Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients

T. W. Axelrad; B. Steen; D. W. Lowenberg; W. R. Creevy; T. A. Einhorn

doi:10.1302/0301-620X.90B12.20975

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Trauma

Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients

T. W. Axelrad
B. Steen
D. W. Lowenberg
W. R. Creevy
T. A. Einhorn

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Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients

Axelrad TW, Steen B, Lowenberg DW, Creevy WR, Einhorn TA. Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients. J Bone Joint Surg Br. 2008;90-B(12):1617-1622. doi:10.1302/0301-620X.90B12.20975

Axelrad, T. W., et al. “Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients.” The Journal of Bone & Joint Surgery British Volume, vol. 90-B, no. 12, 2008, pp. 1617-1622., https://doi.org/10.1302/0301-620X.90B12.20975

Axelrad, T. W., Steen, B., Lowenberg, D. W., Creevy, W. R., & Einhorn, T. A. (2008). Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients. The Journal of Bone & Joint Surgery British Volume, 90-B(12), 1617-1622. https://doi.org/10.1302/0301-620X.90B12.20975

Axelrad, T. W., Steen, B., Lowenberg, D. W., Creevy, W. R. and Einhorn, T. A. (2008) “Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients.” The Journal of Bone & Joint Surgery British Volume, 90-B(12), pp. 1617-1622. Available at: https://doi.org/10.1302/0301-620X.90B12.20975

Axelrad, T. W., B. Steen, D. W. Lowenberg, W. R. Creevy, and T. A. Einhorn. “Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients.” The Journal of Bone & Joint Surgery British Volume 90-B, no. 12 (2008): 1617-1622. https://doi.org/10.1302/0301-620X.90B12.20975

Axelrad TW, Steen B, Lowenberg DW, Creevy WR, Einhorn TA. Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients. J Bone Joint Surg Br. 2008 Dec 1;90-B(12):1617-1622. https://doi.org/10.1302/0301-620X.90B12.20975

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Abstract

Heterotopic ossification occurring after the use of commercially available bone morphogenetic proteins has not been widely reported. We describe four cases of heterotopic ossification in patients treated with either recombinant bone morphogenetic protein 2 or recombinant bone morphogenetic protein 7. We found that while some patients were asymptomatic, heterotopic ossification which had occurred around a joint often required operative excision with good results.

Correspondence should be sent to Professor T. A. Einhorn; e-mail: Thomas.Einhorn@bmc.org

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Journal

The Journal of Bone & Joint Surgery British Volume

Volume

90-B No.12 | Pages 1617 - 1622

Section

Trauma

Published

01 December 2008

DOI

Authors

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T. W. Axelrad

Resident Orthopaedic Surgeon

Boston University Medical Center, 850 Harrison Avenue, Dowling 2 North, Boston, Massachusetts 02118, USA.

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B. Steen

Resident Orthopaedic Surgeon

Boston University Medical Center, 850 Harrison Avenue, Dowling 2 North, Boston, Massachusetts 02118, USA.

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D. W. Lowenberg

Professor

Department of Orthopaedic Surgery, California Pacific Medical Center, 2100 Webster Street Suite 117, San Francisco 94115, USA.

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W. R. Creevy

Professor

Boston University Medical Center, 850 Harrison Avenue, Dowling 2 North, Boston, Massachusetts 02118, USA.

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T. A. Einhorn

Professor

Department of Orthopaedic Surgery, Boston University Medical Center, Doctors Office Building, Suite 808, 720 Harrison Avenue, Boston, Massachusetts 02118, USA.

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