Abstract
1. Experiments have been carried out in lambs to determine the source of nutrition of the joint cartilage of an immature animal. A wedge of bone with its overlying cartilage was removed from the knee joint and then replaced in its original position, so that the bone was infarcted but the cartilage remained in normal relationship with the joint.
2. In these circumstances degeneration of the cartilage occurred and proliferation ceased until revascularisation of the bone was established.
3. It is therefore concluded that growing cartilage derives a significant part of its nutrition from the underlying bone. The possibility that it also receives a contribution from synovial fluid has not been excluded.
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