A classification of a group of malformations of the extremities is given and an underlying common pattern is developed from a survey of 693 deformed limbs. It is characterised by a certain reduction tendency of the affected bones and the malformed extremity, an axis of malformation and an interdependence between the proximal and peripheral parts of the deformed limbs. The group, called dysmelia, has a common morphology, but morphologically identical types have been seen caused by thalidomide and as hereditary or sporadic cases. An attempt has been made not only to name and classify these deformities but also to clarify the underlying principles of their morphology. This will enable the teratologist to see the pattern of these malformations in comparison with that of normal development of the limbs and of experimentally induced limb defects.

1. A group of children with congenital malformations of the lower back involving the spinal cord or nerve roots is described. The malformations have little or no resemblance to spinal rachischisis, either embryologically or clinically. The lesions found are often complex.

2. It is considered from clinical and operative findings that the malformations are, in many patients, responsible for increasing neural damage in childhood and even in later life.

3. Early investigation and operative treatment are recommended.

1. A relatively simple method of occipito-cervical fusion using autogenous bone chips without internal fixation is described.

2. In patients with atlanto-axial subluxation posterior fusion from the occiput to the axis rather than from the atlas to the axis is more reliable and is preferred. Inclusion of the occiput adds no more than a few degrees to the restriction of movement that follows C. 1-2 fusion.

3. The indications for occipito-cervical fusion are discussed, particularly in relation to C. 1-2 instability in rheumatoid arthritis.

1. A parallel study has been made of fifty patients presenting with a sternomastoid tumour and fifty-two patients presenting with muscular torticollis.

2. In the birth histories of both these groups there was a high incidence of breech, forceps and primiparous births. The distribution of each was strikingly similar.

3. Sternomastoid tumours were right-sided in three-quarters of all cases and in an even higher proportion of the breech births. There was twice the expected incidence of plagiocephaly. Only one in seven proceeded to muscular torticollis, but in some of the remainder minor residua could be detected.

4. Muscular torticollis presented at any age, but one-third commenced in the first year of life. Only one in five gave a history of previous sternomastoid tumour. The contracture showed a predilection for the clavicular head, and was generally associated with some degree of facial asymmetry.

5. Nine of a combined 102 cases had a first or second degree similarly affected relative.

6. It is concluded that whatever the condition in the muscle at birth, it has three inconstant and variable sequelae. The torticollis may resolve completely; it may become clinically manifest as a tumour; or it may remain clinically latent, subsequently undergoing a variable degree of cicatrisation to produce torticollis.

7. The treatment of established torticollis by open division is described and the follow-up in thirty-six cases recorded.

8. This operation can be relied on to cure the principal deformity, but is accompanied by a number of minor cosmetic defects. Of these the most striking are tight bands apparently due to anomalous reattachment of the clavicular head, and loss of the sternomastoid column of the neck.

9. The method could not be relied on to cure facial asymmetry completely, even in the early years of life. However, there was some evidence to suggest that persistence of asymmetry was allied to persistence of other residua of the torticollis, for example fascial bands.

1. The orthopaedic features of 100 patients with the Ehlers-Danlos syndrome are described.

2. The significance of these findings is discussed and comment is made of their relationship to the other stigmata of the syndrome.

1. In chronic osteomyelitis grafting a cavity with split skin is a reliable method of treatment. The skin cover so obtained is durable.

2. The method may be used with good prospects of success even when the cavity is large and there is extensive disease of bone.

3. Operation is indicated for the relief of pain, to close a sinus or sinuses, to obtain healing of an ulcer or to prevent recurrent episodes of acute infection.

4. The technique of operation employed in eleven cases is described and illustrative case reports are given.

1. Sixty-seven patients with subacute haematogenous osteomyelitis are reported.

2. The benign nature of the disease is noted.

3. The clinical types of infection are reported, with regard to the site of the lesion.

4. The treatment is described.

1. Three cases of osteomyelitis of a metatarsal sesamoid bone are described.

2. The diagnosis should be considered in patients with acute pain under the first metatarsophalangeal joint, particularly if the temperature is elevated.

3. Failure ofdiagnosis may lead to persistent disability until sinus formation and sequestration dictate operative intervention.

