evaluation, pedobarography, and gait analysis, X-rays and ASK (activity scale for kids) questionnaire.

Background

The new Fassier-Duval Telescopic IM System (FD-rod) has the advantage of a single entry point over the traditional telescopic rods such as the Bailey-Dubow or Sheffield rods. Although encouraging early results were presented by François Fassier, there is no formal publication in the literature as yet.

Methods

The first 24 consecutive cases (age 1.5-12.5 years) with a minimum of 1 year follow-up (1-2.4 years) after femoral and/or tibial FD-rods were reviewed to assess complications involving migration, non-telescoping, joint intrusion, infections and re-operation rates in patients with Osteogenesis imperfecta (OI, 15 cases), congenital tibial pseudarthrosis (CPT) in Neurofibromatosis Type1 (NF1, 2 cases), and Epidermal Naevus syndrome (1 case). In 6 cases of patients with Hypophosphataemic Rickets FD-rods were combined with an Ilizarov frame.

Purpose

To determine, in skeletally immature children with acceptably angulated (< = 15 degrees deformity at presentation) distal radius fractures, if a pre-fabricated wrist splint is at least as effective as a cast.

Methods

A randomised controlled, non-inferiority, single blinded, single-centre trial was performed. The primary outcome was physical function at six weeks. Secondary outcomes included angulation, wrist range of motion, strength, pain, and patient preferences.

Aim

Up to 34% of fractures of the distal radius in children can ‘re-displace’ early after reduction. Main risk factors are initial displacement (bayonet apposition, > 50% translation, and > 30°angulation), isolated distal radius fracture, associated ulna fracture at the same level, inadequate initial closed reduction and poor casting technique. This study was to identify the rate of ‘re-displacement’ following first successful reduction in distal radius fractures. We also assessed the risk factors associated with initial injury and compared the efficacy of the available indices to assess the quality of casting.

Materials & Methods

We performed a case note based radiographic analysis of 90 distal radius fractures treated at our centre from 2005 to 2008. A cohort of 18 patients with re-displacement was compared with 72 patients with maintenance of reduction. Radiological indices were calculated to assess the quality of casting technique. The patient and fracture demographics were compared between the two groups. Statistical analysis was carried out using ANOVA, Fisher's Exact Test and multiple logistic regression analysis.

Background

Arthrogryposis Multiplex Congenita is a rare congenital disorder associated with multiple musculoskeletal contractures which causes substantial morbidity. Knee involvement is commonly seen among children with arthrogryposis, with flexion contracture being the most frequent. The purpose of this study was to assess the effectiveness of orthopaedic procedures, namely distal femoral supracondylar extension osteotomy and/or Ilizarov external fixator, on the ambulation status of children with knee flexion contracture and whether any functional gains are maintained at the latest follow-up.

Methods

Fifteen patients were identified and their medical records reviewed. The mean age at their first surgery was 7.6 years (range, 2-16 years). The etiology for all patients was amyoplasia. The mean length of follow-up was 58 months (range, 12-117 months). Contractures were treated with femoral extension osteotomy (n=8), Ilizarov external fixator (n=2), or both (n=5).

Introduction

Habitual dislocation of the patella is rare in children. Several procedures have been described to stabilise the patella by lateral release and medial check-reins. The results are unpredictable. The failure is probably due to passive stretching of the static stabilisers of the patella ie. tendons and capsule. The aim of this paper is to describe the outcome of Pes Anserinus transfer for habitual dislocation of the patella in children.

Methods

Eleven children (13 knees) were reviewed retrospectively between 1990 and 2008 following surgical realignment. The age ranged between 5-13 years. Two had ligamentous laxity. Nine dislocated in flexion and 2 in extension. Through a lateral incision the iliotibial band, vastus lateralis and lateral capsule were released. Through a medial incision the capsule was reefed and the pes anserinus insertion was transferred to the medial side of the patella and its tendon. The vastus lateralis was reattached more proximally to the rectus. Quadriceps rehabilitation was started 4 weeks following plaster immobilisation.

Purpose

In recent years, it has become increasingly common to publish the level of evidence of orthopaedic research in journal publications. Our primary research question is: is there an improvement in the levels of evidence of articles published in paediatric orthopaedic journals over time? In addition, what is the current status of levels of evidence in paediatric orthopaedic journals?

Methods

All articles in the Journal of Paediatric Orthopaedics-A and Journal of Paediatric Orthopaedics-B for 2001, 2002, 2007 and 2008, and in the Journal of Children's Orthopaedics for 2007 and 2008, were collected. Animal, cadaveric and basic science studies, expert opinion and review articles were then excluded. The 750 remaining articles were blinded and put in random order. The abstract, introduction and methods of each article were independently reviewed. According to the currently accepted grading system, study type (therapeutic, prognostic, diagnostic, economic) and level of evidence (I, II, III, IV) were assigned. Inter- and intra-observer reliability were investigated.

Purpose

The purpose of this study was to investigate the difference in the level of pre- and 6 months post-operative objective and subjective measures of disability between patients with full-thickness rotator cuff tears and those with impingement syndrome/low grade partial thickness rotator cuff tears. Impact of age, gender, and job demands was taken into consideration.

Methods

Standardised pre- and post-operative data were collected on consecutive patients who had undergone surgery related to rotator cuff pathology. A disease-specific disability measure, the Western Ontario Rotator Cuff (WORC) Index which explores five domains of physical symptoms – life style, work, sports, and emotions – was the primary outcome. Paired and independent non-parametric statistics and multivariable regression analysis were performed.

Hypothesis

Reverse shoulder arthroplasty has good mid-term results for rotator cuff deficient arthritic conditions.

Methods and Analysis

103 reverse shoulder arthroplasties were performed in 91 patients from January 2003 to September 2009. Twelve patients had bilateral reverse shoulder arthroplasties.

Background

Cuff tear arthropathy represents a challenging problem to the shoulder arthoplasty surgeon. Poor results of conventional total shoulder arthroplasty in cuff deficient shoulders due to glenoid component loosening have meant hemiarthroplasty has been the traditional preferred option. Recently reverse total shoulder arthroplasty (RSA) has gained increasing popularity due to a clinical perception of an improved functional outcome. This is despite the lack of comparative data, particularly in relation to modern hemiarthroplasty prostheses. The aim of this study was to compare the early functional results of Hemiarthroplasty versus RSA in the management of cuff-tear arthropathy.

Material and Methods

Patients were identified from the New Zealand National Joint Registry and matched for age, sex, and American Society of Anesthesiologists scores.102 primary hemiarthroplasties performed for cuff tear arthropathy were compared with 102 RSAs performed for the same diagnosis. Oxford shoulder scores (OSS) were collected prospectively at 6 months and five years post operatively together with mortality and revision rates.

Background

Fractures of the radial head result from an axial force that causes impaction against the capitellum. Associated lesions of the capitellum in this pattern of injury have been previously reported in the orthopaedic literature as an uncommon occurrence.

Methods

All patients presenting to the clinics of the senior surgeon between 1998-2008 with radial head fractures requiring surgery were included. Data collected included demographics (age, gender, side of injury), mechanism, timing of injury and injury type (Mason classification). Intraoperative findings including evidence of union, capitellar injury, associated joint dislocation, collateral ligament injury, and any other fractures around the elbow were documented.

Aims

Compression and absolute stability are important in intra-articular fractures such as transverse olecranon fractures. This biomechanical study aims to compare tension band wiring (TBW) with plate fixation by measuring compression within the fracture.

Methods

A cross-over design and synthetic ulna models were used to reduce variation between samples. Identical transverse fractures were created using a 0.5mm saw blade and cutting jig. A Tekscan(tm) force transducer was calibrated and placed within the fracture gap. Twenty TBW or Acumed(tm) plate fixations were performed according to the recommended technique.

Compression was measured while the constructs were static and during simulated elbow range of movement exercises. Dynamic testing was performed using a custom jig reproducing cyclical triceps contraction of 20N and reciprocal brachialis contraction of 10N. Both fixation methods were tested on each sample. Half were randomly allocated to TBW first and half to plating first. Data was recorded using F-scan (v 5.72) and analysed using SPSS(tm) (v 16). Paired T-tests compared overall compression and compression at the articular side of the fracture.

Background

For correction of cubitus varus deformity many types of osteotomies and fixation methods have been described, but besides technical difficulties, they have limitations such as non-union, stiffness of the elbow joint and neurovascular injury. The prominence of the lateral condyle can also give rise to a poor cosmetic result. To overcome these problems, we reviewed the results of simple dome osteotomy with fixation by cross pins.

