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Bone & Joint Research
Vol. 12, Issue 9 | Pages 580 - 589
20 Sep 2023
Global and local fat effects on bone mass and quality in obesity
Dai X Liu B Hou Q Dai Q Wang D Xie B Sun Y Wang B
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Aims

The aim of this study was to investigate the global and local impact of fat on bone in obesity by using the diet-induced obese (DIO) mouse model.

Methods

In this study, we generated a diet-induced mouse model of obesity to conduct lipidomic and 3D imaging assessments of bone marrow fat, and evaluated the correlated bone adaptation indices and bone mechanical properties.

Bone & Joint Research
Vol. 11, Issue 4 | Pages 251 - 251
30 Apr 2022
Corrigenda
Wang X Wang D Xia P Cheng K Wang Q Wang X Lin Q Song J Chen A Li X
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Bone & Joint Research
Vol. 10, Issue 10 | Pages 693 - 703
1 Oct 2021
Ultrasound-targeted simvastatin-loaded microbubble destruction promotes OA cartilage repair by modulating the cholesterol efflux pathway mediated by PPARγ in rabbits
Wang X Wang D Xia P Cheng K Wang Q Wang X Lin Q Song J Chen A Li X
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Aims

To evaluate the effect of ultrasound-targeted simvastatin-loaded microbubble destruction (UTMDSV) for alleviation of the progression of osteoarthritis (OA) in rabbits through modulation of the peroxisome proliferator-activated receptor (PPARγ).

Methods

In vitro, OA chondrocytes were treated with ultrasound (US), US-targeted microbubble destruction (UTMD), simvastatin (SV), and UTMDSV on alternate days for four weeks. Chondrocytes were also treated with PPARγ inhibitor, PPARγ inhibitor+ UTMDSV, and UTMDSV. The cholesterol efflux rate and triglyceride levels were measured using an assay kit and oil red O staining, respectively. In vivo, the OA rabbits were treated with a single intra-articular injection of UTMD, SV, and UTMDSV every seven days for four weeks. Cartilage histopathology was assessed by safranin-O staining and the Mankin score. Total cholesterol (TC) and high-density lipoprotein-cholesterol (HDL-C) in rabbit knee synovial fluid were detected by enzyme-marker assay. Aggrecan, collagen II, and PPARγ expression levels were analyzed by Western blotting (WB).