header advert
Results 1 - 2 of 2
Results per page:
The Bone & Joint Journal
Vol. 103-B, Issue 3 | Pages 522 - 529
1 Mar 2021
Nichol T Callaghan J Townsend R Stockley I Hatton PV Le Maitre C Smith TJ Akid R


The aim of this study was to develop a single-layer hybrid organic-inorganic sol-gel coating that is capable of a controlled antibiotic release for cementless hydroxyapatite (HA)-coated titanium orthopaedic prostheses.


Coatings containing gentamicin at a concentration of 1.25% weight/volume (wt/vol), similar to that found in commercially available antibiotic-loaded bone cement, were prepared and tested in the laboratory for: kinetics of antibiotic release; activity against planktonic and biofilm bacterial cultures; biocompatibility with cultured mammalian cells; and physical bonding to the material (n = 3 in all tests). The sol-gel coatings and controls were then tested in vivo in a small animal healing model (four materials tested; n = 6 per material), and applied to the surface of commercially pure HA-coated titanium rods.

The Journal of Bone & Joint Surgery British Volume
Vol. 72-B, Issue 6 | Pages 1008 - 1009
1 Nov 1990
Callaghan J Dysart S Savory C Hopkinson W

One hundred hips in patients who had had primary uncemented replacements were followed up for one or two years, and assessed by five different methods. All produced different results. The Hospital for Special Surgery rating produced the most optimistic assessment and the Merle d'Aubigne rating the most pessimistic. The functional class of the patients, as defined by Charnley in 1979, significantly affected the ratings, and these should clearly be included in all rating systems. Moreover, if systems are to be compared, they should all use descriptive words, such as limp or pain, in precisely the same way.