Methods

From 2003 to 2007, eleven children with cubitus varus deformity having full range of movements and good elbow function had surgery. The average age was 9.2 years (range, 7 to 13) and M:F ratio was 4:1. Through a posterior triceps splitting approach a dome-shaped osteotomy is fashioned, the distal part of humerus is aligned as planned and then fixation by cross pinning is achieved. Patients were followed for two years. Pre-operative and post-operative humeral-elbow angles, ranges of motion and lateral prominence indices were compared. The results were evaluated according to the modified criteria of Oppenheim et al.

Background

Comminuted radial head fractures are challenging to treat with open reduction and internal fixation. Complicating matters further, radial head fractures are often associated with other elbow fractures and soft tissue injuries. Radial head arthroplasty is a favorable technique for the treatment of radial head fractures. The purpose of this study was to evaluate the functional outcomes of radial head arthroplasty using Modular Pyrocarbon radial head prosthesis in patients with unreconstructible radial head fractures.

Methods

This single surgeon, single centre study retrospectively reviewed the functional and radiological outcomes of 21 consecutive patients requiring radial head arthroplasty for unreconstructible radial head fractures between July 2003 and July 2009. Patients were at least one year post-op and completed a Short-Form 36 (SF-36) questionnaire, the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, and the Mayo Elbow Performance Index (MEPI). These patients were independently physically examined and their post-operative radiographs were independently reviewed.

Background

Rotator cuff tears pose a huge socioeconomic burden. Our study uses Fourier transform infrared spectroscopy (FTIR) as it is a quick, non-manipulative and non-destructive test, which can identify a wide range of chemical targets from small intraoperatively obtained specimens. The aim of this study was (i) to characterise the chemical and structural composition of rotator cuff tendons and (ii) to identify structural differences between anatomically distinct tear sizes. Such information may help to identify specific biomarkers of rotator cuff tear pathologies, which in turn could allow early identification and monitoring of disease progression. FTIR may provide insight into the different healing rates of different tear sizes.

Methods

The infrared spectra of 81 torn rotator cuff tendons were measured using a FTIR spectrometer. The rotator cuff tear sizes were classified as partial, small, medium, large and massive, and compared to 14 normal controls. All spectra were classified using standard multivariate analysis; principal component analysis, partial least square and discriminant function analysis.

Aim

Biomechanical models of the shoulder have been used to measure forces and glenohumeral pressures. Their results have been found to vary. The aim of this study was to produce a biomechanical model to replicate the biomechanical principles of the glenohumeral joint and to measure the centre of pressure on the glenoid through a mid-range of arm movement with an intact and a compromised rotator cuff.

Method

The model consisted of anatomic saw-bones of a scapula and proximal humerus with calibrated extension springs to mimic rotator cuff muscles. Glenoid pressures were measured using pressure sensitive film. The joint was examined through a mid-range of movement with an intact rotator cuff and a supraspinatus deficiency.

Purpose

Chemokines produced by synoviocytes of the subacromial bursa are up-regulated in subacromial inflammation (bursitis) and rotator cuff disease. SDF-1a is an important chemotactic factor in the subacromial bursa that stimulates recruitment of inflammatory cells; however, its mechanism of induction and regulation in the subacromial bursa is unknown. We hypothesised that SDF-1a production in bursal synoviocytes may be induced by local cytokines such as interleukin IL-1β and IL-6.

Methods

Subacromial bursa specimens were obtained following an institutional review board-approved protocol from patients undergoing shoulder surgery. Bursal specimens were stained with anti-human antibodies to IL-1, IL-6 and SDF-1a by immunohistochemistry and compared to normal and rheumatoid controls. Bursal cells were also isolated from specimens and cultured. Cultured cells were labelled with fluorescent probes and analysed by flow cytometry to determine cell lineage. Early-passaged cells were then treated with cytokines IL-1β and IL-6 and SDF-1a production and expression were measured by ELISA and RT-PCR.

Purpose

To examine measurement properties of four disability outcomes in patients with advanced osteoarthritis of the glenohumeral joint.

Methods

This was a prospective longitudinal study of patients with advanced osteoarthritis of the glenohumeral joint who underwent a Total Shoulder Arthroplasty (TSA) and were followed for 6 months. Four measures [Western Ontario Osteoarthritis Shoulder (WOOS) Index, the American Shoulder and Elbow Surgeons (ASES) assessment, Constant-Murley score (CMS), and Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH)] were completed 2-3 weeks before surgery and at 6 months after surgery.

Introduction

The incidence of acetabular fractures in the elderly population is increasing. Treatment with staged or acute total hip arthroplasty (THA) is occasionally required. The role of acute THA however, remains controversial. The purpose of our study was to assess the outcomes of a subgroup of elderly patients who underwent early simultaneous open reduction and internal fixation (ORIF) and primary THA for displaced acetabular fractures.

Materials and Methods

86 patients underwent ORIF for displaced acetabular fractures at The Alfred Hospital, Melbourne between August 2007 and August 2009. Eight of these patients underwent early simultaneous ORIF and primary THA. Mean age was 79 years. Mean time between injury and surgery was 4 days. Mean time of follow-up was 19 months. There were 3 both-column fractures, 2 anterior column, 1 posterior wall, 1 transverse with posterior wall and 1 T-shaped. Two patients had an associated neck of femur fracture and two had an impaction fracture of the femoral head. The Harris and Oxford hip scores were used to assess clinical outcome. Radiographs were analysed for component loosening.

Introduction

The treatment of displaced femoral neck fractures in elderly patients is under debate. Hemiarthroplasty is a recognised treatment for elderly patients with reduced capacity for mobilisation. Controversy exists around cemented or uncemented implants for hemiarthroplasty in this population. The aim of this study is to investigate outcomes of cemented vs uncemented hemiarthroplasty implants to two years post operation.

Methods

All elderly patients presenting to one institution with a displaced subcapital neck of femur fracture were offered inclusion. One hundred and sixty patients (mean age, 85 years) with acute displaced femoral neck fractures were randomly allocated to be treated with cemented Exeter, or uncemented Zweymüller Alloclassic Hemiarthroplasty. Clinical and radiologic follow-up to two years with the main outcome measurements being pain, mortality, mobility, complications, reoperations, and quality of life using validated scores recorded by a blinded outcome assessor.

Objectives

To determine whether a delay to surgery (>36Hours) affects mortality rate, length of stay and post-operative complications following hip fracture surgery.

Methods

Data collected by dedicated Audit staff using a proforma designed in accordance with the ‘Standardised Audit of Hip Fractures in Europe’ (SAHFE). A prospective Observational Study, all patients (n=7207) admitted and who underwent surgery during a 10-year period from May 1999 to May 2009 have been considered. Chi square tests and independent sample t tests were used for basic statistical analyses. Mortality data were analysed using Kaplan Meier survival analysis and cox regression analysis. p < 0.05 was considered significant.

Purpose

The objective of this meta-analysis was to compare the effects of early and delayed surgery on the risk of mortality, common post-operative complications, and length of hospital stay among elderly hip fracture patients.

Methods

We searched MEDLINE and EMBASE for relevant prospective studies evaluating surgical delay in patients undergoing surgery for hip fractures published in all languages between 1966 and 2008. Two reviewers independently assessed methodological quality and extracted relevant data.

Aim

To evaluate the outcome and complications of pubic symphysis plating in the stabilisation of traumatic anterior pelvic ring injuries.

Methods

All patients who underwent anterior pelvic ring stabilisation with a pubic symphysis plate in a tertiary referral pelvic and acetabular reconstruction unit were studied. Patients were followed up annually for five years with AP, inlet and outlet radiographs at each visit. The fracture classification, type of fixation (including additional posterior fixation), and incidence of metalwork failure were recorded.

Introduction

Successful tendon repairs are reliant on the suture material having high tensile strength, no or little tissue response, good handling characteristics and little elastic/plastic deformation. Plastic deformation contributes to gap formation at a tendon repair site. Previous research has shown a gap greater than 4mm is likely to fail. Pre-tensioning is a commonly used method to improve the handling properties of sutures. This study investigates whether the plastic deformation demonstrated by two suture materials used in flexor tendon repair is affected by manual pre-tensioning.

Material/Methods

Twenty lengths of 3/0 Prolene (Ethicon, UK) and 3/0 Ethibond Excel (Ethicon, UK) were selected. Half of the sutures in each group were manually pre-tensioned (longitudinal stretch of 15N for 3s) prior to knot tying (standard surgical knot with six throws) and half were knotted without pre-tensioning. The suture lengths were measured before and after a standardised cyclical loading regime on a tensile tester. The regime was designed to represent the finger flexion forces produced in an active rehabilitation programme after tendon repair. All sutures were subsequently tested to their ultimate tensile strength.