4. Early antibiotic therapy may lead to resolution of the infection.

1. A case of compression of the deep branch of the ulnar nerve is described.

2. Anatomical evidence is presented that the reason for the special liability of the deep branch to be compressed by ganglia in this region is its relationship to a ligamentous band which passes from the pisiform bone to the hamate superficial to the deep branch of the ulnar nerve.

3. This band, though constant, has not been well recognised.

1. A case of bilateral extensordigitorum brevismanuscausingsymptomsisdescribed. A review of the literature has revealed fourteen previous cases in which the anomaly was recognised.

2. The phylogenetic and morphological significance of this atavistic structure is considered.

3. Observations are made on the clinical features of the condition. It usually presents in a young male manual worker who complains of pain and swelling on the dorsum of the hand after heavy work. There is a visible swelling with the physical characteristics of a small fleshy extensor muscle.

4. Various methods of treatment are discussed. If the symptoms warrant operation total ablation of the muscle is suggested.

1. Locking of the metacarpo-phalangeal joint from articular derangements is rare.

2. A case due to an intra-articular loose body is described.

3. The literature is reviewed. The commonest cause is catching of the volar capsule or collateral ligaments on osteophytes about the metacarpal head, but intra-articular bands, incongruities of the articular surface and entrapment of the sesamoid have also been described.

4. An analysis of the reported cases suggests the likely cause in the individual patient.

5. Operation is usually required to restore joint motion.

1. All traceable Syme amputees attending the Edinburgh limb centre have been seen and reviewed. They number sixty-seven. Forty had amputations twenty-five or more years before.

2. There are seventy-one surviving stumps. One has failed.

3. Records of all the below-knee amputees reveal five further failures of Syme stumps. The causes of failure are discussed.

4. Problems in the Syme stump are rare after the first year. The early difficulties are discussed.

5. We conclude that a patient with Syme's amputation can expect his stump to give a lifetime of service.

1. One hundred cases of arthrodesis of first metatarso-phalangeal joint have been reviewed after a post-operative interval of at least ten years.

2. Seventy-seven per cent of patients were completely satisfied with the late results ; only 9 per cent were dissatisfied.

3. The two major factors leading to poor results were found to be malposition of the arthrodesis, and interphalangeal osteoarthritis.

4. The ideal position for fusion is considered to be in at least 20 degrees of valgus, preferably between 20 and 30 degrees ; between 20 and 40 degrees of dorsiflexion ; and most importantly, neutral rotation.

5. The precise operative technique is not important provided it maintains the position obtained at operation until the arthrodesis is sound.

1. The literature on fractures of the postero-superior aspect of the calcaneus is reviewed.

2. The mechanical distinction between "beak" fractures and avulsion fractures is questioned, and the dangers of a purely radiological diagnosis are stressed.

3. When a complete avulsion is suspected on clinical grounds, open reduction should be done.

1. A case of disruption of patellar ligament is described.

2. An association with previous steroid infiltration is present in this case.

1. A case of traumatic aneurysm of the descending genicular artery complicating elective operation on the knee joint is reported.

2. The aneurysm was mainly intra-articular, presenting as a pulsating haemarthrosis soon after operation.

3. The pathogenesis, symptomatology, diagnosis and management are briefly discussed.

A case of injury of the axillary artery complicating a closed fracture of the neck of the humerus in a woman of eighty-six is reported. Spasm was not relieved despite repeated instillation of papaverine. Gangrene developed and amputation above the elbow was required.

1. Four cases of osteomalacia secondary to vitamin D deficiency have been investigated histologically and with the electron microscope.

2. Three main types of cells were found along the osteoid tissue. Cells of Group 1 are like normal osteoblasts, except that their cytoplasm has an ordered granular endoplasmic reticulum, without enlarged cysternae. Moreover, it contains isolated rosettes of glycogen. Cells of Group 2 are like young progenitor cells. There are almost no rough cysternae in the cytoplasm. This contains clusters of glycogen, isolated ribosomes and many mitochondria. Cells of Group 3 are structurally like "resting" flat osteoblasts in normal bone.

3. The paper discusses how the presence of the three groups may be related to vitamin D deficiency or secondary hyperparathyroidism.