Purpose

Osteoarthritis of the trapezio-metacarpal joint (TMJ or basal thumb joint) is a common condition causing significant disability. A range of non-operative and operative management options can be used for its treatment. One of the most common conservative treatments is a steroid injection into the joint. To confirm correct placement of the steroid it is preferable to use X-ray image intensification. Few previous studies have audited effectiveness, particularly with the use of radiological guidance.

Methods

This clinical observational study prospectively reviewed the longevity of benefit of steroid injections into the TMJ. They were followed up until the analgesic effects ceased with a questionnaire including visual analogue scores. The clinical improvement was compared with the degree of radiological osteoarthritis (Eaton grade). Seventy-seven patients were recruited with a median age of 62 years and injected with steroid and local anaesthetic under radioscopic guidance.

Introduction

Evaluating the success of a treatment has changed. Currently, the emphasis is on patient-rated outcome scores rather than surgeon recording of outcome measures. Functional outcome and patient satisfaction following Dupuytren's disease surgery is poorly quantified in the literature. This study aimed to assess subjective patient hand function, disability and satisfaction using a PEM score and its correlation with residual contracture.

Methods

Percutaneous Needle Fasciotomy (PNF) is performed in our outpatient clinic to treat Dupuytren's contracture at MCP joints. A validated patient completed questionnaire (PEM) was used to record patient demographics, side of surgery, finger involved, time since surgery, residual symptoms, disability, subjective hand function and satisfaction. The questionnaire was posted to all patients who had PNF over the study period (n=68) along with a stamped addressed envelope and participant information sheet.

Objective

To assess patterns of recurrence in patients with Dupuytren's disease after surgery for proximal interphalangeal joint (PIPJ) deformity.

Methods

81 patients (94 fingers) with Duputyren's contracture of the proximal interphalangeal joint underwent surgery to have either a ‘firebreak’ skin graft (46 fingers) or a fasciectomy (48 fingers). They were reviewed after three weeks, six weeks, 6, 12, 24 and 36 months to note the range of movement and recurrence. Both groups were similar with regard to age, gender and factors considered to influence the outcome such as bilateral disease, family history, and the presence of diabetes, smoking and alcohol intake.

Introduction

Getting the distal locking screw lengths right in volar locking plate fixation of distal radius is crucial. Long screws can lead to extensor tendon ruptures whereas short screws can lead to failure of fixation, especially if there is dorsal comminution of the fracture. The aim of our study was to determine the distal radius anatomy in relation to sagittal lengths and distance between dorsal bone edge and extensor tendons based on MRI scan.

Method

One hundred consecutive MRI scans of wrist were reviewed by two of the authors on two occasions. All MRI scans were performed for different wrist pathologies except distal radius fractures or tumours. An axial image, two cuts proximal to the last visible articular surface, was selected. Sagittal length at 5 different widths, maximum volar width, radial overhang over distal radio-ulnar joint and the distance between dorsal bone edge and extensor tendons were measured.

Aim

With the current wave of enthusiasm for internal fixation with volar locking plates in the treatment of distal radial fractures, radiology of the wrist needs review.

With current standardised x-rays of the wrist there is often an appearance of intra-articular screws. This is on account of the objective of getting very distal subchondral fixation and fixation into the radial styloid. As a consequence, due to the volar tilt and radial inclination of the ‘anatomic’ wrist, fixation is often perceived and reported to be intra-articular.

It is proposed in this study that ‘standard’ wrist x-rays post-internal fixation be taken with 20° elbow flexion on the lateral view to counteract radial inclination.

The postero-anterior view should be angled 10° to view the joint without the effect of normal radial tilt.

Method and Materials

30 consecutive wrists treated by fixed angled volar fixation were analysed. In each case standard x-rays and the proposed ‘20, 10’ radiographs were obtained. The ‘20, 10’ x-rays were taken with a custom-made set of bolsters set at 20° and 10° for the Lateral and PA views. Each set of x-rays (a standard PA and lateral and the so called ‘20, 10’ proposed radiographs) were commented on by 2 Radiologists and 2 Orthopaedic Surgeons.

Aim

Fixation of distal radial fractures via the volar approach has become a commonly performed procedure over the past few years. This study is to highlight potential pitfalls with this ‘everyday’ procedure and to perhaps temper over-enthusiasm for plating all wrist fractures.

Method and materials

164 consecutive cases of wrist fracture treated by means of fixed angle volar fixation were looked at. In each case any recorded complication prior to completion of treatment was documented. The complications were divided into major and minor depending on the severity and long-term outcome and overall result.

Introduction

Ulnar shortening osteotomy has become an accepted treatment for a variety of ulnar sided wrist disorders. We have been performing ulnar shortening with an oblique osteotomy cut with the aid of a commercially available jig. The osteotomy is then fixed with a Dynamic Compression Plate. The aim of this study was to report the complications following ulnar shortening.

Methods

We retrospectively analysed 56 consecutive ulnar shortening osteotomies. There were 36 female and 19 male patients. The mean age was 45 years. The mean follow-up was 399 days. 25 patients had pre-operative MRI scans and in 34 arthroscopy of the wrist had been performed. 22 tears of the triangular fibrocartilage complex were recorded on arthroscopy. In all cases shortening had been performed with the aid of a jig and bone resection performed in an oblique orientation. Dynamic Compression Plates were used for fixation and a lag screw was inserted through one of the plate-holes and across the osteotomy site. Radiographs were evaluated for pre-operative and post-operative ulnar variances and post-operatively for bony union.

Introduction

Rolando type base of thumb metacarpal fractures are potentially debilitating injuries, which can be difficult to manage because of their inherent instability. Malunion is associated with stiffness, pain and weakness of pinch grip. We aimed to assess the outcome of a simple technique for the treatment of this fracture using the principle of ligamentotaxis, with a static, 2-pin external fixator spanning the trapeziometacarpal joint. We present the results and functional outcomes of this technique.

Methods

A consecutive series of 8 patients (7 males, 1 female) with Rolando type intra-articular fractures of the base of the first metacarpal was retrospectively reviewed. All cases were performed by the senior author using a static, 2-pin Mini-Hoffman external fixator. Case notes and radiographs were reviewed, and patients' functional outcome assessed using the Quick Disability of Arm, Shoulder and Hand (Quick DASH) scoring system. Mean age of the group was 32.8 years (range 18.1-52.3 years). Mean follow-up was 2.7 years (range 3.5 months to 6.0 years).

Purpose

To characterise inflammatory cell subtypes in early human tendinopathy we explored the phenotype and quantification of inflammatory cells in torn and control tendon samples.

Design

Controlled laboratory study

Aim

To delineate which of four common and easily constructed Ilizarov frame configurations is best at resisting shear displacement.

Methods

Four Ilizarov frames were constructed on Sawbones™ Tibiae taking into account soft tissue and neuro-vascular limitations in frame design. The designs consisted of a standard all wire frame, an opposing olive wire standard frame, a perpendicular trans-fracture opposing olive wire frame and a perpendicular half pin frame. These were tested over three cycles in compression on a load-testing machine with movement in the plane of the fracture measured using a clip gauge. Each frame was tested to the maximum displacement of the clip gauge or a total single cycle compressive load of 700N, whichever limit occurred first.

Introduction

Segmental tibia fractures are high-energy injuries that are difficult to treat. We report on the use of the Ilizarov Method to treat 40 consecutive AO 4.2C (35) and AO 4.2B3 (5) fractures by a single surgeon. Fractures with bone loss requiring transport were excluded, as were fractures initially treated with nail or plate. Patients: 28 adult males, 12 adult females, mean age 43. The most common mechanism of injury was RTA (50%). Twelve patients (30%) had associated injuries. Nineteen (48%) fractures were open (6 Gustillo-Anderson 3A, 13 Gustillo-Anderson 3B) and 21 closed; 24 (60%) had temporary monolateral external fixation before definitive treatment. The mean time from injury to definitive Ilizarov frame was 8 days.

Results

37 (93%) healed without the need for any bone-stimulating procedure. The other 3 healed with further procedures and a second frame. There were no amputations and no deep infections. None required intervention for malunion. The total time to healing was calculated from date of injury to frame removal. Open fractures (mean 214 days, median 182) took longer to heal than closed fractures (mean 177 days, median 177). Minor complications included snapped wires (2) and minor pinsite infections treated with oral antibiotics (9). Clinical scores were available for 25 of the 40 patients (median 55 months post-injury) with ‘Good’ Olerud and Molander ankle scores (median 80), ‘Excellent’ Lysholm knee scores (median 99), median Tegner activity score of 4 (comparable to ‘moderately heavy labour’) and above mean population SF12 scores (mean PCS 52, mean MCS 54)

Introduction

Open tibial fractures are associated with an increased risk of infection. The infection rate increases with increasing severity and grade of fracture. Various management options available for fracture treatment are in turn associated with complications including infection. Circular fine-wire fixators cause minimal intra-operative soft tissue disruption and possibly have a better outcome and low complication rates.

Objectives

To analyse the effectiveness of circular fine-wire fixators in managing open tibial fractures and to determine the incidence of complications, particularly infection associated with use of these fixators.

Introduction

We present our experience of lower limb reconstruction for patients with obvious defects in the tibia, by bone transport using a stacked Taylor Spatial Frame.

Methods

A retrospective review of 40 patients treated between 2003 and 2009. There were 19 cases of infected non union, 9 cases of acute bone loss following fracture, 6 cases of chronic osteomyelitis, 4 cases of aseptic non union, 1 case of neurofibromatosis and 1 case of a loose and infected total ankle replacement.

Background

Leg length discrepancy (LLD) after intramedullary nailing of femoral shaft fractures is a common problem reported in up to 43% of cases. Comminuted fractures with radiographic loss of bony landmarks have an increased possibility of being fixed with unequal leg lengths.

Aims

The purpose of this report is to evaluate the efficacy of routinely obtaining a CT scanogram post-operatively on patients of comminuted femoral shaft fractures treated with intramedullary nailing and immediate correction of limb length inequality if indicated.

Introduction

Humeral non-union may present a challenging problem. The instability from the un-united fracture leads to pain, disability and significant morbidity. The incidence of humeral shaft non-union as a complication of both operative and non-operative treatment is approximately 8% to 12%. This retrospective study reviews the results of surgical treatment of humeral fracture non-union performed by a single surgeon with a consistent surgical protocol.

Material and Method

We present a retrospective analysis of a series of 51 consecutive cases of humeral fracture non-union treated in our limb reconstruction centre. Data were collected on mechanism of injury, associated co-morbidities, smoking, use of NSAIDs and treatment before referral. Patients were followed up to clinical and radiological union.

Background

Identification of novel therapeutics to accelerate acute fracture healing remains critical. A prostaglandin EP-2 receptor agonist (CP-533,536) has demonstrated acceleration of fracture healing in preclinical models. The objective of this study is to assess the efficacy of a single dose of CP-533,536 in subjects with a closed fracture of the tibial shaft using radiographic measurements compared to placebo treatment.

Methods

In a phase II randomised, blinded, placebo-controlled trial, the efficacy of a single local injection of three doses of CP-533,536 (0.5mg, 1.5mg and 15mg) was compared to a placebo and a standard of care arm in patients with closed tibial shaft fractures. The tibial fractures were treated with reamed inter-locked intramedullary nails. Patients were followed at two week intervals to six months with a final evaluation at one year. Fracture healing was independently adjudicated by a radiologist panel and an orthopaedic surgeon panel.

Introduction

Varus positioning of cemented ‘composite beam’ stems is associated with increased risks of aseptic loosening and stem fracture. We investigated whether the incidence of varus malalignment of the Exeter polished, double taper design in a multicentre prospective study adversely affected outcome after total hip replacement (THR).

Materials & Methods

A multicentre prospective study of 1189 THR was undertaken to investigate whether there is an association between surgical outcome and femoral stem malalignment. The primary outcome measure was the change in the Oxford hip score (OHS) at five years. Secondary outcomes included the rate of dislocation and revision, stem subsidence, quality of cementing. 938 (79.89%) were followed-up at five years.

Background

Correct positioning of the femoral component in resurfacing hip arthroplasty (RHA) is an important factor in successful long-term outcomes. The purpose of computer-assisted navigation (CAS) in resurfacing is to insert the femoral neck guide wire with greater accuracy and to help size the femoral component, thus reducing the risk of notching at the head and neck junction. Several recent studies reported satisfactory precision and accuracy of CAS. However, there is little evidence that CAS is useful in the presence of anatomical deformities of the proximal femur, which is frequently observed in young patients with secondary degenerative joint disease.

Aim

The purpose of this in vitro study was to determine the accuracy of an image-free RHA navigation system in the presence of angular deformity of the neck, pistol grip deformity of the head and neck junction and slipped upper femoral epiphysis deformity.

Background

The New Zealand Joint Registry was started in 1999. An audit in 2009 showed 98% compliance. Ten year results were published in 2009. For Total Hip Replacement it showed that dislocation was the most common cause for revision (35%).

Methods

We reviewed the rate of revision for dislocation in the two most common diagnostic groups, Osteoarthritis (86%) and Acute Fracture NOF (3.6%) relative to the two most common surgical approaches, posterior and lateral. We also sought to analyse whether larger femoral head sizes decreased the dislocation rate.

Hypothesis

Successful total hip arthroplasty (THA) in the presence of developmental dysplasia of the hip (DDH) depends on restoration of the anatomic centre of hip rotation and may require simultaneous femoral osteotomy. Techniques using uncemented components are widely reported. In osteopenic bone an all-cemented technique may be more appropriate; however, the outcome following this procedure is not known. We present the results of a series of thirty-five cemented THA with simultaneous subtrochanteric osteotomy.

Methods and analysis

28 patients with DDH (35 hips) who underwent this procedure at a mean age of 47.3 years were retrospectively reviewed. Two patients (two hips) died within 12 months of surgery. The clinical notes and radiographs of the remaining patients were reviewed with a minimum follow-up of 2 years (mean, 5.6 years; range, 2-14 years). Complications were noted. SF-12 and Oxford hip scores (OHS) were recorded for 18 patients pre-operatively and after 6 and 12 months.

Introduction

Despite evidence of long term survival of cemented femoral stem prostheses, studies have shown concerns in the longevity of the cemented sockets. This has led to a rise in the use of uncemented and hybrid implants (with uncemented cup and cemented stem) without long term studies to determine evidence for their use. We aimed to assess whether there is any difference in clinical outcome between cemented and non-cemented acetabular fixation in elderly patients.

Patients and Methods

Between February 2001 and August 2006 186 patients over 72 years of age were prospectively randomised to receive either a cemented Exeter cup or a HA coated press fit cementless cup. Both groups received a cemented Exeter stem. The patients were assessed pre-operatively and reviewed at 6 weeks, 6 months and yearly in a research clinic, by an independent observer. Outcome measures were the Merle D'Aubigné, Postel, Oxford Hip and Visual analogue pain scores. The implants were also assessed radiographically and all complications were recorded.

Aim

The purpose of this study was to perform a randomised controlled trial (RCT) to compare the >20 year outcomes of cemented versus cementless Mallory Head total hip replacements (THRs).

Methods

Two hundred and fifty patients with unilateral osteoarthritis of their hip, a mean age of 64 years and 48% of whom were female were randomised to receive either a cemented (n=124) or cementless (n=126) THR.

Hypothesis

The Synergy femoral component was introduced in 1996 as a second generation titanium proximally porous-coated tapered stem with dual offsets to help better restore femoral offset at THR. The purpose of this prospective study was to evaluate the long-term (minimum 10 year) clinical and radiographic results and survivorship of this femoral component at our institution.

Methods & Analysis

From 1996 to 1999, 256 cementless Synergy femoral components were inserted and followed prospectively in 254 patients requiring THR. 185 were standard offset stems (72.3%) while 71 stems (27.7%) were high offset. The average follow-up was 11.2 years (range 10.0 to 12.9 years). Average age at index THR was 58.9 year. Two hundred and eight stems had standard porous coating while 48 had additional HA coating. Fifty-two cases were either lost to follow-up or had died prior to 10 years follow-up. Patients were followed prospectively using validated clinical outcome scores and radiographs. Kaplan-Meier survival analysis was performed.

Background

We present the results of cementless total hip arthroplasty using anatomically adapted stem and hemispherical cup with a fully coated Spongiosa metal surface, first introduced in 1982, which aims to achieve a surface structure approaching that of human cancellous bone. This implant is still being used in clinical practice with minor modifications.

Aim

The aim of the study is to determine the long-term outcomes of spongiosa-I metal surface hip arthroplasty over minimum of twenty years follow-up.

Aim

To study the efficacy of Hydroxyapatite (HAC) Ceramic Coated hip arthroplasty. Is it suitable for the younger patient?