4. Malacic osteoid tissue consists of apparently normal collagen fibrils. Both optical and electron microscopy show that this tissue can calcify. But calcification stops at an early stage, or proceeds much more slowly than normal. So large areas ofosteoid tissue are left uncalcified.

5. Calcium salts are laid down either as needle-shaped crystals exactly like those in normal bone, or else abnormally. Where abnormal they either appear in a finely granular, almost amorphous form, or else acquire a characteristic star-like crystalline structure.

6. Where calcification takes place bundles of laterally aggregated collagen fibrils are found.

1. The surface of mature adult human articular cartilage from the knee has been studied by electron microscopy in eleven patients ranging in age from thirty-seven to eighty-three years. The ultrastructural appearance varies from person to person and often from area to area in the same specimen. These variations range from an intact surface to one showing overt fibrillation visible with the light microscope.

2. In areas where the articular surface appears intact the underlying superficial matrix consists of closely packed collagen fibres with only a small amount of interfibrillary ground substance. The collagen fibres show a predominantly tangential orientation in this region of the cartilage. Osmophilic lipidic bodies are sometimes seen in the matrix very close to the joint surface.

3. The appearances under the electron microscope are altered in what is interpreted as an early ultrastructural change in the development of cartilage fibrillation. In the affected areas the collagen fibres show abnormally wide separation by an excessive amount of interfibrillary matrix. Collagen fibres become directly exposed to the joint cavity, and the surface can also show accumulations of finely granular material and sometimes tuft-like projections containing collagen fibres and fine fibrils. At a slightly later stage shallow clefts and steeply sloping curves are apparent at the surface. It is suggested that these various alterations precede the development of overt fibrillation visible under the light microscope.

4. Electron micrographs occasionally show small "blisters" at the articular surface. Electron microscopy has not given evidence of shedding of cells into the joint cavity from non-fibrillated areas of adult human articular cartilage. Cells can, however, sometimes become exposed at the surface in fibrillated areas.

1. The structure ofthe cancellous bone ofthe third lumbarvertebral body from a twenty-year-old woman who died from head injuries was studied, using serial section reconstruction techniques.

2. In addition to the construction of enlarged models from different regions of the vertebral body, measurements were made of the bone area, the surface area, and the thickness and spacing of the bony structures.

3. The vertebral spongiosa consists of a complex network of bony plates perforated by rounded openings of varying size. The plates show preferential orientation in the vertical and horizontal planes, and the amount of bone is greatest towards the upper and lower surfaces of the vertebral body.

4. The mechanical significance of the structure of the vertebral spongiosa is discussed.

1. In two-month-old rabbits the femoral heads were made necrotic by transecting the ligament of the femoral head and applying a ligature around the femoral neck. The animals were killed at different periods, from six hours to twenty-one weeks after the operation. The changes in the femoral heads were studied histologically, microradiographically and radiographically.

2. In the first three weeks the necrotic bone marrow was penetrated by granulation tissue in which cellular differentiation gradually developed. Subsequently large quantities of new bone were deposited on the dead trabeculae. This led to an increase in the bone volume at the expense of the marrow volume; this increase coincided with an increase in the radiographic density (sclerosis) of the femoral head. The new bone tissue was attached to the necrotic trabeculae by a specific cement line and showed the features of woven bone. At a later stage lamellar bone was deposited. From six weeks on a normal bone-marrow ratio was gradually restored with concomitant radiographic loss of sclerosis.

3. It is suggested that mechanical weakening of the femoral head is the consequence of this late post-operative restoration of the normal pre-operative bone-to-marrow ratio, the new bone trabeculae being mechanically inferior because of the presence of woven bone and cement lines. This weakness may initiate collapse and deformation of the revascularised femoral head.

We are grateful to Dr Robert A. Goldstone of Paterson, New Jersey, for pointing out an error in the article by M. R. Colwill and R. H. Maudsley on "The Management of Gas Gangrene with Hyperbaric Oxygen Therapy" in this Journal of November 1968, 50-B, 732. On page 742, the second line should read "They recommend the use of/ow molecular weight dextran (dextran 40, Rheomacrodex) to prevent the sludging and thrombosis that also occur . . ." The correction is important because high molecular weight dextran (dextran 70, Macrodex) would not be expected to have the desired effect.