Methods

This series of 2390 primary HAC hip arthroplasties has been studied for up to 21 years. (569 hips over 10 years including 98 hips over 15 years) Patients are assessed by Harris Hip Score and plain X-ray. The prosthesis consists of a fully coated stem and a fully coated acetabulum. A ceramic head articulates with an acetabular liner which is either plastic (UHMW polythene) or ceramic. No cement is used. HA coated implants are physiologically fixed to cancellous bone by a process of osseointegration. Other uncemented implants are pathologically fixed by fibrous scar tissue. These two methods of fixation should be considered separately and not combined as ‘uncemented’.

Introduction

Wear of the ultra high molecular weight polyethylene (UHMWPE) cup and the resulting loosening has been shown to limit the long-term results of the Charnley low-frictional torque arthroplasty (LFA). Factors affecting wear rates have been studied: level of patient activity, effective roughness of the stainless steel head, impingement and the possible variations in wear characteristics of UHMWPE. Since patients' activity level cannot be predicted or modified, alternative materials were examined.

Methods and Results

The Charnley 22.225 mm diameter head of alumina ceramic in combination with chemically cross-linked polyethylene cup has now reached over 23 years of clinical and radiographic follow-up. Of the initial 17 patients (19 hips) in the study, 4 patients (4 hips) have died, 1 hip has been revised for deep infection and 3 patients (3 hips) are unable to attend follow-up due to medical problems unrelated to the hip. Nine patients (11 hips) are still attending follow-up at a mean of 22 years 5 months (21 year 3 months-23 years 6 months). The mean age at surgery in this group was 47 years (26-58) and the mean weight 81kgs (54-102). The mean penetration rate was 0.02mm/year and none have exceeded 0.41mm total penetration.

Introduction

Cement pressurisation in the distal humerus is technically difficult due to the anatomy of the humeral intramedullary (IM) cavity. Conventional cement restrictors often migrate proximally or leak, reducing the effect of pressurisation during implantation. Theoretically with a better cement bone interdigitation, the longevity of the elbow replacement can be improved. The aim of this cadaveric study was to evaluate the usefulness of a novel technique for cementation.

Method

Eight paired fresh frozen cadaveric elbows were randomly allocated to conventional cementing techniques or cementing using a paediatric foley catheter as a temporary restrictor. The traditional cementing technique consisted of canal preparation using irrigation, brushing and drying prior to cementation, with no use of a cement restrictor. The new technique involved same canal preparation but prior to cementation a size 8 foley catheter was introduced and the balloon inflated to act as a temporary cement restrictor. The humeri were cut into 10mm sections. Each slice was photographed and radiographed. This dual imaging technique was used to establish the best methodology for evaluation of cement penetration. Cement penetration was calculated as a ratio of the area of intra-medullary cavity occupied by the cement.

Background

An osteochondral defect in the knees of young active patients represents a treatment challenge to the orthopaedic surgeon. Early studies with allogenic cartilage transplantation showed this tissue to be immunologically privileged, showed fresh grafts to maintain hyaline cartilage, and surviving chondrocytes several years after implantation.

Methods

Between January 1978 and October 1995 we enrolled 63 patients in a prospective non-randomised study of fresh osteochondral allografts for post-traumatic distal femur defects in our institute. Five international patients who were lost to follow-up were excluded from this study. The indications for the procedure were: patients younger than 50 years of age having unipolar post-traumatic defects, or osteochondritis dissecans larger than three cm in diameter and one cm in depth.

Purpose

To identify the incidence and reasons for revision of the Oxford prosthesis (OXF) in New Zealand.

Methods

Review and compare UKA and TKA data including patient-generated Oxford scores after operation.

Background

A commonly held belief amongst surgeons and patients is that progression of disease (arthritis) to other compartments is a major cause of early failure of UKRs.

Methods

We analysed the NJR database records of 17,643 primary UKRs performed between April 2003 and April 2009. Where these had been revised the reason for revision was noted.

Background

Unicompartmental knee arthroplasty provides a good alternative to total knee arthroplasty in patients with isolated medial compartment osteoarthritis. Reported ten-year survival for the Oxford medial unicompartmental knee arthroplasty is variable, ranging from 80.2% to 97.7% in the originator series. The aim of this study was to determine the survival and reasons for revision of the Oxford medial unicompartmental knee arthroplasty when performed at a specialist orthopaedic centre.

Methods

Details of consecutive patients undergoing Oxford unicompartmental knee arthroplasty at our centre between January 2000 and December 2009 were collected prospectively. Failure of the implant was defined as conversion to total knee arthroplasty. Survival was determined using the Kaplan-Meier method.

Background

There are different opinions amongst surgeons as to the selection criteria for UKR with regards to age and BMI. Many surgeons perceive higher rates of failure in young or overweight patients or often choose TKR for elderly patients.

Methods

We analysed the registry records (UK National Joint Registry) of 10,104 patients who had undergone UKR with a minimum of two years follow-up from their primary surgery. BMI data was recorded in 1,831 (18%) and age in all. There were 295 deaths and these patients were excluded from our analysis. Patients' BMI were categorised according to Department of Health and WHO (2004) classification (Normal, Pre-Obese, Obese I, Obese II, Obese III)

Background

Unicompartmental knee replacement (UKR) is an established treatment for single compartment end-stage knee arthrosis with good recorded survivorship. Although often used in more active younger patients, patient selection remains controversial. To identify risk factors for early failure we compared patients with UKR failure requiring revision to total knee replacement (TKR) with a control group.

Methods & Results

Between September 2002 and 2008, 812 Oxford Mobile Bearing Medial UKRs were implanted. 21 implants (20 patients) required revision to TKR within 5 years. The leading cause for revision was lateral compartment disease progression (11 patients). In the revision group, 17 patients were female (81%), average age at index surgery was 64.1 (range 48-81) and average BMI 31.8 (range 24.4-41.5). In the control group of all patients who underwent UKR during this period, 348 patients were female (44%), average age was 65.0 (range 36-89) and average BMI 31.2 (range 21.0-61.0).

Radiological assessment of the tibiofemoral valgus (TFV) angle for revision patients was compared with an age and sex matched control group. In the revision group, average TFV angle was +1.5 pre-operatively and +6.1 post-operatively with an average change of +4.6. In the control group average TFV angle was -0.4 pre-operatively and +4.3 post-operatively with an average change of +4.7.

Background

Autologous chondrocyte implantation (ACI) and mosaicplasty (MP) are two methods of repair of symptomatic articular cartilage defects in the adult knee. This study represents the only long-term comparative clinical trial of the two methods.

Methods

A prospective, randomised comparison of the two modalities involving 100 patients with symptomatic articular cartilage lesions was undertaken. Patients were followed for ten years. Pain and function were assessed using the modified Cincinnati score, Bentley Stanmore Functional rating system and visual analogue scores. ‘Failure’ was determined by pain, a poor outcome score and arthroscopic evidence of graft disintegration.

Introduction

Young, high-demand patients with large post-traumatic tibial osteochondral defects are difficult to treat. Fresh osteochondral allografting is a joint-preserving treatment option that is well-established for such defects. Our objectives were to investigate the long-term graft survivorships, functional outcomes and associated complications for this technique.

Methods

We prospectively recruited patients who had received fresh osteochondral allografts for post-traumatic tibial plateau defects over 3cm in diameter and 1cm in depth with a minimum of 5 years follow-up. The grafts were retrieved within 24 hours, stored in cefalozolin/bacitracin solution at 4°C, non-irradiated and used within 72 hours. Tissue matching was not performed but joints were matched for size and morphology. Realignment osteotomies were performed for malaligned limbs. The Modified Hospital for Knee Surgery Scoring System (MHKSS) was used for functional outcome measure. Kaplan-Meier survivorship analysis was performed with conversion to TKR as end point for graft failure.

Aim

We report the results of a modified Fulkerson technique of antero-medialisation of the tibial tubercle, combined with microfracture or abrasion arthroplasty in patients under 60 with patello-femoral osteoarthritis.

Methods

All patients operated between September 1992 and October 2007 were reviewed by an independent observer in clinic or by postal questionnaire, using the Oxford Knee Score, Melbourne Patella Score and a Satisfaction Score. Only patients with Outerbridge Grade 3-4 osteoarthritis of the patello-femoral joint were included. They were assessed pre-operatively with plain x-rays, MRI scans (as well as tracking scans in the last 10 years) and arthroscopically. All patients with tracking scans showed lateral subluxation of the patella. The surgical procedure was a modification of Fulkerson's tibial tubercle osteotomy, with an advancement of 1-1.5cms and a medialisation of 1.5cms. The exposed bone of the patella and trochlea was drilled in the early cases and in the later cases an arthroscopic microfracture or abrasion using a power burr was carried out.

Introduction

In 1976 the senior author presented to the Associations the results of patellectomy with satisfactory results in less than 50% of cases. In 1989 with the increasing success of TKR we started a prospective study of the Lubinus prosthesis for patellofemoral arthritis. After 4 years results were not satisfactory. The main causes of failure were mal-tracking and instability leading to polythene button wear, and arthritic disease progression. A new prosthesis was designed in 1996 to correct these problems.

Methods

We have prospectively recorded the results of a consecutive cohort of 537 Avon arthroplasties. The outcomes have been assessed with survivorship, pain, Oxford and WOMAC scores. We have identified 24 patients from our own series and from tertiary referrals who have persistent pain, due to technical error rather than arthritic disease progression.

Introduction

Unidirectional mobile bearing knees (RP) were developed to optimise the tibio-femoral articulation in an effort to enhance function and reduce polyethylene wear. The self-aligning bearing should also benefit the patello-femoral joint further improving outcome. This study was designed to assess whether these potential benefits are realised in the clinical setting.

Methods

A total of 352 patients undergoing a PS PFC Sigma TKR were randomly allocated to receive either a Mobile Bearing (176 knees) or a Fixed Bearing (176 knees) tibial tray. Within each group a further randomisation for patella resurfacing versus retention was included. All knees were scored using standard outcome tools (Oxford, AKSS, Patella Score) by independent nurse specialists.

Introduction

The precise indications for tibial component metal backing and modularity remain controversial in routine primary total knee arthroplasty. This is particularly true in elderly patients where the perceived benefits of metal backing such as load redistribution and the reduction of polyethylene strain may be clinically less relevant. The cost implications for choosing a metal-backed design over an all-polyethylene design may exceed USD500 per primary knee arthroplasty case.

Methods

A prospective randomised clinical trial was carried out at the QEII Health Sciences Centre, Halifax, Nova Scotia, to compare modular metal-backed versus an all-polyethylene tibial component. Outcome measures included clinical range of motion, radiographs, survivorship, Knee Society Clinical Rating System, WOMAC and SF-12.

Background

An MRI scan of the patient's hip, knee and ankle is used to produce The Signature patient specific jig. The jig is used to aid the accuracy of implantation of a TKR. This study compared the accuracy of implantation of a TKR using The Signature patient specific jig or a standard jig.

Hypothesis

There is no difference in alignment between a patient specific and standard jig assisted TKR.

Aim

We report the results of Cobb I procedure and Rose calcaneal osteotomy for stage II posterior tibial dysfunction in a consecutive series of thirty patients.

Methods

These patients were reviewed prospectively after average of 30 months (range: 12-92 months). An experienced independent, biomechanics specialist carried out the ultrasound examination to assess dynamic function of the posterior tibial tendon at final follow-up.

Purpose

The objective of this study was to compare items from musculoskeletal outcome questionnaires with items generated by pre- and post-operative ankle arthrodesis and arthroplasty patients (patient-selected portion of the Patient-Specific Index (PASI-P)) to determine if existing questionnaires address patients' concerns.

Materials/Methods

Patients (n=142) completed the PASI-P. Items from 6 standardised questionnaires (AAOS, patient-reported portion of AOFAS, FFI, LEFS, SMFA, WOMAC) and PASI-P were matched by 3 reviewers to corresponding categories in the International Classification of Functioning, Disability and Health (ICF). The ICF classification hierarchy codes broad first categories and increasingly detailed second, third, and fourth categories. The standardised questionnaires were then compared to the ‘gold standard’ of PASI-P.

Background

There are reports of good early results in small numbers of patients implanted with the ‘Moje’ ceramic prosthesis. Published evidence thus far involves only small groups of patients with short-term follow-up. The purpose of this prospective study was to evaluate the emerging mid-term clinical and radiological results from our centre.

Methods

We describe our single-surgeon experience of 63 components in 48 patients at a mean follow-up of 44 months. Patient satisfaction was assessed by questionnaire and radiographic assessment was performed immediately post-operatively and at the maximum follow-up.

Background

Salvage procedures on the 1^st MTPJ following failed arthroplasty, arthrodesis or hallux valgus surgery are difficult and complicated by bone loss. This results in shortened first ray and transfer metatarsalgia. We present our experience of using tri-cortical interposition grafts to manage this challenging problem.

Methods

Between 2002 and 2009 our department performed 21 1^st MTPJ arthrodeses using a tri-cortical iliac crest interposition graft. Surgical fixation was achieved with a compact foot plate. We performed a retrospective review from the medical notes and radiographs along with American Foot and Ankle scores which were collected prospectively.

We analysed the following parameters: time to radiological union, requirement for further surgery, lengthening of 1^st ray and any post operative complications.

Purpose

Identifying optimal treatment strategies for inpatients with traumatic foot and ankle injuries has been hampered by a wide variety of outcome measures with unproven reliability and validity. It remains plausible that the choice of functional outcome measures may influence measurement of treatment effects. This prospective observational study aims to measure the correlation and agreement across six functional outcome measures in patients with traumatic foot and ankle injuries.

Methods

Patients 18 years of age or older with a traumatic foot or ankle injury completed the Short Form-12 (SF-12), Short Musculoskeletal Functional Assessment (SMFA), Foot Function Index (FFI), Foot and Ankle Ability Measure (FAAM), American Academy of Orthopaedic Surgeons (AAOS) Foot and Ankle Questionnaire and American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale at a single follow-up visit. Raw scores were calculated and transformed to a functional level of excellent, very good, good, fair or poor. Pearson correlation co-efficients providing measures of correlation and agreement between functional levels were assessed.

Introduction

Excessive soft tissue swelling will delay surgery for a proportion of patients admitted with ankle fractures. Surgical and anesthetic teams may waste time assessing patients destined to be cancelled due to swelling. The aim of this investigation was to determine factors associated with cancellation.

Methods

Case notes of 87 patients (46 male, 41 female), mean age 43 years (range, 13 to 80) who underwent ankle fracture fixation were retrospectively analysed. 31 of 87 ankles (36%) were unsuitable for day after admission surgery due to swelling. Factors investigated included age, gender, mechanism of injury, fracture configuration and necessity for reduction on arrival in the emergency department due to dislocation; each factor was independently analysed for significance using Fisher's exact test.

Background

Ankle fractures represent an increasing workload, particularly in the elderly female population. The posterior tibial tendon is exposed to injury during displaced medial malleolar fractures. Posterior tibial tendon dysfunction delays rehabilitation and results in significant morbidity and is most prevalent in women over 40.

Objective

To ascertain whether posterior tibial tendon should be routinely explored in displaced medial malleolar fractures and consequently should post-operative rehabilitation of ankle fractures be modified. Intra-operative assessment of the tendon may help with this diagnosis and consequently alter post-operative rehabilitation.

Background

Patients with diabetes who sustain an ankle fracture are at increased risk for complications including higher rates of in-hospital mortality, in-hospital post-operative complications, length of stay and non-routine discharges.

Aim

The purpose of this study was to retrospectively compare the complications associated with operatively treated ankle fractures in a group of patients with uncomplicated diabetes versus a group of patients with complicated diabetes. Complicated diabetes was defined as diabetes associated with end organ damage such as peripheral neuropathy, nephropathy and/or PAD. Uncomplicated diabetes was defined as diabetes without any of these associated conditions. Our hypothesis was that patients with uncomplicated diabetes would experience fewer complications than those patients with complicated diabetes.

Aim

The purpose of this clinical series is to prospectively review the mid-term clinical and radiographic outcomes of the Scandinavian Total Ankle Replacement (STAR) performed at two academic Canadian University centres.

Methods

Between 1998 and 2005, 111 STAR were implanted into 98 patients at two Canadian centres. Prospective clinical and radiographic follow-up was performed. Validated and non-validated outcome questionnaires consisting of the AAOS foot and ankle questionnaire, AOFAS Hindfoot score, Foot Function Index (FFI), Ankle Osteoarthritis Scale (AOS) were completed. Sixty four patients were followed with these scores prospectively and 50 retrospectively. Both groups had prospective radiographic follow-up using measures described by Hintermann et al, and Wood et al.

Introduction

Coronal plane deformity can pose difficulties with balancing in Total Ankle Replacement (TAR). Current reports outline improved outcomes in the presence of varus deformity. Soft tissue balancing techniques are well described, but are limited by no link to eitiology and pathoanatomy of the deformity.

Method

A prospective review of all the TAR by the senior author was performed to identify cases of pre-operative varus greater than 10°. A chart review was performed to identify aetiology, intraoperative findings, and operative techniques to achieve a balanced TAR. X-rays were examined to measure deformity and amount of correction. Volumetric rendering and segmentalisation was performed on pre- and post-CTs to identify anatomical defects, osteophyte formation, rotational and translational changes of the hindfoot joints.

Background

Subtalar fusion is traditionally an open procedure with potentially significant complications but there is little published on arthroscopic subtalar arthrodesis.

Methods

We present the first UK series of 33 arthroscopic subtalar fusions in 32 patients, with a variety of pathologies

Introduction

The advantage of using SPECT-CT over conventional bone scanning is that it has the promise of linking the multiplanar reconstructional images of CT with the functional analysis of bone scintigraphy. It delivers information regarding new pathology and is regarded as more sensitive and specific. We present our experience of use of the SPECT-CT in the analysis of continued or recurrent pain post-foot and ankle arthrodesis.

Methods and Materials

A retrospective analysis of all post-arthrodesis patients with continued pain who underwent SPECT-CT was carried out. The scans and notes from clinical examination were evaluated. The request for the scan was at the clinician's discretion and was reserved for presentations where the diagnosis was unclear on clinical and radiological grounds.

Background

Microdiscectomy involves substantial aggressive excision of disc material from the intervertebral space to prevent reherniation. However, the recent trend is towards conservative disc removal and simple fragment excision (sequestrectomy).

Aim

To compare the clinical outcome of microdiscectomy and sequestrectomy

Introduction

Total disc replacement (TDR) provides an alternative to fusion that is designed to preserve motion at the treated level and restore disc height. The effects of TDR on spine biomechanics at the treated and adjacent levels are not fully understood. Thus, the present study investigated facet changes in contact pressure, peak contact pressure, force, peak force, and contact area at the facet joints after TDR.

Methods

Seven fresh-frozen human cadaveric lumbar spines were potted at T12 and L5 and installed in a 6-DOF displacement-controlled testing system. Displacements of 15° flexion/extension, 10° right/left bending, and 10° right/left axial rotation were applied. Contact pressure, peak contact pressure, force, peak force and contact area for each facet joint were recorded at L2-L3 and L3-L4 before and after TDR at L3-L4 (ProDisc-L, Synthes Spine). The data were analysed with ANOVAs/t-tests.

Introduction

In degenerative lumbar spine, it seems possible that foraminal stenosis is over-diagnosed as axial scanning is not performed in the plane of the exiting nerve root. We carried out a two-part study to determine the true incidence of foraminal stenosis.

Patients and Methods

Initially we performed a retrospective analysis of radiology reports of conventional Magnetic Resonance Imaging in 100 cases of definite spinal stenosis to determine the incidence of reported ‘foraminal stenosis’. Subsiquently we performed a prospective study of MRI including fine slice T2 and T2 STIR coronal sequences in 100 patients with suspected stenosis. Three surgeons and one radiologist independently compared the diagnoses on conventional axial and sagittal sequences with the coronal scans.

Hypothesis

Lumbar spinal stenosis (LSS) is diagnosed by a history of claudication, clinical investigation, cross-sectional area (CSA) of the dural sac on MRI or CT, and walking distance on the treadmill test. As radiological findings do not always correlate with clinical symptoms, additional diagnostic signs are needed. In patients without LSS, we observe the sedimentation of lumbar nerve roots to the dorsal part of the dural sac on supine MRI scans. In patients with LSS, this sedimentation is rarely seen. We named this phenomenon ‘sedimentation sign’ and defined the absence of sedimenting nerve roots as positive sedimentation sign for the diagnosis of LSS. We hypothesised that the new sedimentation sign discriminates between non-specific low back pain (LBP) and LSS.

Methods and analysis

This prospective case-control study included 200 patients in an orthopaedic in- and outpatient clinic. Patients in the LBP group (n=100) had low back pain, a cross-sectional area (CSA) of the dural sac >120mm², and a walking distance >1000m; patients in the LSS group (n=100) showed claudication, a CSA < 80mm², and a walking distance < 200m.

Study Design

A prospective cohort study was carried out looking at the functional outcome and post-procedure translational segmental instability after multi-level lumbar decompression using a Hinge osteotomy technique.

Objective

The Hinge osteotomy technique involves unilateral subperiosteal muscle dissection with osteotomy of the base of the spinous processes thereby preserving the integrity of the posterior elements. The objective of this study was to demonstrate the results of this technique clinically and radiologically.

Introduction

Neurological involvement occurs in 10-30% cases of caries spine. Surgical debridement and stabilisation is needed to decompress the cord and prevent progression of deformity. This prospective study was undertaken to determine the efficacy of operative treatment in the management and neurological recovery in patients with caries spine with neural deficit.

Material & methods

20 patients, 14 male, 6 female, were included and followed up for 1 year after surgery. The mean age was 39.45 years. 10 patients had complete paraplegia and 9 patients had paraparesis. 1 patient with cervical involvement had quadriplegia. Anterior decompression and stabilisation was done in all the cases. Objective of surgery was adequate debridement of diseased foci, decompression of cord and stabilisation of spine with correction of deformity. In 19 (95%) patients there with thoraco-lumbar involvement. This was addressed with a titanium mesh cage filled with impacted bone graft and supplemented with 2 Moss Miami screws and a rod construct. In the cervical spine, cervical spine locking plate was used for stabilisation after decompression and bone grafting (tricortical iliac crest graft).

Introduction

Pedicle screw fixation is considered gold standard as it provides stable and adequate fixation of all the three columns of spine. Mal-placement of screws in dorso-lumbar region, using fluoroscopic control only, varies from 15% to 30 %. The aim of this study was to determine whether accuracy of pedicle screw placement can be improved using CT based navigation technique.

Material & methods

15 patients with fracture of D12 in 4 patients, L1 in 6 patients, L2 in 4 patients, and L4 in 1 patient underwent pedicle screw fixation using CT based navigation. Each fracture was fixed with 4 pedicle screws, 2 each in one level above and one level below the fractured vertebrae. A total of 60 pedicle screws was inserted. A pre-operative 1mm slice planning CT scan was taken from two levels above to two levels below the fractured vertebrae. It was loaded into the workstation and pre-operative planning was made of screw trajectory and screw size i.e. thickness and length, according to the dimensions of the pedicle and vertebral body. Screws were then inserted using opto-electronic navigation system. Screw placement was analysed in all patients using post-operative CT scan and graded according to the Laine's system.

Background

The transverse skin incision for anterior cervical spine surgery is not extensile, thus it must be made at the accurate level. The use of palpable bony landmarks is unreliable due to anatomical variations and pre-operative fluoroscopy to identify the level takes up operating room time, increases the radiation dose to the patient and increases the overall cost of the operation.

Objective

To describe a simple, fast and inexpensive method of accurate transverse skin incision placement for anterior cervical spine surgery and to report on its use in 54 consecutive adult patients.

Introduction

Sacro-coccygeal chordomas pose a difficult diagnostic and therapeutic problem due to late presentation, large size, soft-tisue extension, difficulties in obtaining adequate resection margins, higher local recurrence rate and uncertain effectiveness of adjuvant treatment. We present a series of 21 patients of sacral chordomas obtained from Scottish Bone Tumour Registry to analyse predictors of local control and survival.

Patients and methods

The clinical and morphologic features, type of treatment and follow-up of 21 consecutive patients with sacral chordoma were retrospectively reviewed and analysed.

Objective

To evaluate functional and oncological outcomes following sacral resection

Methods

A retrospective review was conducted of 97 sacral tumours referred to tertiary referral spinal or oncology unit between 2004 and 2009.

Background

The process of osteolysis is well studied both in vivo and in vitro. Although multiple pathways have been implicated in osteolytic change and animal models have been developed there are few human tissue studies. There are no extensive human tissue studies comparing osteoarthritic hips to well fixed and loose prostheses.

Methods

We have investigated 96 genes previously implicated in the osteolytic pathway. Genes were included based on previous implication in osteolysis in basic science studies. Candidates included cytokines, growth factors, apoptotic factors, matrix proteinases, interleukins, apoptotic proteins and macrophage activators.

Background

Despite aggressive debridement, thorough irrigation, administration of systemic antibiotics and staged treatment, many open fractures still become infected. A graft that can promote bone regeneration and prevent infection could decrease complications. Polyurethane (PUR) scaffolds have been previously shown in separate studies to be non-toxic, osteoconductive, can promote bone growth through BMP delivery and prevent infection by having sustained release of an antibiotic. This scaffold can deliver both BMP and vancomycin simultaneously; the purpose of this study is to determine if the co-delivery of the antibiotic inhibits bone formation.

Methods

Using an established critical size defect rat femur model, the amount of bone formation created by PUR scaffolds containing low and high doses of rhBMP-2 (2.4 μg and 22.4 μg respectively) and 0.8 mg vancomycin (8% of graft by weight) were compared to scaffolds that contained rhBMP-2 without antibiotics. After 4 weeks, the femurs were harvested and bone growth was assessed using microCT.

Background

Staphylococcus epidermidis is one of the main organisms associated with prosthetic joint infections. One of the major pathogenic attributes of this organism is the ability to form biofilms, making it extremely resistant to currently available antimicrobial therapies. There is, therefore, an urgent requirement for novel agents that are effective against this organism. Antimicrobial peptides represent a novel group of agents that show good activity towards biofilm-forming S. epidermidis. Antimicrobial peptides are particularly interesting due to their multiple modes of action which are thought to reduce the rate of resistance development to the agents.

Aim

The aim of the current study was to assess the effect of antimicrobial peptides gallidermin and novel peptide NI01 on the growth of reference and clinical isolates of S. epidermidis on polymethylmethacrylate (PMMA) cement following incorporation of the peptides.

Background

As the number of studies in the literature is increasing, orthopaedic surgeons rely heavily on meta-analyses as their primary source of scientific evidence. The objectives of this review were to assess the scientific quality and number of published meta-analyses on orthopaedic-related topics over time.

Methods

We conducted, in duplicate and independently, a systematic review of published meta-analyses in orthopaedics in the years 2005 and 2008 and compared them with a previous systematic review of meta-analyses from 1969-1999. A search of electronic databases (Medline, EMBASE, and the Cochrane Database of Systematic Reviews (CDSR)) was performed to identify meta-analyses published in 2005 and 2008. We searched bibliographies and contacted content experts to identify additional relevant studies. Two investigators used the Oxman and Guyatt Index to assess the quality of the studies and abstracted relevant data.

Objective

To evaluate the effect of claiming compensation on health status for people with mild to moderate injuries sustained in road traffic collisions (RTC).

Methods

The design was a prospective cohort study in the Australian Capital Territory (ACT), Australia and a fault based compensation system. The subjects were people with mild to moderate musculoskeletal injuries who presented to the emergency department within 7 days of an RTC. Outcome Measures were Physical Component Score (PCS) and Mental Component Score (MCS) of the Short Form 36 (SF-36) health status measure; Hospital Anxiety and Depression Scale (HADS); and the Functional Rating Index (FRI). These measures were recorded immediately RTC, and at 6 and 12 months.

Aim

Ultrahigh molecular weight polyethylene (UHMWPE) has been used for many years as a bearing surface in total joint replacement (TJR). However, late-state failure in TJR is predominantly caused by osteolysis mediated by wear particles. We tested our hypothesis that UHMWPE nanoparticles are important determinants in activating dendritic cells (DCs).

Methods

UHMWPE wear particles generated from a knee simulator were profiled using an atomic force microscopy and fractionated into six fractions: 0.05-0.2, 0.2-0.8, 0.8-1, 1-5, 5-10, and 10-20 micrometer. Effects of each fraction, a mixture of nano-sized fractions, and a mixture of all fractions on the activation of mice spleen DCs were determined using flow cytometry with specific antibodies of anti-CD11c-APC, anti-CD80-PE, anti-CD11b-PerCp, anti-CD86-Biotin and streptavidin-FITC. Supernatant from DCs treated with wear particles were assayed for IL-1beta, IL-6, IL-12/23, TNF-alpha and IFN-gamma. Activation of human osteoclasts (OCs) by wear particles were determined using TRAP stain.

Background

70% of breast cancer patients develop metastatic bone deposits, predominantly spinal metasases. Adult Mesenchymal Stem Cells (MSCs) are multiprogenitor stem cells found within the bone marow which have the ability to self-renew and differentiate into multiple cell types. MSCs home specifically to tumour sites, highlighting their potential as delivery vehicles for therapeutic agents. However studies show they may also increase tumour metastatic potential.

Aim

To investigate interactions between MSCs and breast cancer cells to further elucidate their role in the tumour microenvironment and hence understand factors involved in stimulating the formation of bone metastases.

Objective

High molecular weight hyaluronan (HA) is widely used in the treatment of osteoarthritis (OA) and rheumatoid arthritis (RA) by intra-articular injection. However, comparative studies of HA actions on catalytically activated cartilages in different pathologic conditions have rarely been investigated. Fibronectin fragments increased in OA and RA joints are known to cause cartilage damage through their catabolic activities. This study aimed to compare the inhibitory effects of HA on nitric oxide (NO) production by COOH-terminal heparin-binding fibronectin fragment (HBFN-f) between normal and diseased cartilages.

Methods

Articular cartilage explants from normal, OA, or RA joints or isolated chondrocytes in monolayer were incubated with HBFN-f in the presence or absence of HA. Secreted NO levels in conditioned media were determined. Induction of inducible nitric oxide synthase (iNOS) and activation of nuclear factor-?B (NF-?B) were assessed with immunoblotting. Cultures were pre-treated with the specific inhibitor to evaluate the role of NF-?B in HBFN-f action. Immunofluorescence histochemistry was performed using fluoresceinated anti-CD44 antibody.

Purpose

There has been recent interest in gender-specific arthroplasty implant design but little evidence to support their use. We hypothesised that outcomes among arthroplasty patients are affected by gender.

Methods

Patients were retrospectively identified from a prospective database of TJRs performed at one centre among six surgeons over a ten-year period (1998-2008). Demographics, pre-operative and 1-year clinical Knee Society (KSS), Harris Hip (HHS), and Oxford scores were collected. Gender differences were analysed using independent samples t-test and chi-square.

Background

Deciding how to allocate scarce surgical resources is a worldwide issue. These decisions are difficult when considering procedures aimed primarily at improving functional quality of life, such as lower extremity joint replacement (LEJR) surgery, and procedures perceived as life preserving which also have impacts on physical function, such as coronary artery bypass graft (CABG) surgery. Comparing functional outcomes of these two procedures may provide further evidence to guide resource allocation decisions.

Methods

We compared patient-reported functional outcomes following CABG and LEJR surgery using standardised, validated outcome metrics. A retrospective review of prospectively collected pre- and post-operative health related quality of life (SF-36) measures were conducted from 105 patients undergoing elective CABG and 105 elective LEJR surgery patients. Patients were matched based on gender and age.

Background

In October 2008, CMS instituted a new “No payment for preventable complications“ programme and has released a list of conditions for which it intends to expand the programme in 2009. Although not reimbursing for preventable complications is justifiable, some of the proposed target conditions are lacking in both adequate diagnostic testing accuracy and preventability.

Aims

This study examines the effects of imperfect sensitivity and specificity of diagnostic testing, the prevalence of condition, and the rate of surveillance on the ratio of numbers of DVT/PE diagnosed and those that actually occur.

Introduction

Reducing infection in total joint replacement by using ultra clean air and protective enclosed suits (space suits) has become the standard in many operating theatres without good supporting evidence. This study examined the impact of laminar flow and space suits on the rate of revision for early infection following total hip (THR) and knee (TKR) replacement.

Method

We used the 10-year results of the New Zealand Joint Registry to compare the rates of revision for early infection between laminar flow and conventional theatres both with and without the use of space suits. We separated hospitals and surgeons who had worked with and without space suits in both environments to exclude other confounding variables.

Background

Surgical quality improvement has received increasing attention in recent years, yet it isn't clear where orthopaedic surgeons should focus their efforts for the greatest impact on peri-operative safety and quality. We sought to guide these efforts by prioritising orthopaedic procedures according to their relative contribution to overall morbidity, mortality, and excess length of stay.

Methods

We used data from the American College of Surgeons' National Surgery Quality Improvement Program (ACS-NSQIP) to identify all patients undergoing an orthopaedic procedure between 2005 and 2007 (n=7,970). Patients were assigned to 44 unique procedure groups based on Current Procedural and Terminology codes. We first assessed the relative contribution of each procedure group to overall morbidity and mortality in the first 30 days, and followed with a description of their relative contribution to excess length of stay.

Background

There has been widespread interest in medical errors since the publication of ‘To Err is Human’ by the Institute of Medicine in 1999. The Patient Safety Committee of the American Academy of Orthopaedic Surgeons has compiled results of a member survey to identify trends in orthopaedic errors that would help direct quality assurance efforts.

Methods

Surveys were sent to 5,540 Academy fellows; 917 were returned (response rate 16.6%) with 53% (483/917) reporting an observed medical error in the last 6 months.